Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

PubWeight™: 3.81‹?› | Rank: Top 1%

🔗 View Article (PMC 3186939)

Published in Cell on September 30, 2011

Authors

Roberto Chiarle1, Yu Zhang, Richard L Frock, Susanna M Lewis, Benoit Molinie, Yu-Jui Ho, Darienne R Myers, Vivian W Choi, Mara Compagno, Daniel J Malkin, Donna Neuberg, Stefano Monti, Cosmas C Giallourakis, Monica Gostissa, Frederick W Alt

Author Affiliations

1: Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Articles citing this

(truncated to the top 100)

Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02

Identification of early replicating fragile sites that contribute to genome instability. Cell (2013) 3.99

Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. Cell (2012) 3.21

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat Biotechnol (2014) 2.99

High order chromatin architecture shapes the landscape of chromosomal alterations in cancer. Nat Biotechnol (2011) 2.63

Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma. Cell (2015) 2.51

DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature (2012) 2.44

Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell (2013) 2.32

End-joining, translocations and cancer. Nat Rev Cancer (2013) 2.13

Functional implications of genome topology. Nat Struct Mol Biol (2013) 2.13

Transcription as a source of genome instability. Nat Rev Genet (2012) 1.94

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods (2013) 1.88

Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell (2016) 1.88

Tyrosine kinase gene rearrangements in epithelial malignancies. Nat Rev Cancer (2013) 1.80

Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat Rev Immunol (2012) 1.80

Histone modifications predispose genome regions to breakage and translocation. Genes Dev (2015) 1.67

The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64

Higher-order chromatin structure: bridging physics and biology. Curr Opin Genet Dev (2012) 1.60

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell (2014) 1.58

RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep (2013) 1.53

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability. Cell (2014) 1.43

Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells. Nature (2017) 1.43

Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet (2014) 1.33

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A (2012) 1.31

Close proximity to Igh is a contributing factor to AID-mediated translocations. Mol Cell (2012) 1.23

Regulation of AID, the B-cell genome mutator. Genes Dev (2013) 1.21

Divergent transcription: a driving force for new gene origination? Cell (2013) 1.20

Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes. Cell (2015) 1.17

Long-Range Chromatin Interactions. Cold Spring Harb Perspect Biol (2015) 1.16

Gene editing: not just for translation anymore. Nat Methods (2011) 1.16

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells. Nature (2014) 1.16

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A (2014) 1.15

Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell (2014) 1.15

Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair. Adv Immunol (2014) 1.11

Regulation of Aicda expression and AID activity. Autoimmunity (2013) 1.11

Generation of an HIV resistant T-cell line by targeted "stacking" of restriction factors. Mol Ther (2013) 1.10

DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice. Nucleic Acids Res (2013) 1.09

Three-dimensional genome architecture influences partner selection for chromosomal translocations in human disease. PLoS One (2012) 1.08

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature (2015) 1.05

The AID-induced DNA damage response in chromatin. Mol Cell (2013) 1.04

Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome. Proc Natl Acad Sci U S A (2014) 1.03

Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases. Nat Rev Genet (2016) 1.03

AID-induced remodeling of immunoglobulin genes and B cell fate. Oncotarget (2014) 1.02

Mapping genomic hotspots of DNA damage by a single-strand-DNA-compatible and strand-specific ChIP-seq method. Genome Res (2012) 1.01

Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq. Genome Res (2016) 1.01

Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders. Am J Hum Genet (2015) 1.00

A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells. Nat Immunol (2013) 0.97

Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery. Nat Methods (2015) 0.96

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes. Elife (2014) 0.96

Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proc Natl Acad Sci U S A (2016) 0.96

Breaking bad: R-loops and genome integrity. Trends Cell Biol (2015) 0.95

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med (2012) 0.95

Perspectives of integrative cancer genomics in next generation sequencing era. Genomics Inform (2012) 0.94

Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proc Natl Acad Sci U S A (2014) 0.93

IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas. Blood (2012) 0.93

53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma. Mol Cell (2013) 0.93

Understanding spatial organizations of chromosomes via statistical analysis of Hi-C data. Quant Biol (2013) 0.93

Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res (2012) 0.92

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A. J Biol Chem (2012) 0.92

Complex correlations: replication timing and mutational landscapes during cancer and genome evolution. Curr Opin Genet Dev (2014) 0.92

Differential programming of B cells in AID deficient mice. PLoS One (2013) 0.91

Origin of immunoglobulin isotype switching. Curr Biol (2012) 0.91

S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation. Genes Dev (2016) 0.90

Chromosome position determines the success of double-strand break repair. Proc Natl Acad Sci U S A (2015) 0.90

Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proc Natl Acad Sci U S A (2013) 0.90

AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. PLoS One (2012) 0.89

A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation. Genes Dev (2015) 0.89

Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications. Semin Immunol (2012) 0.89

Epigenetic targeting of activation-induced cytidine deaminase. Proc Natl Acad Sci U S A (2014) 0.88

Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation. Proc Natl Acad Sci U S A (2012) 0.88

The dual nature of mismatch repair as antimutator and mutator: for better or for worse. Front Genet (2014) 0.88

Identification of core DNA elements that target somatic hypermutation. J Immunol (2012) 0.88

Deciphering the Code of the Cancer Genome: Mechanisms of Chromosome Rearrangement. Trends Cancer (2015) 0.86

Fusion FISH imaging: single-molecule detection of gene fusion transcripts in situ. PLoS One (2014) 0.86

Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer Immunol Res (2014) 0.86

AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination. Front Immunol (2014) 0.85

Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Nucleic Acids Res (2014) 0.85

Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nat Rev Mol Cell Biol (2017) 0.85

The origin of B cell recurrent chromosomal translocations: proximity versus DNA damage. Mol Cell (2013) 0.84

Mapping the precision of genome editing. Nat Biotechnol (2015) 0.84

Genomic hallmarks of genes involved in chromosomal translocations in hematological cancer. PLoS Comput Biol (2012) 0.83

The cellular etiology of chromosome translocations. Curr Opin Cell Biol (2013) 0.83

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nat Protoc (2016) 0.83

Chromosomal Rearrangements in Cancer: Detection and potential causal mechanisms. Mol Cell Oncol (2014) 0.83

Causes and consequences of nuclear envelope alterations in tumour progression. Eur J Cell Biol (2016) 0.83

Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity. Nat Rev Immunol (2016) 0.82

Back to the origin: reconsidering replication, transcription, epigenetics, and cell cycle control. Genes Cancer (2012) 0.82

Targeted cancer therapy: what if the driver is just a messenger? Cell Cycle (2011) 0.82

Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Nat Commun (2016) 0.82

Cyclin-dependent kinases regulate Ig class switching by controlling access of AID to the switch region. J Immunol (2015) 0.82

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Nat Commun (2016) 0.81

Generation and repair of AID-initiated DNA lesions in B lymphocytes. Front Med (2014) 0.81

Mechanisms of human lymphoid chromosomal translocations. Nat Rev Cancer (2016) 0.81

Quantitative detection of rare interphase chromosome breaks and translocations by high-throughput imaging. Genome Biol (2015) 0.81

AID-initiated DNA lesions are differentially processed in distinct B cell populations. J Immunol (2014) 0.81

Highly sensitive and unbiased approach for elucidating antibody repertoires. Proc Natl Acad Sci U S A (2016) 0.80

Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes. DNA Repair (Amst) (2015) 0.80

DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2015) 0.80

Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia. Eur J Immunol (2014) 0.80

Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. J Exp Med (2016) 0.79

Articles cited by this

Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83

The cancer genome. Nature (2009) 23.13

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83

Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science (2008) 16.48

Targeting DNA double-strand breaks with TAL effector nucleases. Genetics (2010) 14.49

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80

An improved PCR method for walking in uncloned genomic DNA. Nucleic Acids Res (1995) 8.66

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature (2001) 6.70

IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05

Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell (2009) 5.74

Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature (2008) 5.11

Genetic manipulation of genomes with rare-cutting endonucleases. Trends Genet (1996) 5.07

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29

Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome. Genome Res (2010) 4.22

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53

The connection between transcription and genomic instability. EMBO J (2002) 3.44

Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene (2001) 3.32

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci U S A (2000) 3.21

Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94

Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol (2010) 2.80

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Nat Struct Mol Biol (2010) 2.65

Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science (2006) 2.49

Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27

Cotranscriptional processes and their influence on genome stability. Genes Dev (2006) 2.23

Spatial genome organization in the formation of chromosomal translocations. Semin Cancer Biol (2006) 2.12

Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc. Nat Immunol (2004) 2.00

Balancing AID and DNA repair during somatic hypermutation. Trends Immunol (2009) 1.86

AID targeting in antibody diversity. Adv Immunol (2011) 1.78

The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol (2010) 1.77

Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu Rev Immunol (2011) 1.75

Zinc-finger nuclease based genome surgery: it's all about specificity. Curr Gene Ther (2011) 1.56

Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc Natl Acad Sci U S A (2002) 1.44

AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements. J Exp Med (2007) 1.37

Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex. Proc Natl Acad Sci U S A (2007) 1.34

Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proc Natl Acad Sci U S A (2009) 1.25

Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target? Clin Cancer Res (2011) 1.21

The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy. Protein Eng Des Sel (2010) 1.15

Breaking the rules of cancer. Nat Med (2006) 1.09

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proc Natl Acad Sci U S A (2010) 1.08

Chromosomal location targets different MYC family gene members for oncogenic translocations. Proc Natl Acad Sci U S A (2009) 1.07

Interallelic class switch recombination contributes significantly to class switching in mouse B cells. J Immunol (2005) 1.05

Articles by these authors

Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38

Initial genome sequencing and analysis of multiple myeloma. Nature (2011) 17.28

Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18

The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood (2004) 11.07

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med (2011) 11.07

Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med (2011) 9.90

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell (2013) 9.24

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14

Complete Khoisan and Bantu genomes from southern Africa. Nature (2010) 9.06

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell (2005) 7.99

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A (2006) 6.80

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48

The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28

Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09

Community-based therapy for multidrug-resistant tuberculosis in Lima, Peru. N Engl J Med (2003) 6.07

IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76

SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68

DNA repair, genome stability, and aging. Cell (2005) 5.52

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26

Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A (2008) 4.43

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood (2003) 4.43

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood (2010) 4.35

Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29

Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron (2002) 4.18

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14

Production and characterization of adeno-associated viral vectors. Nat Protoc (2006) 4.11

Phase III trial of doxorubicin, paclitaxel, and the combination of doxorubicin and paclitaxel as front-line chemotherapy for metastatic breast cancer: an intergroup trial (E1193). J Clin Oncol (2003) 4.07

iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell (2009) 4.04

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04

Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94

Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood (2004) 3.84

Synthetic spike-in standards for RNA-seq experiments. Genome Res (2011) 3.58

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol (2002) 3.55

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53

Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts. J Clin Oncol (2006) 3.53

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood (2007) 3.52

Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46

Familial cancer associated with a polymorphism in ARLTS1. N Engl J Med (2005) 3.35

SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33

Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J Clin Oncol (2007) 3.29

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21

Label-free oxygen-metabolic photoacoustic microscopy in vivo. J Biomed Opt (2011) 3.16

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A (2011) 3.14

Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. J Exp Med (2006) 3.14

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12

Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood (2009) 3.02

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature (2002) 3.02

The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem (2008) 3.01

Mechanism and control of class-switch recombination. Trends Immunol (2002) 2.95

Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94

Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. J Clin Oncol (2012) 2.92

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88

Demasculinization of X chromosomes in the Drosophila genus. Nature (2007) 2.85

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85

Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res (2002) 2.83

AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77

Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proc Natl Acad Sci U S A (2013) 2.75

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74

Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73

The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) (2004) 2.72

The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev (2003) 2.72

Comparative gene marker selection suite. Bioinformatics (2006) 2.71

PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease. Cancer Cell (2003) 2.70

A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2009) 2.67

Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res (2009) 2.64

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63

CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62

Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells (2010) 2.62

Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nanotechnol (2007) 2.61