|
1
|
Principal components analysis corrects for stratification in genome-wide association studies.
|
Nat Genet
|
2006
|
115.71
|
|
2
|
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
Nat Genet
|
2010
|
9.90
|
|
3
|
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
|
N Engl J Med
|
2007
|
9.80
|
|
4
|
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
|
Science
|
2010
|
9.61
|
|
5
|
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
|
PLoS Genet
|
2009
|
8.39
|
|
6
|
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|
Nat Genet
|
2008
|
7.07
|
|
7
|
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.
|
Nat Genet
|
2006
|
6.98
|
|
8
|
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
|
Nat Genet
|
2008
|
6.42
|
|
9
|
Analysis and application of European genetic substructure using 300 K SNP information.
|
PLoS Genet
|
2008
|
6.42
|
|
10
|
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.
|
Nat Genet
|
2012
|
5.11
|
|
11
|
Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.
|
PLoS Genet
|
2008
|
5.08
|
|
12
|
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
|
Proc Natl Acad Sci U S A
|
2007
|
4.71
|
|
13
|
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
Nat Genet
|
2012
|
4.46
|
|
14
|
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.
|
Nat Genet
|
2012
|
4.41
|
|
15
|
Electronic medical records for discovery research in rheumatoid arthritis.
|
Arthritis Care Res (Hoboken)
|
2010
|
4.15
|
|
16
|
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.
|
Nat Genet
|
2009
|
3.86
|
|
17
|
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
PLoS Genet
|
2011
|
3.68
|
|
18
|
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.
|
Am J Hum Genet
|
2007
|
3.62
|
|
19
|
Defining the role of the MHC in autoimmunity: a review and pooled analysis.
|
PLoS Genet
|
2008
|
3.54
|
|
20
|
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
|
Nat Genet
|
2009
|
3.52
|
|
21
|
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
Nat Genet
|
2009
|
3.36
|
|
22
|
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
|
Nat Genet
|
2012
|
3.04
|
|
23
|
Portability of an algorithm to identify rheumatoid arthritis in electronic health records.
|
J Am Med Inform Assoc
|
2012
|
2.94
|
|
24
|
X chromosome-inactivation patterns of 1,005 phenotypically unaffected females.
|
Am J Hum Genet
|
2006
|
2.33
|
|
25
|
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
|
Nat Genet
|
2012
|
2.31
|
|
26
|
Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.
|
Am J Hum Genet
|
2011
|
2.27
|
|
27
|
Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data.
|
BMC Proc
|
2009
|
2.12
|
|
28
|
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.
|
Arthritis Rheum
|
2010
|
2.08
|
|
29
|
Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia.
|
Nat Genet
|
2006
|
2.07
|
|
30
|
Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions.
|
J Infect Dis
|
2010
|
2.05
|
|
31
|
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
|
Mol Med
|
2008
|
1.97
|
|
32
|
Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.
|
Arthritis Rheum
|
2009
|
1.87
|
|
33
|
Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.
|
PLoS Genet
|
2008
|
1.80
|
|
34
|
Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach.
|
Inflamm Bowel Dis
|
2013
|
1.71
|
|
35
|
Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus.
|
Mol Med
|
2008
|
1.69
|
|
36
|
Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease.
|
Inflamm Bowel Dis
|
2013
|
1.60
|
|
37
|
Informed conditioning on clinical covariates increases power in case-control association studies.
|
PLoS Genet
|
2012
|
1.57
|
|
38
|
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.
|
PLoS Genet
|
2013
|
1.54
|
|
39
|
Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
|
Ann Rheum Dis
|
2010
|
1.53
|
|
40
|
Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study.
|
Rheumatology (Oxford)
|
2010
|
1.53
|
|
41
|
Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12.
|
Am J Hum Genet
|
2012
|
1.46
|
|
42
|
Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls.
|
Arthritis Rheum
|
2013
|
1.43
|
|
43
|
Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits.
|
BMC Proc
|
2007
|
1.36
|
|
44
|
Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis.
|
Am J Hum Genet
|
2012
|
1.35
|
|
45
|
Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.
|
Arthritis Rheum
|
2010
|
1.34
|
|
46
|
Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge.
|
Nat Genet
|
2013
|
1.21
|
|
47
|
Autosomal dominant mutations affecting X inactivation choice in the mouse.
|
Science
|
2002
|
1.12
|
|
48
|
Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.
|
Ann Rheum Dis
|
2012
|
1.10
|
|
49
|
Automatic prediction of rheumatoid arthritis disease activity from the electronic medical records.
|
PLoS One
|
2013
|
1.09
|
|
50
|
Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.
|
PLoS One
|
2011
|
1.06
|
|
51
|
Modeling disease severity in multiple sclerosis using electronic health records.
|
PLoS One
|
2013
|
1.06
|
|
52
|
PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.
|
J Autoimmun
|
2013
|
0.94
|
|
53
|
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.
|
Int J Epidemiol
|
2015
|
0.93
|
|
54
|
Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.
|
PLoS Genet
|
2013
|
0.93
|
|
55
|
Lipid and lipoprotein levels and trend in rheumatoid arthritis compared to the general population.
|
Arthritis Care Res (Hoboken)
|
2013
|
0.92
|
|
56
|
Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis.
|
Mol Med
|
2009
|
0.88
|
|
57
|
An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse.
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Genetics
|
2003
|
0.87
|
|
58
|
Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis.
|
Am J Gastroenterol
|
2013
|
0.87
|
|
59
|
Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges.
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Curr Opin Rheumatol
|
2014
|
0.86
|
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60
|
Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls.
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Ann Rheum Dis
|
2013
|
0.86
|
|
61
|
A novel polymorphism of the human CD40 receptor with enhanced function.
|
Blood
|
2008
|
0.86
|
|
62
|
Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.
|
Arthritis Rheum
|
2012
|
0.85
|
|
63
|
Shared genetic risk factors for type 1 diabetes and celiac disease.
|
N Engl J Med
|
2008
|
0.84
|
|
64
|
Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis.
|
Arthritis Rheum
|
2009
|
0.83
|
|
65
|
HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: hierarchical classification systems, amino acid positions, and residues.
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Arthritis Rheumatol
|
2014
|
0.82
|
|
66
|
The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.
|
Arthritis Rheum
|
2009
|
0.81
|
|
67
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GWAS implicates a role for quantitative immune traits and threshold effects in risk for human autoimmune disorders.
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Curr Opin Immunol
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2012
|
0.80
|
|
68
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Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes.
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Pharmacogenet Genomics
|
2013
|
0.80
|
|
69
|
A broad analysis of IL1 polymorphism and rheumatoid arthritis.
|
Arthritis Rheum
|
2008
|
0.79
|
|
70
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Genomic technology applied to pharmacological traits.
|
JAMA
|
2011
|
0.78
|
|
71
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Unlocking the pathogenesis of celiac disease.
|
Nat Genet
|
2010
|
0.78
|
|
72
|
The chromosome 7q region association with rheumatoid arthritis in females in a British population is not replicated in a North American case-control series.
|
Arthritis Rheum
|
2009
|
0.77
|
|
73
|
Association of rheumatoid arthritis risk alleles with response to anti-TNF biologics: results from the CORRONA registry and meta-analysis.
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Inflammation
|
2013
|
0.76
|
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74
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Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.
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Ann Rheum Dis
|
2012
|
0.76
|
|
75
|
Personalized medicine in rheumatoid arthritis: miles to go before we sleep.
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Arthritis Rheum
|
2011
|
0.76
|
|
76
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Editorial: entering the age of whole-exome sequencing in rheumatic diseases: novel insights into disease pathogenicity.
|
Arthritis Rheum
|
2013
|
0.76
|