Published in Crit Care on May 05, 2009
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care (2010) 1.72
The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children. Crit Care (2010) 1.62
Biomarkers of endothelial activation/dysfunction in infectious diseases. Virulence (2013) 1.42
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care (2011) 1.25
Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit Care (2010) 1.23
A high angiopoietin-2/angiopoietin-1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia. Crit Care (2013) 1.12
Angiopoietin-2-driven vascular remodeling in airway inflammation. Am J Pathol (2010) 1.07
Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS. Virulence (2013) 0.95
Imbalances in serum angiopoietin concentrations are early predictors of septic shock development in patients with post chemotherapy febrile neutropenia. BMC Infect Dis (2010) 0.90
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis. MAbs (2012) 0.89
Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass. Cytokine (2012) 0.86
Expression and functional roles of angiopoietin-2 in skeletal muscles. PLoS One (2011) 0.85
Lipopolysaccharide (LPS)-mediated angiopoietin-2-dependent autocrine angiogenesis is regulated by NADPH oxidase 2 (Nox2) in human pulmonary microvascular endothelial cells. J Biol Chem (2015) 0.84
Gingipains from the Periodontal Pathogen Porphyromonas gingivalis Play a Significant Role in Regulation of Angiopoietin 1 and Angiopoietin 2 in Human Aortic Smooth Muscle Cells. Infect Immun (2015) 0.84
Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass. PLoS One (2015) 0.83
The angiogenic factors and their soluble receptors in sepsis: friend, foe, or both? Crit Care (2013) 0.81
Does low angiopoietin-1 predict adverse outcome in sepsis? Crit Care (2010) 0.81
Role of angiopoietin/tie2 in critical illness: promising biomarker, disease mediator, and therapeutic target? Scientifica (Cairo) (2012) 0.81
Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia. Exp Transl Stroke Med (2012) 0.79
Plasma angiopoietin 2 concentrations are related to impaired lung function and organ failure in a clinical cohort receiving high-dose interleukin 2 therapy. Shock (2014) 0.75
Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma. PLoS One (2016) 0.75
Clinical outcome, proteome kinetics and angiogenic factors in serum after thermoablation of colorectal liver metastases. BMC Cancer (2013) 0.75
Early Prediction of Persistent Organ Failure by Serum Angiopoietin-2 in Patients with Acute Pancreatitis. Dig Dis Sci (2016) 0.75
Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns. Shock (2017) 0.75
Is VEGF a marker of severity of scrub typhus infection? Eur J Clin Microbiol Infect Dis (2015) 0.75
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science (1999) 6.96
Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58
Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med (2006) 5.49
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood (2003) 5.22
Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med (2006) 3.72
The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood (2004) 3.50
Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol (2006) 3.21
The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol (2006) 3.11
Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ Res (1997) 2.58
Protective role of angiopoietin-1 in endotoxic shock. Circulation (2004) 2.53
The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci (2005) 2.35
Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage. J Pharmacol Exp Ther (2005) 2.18
Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators. Crit Care Med (2007) 2.14
Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting? Crit Care Med (2009) 1.99
Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care (2008) 1.94
Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients. Thorax (2008) 1.91
Admission angiopoietin levels in children with septic shock. Shock (2007) 1.82
Selective release of molecules from Weibel-Palade bodies during a lingering kiss. Blood (2008) 1.70
Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome. Shock (2008) 1.62
Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan/pravastatin. J Hypertens (2009) 1.54
Inhibition of p38 mitogen-activated protein kinase: dose-dependent suppression of leukocyte and endothelial response after endotoxin challenge in humans. Crit Care Med (2002) 1.49
Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock (2009) 1.47
Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target? Crit Care (2009) 1.45
Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care (2005) 1.42
Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J Biol Chem (2002) 1.38
Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin. Am J Respir Crit Care Med (1999) 1.19
Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays. Crit Care (2008) 1.19
Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers. Clin Exp Immunol (2001) 1.16
Regulation of angiopoietin expression by bacterial lipopolysaccharide. Am J Physiol Lung Cell Mol Physiol (2008) 1.07
The Tie2 receptor antagonist angiopoietin 2 facilitates vascular inflammation in systemic lupus erythematosus. Ann Rheum Dis (2008) 0.99
Circulating angiopoietin-2 is a marker and potential mediator of endothelial cell detachment in ANCA-associated vasculitis with renal involvement. Nephrol Dial Transplant (2009) 0.98
Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies. Blood (2008) 0.98
Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis. Regul Pept (2005) 0.92
Time course of endothelial damage in septic shock: prediction of outcome. Crit Care (2005) 0.89
Expression and regulation of murine macrophage angiopoietin-2. Cell Immunol (2005) 0.85
Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit? Crit Care (2009) 0.80
Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: prospective case series. Hypertension (2012) 6.70
Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens (2009) 4.87
The renal arterial resistance index and renal allograft survival. N Engl J Med (2003) 4.36
New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003. Transplantation (2003) 3.79
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res (2004) 3.03
Heavy metal--rely on gut feelings: novel diagnostic approach to test drug compliance in patients with lanthanum intake. Nephrol Dial Transplant (2007) 2.96
Wegener's granulomatosis. Lancet (2006) 2.83
Pathogenesis and management of hypertension after kidney transplantation. J Hypertens (2011) 2.66
A good death. Intensive Care Med (2006) 2.52
Immunosuppressive treatment protects against angiotensin II-induced renal damage. Am J Pathol (2002) 2.50
Potential cellular and molecular causes of hypertrophic scar formation. Burns (2008) 2.39
Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients. Hypertension (2010) 2.38
Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study. BMJ (2012) 2.32
Circulating miR-210 predicts survival in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol (2011) 2.27
Diagnostic accuracy of subcutaneous abdominal fat tissue aspiration for detecting systemic amyloidosis and its utility in clinical practice. Arthritis Rheum (2006) 2.20
Erythropoietin regulates endothelial progenitor cells. Blood (2003) 2.18
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase. Circulation (2003) 2.15
Angiogenesis in synchronous and metachronous colorectal liver metastases: the liver as a permissive soil. Ann Surg (2012) 2.13
Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans. Circulation (2003) 2.12
Stimulation of endothelial progenitor cells: a new putative therapeutic effect of angiotensin II receptor antagonists. Hypertension (2005) 2.01
Accuracy and feasibility of point-of-care and continuous blood glucose analysis in critically ill ICU patients. Crit Care (2006) 2.01
Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis. Lancet (2003) 2.00
Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study. J Am Soc Nephrol (2005) 2.00
Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis. Arthritis Rheum (2006) 1.98
RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature. Drug Resist Updat (2005) 1.98
Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Blood Press (2009) 1.98
Generating hypotheses by discovering implicit associations in the literature: a case report of a search for new potential therapeutic uses for thalidomide. J Am Med Inform Assoc (2003) 1.97
Renal cell carcinoma in transplant recipients with acquired cystic kidney disease. Clin J Am Soc Nephrol (2007) 1.95
Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care (2008) 1.94
PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest (2011) 1.88
The Hannover Dialysis Outcome study: comparison of standard versus intensified extended dialysis for treatment of patients with acute kidney injury in the intensive care unit. Nephrol Dial Transplant (2009) 1.86
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol (2009) 1.86
Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis. Crit Care Med (2014) 1.83
Nephrogenesis is induced by partial nephrectomy in the elasmobranch Leucoraja erinacea. J Am Soc Nephrol (2003) 1.83
Novel baroreflex activation therapy in resistant hypertension: results of a European multi-center feasibility study. J Am Coll Cardiol (2010) 1.82
Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation. Circulation (2004) 1.81
Protocol biopsy of the stable renal transplant: a multicenter study of methods and complication rates. Transplantation (2003) 1.79
Mean glucose level is not an independent risk factor for mortality in mixed ICU patients. Intensive Care Med (2006) 1.76
Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study. J Am Soc Nephrol (2005) 1.74
Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy. Circulation (2009) 1.73
Complement 5a receptor inhibition improves renal allograft survival. J Am Soc Nephrol (2008) 1.72
Towards a feasible algorithm for tight glycaemic control in critically ill patients: a systematic review of the literature. Crit Care (2006) 1.70
Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease. J Am Soc Nephrol (2002) 1.70
Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury. Crit Care (2010) 1.65
MicroRNAs as mediators and therapeutic targets in chronic kidney disease. Nat Rev Nephrol (2011) 1.65
Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophages. Arthritis Rheum (2003) 1.65
Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin. J Control Release (2003) 1.63
Rapid screening of glomerular slit diaphragm integrity in larval zebrafish. Am J Physiol Renal Physiol (2007) 1.63
Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects. Circulation (2003) 1.63
Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy. Kidney Int (2005) 1.63
Quality of interhospital transport of critically ill patients: a prospective audit. Crit Care (2005) 1.57
Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury. Nephrol Dial Transplant (2012) 1.55
Impact of high glucose and transforming growth factor-β on bioenergetic profiles in podocytes. Metabolism (2012) 1.55
Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients: Response to Plank et al. Diabetes Care (2006) 1.55
Efficacy and cardiovascular tolerability of extended dialysis in critically ill patients: a randomized controlled study. Am J Kidney Dis (2004) 1.55
Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan/pravastatin. J Hypertens (2009) 1.54
In-center intermittent peritoneal dialysis: retrospective ten-year single-center experience with thirty consecutive patients. Perit Dial Int (2008) 1.54
Early calcification of renal allografts detected by protocol biopsies: causes and clinical implications. Am J Transplant (2005) 1.54
Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome. Intensive Care Med (2009) 1.53
Valsartan in combination with lisinopril versus the respective high dose monotherapies in hypertensive patients with microalbuminuria: the VALERIA trial. J Hypertens (2008) 1.52
Inhibition of p38 mitogen-activated protein kinase: dose-dependent suppression of leukocyte and endothelial response after endotoxin challenge in humans. Crit Care Med (2002) 1.49
Agonistic antibodies directed at the angiotensin II, AT1 receptor in preeclampsia. J Soc Gynecol Investig (2006) 1.49
Angiopoietin-2 in acute liver failure. Crit Care Med (2012) 1.48
TNF-alpha--accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism. Kidney Int (2002) 1.48
Effects of levosimendan for low cardiac output syndrome in critically ill patients: systematic review with meta-analysis and trial sequential analysis. Intensive Care Med (2014) 1.48
A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets. Bioconjug Chem (2004) 1.47
Duration of fecal shedding of Shiga toxin-producing Escherichia coli O104:H4 in patients infected during the 2011 outbreak in Germany: a multicenter study. Clin Infect Dis (2013) 1.46
Quality of interhospital transport of the critically ill: impact of a Mobile Intensive Care Unit with a specialized retrieval team. Crit Care (2011) 1.46
Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis. Crit Care Med (2015) 1.45
Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target? Crit Care (2009) 1.45
Identification and validation of urinary biomarkers for differential diagnosis and evaluation of therapeutic intervention in anti-neutrophil cytoplasmic antibody-associated vasculitis. Mol Cell Proteomics (2009) 1.41
Adjunct nitrous oxide normalizes vascular reactivity changes after hemorrhagic shock in mice under isoflurane anesthesia. Anesthesiology (2009) 1.40
Incidence of polyomavirus-nephropathy in renal allografts: influence of modern immunosuppressive drugs. Nephrol Dial Transplant (2003) 1.40
Viral Origin, Clinical Course, and Renal Outcomes in Patients With BK Virus Infection After Living-Donor Renal Transplantation. Transplantation (2016) 1.39
A pocket guide to identify patients at risk for chronic kidney disease after liver transplantation. Transpl Int (2015) 1.39
Tumor vessel biology in pediatric intracranial ependymoma. J Neurosurg Pediatr (2010) 1.38
Incidence of C4d stain in protocol biopsies from renal allografts: results from a multicenter trial. Am J Transplant (2005) 1.37
Increase of infectious complications in ABO-incompatible kidney transplant recipients--a single centre experience. Nephrol Dial Transplant (2011) 1.36
Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes (2008) 1.36
Renal resistance index and progression of renal disease. Hypertension (2002) 1.35
Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin. Kidney Int (2003) 1.33
Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells. Circulation (2004) 1.32
Differential effects of NF-{kappa}B and p38 MAPK inhibitors and combinations thereof on TNF-{alpha}- and IL-1{beta}-induced proinflammatory status of endothelial cells in vitro. Am J Physiol Cell Physiol (2005) 1.32
Increased circulating endothelial progenitor cells in septic patients: correlation with survival. Crit Care Med (2007) 1.32