STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med (2007) 12.24

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90

Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet (2008) 6.42

Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet (2009) 4.79

Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42

Th17 cells in human disease. Immunol Rev (2008) 4.27

Cytokine signaling modules in inflammatory responses. Immunity (2008) 4.09

Progress and promise of genome-wide association studies for human complex trait genetics. Genetics (2010) 3.81

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med (2009) 3.70

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet (2011) 3.68

Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity (2011) 3.24

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet (2010) 3.15

Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus. PLoS One (2009) 2.98

JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity (2012) 2.85

Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun (2009) 2.78

CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun (2008) 2.76

Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet (2010) 2.74

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet (2013) 2.60

The innate immune system in SLE: type I interferons and dendritic cells. Lupus (2008) 2.52

Recent advances in the genetics of autoimmune disease. Annu Rev Immunol (2009) 2.41

Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. J Immunol (2009) 2.39

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet (2010) 2.34

Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet (2012) 2.31

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A (2009) 2.31

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30

Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies. Arthritis Rheum (2009) 2.19

Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat Rev Rheumatol (2010) 2.18

Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data. BMC Proc (2009) 2.12

A genomic approach to human autoimmune diseases. Annu Rev Immunol (2010) 2.10

Genomic views of STAT function in CD4+ T helper cell differentiation. Nat Rev Immunol (2011) 2.09

Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet (2008) 2.08

Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med (2007) 2.08

Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis. Ann Rheum Dis (2008) 2.01

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet (2008) 1.98

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet (2013) 1.93

Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations. Arthritis Rheum (2009) 1.92

Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet (2011) 1.92

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. Ann Rheum Dis (2010) 1.90

Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet (2008) 1.80

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet (2013) 1.79

Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis. Nat Rev Rheumatol (2012) 1.78

Type I interferons: crucial participants in disease amplification in autoimmunity. Nat Rev Rheumatol (2010) 1.73

The interferon-alpha signature of systemic lupus erythematosus. Lupus (2010) 1.69

Interferon alpha as a primary pathogenic factor in human lupus. J Interferon Cytokine Res (2011) 1.69

Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. Mol Med (2008) 1.69

A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genet (2011) 1.68

Peripheral blood gene expression profiling in Sjögren's syndrome. Genes Immun (2009) 1.66

Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat Genet (2012) 1.64

Complement drives Th17 cell differentiation and triggers autoimmune arthritis. J Exp Med (2010) 1.62

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet (2011) 1.62

Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis. Arthritis Res Ther (2008) 1.62

Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Res Ther (2008) 1.61

Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important. Arthritis Rheum (2009) 1.60

Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol (2008) 1.59

A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA. Arthritis Rheum (2009) 1.59

Recent advances in the genetics of rheumatoid arthritis. Curr Opin Rheumatol (2010) 1.58

Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic pattern. Chest (2009) 1.56

Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk. Ann Rheum Dis (2010) 1.53

A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2. PLoS Genet (2008) 1.53

STAT4: genetics, mechanisms, and implications for autoimmunity. Curr Allergy Asthma Rep (2008) 1.53

Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study. Arthritis Res Ther (2009) 1.52

Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality. J Rheumatol (2009) 1.51

Genetic regulation of serum cytokines in systemic lupus erythematosus. Transl Res (2009) 1.49

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Am J Hum Genet (2012) 1.49

Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus. Arthritis Res Ther (2010) 1.45

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk. Ann Rheum Dis (2008) 1.42

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis (2011) 1.41

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet (2012) 1.41

Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls. Hepatology (2008) 1.40

Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations. J Autoimmun (2009) 1.38

Developments in the scientific understanding of rheumatoid arthritis. Arthritis Res Ther (2009) 1.38

A new gene-based association test for genome-wide association studies. BMC Proc (2009) 1.37

Synthetic associations in the context of genome-wide association scan signals. Hum Mol Genet (2010) 1.36

Recent advances in the genetics of systemic lupus erythematosus. Expert Rev Clin Immunol (2010) 1.35

Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans. Arthritis Rheum (2010) 1.34

T cells in rheumatoid arthritis. Arthritis Res Ther (2008) 1.33

Rheumatoid arthritis: a view of the current genetic landscape. Genes Immun (2008) 1.32

Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Ann Rheum Dis (2010) 1.31

Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. Arthritis Res Ther (2008) 1.31

New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation. Semin Cell Dev Biol (2008) 1.31

The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1. Arthritis Rheum (2010) 1.28

The search for lupus biomarkers. Best Pract Res Clin Rheumatol (2009) 1.26

The Current STATus of lymphocyte signaling: new roles for old players. Curr Opin Immunol (2009) 1.26

Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment. Arthritis Res Ther (2010) 1.26

Genetic imprinting of autoantibody repertoires in systemic lupus erythematosus patients. Clin Exp Immunol (2008) 1.25

Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. Ann Rheum Dis (2010) 1.25

Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations. Genes Immun (2009) 1.25

Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J Exp Med (2008) 1.24

Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines. Arthritis Rheum (2009) 1.24

Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics. Gastroenterology (2013) 1.24

Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species. Biochem Soc Trans (2008) 1.23

Genetics of rheumatoid arthritis: what have we learned? Immunogenetics (2011) 1.21

The lupus family registry and repository. Rheumatology (Oxford) (2010) 1.21

Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis. Arthritis Rheum (2009) 1.20

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum (2011) 1.19

Cell damage and autoimmunity: a critical appraisal. J Autoimmun (2008) 1.19

A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese. PLoS Genet (2012) 1.17

Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease. Environ Health Perspect (2008) 1.17

Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23

Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71

The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum (1982) 67.54

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49

Efficiency and power in genetic association studies. Nat Genet (2005) 25.56

Association mapping in structured populations. Am J Hum Genet (2000) 16.79

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 13.71

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet (2004) 12.25

T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol (2007) 12.20

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56

Demonstrating stratification in a European American population. Nat Genet (2005) 9.49

Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum (2000) 6.88

A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum (2004) 6.63

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet (2005) 6.61

Statistics notes. The odds ratio. BMJ (2000) 5.61

European population substructure: clustering of northern and southern populations. PLoS Genet (2006) 5.27

The New York Cancer Project: rationale, organization, design, and baseline characteristics. J Urban Health (2004) 5.21

Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol (2007) 5.16

Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet (2005) 5.00

Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum Dis (2003) 4.36

High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33. Genes Immun (2006) 3.86

Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families. Arthritis Rheum (2003) 3.73

Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci U S A (1998) 3.35

Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev (2004) 3.18

Predicting mortality in patients with rheumatoid arthritis. Arthritis Rheum (2003) 3.13

The genetics revolution and the assault on rheumatoid arthritis. Arthritis Rheum (1999) 2.92

Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles. Arthritis Rheum (2005) 2.88

PTPN22: setting thresholds for autoimmunity. Semin Immunol (2006) 2.54

Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus. PLoS Med (2006) 2.53

Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med (2007) 2.08

HLA-DRB1 genotype associations in 793 white patients from a rheumatoid arthritis inception cohort: frequency, severity, and treatment bias. Arthritis Rheum (2002) 2.07

Genetics of autoimmune diseases--disorders of immune homeostasis. Nat Rev Genet (2006) 1.96

Hopkins Lupus Cohort. 1999 update. Rheum Dis Clin North Am (2000) 1.82

Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J Immunol (2001) 1.81

Genome-wide meta-analysis for rheumatoid arthritis. Hum Genet (2006) 1.75

Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris. J Dermatol Sci (2002) 1.75

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci U S A (2002) 1.69

Genome scan meta-analysis of rheumatoid arthritis. Rheumatology (Oxford) (2005) 1.65

Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol (2002) 1.64

IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol (2002) 1.61

Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort. Genes Immun (2007) 1.60

Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. J Immunol (2003) 1.54

Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2. Am J Hum Genet (2000) 1.47

Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis. Ann Neurol (2006) 1.28

Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23. Arthritis Rheum (2004) 1.27

The immunogenetics of rheumatoid arthritis. Springer Semin Immunopathol (1992) 1.20

Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis. J Immunol (2007) 1.18

NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation. J Leukoc Biol (2006) 1.11

Therapeutic potential of oligonucleotides expressing immunosuppressive TTAGGG motifs. Ann N Y Acad Sci (2005) 1.10

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Structure validation by Calpha geometry: phi,psi and Cbeta deviation. Proteins (2003) 32.38

Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30

Strong association of de novo copy number mutations with autism. Science (2007) 27.84

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49

Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66

Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics (2008) 15.77

Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat Genet (2006) 14.76

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet (2004) 13.71

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Pooled association tests for rare variants in exon-resequencing studies. Am J Hum Genet (2010) 13.18

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med (2007) 12.24

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A (2003) 11.65

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (2010) 9.61

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med (2008) 9.61

A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum (2006) 9.52

Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet (2012) 9.43

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet (2007) 8.74

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet (2009) 8.39

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature (2012) 8.10

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med (2006) 7.75

Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet (2008) 7.36

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16

Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet (2006) 6.98

Calculating measures of biological interaction. Eur J Epidemiol (2005) 6.82