Published in J Biol Chem on February 03, 2005
TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing. J Biol Chem (2008) 1.98
Defective splicing, disease and therapy: searching for master checkpoints in exon definition. Nucleic Acids Res (2006) 1.89
A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators. Proc Natl Acad Sci U S A (2008) 1.56
Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome. J Biol Chem (2008) 1.22
hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c. RNA (2007) 1.19
SR protein-mediated inhibition of CFTR exon 9 inclusion: molecular characterization of the intronic splicing silencer. Nucleic Acids Res (2007) 1.17
SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy. Mol Cell Biol (2006) 1.13
Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies. Proc Natl Acad Sci U S A (2005) 1.10
SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations. Mol Cell Neurosci (2006) 1.04
HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition. Nucleic Acids Res (2013) 1.00
The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B. RNA (2012) 1.00
Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. J Biol Chem (2011) 0.89
Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies. BMC Neurosci (2008) 0.89
Concentration dependent selection of targets by an SR splicing regulator results in tissue-specific RNA processing. Nucleic Acids Res (2006) 0.89
Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol (2014) 0.89
An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia. Gene (2011) 0.85
Post-transcriptional regulation in corticogenesis: how RNA-binding proteins help build the brain. Wiley Interdiscip Rev RNA (2015) 0.84
Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. J Alzheimers Dis (2014) 0.82
Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain. PLoS One (2014) 0.78
Single neuron transcriptomics identify SRSF/SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing. Sci Rep (2016) 0.75
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. Science (2005) 4.54
Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med (2013) 3.81
Rationally designed, polymeric, extended metal-ciprofloxacin complexes. Chemistry (2005) 3.56
Alternative splicing and disease. Biochim Biophys Acta (2008) 3.47
ASD: the Alternative Splicing Database. Nucleic Acids Res (2004) 3.26
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells (2010) 3.24
Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA. Hum Mol Genet (2004) 2.23
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med (2007) 2.17
A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists. Arthritis Rheum (2007) 2.11
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab (2011) 2.08
Function of alternative splicing. Gene (2012) 2.00
Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87. Cancer Lett (2008) 1.93
Pre-mRNA secondary structures influence exon recognition. PLoS Genet (2007) 1.92
Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies. J Invest Dermatol (2012) 1.91
Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Genes Dev (2002) 1.89
Phosphorylation of tau by fyn: implications for Alzheimer's disease. J Neurosci (2004) 1.88
The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing. Hum Mol Genet (2010) 1.83
SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis. PLoS One (2011) 1.70
Tau protects microtubules in the axon from severing by katanin. J Neurosci (2006) 1.69
A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology (2014) 1.66
Global occurrence of archaeal amoA genes in terrestrial hot springs. Appl Environ Microbiol (2008) 1.65
A fungal phylogeny based on 82 complete genomes using the composition vector method. BMC Evol Biol (2009) 1.61
Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis. Arthritis Rheum (2006) 1.60
Association of Interferon- and transforming growth factor β-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis. Arthritis Rheumatol (2014) 1.58
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum (2011) 1.51
The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease. J Neurochem (2005) 1.51
Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana. Silence (2012) 1.49
Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions. Arthritis Res Ther (2007) 1.47
The YTH domain is a novel RNA binding domain. J Biol Chem (2010) 1.45
Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? PLoS One (2008) 1.42
Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci U S A (2007) 1.39
Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J Neurosci (2011) 1.39
Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3. PLoS One (2008) 1.38
Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol (2007) 1.35
Splicing factor Tra2-beta1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene. Cancer Res (2006) 1.34
Substances that can change alternative splice-site selection. Biochem Soc Trans (2008) 1.34
Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet (2007) 1.33
Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol (2012) 1.32
Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension. Arthritis Rheum (2011) 1.31
Expression of splicing factors in human ovarian cancer. Oncol Rep (2004) 1.31
The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. PLoS One (2013) 1.29
The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J (2010) 1.28
Defects in pre-mRNA processing as causes of and predisposition to diseases. DNA Cell Biol (2002) 1.28
YTH: a new domain in nuclear proteins. Trends Biochem Sci (2002) 1.25
Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. PLoS One (2010) 1.25
Ischemia induces a translocation of the splicing factor tra2-beta 1 and changes alternative splicing patterns in the brain. J Neurosci (2002) 1.24
Broadly predicting specific gene functions with expression similarity and taxonomy similarity. Gene (2005) 1.23
Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. J Biol Chem (2009) 1.23
Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-β1. Nat Struct Mol Biol (2011) 1.22
Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. J Biol Chem (2003) 1.22
Processing of snoRNAs as a new source of regulatory non-coding RNAs: snoRNA fragments form a new class of functional RNAs. Bioessays (2012) 1.22
Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J Cell Biol (2002) 1.20
The analysis of the drug-targets based on the topological properties in the human protein-protein interaction network. J Drug Target (2009) 1.20
Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One (2009) 1.20
Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis. J Invest Dermatol (2013) 1.19
Prevalence of drug-resistant tuberculosis in mainland China: systematic review and meta-analysis. PLoS One (2011) 1.19
Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism. Biochem Biophys Res Commun (2002) 1.19
Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J Neurochem (2004) 1.17
Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol (2010) 1.17
The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One (2009) 1.16
Identification and comparative analysis of drought-associated microRNAs in two cowpea genotypes. BMC Plant Biol (2011) 1.16
Antimalarial agents: closing the gate on Toll-like receptors? Arthritis Rheum (2006) 1.15
Willingness to accept HIV pre-exposure prophylaxis among Chinese men who have sex with men. PLoS One (2012) 1.14
Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms. J Biol Chem (2002) 1.14
Emerin interacts in vitro with the splicing-associated factor, YT521-B. Eur J Biochem (2003) 1.12
Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol (2012) 1.11
Human papillomavirus infection and laryngeal cancer risk: a systematic review and meta-analysis. J Infect Dis (2012) 1.11
Microfibril-associated MAGP-2 stimulates elastic fiber assembly. J Biol Chem (2006) 1.10
Anal human papillomavirus infection among HIV-infected and uninfected men who have sex with men in Beijing, China. J Acquir Immune Defic Syndr (2013) 1.10
Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron (2002) 1.09
Immediate removal of posteriorly dislocated lens fragments through sclerocorneal incision during cataract surgery. Br J Ophthalmol (2012) 1.09
The complete chloroplast genome sequence of Cephalotaxus oliveri (Cephalotaxaceae): evolutionary comparison of cephalotaxus chloroplast DNAs and insights into the loss of inverted repeat copies in gymnosperms. Genome Biol Evol (2013) 1.08
p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1. Mol Cell Neurosci (2004) 1.06
Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation. Arthritis Rheum (2002) 1.06
Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest (2015) 1.06
The prevalence of human parvovirus B19 DNA and antibodies in blood donors from four Chinese blood centers. Transfusion (2011) 1.05
Association of human papillomavirus infection and abnormal anal cytology among HIV-infected MSM in Beijing, China. PLoS One (2012) 1.05
Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiol Aging (2011) 1.04
SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations. Mol Cell Neurosci (2006) 1.04
The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. Hum Mol Genet (2004) 1.04
TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J Immunol (2009) 1.03
Pre-mRNA missplicing as a cause of human disease. Prog Mol Subcell Biol (2006) 1.03
Single molecule profiling of tau gene expression in Alzheimer's disease. J Neurochem (2007) 1.02
Visual mismatch negativity elicited by facial expressions: new evidence from the equiprobable paradigm. Behav Brain Funct (2012) 1.01
Direct cloning of double-stranded RNAs from RNase protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression. Nucleic Acids Res (2011) 1.01
Brain-specific change in alternative splicing of Tau exon 6 in myotonic dystrophy type 1. Biochim Biophys Acta (2005) 1.01
ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I. J Neurosci Res (2006) 1.01
High throughput sequencing reveals novel and abiotic stress-regulated microRNAs in the inflorescences of rice. BMC Plant Biol (2012) 1.01
Identification and molecular characterization of a novel flavivirus isolated from geese in China. Res Vet Sci (2012) 1.01
Prevalence and related risk behaviors of HIV, syphilis, and anal HPV infection among men who have sex with men from Beijing, China. AIDS Behav (2013) 0.99
Globally predicting protein functions based on co-expressed protein-protein interaction networks and ontology taxonomy similarities. Gene (2006) 0.99
Rapid generation of splicing reporters with pSpliceExpress. Gene (2008) 0.99
Influence of warfarin dose-associated genotypes on the risk of hemorrhagic complications in Chinese patients on warfarin. Int J Hematol (2012) 0.98
Intravitreal bevacizumab versus triamcinolone acetonide for macular edema due to branch retinal vein occlusion: a matched study. Chin Med J (Engl) (2009) 0.98