Peter H Backx

Author PubWeight™ 135.31‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 2008 9.87
2 Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 2002 5.02
3 Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 2002 4.35
4 The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol 2004 2.90
5 Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters. Am J Physiol Regul Integr Comp Physiol 2008 2.62
6 L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat Med 2003 2.38
7 GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med 2013 2.31
8 Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol 2003 2.19
9 The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell 2005 2.19
10 Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat Methods 2013 2.14
11 Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A 2011 1.92
12 Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem 2006 1.92
13 Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling. Circ Res 2002 1.71
14 Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circ Res 2006 1.71
15 Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A 2004 1.63
16 RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res 2008 1.61
17 Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension 2010 1.59
18 Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol 2005 1.58
19 Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol 2007 1.55
20 Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells 2008 1.54
21 Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q. Heart Rhythm 2012 1.53
22 Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy. J Mol Med (Berl) 2006 1.46
23 Do mesenchymal stromal cells transdifferentiate into functional cardiomyocytes? Circ Res 2008 1.46
24 The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy. J Am Coll Cardiol 2011 1.46
25 Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor. Endocrinology 2010 1.42
26 Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res 2007 1.40
27 MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. J Clin Invest 2011 1.39
28 Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation 2003 1.36
29 Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol 2006 1.35
30 Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol 2008 1.32
31 Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. Mol Cell Proteomics 2007 1.31
32 Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization. Hypertension 2007 1.31
33 Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circ Res 2002 1.31
34 Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2. J Physiol 2003 1.30
35 Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circ Res 2005 1.29
36 PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nat Neurosci 2011 1.28
37 Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation. Proc Natl Acad Sci U S A 2006 1.24
38 PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Circ Res 2007 1.22
39 Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation 2004 1.22
40 The role of ACE2 in cardiovascular physiology. Trends Cardiovasc Med 2003 1.21
41 The role of thin filament cooperativity in cardiac length-dependent calcium activation. Biophys J 2010 1.15
42 Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice. Am J Physiol Cell Physiol 2011 1.12
43 Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovasc Res 2008 1.11
44 Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway. J Pharmacol Exp Ther 2007 1.09
45 Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling. Stroke 2010 1.09
46 Selective inhibition of inward rectifier K+ channels (Kir2.1 or Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes. Circ Res 2004 1.09
47 Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proc Natl Acad Sci U S A 2006 1.08
48 Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients. Am J Physiol Heart Circ Physiol 2002 1.05
49 Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circ Res 2010 1.03
50 Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B. Proc Natl Acad Sci U S A 2010 1.03
51 Tbx5-dependent pathway regulating diastolic function in congenital heart disease. Proc Natl Acad Sci U S A 2008 1.02
52 Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ Res 2008 1.02
53 Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression. Circ Res 2011 1.02
54 Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes. Circulation 2002 1.01
55 Lithium-induced sinus node disease at therapeutic concentrations: linking lithium-induced blockade of sodium channels to impaired pacemaker activity. Can J Cardiol 2007 1.01
56 Iroquois homeodomain transcription factors in heart development and function. Circ Res 2012 0.97
57 Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits. J Biol Chem 2006 0.96
58 Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart. Circ Res 2012 0.95
59 Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles. Br J Pharmacol 2006 0.95
60 Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circ Res 2005 0.94
61 Altered heart rate and sinoatrial node function in mice lacking the cAMP regulator phosphoinositide 3-kinase-gamma. Circ Res 2007 0.94
62 Conduction through the inward rectifier potassium channel, Kir2.1, is increased by negatively charged extracellular residues. J Gen Physiol 2005 0.94
63 Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin. Clin Sci (Lond) 2011 0.93
64 Regulation of proliferation and membrane potential by chloride currents in rat pulmonary artery smooth muscle cells. Hypertension 2009 0.93
65 The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents. Cardiovasc Res 2004 0.92
66 Phosphoinositide 3-kinase gamma regulates cardiac contractility by locally controlling cyclic adenosine monophosphate levels. Trends Cardiovasc Med 2006 0.92
67 Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation 2002 0.91
68 Enhanced cell volume regulation: a key protective mechanism of ischemic preconditioning in rabbit ventricular myocytes. J Mol Cell Cardiol 2003 0.89
69 α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes. Am J Physiol Heart Circ Physiol 2012 0.89
70 Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1. Endocrinology 2006 0.88
71 The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function. Circ Res 2010 0.88
72 A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor. Mol Pharmacol 2005 0.87
73 Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. Mol Cell Biol 2012 0.87
74 Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation. Circ Arrhythm Electrophysiol 2011 0.86
75 2-hydroxyoleic acid affects cardiomyocyte [Ca2+]i transient and contractility in a region-dependent manner. Am J Physiol Heart Circ Physiol 2008 0.86
76 Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition. Cardiovasc Res 2002 0.84
77 Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials. Basic Res Cardiol 2011 0.83
78 Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice. Physiol Genomics 2007 0.83
79 Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction. Circulation 2012 0.83
80 Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther 2013 0.82
81 Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts. PLoS One 2013 0.82
82 L-tryptophan ethyl ester dilates small mesenteric arteries by inhibition of voltage-operated calcium channels in smooth muscle. Br J Pharmacol 2012 0.82
83 Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy. Cardiovasc Res 2010 0.81
84 Dissection of the voltage-activated potassium outward currents in adult mouse ventricular myocytes: I(to,f), I(to,s), I(K,slow1), I(K,slow2), and I(ss). Basic Res Cardiol 2011 0.81
85 Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn rats. Free Radic Biol Med 2010 0.81
86 Mesenchymal stem cell transplantation mitigates electrophysiological remodeling in a rat model of myocardial infarction. J Cardiovasc Electrophysiol 2013 0.81
87 Regulation of murine cardiac function by phosphodiesterases type 3 and 4. Curr Opin Pharmacol 2011 0.80
88 Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells. J Hypertens 2014 0.80
89 Molecular components of transient outward potassium current in cultured neonatal rat ventricular myocytes. J Mol Med (Berl) 2002 0.79
90 Permeable ions differentially affect gating kinetics and unitary conductance of L-type calcium channels. Biochem Biophys Res Commun 2005 0.79
91 I(Ks) block by HMR 1556 lowers ventricular defibrillation threshold and reverses the repolarization shortening by isoproterenol without rate-dependence in rabbits. J Cardiovasc Electrophysiol 2007 0.78
92 Role of phosphatidylinositol-3 kinase-gamma in the actions of glucagon-like peptide-2 on the murine small intestine. Am J Physiol Endocrinol Metab 2007 0.78
93 Electrophysiological profiling of cardiomyocytes in embryonic bodies derived from human embryonic stem cells: therapeutic implications. Circ Res 2003 0.77
94 Adrenomedullary catecholamine, pressor and chronotropic responses to human coagulation beta-FXIIa mediated by endogenous kinins. J Hypertens 2008 0.77
95 P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels. PLoS One 2009 0.77
96 Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families. J Hypertens 2007 0.77
97 A new enzyme-linked immunosorbent assay recognizing both rat and human activated coagulation Factor XII (FXIIa). J Immunol Methods 2012 0.76
98 The electrophysiological development of cardiomyocytes. Adv Drug Deliv Rev 2016 0.76
99 Patch-clamp technique in ESC-derived cardiomyocytes. Methods Mol Biol 2014 0.76
100 Sulfhydryl modulation of K+ currents: a possible cross-link between oxidative stress and altered cardiovascular function. J Mol Cell Cardiol 2003 0.75
101 Sulfonylurea receptor expression heterogeneity suggests chamber-specific roles for sarcolemmal KATP channels in heart. Circ Res 2008 0.75
102 Could plugging the oxidation-mediated Ca2+ leak stem the tide of the atrial fibrillation epidemic? Circ Res 2012 0.75
103 Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats. Clin Sci (Lond) 2012 0.75
104 Serving up the ping-pong mechanisms for biventricular ventricular tachycardia. Heart Rhythm 2011 0.75
105 Atrial fibrillation and the athletic heart. Curr Opin Cardiol 2015 0.75
106 Role of Cl- currents in rat aortic smooth muscle activation by prostaglandin F2 alpha. Eur J Pharmacol 2003 0.75
107 Heart failure in congenital heart disease: the role of genes and hemodynamics. Pflugers Arch 2014 0.75
108 Coagulation factor XIIa-kinin-mediated contribution to hypertension of chronic kidney disease. J Hypertens 2014 0.75
109 Non-Michaelis-Menten kinetics model for conductance of low-conductance potassium ion channels. Phys Rev E Stat Nonlin Soft Matter Phys 2005 0.75