Published in Thorax on June 17, 2008
Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med (2012) 2.32
Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med (2013) 2.17
Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care (2008) 1.94
Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS One (2009) 1.93
Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med (2012) 1.81
Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Blood (2012) 1.58
The temporal kinetics of circulating angiopoietin levels in children with sepsis. Pediatr Crit Care Med (2014) 1.50
Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target? Crit Care (2009) 1.45
Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis. Crit Care (2009) 1.41
Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med (2010) 1.32
The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care (2011) 1.25
Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin (2011) 1.23
Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit Care (2010) 1.23
Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality. Intensive Care Med (2009) 1.16
Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS. Intensive Care Med (2009) 1.07
Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome. Intensive Care Med (2016) 1.06
Clinical utility of biomarkers of endothelial activation in sepsis--a systematic review. Crit Care (2012) 1.04
Biomarkers in acute lung injury--marking forward progress. Crit Care Clin (2011) 0.95
Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS. Virulence (2013) 0.95
A genetic variant of hypoxia-inducible factor-1alpha is associated with adverse outcomes in acute kidney injury. Kidney Int (2009) 0.93
Clinical and biological heterogeneity in acute respiratory distress syndrome: direct versus indirect lung injury. Clin Chest Med (2014) 0.91
Imbalances in serum angiopoietin concentrations are early predictors of septic shock development in patients with post chemotherapy febrile neutropenia. BMC Infect Dis (2010) 0.90
Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells. PLoS One (2011) 0.89
Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis. Am J Physiol Heart Circ Physiol (2012) 0.88
Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury. Am J Respir Cell Mol Biol (2012) 0.87
Ratio of angiopoietin-2 to angiopoietin-1 predicts mortality in acute lung injury induced by paraquat. Med Sci Monit (2013) 0.86
Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass. Cytokine (2012) 0.86
Angiopoietin-2 and outcome in patients with acute decompensated heart failure. Clin Res Cardiol (2014) 0.85
The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation. Tissue Barriers (2015) 0.85
Novel interventional approaches for ALI/ARDS: cell-based gene therapy. Mediators Inflamm (2011) 0.84
TNF-receptor inhibitor therapy for the treatment of children with idiopathic pneumonia syndrome. A joint Pediatric Blood and Marrow Transplant Consortium and Children's Oncology Group Study (ASCT0521). Biol Blood Marrow Transplant (2014) 0.83
Serum vascular endothelial growth factor and angiopoietin-2 are associated with the severity of systemic inflammation rather than the presence of hemoptysis in patients with inflammatory lung disease. Yonsei Med J (2012) 0.83
Angiogenic factors and their soluble receptors predict organ dysfunction and mortality in post-cardiac arrest syndrome. Crit Care (2012) 0.82
Role of angiopoietin/tie2 in critical illness: promising biomarker, disease mediator, and therapeutic target? Scientifica (Cairo) (2012) 0.81
Neutrophil-endothelial interactions mediate angiopoietin-2-associated pulmonary endothelial cell dysfunction in indirect acute lung injury in mice. Am J Respir Cell Mol Biol (2014) 0.81
Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit? Crit Care (2009) 0.80
Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis. PLoS One (2012) 0.80
Prognostic factors in the acute respiratory distress syndrome. Clin Transl Med (2015) 0.80
Serum angiopoietin is associated with lung function in patients with asthma: a retrospective cohort study. BMC Pulm Med (2014) 0.79
Using angiogenic factors and their soluble receptors to predict organ dysfunction in patients with disseminated intravascular coagulation associated with severe trauma. Crit Care (2012) 0.79
Approach to the patient with the acute respiratory distress syndrome. Clin Chest Med (2014) 0.78
Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation. Curr Opin Organ Transplant (2015) 0.78
Endothelial permeability following coronary artery bypass grafting: an observational study on the possible role of angiopoietin imbalance. Crit Care (2016) 0.77
von Willebrand factor and angiopoietin-2: toward an acute lung injury endothelial endophenotype? Crit Care Med (2012) 0.77
Potential Agents against Plasma Leakage. ISRN Pharmacol (2011) 0.77
Recombinant human activated protein C in the treatment of acute respiratory distress syndrome: a randomized clinical trial. PLoS One (2014) 0.77
A plethora of angiopoietin-2 effects during clinical sepsis. Crit Care (2010) 0.75
Plasma Biomarker Analysis in Pediatric ARDS: Generating Future Framework from a Pilot Randomized Control Trial of Methylprednisolone: A Framework for Identifying Plasma Biomarkers Related to Clinical Outcomes in Pediatric ARDS. Front Pediatr (2016) 0.75
Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Elevated in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome. PLoS One (2016) 0.75
Early changes of plasma angiopoietin-2 in patients with multiple trauma. World J Emerg Med (2011) 0.75
Angiopoietin-2 Levels as Predictors of Outcome in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome. Dis Markers (2017) 0.75
Early Prediction of Persistent Organ Failure by Serum Angiopoietin-2 in Patients with Acute Pancreatitis. Dig Dis Sci (2016) 0.75
Management of invasive pulmonary aspergillosis in non-neutropenic critically ill patients. Intensive Care Med (2007) 2.19
Fibrin structure and wound healing. J Thromb Haemost (2006) 2.07
Natural killer cells and CD4+ T-cells modulate collateral artery development. Arterioscler Thromb Vasc Biol (2007) 1.94
Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor alpha, interleukin 1 and phorbol ester. Biochem J (1993) 1.83
Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil. Eur Respir J (2010) 1.63
Role of fibrin matrix in angiogenesis. Ann N Y Acad Sci (2001) 1.51
Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis-related characteristics in vitro. J Thromb Haemost (2008) 1.49
Perivenous application of fibrin glue reduces early injury to the human saphenous vein graft wall in an ex vivo model. Eur J Cardiothorac Surg (2002) 1.48
Endothelial insulin receptor expression in human atherosclerotic plaques: linking micro- and macrovascular disease in diabetes? Atherosclerosis (2012) 1.41
Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells. Adv Dent Res (1998) 1.39
Involvement of Rho kinase in endothelial barrier maintenance. Arterioscler Thromb Vasc Biol (2007) 1.37
Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells. J Biol Chem (1998) 1.35
Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients. Arterioscler Thromb Vasc Biol (2002) 1.26
Transport of trehalose in Salmonella typhimurium. J Bacteriol (1986) 1.23
Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulation. Ann Vasc Surg (2008) 1.19
Unfractionated and low molecular weight heparin affect fibrin structure and angiogenesis in vitro. Cancer Res (2000) 1.18
A novel and simple immunocapture assay for determination of gelatinase-B (MMP-9) activities in biological fluids: saliva from patients with Sjögren's syndrome contain increased latent and active gelatinase-B levels. Matrix Biol (1998) 1.12
Role and localization of urokinase receptor in the formation of new microvascular structures in fibrin matrices. Am J Pathol (1999) 1.08
Dexamethasone decreases the pro- to anti-inflammatory cytokine ratio during cardiac surgery. Br J Anaesth (2002) 1.07
Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA/Rho kinase-myosin phosphatase axis. Am J Physiol Cell Physiol (2008) 1.06
Angiogenesis and anti-angiogenesis: perspectives for the treatment of solid tumors. Ann Oncol (1999) 1.06
Systematic review of uncalibrated arterial pressure waveform analysis to determine cardiac output and stroke volume variation. Br J Anaesth (2014) 1.05
Influence of fibrin structure on the formation and maintenance of capillary-like tubules by human microvascular endothelial cells. Angiogenesis (1998) 1.03
Potential role of platelets in endothelial damage observed during treatment with cisplatin, gemcitabine, and the angiogenesis inhibitor SU5416. J Clin Oncol (2003) 1.02
Impact of diabetes duration and cardiovascular risk factors on mortality in type 2 diabetes: the Hoorn Study. Eur J Clin Invest (2002) 1.01
Human platelet lysate as a fetal bovine serum substitute improves human adipose-derived stromal cell culture for future cardiac repair applications. Cell Tissue Res (2012) 0.97
Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus. Biochem Soc Trans (2003) 0.96
CD133+ circulating haematopoietic progenitor cells predict for response to sorafenib plus erlotinib in non-small cell lung cancer patients. Br J Cancer (2009) 0.96
Mannan binding lectin in febrile adults: no correlation with microbial infection and complement activation. J Clin Pathol (2003) 0.95
Amadori-albumin correlates with microvascular complications and precedes nephropathy in type 1 diabetic patients. Eur J Clin Invest (2002) 0.94
Molecular mechanisms of acute renal failure following ischemia/reperfusion. Int J Artif Organs (2004) 0.94
Urokinase receptor expression on human microvascular endothelial cells is increased by hypoxia: implications for capillary-like tube formation in a fibrin matrix. Blood (2000) 0.94
Could recombinant insulin compounds contribute to adenocarcinoma progression by stimulating local angiogenesis? Diabetologia (2010) 0.93
Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions. Hum Reprod (2008) 0.92
Effect of fluid loading with saline or colloids on pulmonary permeability, oedema and lung injury score after cardiac and major vascular surgery. Br J Anaesth (2005) 0.92
Hypoxia in combination with FGF-2 induces tube formation by human microvascular endothelial cells in a fibrin matrix: involvement of at least two signal transduction pathways. J Cell Sci (2001) 0.92
Pulmonary abnormalities after cardiac surgery are better explained by atelectasis than by increased permeability oedema. Acta Anaesthesiol Scand (2005) 0.92
Why is soluble intercellular adhesion molecule-1 related to cardiovascular mortality? Eur J Clin Invest (2002) 0.91
Acute necrotizing pancreatitis following inadvertent extensive splenic artery embolisation for trauma. Br J Radiol (2009) 0.90
Molecular weight fibrinogen variants determine angiogenesis rate in a fibrin matrix in vitro and in vivo. J Thromb Haemost (2006) 0.89
Is pulmonary edema associated with a high extravascular thermal volume? Crit Care Med (2004) 0.88
N(epsilon)-(carboxymethyl)lysine depositions in intramyocardial blood vessels in human and rat acute myocardial infarction: a predictor or reflection of infarction? Arterioscler Thromb Vasc Biol (2006) 0.87
HARP induces angiogenesis in vivo and in vitro: implication of N or C terminal peptides. Biochem Biophys Res Commun (2001) 0.87
The role of procalcitonin in a decision tree for prediction of bloodstream infection in febrile patients. Clin Microbiol Infect (2006) 0.86
Accelerated atherosclerosis and calcification in vein grafts: a study in APOE*3 Leiden transgenic mice. Circ Res (2002) 0.84
Angiotensin converting enzyme inhibiting therapy is associated with lower vitreous vascular endothelial growth factor concentrations in patients with proliferative diabetic retinopathy. Diabetologia (2002) 0.84
Regulation of plasminogen activator production by endothelial cells: role in fibrinolysis and local proteolysis. Int J Radiat Biol (1991) 0.83
Possible role of imatinib in clinical pulmonary veno-occlusive disease. Eur Respir J (2008) 0.83
Clinical implications of heart-lung interactions. Neth J Med (2010) 0.82
Molecular weight fibrinogen variants alter gene expression and functional characteristics of human endothelial cells. J Thromb Haemost (2010) 0.82
Impact of apolipoprotein(a) on in vitro angiogenesis. Arterioscler Thromb Vasc Biol (2001) 0.82
Basic concepts of fluid responsiveness. Neth Heart J (2013) 0.81
Genistein reduces tumor necrosis factor alpha-induced plasminogen activator inhibitor-1 transcription but not urokinase expression in human endothelial cells. Blood (1994) 0.81
Inhibition of accelerated atherosclerosis in vein grafts by placement of external stent in apoE*3-Leiden transgenic mice. Arterioscler Thromb Vasc Biol (2002) 0.80
Effect of sevoflurane on the ex vivo secretion of TNF-alpha during and after coronary artery bypass surgery. Eur J Anaesthesiol (2003) 0.80
Cardiopulmonary interactions during mechanical ventilation in critically ill patients. Neth Heart J (2013) 0.80
An update on acute kidney injury after cardiac surgery. Acta Clin Belg Suppl (2007) 0.80
Assessing effects of PEEP and global expiratory lung volume on regional electrical impedance tomography. J Med Eng Technol (2009) 0.80
Inhibition of angiogenesis by blockers of volume-regulated anion channels. Gen Pharmacol (2000) 0.79
Pulmonary embolism causes endomyocarditis in the human heart. Heart (2007) 0.79
Role of fibrin and plasminogen activators in repair-associated angiogenesis: in vitro studies with human endothelial cells. EXS (1997) 0.79
C57BL/6 NK cell gene complex is crucially involved in vascular remodeling. J Mol Cell Cardiol (2013) 0.78
Improvement of glycaemic control in type 2 diabetes: favourable changes in blood pressure, total cholesterol and triglycerides, but not in HDL cholesterol, fibrinogen, Von Willebrand factor and (pro)insulin. Neth J Med (2003) 0.78
Unusual association of Hodgkin's disease and sarcoidosis. Neth J Med (2002) 0.78
The role of inducible nitric oxide synthase in lipopolysaccharide-mediated hyporeactivity to vasoconstrictors differs among isolated rat arteries. Clin Sci (Lond) (2002) 0.77
Vascular endothelial growth factor enhances the expression of urokinase receptor in human endothelial cells via protein kinase C activation. Thromb Haemost (2001) 0.77
Steroids and cytokines in endometrial angiogenesis. Anticancer Res (2002) 0.77
Aberrant fibrin formation and cross-linking of fibrinogen Nieuwegein, a variant with a shortened Aalpha-chain, alters endothelial capillary tube formation. Blood (2001) 0.77
Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 : Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine. Intensive Care Med (2017) 0.77
Angiogenic growth factors and their receptors in first-trimester human decidua of pregnancies further complicated by preeclampsia or fetal growth restriction. Reprod Sci (2008) 0.76
Long-term outcome after 60 days of intensive care. Anaesthesia (2005) 0.75
Do we need alternatives for bicarbonate and anion gap? Minerva Anestesiol (2013) 0.75
Use of synthetic colloids in sepsis: a critical review on efficacy, safety and patient benefits. Minerva Anestesiol (2011) 0.75
An isotype-specific spot-ELISA for the enumeration of antibody-secreting hybridomas and the determination of isotype switch variants. J Immunol Methods (1991) 0.75
A review of the hemodynamic effects of external leg and lower body compression. Minerva Anestesiol (2013) 0.75
Effect of prior statin therapy on capillary permeability in the lungs after cardiac or vascular surgery. Eur Respir J (2006) 0.75
[Acute respiratory distress syndrome more frequently diagnosed in intensive care patients in the Netherlands than would occur according to internationally established criteria]. Ned Tijdschr Geneeskd (2002) 0.75