Published in Crit Care Med on November 01, 2012
The temporal kinetics of circulating angiopoietin levels in children with sepsis. Pediatr Crit Care Med (2014) 1.50
Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis. Crit Care Med (2015) 1.45
Biomarkers of endothelial activation/dysfunction in infectious diseases. Virulence (2013) 1.42
Moving forward in sepsis research. Am J Respir Crit Care Med (2013) 1.04
Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction. Virulence (2013) 1.02
Receptor tyrosine kinase-mediated angiogenesis. Cold Spring Harb Perspect Biol (2013) 1.01
Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study. BMC Med (2015) 0.98
Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS. Virulence (2013) 0.95
Biomarkers for Sepsis: What Is and What Might Be? Biomark Insights (2015) 0.87
Therapeutic plasma exchange as rescue therapy in severe sepsis and septic shock: retrospective observational single-centre study of 23 patients. BMC Anesthesiol (2014) 0.87
Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis? World J Exp Med (2015) 0.85
The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation. Tissue Barriers (2015) 0.85
Tissue- and Serum-Associated Biomarkers of Hepatocellular Carcinoma. Biomark Cancer (2016) 0.85
Delivery of therapeutic siRNA to the lung endothelium via novel Lipoplex formulation DACC. Mol Ther (2014) 0.84
Effect of extracorporeal cytokine removal on vascular barrier function in a septic shock patient. J Intensive Care (2017) 0.83
Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction. Crit Care (2015) 0.83
Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness. PLoS One (2015) 0.83
Role of angiopoietin/tie2 in critical illness: promising biomarker, disease mediator, and therapeutic target? Scientifica (Cairo) (2012) 0.81
Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest (2016) 0.81
Renal endothelial injury and microvascular dysfunction in acute kidney injury. Semin Nephrol (2015) 0.81
Gene control of tyrosine kinase TIE2 and vascular manifestations of infections. Proc Natl Acad Sci U S A (2016) 0.80
Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients. Crit Care (2016) 0.78
Angiopoietin-1, angiopoietin-2 and bicarbonate as diagnostic biomarkers in children with severe sepsis. PLoS One (2014) 0.78
Angiogenesis-related biomarkers in patients with alcoholic liver disease: their association with liver disease complications and outcome. Mediators Inflamm (2014) 0.78
Fixing the leak: targeting the vascular endothelium in sepsis. Crit Care (2012) 0.78
A tale of two ligands: angiopoietins, the endothelium, and outcomes. Crit Care (2013) 0.77
Prognostic significance of the angiopoietin-2/angiopoietin-1 and angiopoietin-1/Tie-2 ratios for early sepsis in an emergency department. Crit Care (2015) 0.76
Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis. Crit Care (2016) 0.75
Angiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defense. PLoS One (2015) 0.75
Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems. Clin Sci (Lond) (2017) 0.75
Is angiopoietin-2 the key piece in the sepsis puzzle?*. Crit Care Med (2012) 0.75
Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis. Int J Mol Sci (2017) 0.75
Plasma angiopoietin 2 concentrations are related to impaired lung function and organ failure in a clinical cohort receiving high-dose interleukin 2 therapy. Shock (2014) 0.75
Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4. Mediators Inflamm (2015) 0.75
Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling. J Clin Invest (2016) 0.75
Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis. Sci Rep (2017) 0.75
The authors reply. Crit Care Med (2015) 0.75
Beyond single-nucleotide polymorphisms: genetics, genomics, and other 'omic approaches to acute respiratory distress syndrome. Clin Chest Med (2014) 0.75
Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns. Shock (2017) 0.75
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics (1988) 70.41
Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med (1996) 35.00
The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med (2003) 32.30
The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science (1997) 15.48
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell (1996) 13.95
Management of sepsis. N Engl J Med (2006) 9.01
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell (2005) 7.90
Signaling mechanisms regulating endothelial permeability. Physiol Rev (2006) 7.63
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science (1999) 6.96
Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc (2009) 6.71
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell (2002) 6.41
Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58
Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med (2006) 5.49
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood (2003) 5.22
The enigma of sepsis. J Clin Invest (2003) 4.32
Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med (2006) 3.72
The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood (2004) 3.50
Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci U S A (1999) 3.49
Definitions for sepsis and organ failure. Crit Care Med (1992) 2.69
Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med (2006) 2.63
Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit Care Med (2011) 2.59
Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ Res (1997) 2.58
Protective role of angiopoietin-1 in endotoxic shock. Circulation (2004) 2.53
The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci (2005) 2.35
Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage. J Pharmacol Exp Ther (2005) 2.18
Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev Cell (2008) 2.13
Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol (2009) 2.09
Broken barriers: a new take on sepsis pathogenesis. Sci Transl Med (2011) 2.01
Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care (2008) 1.94
Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients. Thorax (2008) 1.91
Admission angiopoietin levels in children with septic shock. Shock (2007) 1.82
Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem (2007) 1.81
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care (2010) 1.72
Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock (2009) 1.47
Cell-based angiopoietin-1 gene therapy for acute lung injury. Am J Respir Crit Care Med (2007) 1.33
Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis. Cytokine (2011) 1.29
The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care (2011) 1.25
Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol (2011) 1.25
Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit Care (2010) 1.23
Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes. Immunol Lett (2009) 1.01
ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. Blood (2003) 0.95
Prowess-shock trial: a protocol overview and perspectives. Shock (2010) 0.95
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med (2004) 14.00
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest (2003) 13.72
Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med (2013) 9.87
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med (2006) 7.06
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med (2011) 6.35
Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med (2006) 6.21
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem (2005) 3.88
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
Do emergency department blood cultures change practice in patients with pneumonia? Ann Emerg Med (2005) 3.80
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med (2006) 3.72
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med (2008) 3.39
Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia. Circulation (2011) 3.33
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14
Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg (2013) 3.14
Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia. Hypertension (2007) 2.77
Urinary placental growth factor and risk of preeclampsia. JAMA (2005) 2.76
Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med (2006) 2.75
Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney Int (2012) 2.74
Vascular endothelial growth factor-A and aldosterone: relevance to normal pregnancy and preeclampsia. Hypertension (2013) 2.70
Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68
Pathogenesis of preeclampsia. Annu Rev Pathol (2010) 2.66
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia. Hypertension (2007) 2.62
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res (2011) 2.55
Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation (2011) 2.55
Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med (2007) 2.52
Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med (2011) 2.30
Vitamin D deficiency and cardiovascular events in patients with coronary heart disease: data from the Heart and Soul Study. Am J Epidemiol (2014) 2.30
Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature (2012) 2.27
Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals. Proc Natl Acad Sci U S A (2007) 2.25
Do outcomes of near syncope parallel syncope? Am J Emerg Med (2010) 2.23
Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc Natl Acad Sci U S A (2013) 2.22
Clinical characterization and outcomes of preeclampsia with normal angiogenic profile. Hypertens Pregnancy (2013) 2.22
Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension (2005) 2.22
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20
Early outcomes among those initiating chronic dialysis in the United States. Clin J Am Soc Nephrol (2011) 2.17
First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab (2004) 2.11
Preeclampsia: the role of angiogenic factors in its pathogenesis. Physiology (Bethesda) (2009) 2.10
Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol (2009) 2.09
Preeclampsia and angiogenic imbalance. Annu Rev Med (2008) 2.05
Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies. Am J Obstet Gynecol (2005) 2.03
Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events? Hypertension (2006) 2.02
Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med (2007) 1.95
Molecular mechanisms of preeclampsia. Microvasc Res (2007) 1.90
PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest (2011) 1.88
Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia. Circulation (2012) 1.88
Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87
Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension (2012) 1.86
Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis. Crit Care Med (2014) 1.83
Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placentalischemia-induced hypertension. Hypertension (2009) 1.82
Admission angiopoietin levels in children with septic shock. Shock (2007) 1.82
Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem (2007) 1.81
Diagnostic utility of soluble fms-like tyrosine kinase 1 and soluble endoglin in hypertensive diseases of pregnancy. Am J Obstet Gynecol (2007) 1.80
Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia. Pediatr Res (2005) 1.78
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care (2010) 1.72
Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link. J Hypertens (2004) 1.71
Genetic variation in APOL1 associates with younger age at hemodialysis initiation. J Am Soc Nephrol (2011) 1.70
National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med (2006) 1.69
Pathophysiology of the clinical manifestations of preeclampsia. Clin J Am Soc Nephrol (2007) 1.69
Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone (2005) 1.68
Pre-eclampsia: clinical manifestations and molecular mechanisms. Nephron Clin Pract (2007) 1.67
Cytomegalovirus-induced mirror syndrome associated with elevated levels of circulating antiangiogenic factors. Obstet Gynecol (2007) 1.67
International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med (2015) 1.64
Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome. Shock (2008) 1.62
Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med (2009) 1.62
Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61
Interferon-α and angiogenic dysregulation in pregnant lupus patients who develop preeclampsia. Arthritis Rheumatol (2015) 1.61
Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock (2011) 1.61
Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study. BMJ (2009) 1.59
Angiogenic factors and preeclampsia. Semin Nephrol (2011) 1.58
Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Blood (2012) 1.58
Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med (2008) 1.58
Development trends for new cancer therapeutics and vaccines. Drug Discov Today (2007) 1.55
VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med (2008) 1.54
Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. J Trauma (2009) 1.53
Risk factors for death in elderly emergency department patients with suspected infection. J Am Geriatr Soc (2009) 1.53
Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. J Biol Chem (2002) 1.51
The glomerular injury of preeclampsia. J Am Soc Nephrol (2007) 1.50
Protease activity of urokinase and tumor progression in a syngeneic mammary cancer model. J Natl Cancer Inst (2006) 1.49
Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation (2013) 1.48
Predictors of bacteremia in emergency department patients with suspected infection. Am J Emerg Med (2012) 1.48