Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMC 2568927)

Published in J Biol Chem on July 24, 2008

Authors

Jianhua Shi1, Tianyi Zhang, Chunlei Zhou, Muhammad Omar Chohan, Xiaosong Gu, Jerzy Wegiel, Jianhua Zhou, Yu-Wen Hwang, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gong, Fei Liu

Author Affiliations

1: Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, P. R. China.

Articles citing this

Mechanisms of tau-induced neurodegeneration. Acta Neuropathol (2009) 2.27

Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res (2010) 2.07

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol (2011) 2.06

Down syndrome--recent progress and future prospects. Hum Mol Genet (2009) 1.85

The role of DYRK1A in neurodegenerative diseases. FEBS J (2010) 1.23

Tau and neurodegenerative disease: the story so far. Nat Rev Neurol (2015) 1.10

Phosphorylation-mediated regulation of alternative splicing in cancer. Int J Cell Biol (2013) 1.00

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome. Nat Rev Neurosci (2015) 0.96

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic Acids Res (2011) 0.95

Tau splicing and the intricacies of dementia. J Cell Physiol (2012) 0.94

Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's? ACS Chem Neurosci (2012) 0.91

Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles. Biochem Pharmacol (2014) 0.90

Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. J Biol Chem (2011) 0.89

Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway. J Cell Sci (2012) 0.88

Hyperphosphorylation-induced tau oligomers. Front Neurol (2013) 0.87

Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A. Neurobiol Aging (2011) 0.87

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. J Biol Chem (2012) 0.86

An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia. Gene (2011) 0.85

Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. J Neuropathol Exp Neurol (2011) 0.85

Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau. J Biol Chem (2014) 0.84

Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations. Gene (2009) 0.84

Splicing factor SC35 promotes tau expression through stabilization of its mRNA. FEBS Lett (2011) 0.83

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial. Biochem Soc Trans (2010) 0.82

Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. J Biol Chem (2015) 0.82

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome. Front Behav Neurosci (2016) 0.79

Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4. ACS Med Chem Lett (2014) 0.79

Dissecting Alzheimer disease in Down syndrome using mouse models. Front Behav Neurosci (2015) 0.79

DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort. BMC Med Genet (2009) 0.79

Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain. PLoS One (2014) 0.78

10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem (2015) 0.78

Molecular and cellular alterations in Down syndrome: toward the identification of targets for therapeutics. Neural Plast (2012) 0.78

Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein. Genes Cancer (2011) 0.78

Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). J Neurosci Res (2013) 0.77

The molecular basis of cognitive deficits in pervasive developmental disorders. Learn Mem (2012) 0.77

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors. PLoS One (2014) 0.77

Tau mis-splicing in the pathogenesis of neurodegenerative disorders. BMB Rep (2016) 0.75

Cyclic AMP-dependent protein kinase A regulates the alternative splicing of CaMKIIδ. PLoS One (2011) 0.75

Articles cited by this

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature (1998) 15.24

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A (1986) 10.13

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron (1989) 8.04

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci (2007) 7.96

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem (1986) 6.91

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science (2001) 6.17

The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol (2007) 6.16

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science (2001) 6.00

A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature (1994) 5.01

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature (2006) 4.80

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J (1996) 4.65

ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol (1985) 3.83

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem (2003) 3.79

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature (2006) 3.61

Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron (1999) 3.49

Structure and novel exons of the human tau gene. Biochemistry (1992) 2.68

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 2.67

Developmentally regulated expression of specific tau sequences. Neuron (1989) 2.62

Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta (2005) 2.46

Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I. Nature (1996) 2.45

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. EMBO J (1998) 2.37

Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors. Proc Natl Acad Sci U S A (1994) 2.34

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A (1996) 2.32

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements. Proc Natl Acad Sci U S A (1999) 2.26

Mutations causing neurodegenerative tauopathies. Biochim Biophys Acta (2005) 2.24

Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell (2005) 2.11

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. Proc Natl Acad Sci U S A (1993) 1.92

The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem (1999) 1.90

Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing. Genes Dev (1998) 1.85

Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis (2000) 1.84

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J (1995) 1.77

Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease. J Biol Chem (2000) 1.59

DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly. J Cell Sci (2003) 1.36

Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein. J Biol Chem (2001) 1.28

Regulation of tau isoform expression and dementia. Biochim Biophys Acta (2005) 1.21

Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. J Biol Chem (2002) 1.20

Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease. J Biol Chem (2003) 1.19

Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies. Neuropathology (2006) 1.18

Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1. J Biol Chem (2005) 1.15

Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain. Brain Res (2004) 1.11

Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. Genes Cells (2004) 1.11

A minimal length between tau exon 10 and 11 is required for correct splicing of exon 10. J Neurochem (2004) 1.07

Arginine/serine-rich protein interaction domain-dependent modulation of a tau exon 10 splicing enhancer: altered interactions and mechanisms for functionally antagonistic FTDP-17 mutations Delta280K AND N279K. J Biol Chem (2005) 1.07

SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations. Mol Cell Neurosci (2006) 1.04

Competition for microtubule-binding with dual expression of tau missense and splice isoforms. Mol Biol Cell (2001) 1.00

The MNB/DYRK1A protein kinase: genetic and biochemical properties. J Neural Transm Suppl (2003) 0.97

Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level. FEBS Lett (2006) 0.97

Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia. Brain (2003) 0.95

The DeltaK280 mutation in MAP tau favors exon 10 skipping in vivo. J Neuropathol Exp Neurol (2007) 0.94

Articles by these authors

The impacts of climate change on water resources and agriculture in China. Nature (2010) 7.35

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol (2005) 6.16

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci (2008) 4.63

The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64

Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A (2011) 3.45

Tube Formation in Nanoscale Materials. Nanoscale Res Lett (2008) 2.83

The dragon strikes: lessons from the Wenchuan earthquake. Anesth Analg (2010) 2.78

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 2.67

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis (2010) 2.62

Application of hyperspectral imaging and chemometric calibrations for variety discrimination of maize seeds. Sensors (Basel) (2012) 2.46

Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta (2005) 2.46

Magnetic resonance imaging of carotid atherosclerosis: plaque analysis. Top Magn Reson Imaging (2007) 2.36

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci (2005) 2.35

Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment. Am J Psychiatry (2011) 2.29

Mechanisms of tau-induced neurodegeneration. Acta Neuropathol (2009) 2.27

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur J Neurosci (2007) 2.24

Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiol Aging (2004) 2.18

Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96

CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimers Dement (2013) 1.90

Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol Aging (2008) 1.89

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement (2011) 1.87

The genomics of selection in dogs and the parallel evolution between dogs and humans. Nat Commun (2013) 1.86

Survival motor neuron protein facilitates assembly of stress granules. FEBS Lett (2004) 1.86

Labeling proteins with small molecules by site-specific posttranslational modification. J Am Chem Soc (2004) 1.84

Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition. PLoS One (2012) 1.82

Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial. Am Heart J (2008) 1.80

Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A (2012) 1.75

GATA transcription factors integrate Wnt signalling during heart development. Development (2008) 1.74

Microtubule-associated protein tau in development, degeneration and protection of neurons. Prog Neurobiol (2008) 1.74

A negative correlation between human carotid atherosclerotic plaque progression and plaque wall stress: in vivo MRI-based 2D/3D FSI models. J Biomech (2008) 1.74

MRI of atherosclerosis in clinical trials. NMR Biomed (2006) 1.71

Emetine regulates the alternative splicing of Bcl-x through a protein phosphatase 1-dependent mechanism. Chem Biol (2007) 1.65

Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes. Cardiovasc Res (2011) 1.64

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am J Pathol (2003) 1.64

Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. J Biol Chem (2005) 1.64

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. J Pathol (2011) 1.63

Plasmonic gold mushroom arrays with refractive index sensing figures of merit approaching the theoretical limit. Nat Commun (2013) 1.61

Evaluation of biocompatibility of polypyrrole in vitro and in vivo. J Biomed Mater Res A (2004) 1.59

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. J Biol Chem (2004) 1.58

HTQC: a fast quality control toolkit for Illumina sequencing data. BMC Bioinformatics (2013) 1.58

Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A (2012) 1.57

Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion. Am J Psychiatry (2009) 1.53

Unusual burns with combined injuries caused by mobile phone explosion: watch out for the "mini-bomb"! J Burn Care Res (2009) 1.53

The multiple roles for Sox2 in stem cell maintenance and tumorigenesis. Cell Signal (2013) 1.52

Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome. Neurosci Lett (2006) 1.48

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain (2009) 1.48

Transcriptome profiling of early developing cotton fiber by deep-sequencing reveals significantly differential expression of genes in a fuzzless/lintless mutant. Genomics (2010) 1.48

Heat stress-responsive transcriptome analysis in heat susceptible and tolerant wheat (Triticum aestivum L.) by using Wheat Genome Array. BMC Genomics (2008) 1.47

Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism. Chem Biol (2004) 1.45

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. FASEB J (2008) 1.43

Autophagy in stem cells. Autophagy (2013) 1.43

Laser doppler perfusion imaging of skin territory to reflect autonomic functional recovery following sciatic nerve autografting repair in rats. Microsurgery (2012) 1.40

Anterior versus posterior routes of reconstruction after esophagectomy: a comparative anatomic study. Ann Thorac Surg (2009) 1.40

Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. J Alzheimers Dis (2013) 1.40

Failure of neuronal maturation in Alzheimer disease dentate gyrus. J Neuropathol Exp Neurol (2008) 1.39

Tau exon 10 alternative splicing and tauopathies. Mol Neurodegener (2008) 1.38

Echo rounds: intraoperative transesophageal echocardiography-guided patent ductus arteriosus ligation in an asymptomatic nonbacterial endocarditis patient. Anesth Analg (2010) 1.38

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. Am J Pathol (2005) 1.37

Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation. Eur J Neurosci (2007) 1.36

NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation. Proc Natl Acad Sci U S A (2013) 1.35

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proc Natl Acad Sci U S A (2006) 1.33

Detection of intracellular cytokines by flow cytometry. Curr Protoc Immunol (2007) 1.32

Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma. Am J Clin Nutr (2013) 1.29

The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. J Biol Chem (2009) 1.27

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. Brain Res Mol Brain Res (2002) 1.27

Video-assisted thoracoscopic solitary pulmonary nodule resection after CT-guided hookwire localization: 43 cases report and literature review. Surg Endosc (2010) 1.26

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. FEBS Lett (2002) 1.26

p62/SQSTM1 involved in cisplatin resistance in human ovarian cancer cells by clearing ubiquitinated proteins. Eur J Cancer (2011) 1.25

A graphene oxide based immuno-biosensor for pathogen detection. Angew Chem Int Ed Engl (2010) 1.24

Mechanism of chronic aristolochic acid nephropathy: role of Smad3. Am J Physiol Renal Physiol (2010) 1.24