Published in Nature on July 24, 2008
DNA resection in eukaryotes: deciding how to fix the break. Nat Struct Mol Biol (2010) 2.81
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Nat Struct Mol Biol (2010) 2.65
Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks. Nat Struct Mol Biol (2010) 2.14
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO J (2010) 2.04
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nat Struct Mol Biol (2010) 1.87
Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell (2009) 1.78
The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair. Cell (2011) 1.60
Repair of double-strand breaks by end joining. Cold Spring Harb Perspect Biol (2013) 1.58
Choreography of recombination proteins during the DNA damage response. DNA Repair (Amst) (2009) 1.40
Limiting the persistence of a chromosome break diminishes its mutagenic potential. PLoS Genet (2009) 1.38
Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae. Genetics (2014) 1.27
Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends. PLoS Genet (2010) 1.25
Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context. J Biol Chem (2011) 1.23
De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes Dev (2010) 1.22
ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex. Nucleic Acids Res (2011) 1.19
Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat Struct Mol Biol (2012) 1.14
Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication. Mol Cell Biol (2009) 1.02
Microhomology directs diverse DNA break repair pathways and chromosomal translocations. PLoS Genet (2012) 1.02
RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks. Mol Cell Biol (2011) 0.99
ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks. PLoS Genet (2010) 0.99
Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break. PLoS Genet (2015) 0.93
Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase. Nucleic Acids Res (2012) 0.87
Chromosome integrity at a double-strand break requires exonuclease 1 and MRX. DNA Repair (Amst) (2010) 0.85
Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline. Genetics (2012) 0.85
ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. PLoS One (2010) 0.83
Structure of the Rad50 DNA double-strand break repair protein in complex with DNA. EMBO J (2014) 0.83
Faithful after break-up: suppression of chromosomal translocations. Cell Mol Life Sci (2009) 0.82
Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae. Genetics (2013) 0.82
The atm-1 gene is required for genome stability in Caenorhabditis elegans. Mol Genet Genomics (2012) 0.79
Phosphorylation of Sae2 Mediates Forkhead-associated (FHA) Domain-specific Interaction and Regulates Its DNA Repair Function. J Biol Chem (2015) 0.78
Connecting the Dots: Interplay between Ubiquitylation and SUMOylation at DNA Double-Strand Breaks. Genes Cancer (2010) 0.77
Role of Double-Strand Break End-Tethering during Gene Conversion in Saccharomyces cerevisiae. PLoS Genet (2016) 0.77
Yeast pol4 promotes tel1-regulated chromosomal translocations. PLoS Genet (2013) 0.77
Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks. PLoS Biol (2016) 0.76
A method for high-throughput production of sequence-verified DNA libraries and strain collections. Mol Syst Biol (2017) 0.75
Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency. Proc Natl Acad Sci U S A (2017) 0.75
Differential radio-sensitivities of human chromosomes 1 and 2 in one donor in interphase- and metaphase-spreads after 60Co gamma-irradiation. BMC Med Phys (2009) 0.75
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18
The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85
Complete Khoisan and Bantu genomes from southern Africa. Nature (2010) 9.06
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell (2008) 7.63
MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings. Trends Genet (2008) 6.00
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron (2002) 4.18
iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell (2009) 4.04
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase. Mol Cell (2002) 3.76
Synthetic spike-in standards for RNA-seq experiments. Genome Res (2011) 3.58
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34
Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol Cell Biol (2003) 3.32
Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J Clin Oncol (2007) 3.29
Label-free oxygen-metabolic photoacoustic microscopy in vivo. J Biomed Opt (2011) 3.16
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A (2011) 3.14
The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem (2008) 3.01
Demasculinization of X chromosomes in the Drosophila genus. Nature (2007) 2.85
A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2009) 2.67
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res (2009) 2.64
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nanotechnol (2007) 2.61
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev (2007) 2.56
Ecology. Importing timber, exporting ecological impact. Science (2005) 2.54
HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J (2006) 2.52
The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev (2007) 2.43
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A (2011) 2.39
Evolution of protein-coding genes in Drosophila. Trends Genet (2008) 2.36
COP1 and ELF3 control circadian function and photoperiodic flowering by regulating GI stability. Mol Cell (2008) 2.34
Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell (2013) 2.32
Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining. Genetics (2007) 2.19
Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell (2013) 2.17
Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev (2010) 2.14
Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks. Nat Struct Mol Biol (2010) 2.14
Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells. Mol Cell Biol (2007) 2.14
ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection? Neurology (2014) 2.08
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. Genome Res (2011) 2.07
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO J (2010) 2.04
Mean arterial pressure required for maintaining patency of extracranial-to-intracranial bypass grafts: an investigation with computational hemodynamic models-case series. Neurosurgery (2012) 2.02
Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil). Proc Natl Acad Sci U S A (2011) 1.99
Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res (2006) 1.97
Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J (2005) 1.94
RSC mobilizes nucleosomes to improve accessibility of repair machinery to the damaged chromatin. Mol Cell Biol (2006) 1.94
Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. Plant Cell (2006) 1.92
Mechano-electronic superlattices in silicon nanoribbons. ACS Nano (2009) 1.91
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell (2008) 1.91
Prevalence and Clinical Features of Detrusor Underactivity among Elderly with Lower Urinary Tract Symptoms: A Comparison between Men and Women. Korean J Urol (2012) 1.88
PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell (2003) 1.88
Alignment of optical maps. J Comput Biol (2006) 1.88
Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3. Neuron (2003) 1.87
Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat Struct Mol Biol (2007) 1.87
Ynamides: a modern functional group for the new millennium. Chem Rev (2010) 1.77
The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks. Mol Cell Biol (2005) 1.76
Reversal of new-onset diabetes through modulating inflammation and stimulating beta-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor. Endocrinology (2010) 1.75
Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents. J Cereb Blood Flow Metab (2010) 1.75
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A (2011) 1.69
MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. Cancer Lett (2008) 1.68
Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods (2012) 1.67
Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell (2010) 1.66
Size-dependent composition and molar extinction coefficient of PbSe semiconductor nanocrystals. ACS Nano (2009) 1.66
The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance. Plant Cell (2010) 1.66
Migrating bubble during break-induced replication drives conservative DNA synthesis. Nature (2013) 1.66
Prognostic significance of undetectable ultrasensitive prostate-specific antigen nadir after radical prostatectomy. Urology (2010) 1.64
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature (2010) 1.64
High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proc Natl Acad Sci U S A (2007) 1.62
Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation by the cAMP-PKA pathway. Hepatology (2013) 1.60
Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. J Neurosci (2008) 1.60
HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Mol Cell (2011) 1.59
Nomograms to predict the pathological stage of clinically localized prostate cancer in Korean men: comparison with western predictive tools using decision curve analysis. Int J Urol (2012) 1.58
Chaos in voice, from modeling to measurement. J Voice (2005) 1.57
Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates. Mol Cell (2008) 1.56
Nonlinear dynamics of phonations in excised larynx experiments. J Acoust Soc Am (2003) 1.56
Prognostic factors for chronic kidney disease after curative surgery in patients with small renal tumors. Urology (2009) 1.55
The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA. Nature (2016) 1.50
Relation of renal dysfunction to the increased risk of stroke and death in female patients with atrial fibrillation. Int J Cardiol (2013) 1.50
SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression. Cancer Res (2012) 1.50
Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation. Nat Struct Mol Biol (2011) 1.50
High frequency of common deletion (4981 bp) in mitochondrial DNA in nasopharyngeal carcinoma and its correlation with patient age and clinical stages. Cancer Biol Ther (2004) 1.47
Genetic analysis of Arabidopsis GATA transcription factor gene family reveals a nitrate-inducible member important for chlorophyll synthesis and glucose sensitivity. Plant J (2005) 1.46
Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. Clin Sci (Lond) (2013) 1.45
Oncogenic role of eIF-5A2 in the development of ovarian cancer. Cancer Res (2004) 1.45
Leber's hereditary optic neuropathy is associated with the T12338C mutation in mitochondrial ND5 gene in six Han Chinese families. Ophthalmology (2010) 1.44
Can conventional magnetic resonance imaging, prostate needle biopsy, or their combination predict the laterality of clinically localized prostate cancer? Urology (2012) 1.44
Partial nephrectomy versus radical nephrectomy for non-metastatic pathological T3a renal cell carcinoma: a multi-institutional comparative analysis. Int J Urol (2013) 1.44
Intrinsic versus environmental influences on T-cell responses in aging. Immunol Rev (2005) 1.43
Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterol (2011) 1.43
The 5-year functional outcomes after radical prostatectomy: a real-life experience in Korea. Asian J Androl (2010) 1.42
Ritodrine in the treatment of preterm labour: a meta-analysis. Indian J Med Res (2005) 1.42
A comparison between the Chinese 2008 and the 7th edition AJCC staging systems for nasopharyngeal carcinoma. Am J Clin Oncol (2015) 1.42
Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Proc Natl Acad Sci U S A (2003) 1.40
A solution to meningiomas at the trigone of the lateral ventricle using a contralateral transfalcine approach. World Neurosurg (2012) 1.40
Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes (2012) 1.40
J-tube technique for double-j stent insertion during laparoscopic upper urinary tract surgical procedures. J Endourol (2014) 1.39
Novel posterior reconstruction technique during robot-assisted laparoscopic prostatectomy: description and comparative outcomes. Int J Urol (2012) 1.39
Miniature inverted-repeat transposable elements (MITEs) have been accumulated through amplification bursts and play important roles in gene expression and species diversity in Oryza sativa. Mol Biol Evol (2011) 1.39
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol (2010) 1.39