Published in Biochim Biophys Acta on June 13, 2008
EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. Proc Natl Acad Sci U S A (2010) 2.48
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am J Pathol (2009) 1.92
Preparing synthetic Aβ in different aggregation states. Methods Mol Biol (2011) 1.26
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. Pharmacol Rev (2009) 1.24
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10
The effects of cholesterol on learning and memory. Neurosci Biobehav Rev (2010) 1.05
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Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. PLoS One (2011) 1.04
Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J Biol Chem (2013) 1.01
Aβ internalization by neurons and glia. Int J Alzheimers Dis (2011) 0.99
Direct observation of single amyloid-β(1-40) oligomers on live cells: binding and growth at physiological concentrations. PLoS One (2011) 0.98
Mechanisms of amyloid-Beta Peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins. Int J Alzheimers Dis (2010) 0.89
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Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation. J Biol Chem (2012) 0.85
β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes. J Biol Chem (2014) 0.85
Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome. Age (Dordr) (2012) 0.84
The nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-β. PLoS One (2010) 0.84
Protein folding and aggregation into amyloid: the interference by natural phenolic compounds. Int J Mol Sci (2013) 0.81
Transmission electron microscopy characterization of fluorescently labelled amyloid β 1-40 and α-synuclein aggregates. BMC Biotechnol (2011) 0.80
Dementia of the eye: the role of amyloid beta in retinal degeneration. Eye (Lond) (2015) 0.79
Synergistic interactions between Alzheimer's Aβ40 and Aβ42 on the surface of primary neurons revealed by single molecule microscopy. PLoS One (2013) 0.79
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Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid-β 1-42. FEBS Lett (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3. Brain (2006) 5.36
ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. Lancet Neurol (2007) 2.80
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nat Genet (2007) 2.63
Germline mutation of INI1/SMARCB1 in familial schwannomatosis. Am J Hum Genet (2007) 2.53
tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. Nat Genet (2008) 2.28
LAD-1/variant syndrome is caused by mutations in FERMT3. Blood (2008) 2.22
Statistical evaluation of SAGE libraries: consequences for experimental design. Physiol Genomics (2002) 2.19
Therapeutic antisense-induced exon skipping in cultured muscle cells from six different DMD patients. Hum Mol Genet (2003) 2.17
Clinical, neuroradiological and genetic findings in pontocerebellar hypoplasia. Brain (2010) 2.15
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N Engl J Med (2002) 2.07
Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis. Hepatology (2013) 2.02
Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2. Ann Neurol (2006) 1.98
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am J Pathol (2009) 1.92
Evaluation of the similarity of gene expression data estimated with SAGE and Affymetrix GeneChips. BMC Genomics (2005) 1.91
Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies. Am J Hum Genet (2010) 1.81
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J Pathol (2012) 1.76
C3-dependent mechanism of microglial priming relevant to multiple sclerosis. Proc Natl Acad Sci U S A (2012) 1.73
The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder. Eur J Hum Genet (2012) 1.71
Classification, diagnosis and potential mechanisms in pontocerebellar hypoplasia. Orphanet J Rare Dis (2011) 1.71
Pontine tegmental cap dysplasia: a novel brain malformation with a defect in axonal guidance. Brain (2007) 1.66
Mechanisms for nonrecurrent genomic rearrangements associated with CMT1A or HNPP: rare CNVs as a cause for missing heritability. Am J Hum Genet (2010) 1.65
Neutrophils in Barth syndrome (BTHS) avidly bind annexin-V in the absence of apoptosis. Blood (2004) 1.65
Human T-cell memory consists mainly of unexpanded clones. Immunol Lett (2010) 1.60
Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome. Nat Genet (2003) 1.57
Germline SMARCB1 mutation predisposes to multiple meningiomas and schwannomas with preferential location of cranial meningiomas at the falx cerebri. Neurogenetics (2011) 1.56
Glucocorticoid-induced changes in gene expression of airway smooth muscle in patients with asthma. Am J Respir Crit Care Med (2013) 1.54
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. J Clin Invest (2010) 1.50
Disease course of Charcot-Marie-Tooth disease type 2: a 5-year follow-up study. Arch Neurol (2003) 1.42
Characterisation of mutations in 77 patients with X-linked myotubular myopathy, including a family with a very mild phenotype. Hum Genet (2002) 1.41
OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas. J Neuropathol Exp Neurol (2006) 1.39
Prion protein amyloidosis with divergent phenotype associated with two novel nonsense mutations in PRNP. Acta Neuropathol (2009) 1.39
In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides. Nucleic Acids Res (2003) 1.38
A sensitive assay for virus discovery in respiratory clinical samples. PLoS One (2011) 1.33
Deep sequencing of virus-infected cells reveals HIV-encoded small RNAs. Nucleic Acids Res (2011) 1.32
Pontocerebellar hypoplasia type 2: a neuropathological update. Acta Neuropathol (2007) 1.32
Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q. Am J Hum Genet (2003) 1.29
Cardiolipin deficiency in X-linked cardioskeletal myopathy and neutropenia (Barth syndrome, MIM 302060): a study in cultured skin fibroblasts. J Pediatr (2002) 1.27
The COMT val158met polymorphism and brain morphometry in healthy young adults. Neurosci Lett (2006) 1.25
Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J Clin Invest (2011) 1.24
Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3. J Nucl Med (2008) 1.23
Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner. Antioxid Redox Signal (2007) 1.23
Expression and distribution of id helix-loop-helix proteins in human astrocytic tumors. Glia (2002) 1.20
A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy. Hum Mol Genet (2011) 1.18
The Phox2B homeobox gene is mutated in sporadic neuroblastomas. Oncogene (2004) 1.18
A mutation in an alternative untranslated exon of hexokinase 1 associated with hereditary motor and sensory neuropathy -- Russe (HMSNR). Eur J Hum Genet (2009) 1.15
Genetic alterations in childhood medulloblastoma analyzed by comparative genomic hybridization. J Pediatr Hematol Oncol (2002) 1.12
Oral high dose ascorbic acid treatment for one year in young CMT1A patients: a randomised, double-blind, placebo-controlled phase II trial. BMC Med (2009) 1.12
DYT6 dystonia: mutation screening, phenotype, and response to deep brain stimulation. Mov Disord (2010) 1.10
125th ENMC International Workshop: Neuromuscular disorders in the Roma (Gypsy) population, 23-25 April 2004, Naarden, The Netherlands. Neuromuscul Disord (2004) 1.09
Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity. Clin Cancer Res (2003) 1.09
Gene expression in early stage cervical cancer. Gynecol Oncol (2008) 1.08
Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo. Mol Biosyst (2010) 1.07
Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings. Behav Brain Funct (2007) 1.06
Kinked collagen VI tetramers and reduced microfibril formation as a result of Bethlem myopathy and introduced triple helical glycine mutations. J Biol Chem (2001) 1.06
The membrane attack complex of the complement system is essential for rapid Wallerian degeneration. J Neurosci (2007) 1.05
SGCE isoform characterization and expression in human brain: implications for myoclonus-dystonia pathogenesis? Eur J Hum Genet (2010) 1.05
Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo. Mol Cancer Ther (2007) 1.04
The establishment of the GENEQOL consortium to investigate the genetic disposition of patient-reported quality-of-life outcomes. Twin Res Hum Genet (2009) 1.03
Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease. Neurodegener Dis (2012) 1.01
Human cytomegalovirus infection induces a rapid and sustained change in the expression of NK cell receptors on CD8+ T cells. J Immunol (2008) 1.01
PMP22 related neuropathies: Charcot-Marie-Tooth disease type 1A and Hereditary Neuropathy with liability to Pressure Palsies. Orphanet J Rare Dis (2014) 1.00
Copy number variation upstream of PMP22 in Charcot-Marie-Tooth disease. Eur J Hum Genet (2009) 1.00
Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma. PLoS One (2012) 0.99
The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease. J Alzheimers Dis (2010) 0.99
Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms. J Cell Sci (2003) 0.98
Human prion diseases in the Netherlands (1998-2009): clinical, genetic and molecular aspects. PLoS One (2012) 0.98
On the in vitro and in vivo properties of four locked nucleic acid nucleotides incorporated into an anti-H-Ras antisense oligonucleotide. Chembiochem (2005) 0.97
Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages. Physiol Genomics (2013) 0.96
Full transcriptome analysis of rhabdomyosarcoma, normal, and fetal skeletal muscle: statistical comparison of multiple SAGE libraries. FASEB J (2005) 0.95
Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration. Int J Biochem Cell Biol (2012) 0.95
Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events. Brain Res Mol Brain Res (2004) 0.95
Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia. Hum Mol Genet (2011) 0.95
Deficiency of the complement regulator CD59a exacerbates Wallerian degeneration. Mol Immunol (2009) 0.94
Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression. Clin Cancer Res (2008) 0.94
Which patient will feel down, which will be happy? The need to study the genetic disposition of emotional states. Qual Life Res (2010) 0.94
Early onset neuropathy in a compound form of Charcot-Marie-Tooth disease. Ann Neurol (2005) 0.93
Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes. Blood (2009) 0.91
Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease. ACS Nano (2012) 0.91
Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation. Chembiochem (2007) 0.91
The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides. Eur J Biochem (2002) 0.91
Complement inhibition accelerates regeneration in a model of peripheral nerve injury. Mol Immunol (2009) 0.90
Recessive MYL2 mutations cause infantile type I muscle fibre disease and cardiomyopathy. Brain (2013) 0.90
Genetic variation and cerebrospinal fluid levels of mannose binding lectin in pneumococcal meningitis patients. PLoS One (2013) 0.90
Soluble complement receptor 1 protects the peripheral nerve from early axon loss after injury. Am J Pathol (2008) 0.89
Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. J Neuroinflammation (2005) 0.89
Targeted sequence capture and GS-FLX Titanium sequencing of 23 hypertrophic and dilated cardiomyopathy genes: implementation into diagnostics. J Med Genet (2013) 0.89
Alternative splicing in the N-terminus of Alzheimer's presenilin 1. Neurogenetics (2004) 0.88
The therapeutic potential of LNA-modified siRNAs: reduction of off-target effects by chemical modification of the siRNA sequence. Methods Mol Biol (2009) 0.88
Deep sequencing whole transcriptome exploration of the σE regulon in Neisseria meningitidis. PLoS One (2011) 0.87
p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity. Circulation (2009) 0.87
PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease. ACS Nano (2012) 0.86
Ubiquitin proteasome system as a pharmacological target in neurodegeneration. Expert Rev Neurother (2006) 0.86
Comparison of CMT1A and CMT2: similarities and differences. J Neurol (2006) 0.86
Common polymorphisms in the complement system and susceptiblity to bacterial meningitis. J Infect (2012) 0.86
Genetic variation in the β2-adrenocepter gene is associated with susceptibility to bacterial meningitis in adults. PLoS One (2012) 0.86
Dopamine metabolism in adults with 22q11 deletion syndrome, with and without schizophrenia--relationship with COMT Val¹⁰⁸/¹⁵⁸Met polymorphism, gender and symptomatology. J Psychopharmacol (2011) 0.85
Genomewide linkage in a large Dutch family with intracranial aneurysms: replication of 2 loci for intracranial aneurysms to chromosome 1p36.11-p36.13 and Xp22.2-p22.32. Stroke (2008) 0.85