Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus.

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Published in Infect Immun on October 01, 1996

Authors

C D'Enfert1, M Diaquin, A Delit, N Wuscher, J P Debeaupuis, M Huerre, J P Latge

Author Affiliations

1: Laboratoire des Aspergillus and Unité d'Histopathologie, Institut Pasteur, Paris, France. denfert@pasteur.fr

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Production of mycophenolic acid by Penicillium roqueforti strains. Appl Environ Microbiol (1979) 0.95

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Antigenic variation of Borrelia turicatae Vsp surface lipoproteins occurs in vitro and generates novel serotypes. Res Microbiol (2000) 0.87

[Cutaneous Alternaria infectoria infection after liver transplantation]. Ann Pathol (1998) 0.87

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[New toxins from Aspergillus fumigatus Fresenius]. C R Acad Sci Hebd Seances Acad Sci D (1978) 0.86

[Photodensitometric determination of "PR-toxin", metabolite of Penicillium roqueforti (author's transl)]. J Chromatogr (1980) 0.86

Control of Candida albicans vaginitis in mice by short-duration butoconazole treatment in situ. Mycoses (1994) 0.86

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Capacity of mouse mast cells to prime T cells and to induce specific antibody responses in vivo. Immunology (2001) 0.81

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