Published in Proc Natl Acad Sci U S A on August 08, 2011
Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature (2014) 5.61
GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and Function. Circ Cardiovasc Genet (2015) 1.42
Gene regulatory networks in cardiac conduction system development. Circ Res (2012) 1.09
Signaling and transcriptional networks in heart development and regeneration. Cold Spring Harb Perspect Biol (2013) 1.07
Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development (2012) 0.94
Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur Heart J (2015) 0.90
Misinterpretation of the mouse ECG: 'musing the waves of Mus musculus'. J Physiol (2014) 0.89
Multilayered regulation of cardiac ion channels. Biochim Biophys Acta (2012) 0.87
Hemodynamic forces regulate developmental patterning of atrial conduction. PLoS One (2014) 0.85
Channeling diversity: gap junction expression in the heart. Heart Rhythm (2011) 0.83
A micropatterning approach for imaging dynamic Cx43 trafficking to cell-cell borders. FEBS Lett (2014) 0.81
Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice. Genesis (2013) 0.81
Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization. Cell Commun Adhes (2014) 0.80
Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cells. Stem Cells (2015) 0.79
Genetic variants and disease: correlate or cause? Eur Heart J (2015) 0.78
Defining the neighborhoods that escort the oocyte through its early life events and into a functional follicle. Mol Reprod Dev (2013) 0.78
NKX2-5 mutations in an inbred consanguineous population: genetic and phenotypic diversity. Sci Rep (2015) 0.78
FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study. PLoS One (2015) 0.77
Electrophysiological patterning of the heart. Pediatr Cardiol (2012) 0.77
Transcription factor ETV1 is essential for rapid conduction in the heart. J Clin Invest (2016) 0.77
Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes. PLoS One (2015) 0.77
Irx3: a conductor of conduction. Circ Res (2011) 0.76
Irx3 is required for postnatal maturation of the mouse ventricular conduction system. Sci Rep (2016) 0.76
MyoR modulates cardiac conduction by repressing Gata4. Mol Cell Biol (2014) 0.75
The Iroquois complex is required in the dorsal mesoderm to ensure normal heart development in Drosophila. PLoS One (2013) 0.75
Associations of NKX2-5 Genetic Polymorphisms with the Risk of Congenital Heart Disease: A Meta-analysis. Pediatr Cardiol (2016) 0.75
IRX3 variant as a modifier of Brugada syndrome with frequent ventricular fibrillation. HeartRhythm Case Rep (2016) 0.75
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol (1998) 10.58
Optical projection tomography as a tool for 3D microscopy and gene expression studies. Science (2002) 10.46
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell (2008) 7.93
Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell (2008) 3.96
The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol (2005) 3.58
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell (2005) 2.19
A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell (2007) 2.12
QRS duration and mortality in patients with congestive heart failure. Am Heart J (2002) 2.10
Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol (2008) 2.08
Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol (1998) 1.89
Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol (1998) 1.85
Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci U S A (2002) 1.81
Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system. Circ Res (2008) 1.69
The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system. J Cell Sci (1993) 1.65
Gap junction channels formed by coexpressed connexin40 and connexin43. Am J Physiol Heart Circ Physiol (2001) 1.58
Tau-beta-galactosidase, an axon-targeted fusion protein. Proc Natl Acad Sci U S A (1994) 1.52
Architectural and functional asymmetry of the His-Purkinje system of the murine heart. Cardiovasc Res (2004) 1.51
Iroquois genes: genomic organization and function in vertebrate neural development. Curr Opin Genet Dev (2002) 1.51
Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart. Dev Biol (2000) 1.46
Cardiac tissue geometry as a determinant of unidirectional conduction block: assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model. Cardiovasc Res (1995) 1.45
Variations of aberrant ventricular conduction in man: evidence of isolated and combined block within the specialized conduction system. An electrocardiographic and vectorcardiographic study. Circulation (1968) 1.45
Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45. Biophys J (2006) 1.40
Comprehensive transthoracic cardiac imaging in mice using ultrasound biomicroscopy with anatomical confirmation by magnetic resonance imaging. Physiol Genomics (2004) 1.40
Early subdivisions in the neural plate define distinct competence for inductive signals. Development (2002) 1.38
Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system. Circ Res (1997) 1.35
Heterotypic gap junction channel formation between heteromeric and homomeric Cx40 and Cx43 connexons. Am J Physiol Cell Physiol (2001) 1.30
Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol (2001) 1.28
The tight junction protein CAR regulates cardiac conduction and cell-cell communication. J Exp Med (2008) 1.23
Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo. Proc Natl Acad Sci U S A (2005) 1.22
Cardiac conduction is required to preserve cardiac chamber morphology. Proc Natl Acad Sci U S A (2010) 1.17
Significance of complete right bundle-branch block with right axis deviation in absence of right ventricular hypertrophy. Br Heart J (1970) 1.16
Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart. Development (2004) 1.16
Block of impulse propagation at an abrupt tissue expansion: evaluation of the critical strand diameter in 2- and 3-dimensional computer models. Cardiovasc Res (1995) 1.15
Functional consequences of heterogeneous gap junction channel formation and its influence in health and disease. Biochim Biophys Acta (2004) 1.13
The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation. Nat Neurosci (2004) 1.11
Expression of two novel mouse Iroquois homeobox genes during neurogenesis. Mech Dev (2000) 1.11
The development of the conduction system in the mouse embryo heart. Dev Biol (1982) 1.11
Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system. Dev Biol (2006) 1.05
Induction of Purkinje fiber differentiation by coronary arterialization. Proc Natl Acad Sci U S A (1999) 1.01
A targeted disruption in connexin40 leads to distinct atrioventricular conduction defects. J Interv Card Electrophysiol (2000) 0.96
Identification of two regulatory elements within the promoter region of the mouse connexin 43 gene. J Biol Chem (1995) 0.95
Voltage-sensitive dye mapping of activation and conduction in adult mouse hearts. Ann Biomed Eng (2000) 0.92
Expression of Irx6 during mouse morphogenesis. Mech Dev (2001) 0.88
The gating mechanism in the distal atrioventricular conducting system. Circulation (1971) 0.81
Cardiac excitation: an interactive process of ion channels and gap junctions. Adv Exp Med Biol (1997) 0.81
Identification of human brain tumour initiating cells. Nature (2004) 38.87
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell (2010) 15.58
VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med (2008) 9.87
Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24
British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary. BMJ (2004) 7.92
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature (2010) 6.69
miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell (2008) 6.59
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N Engl J Med (2015) 6.48
T1, T2 relaxation and magnetization transfer in tissue at 3T. Magn Reson Med (2005) 6.17
Selective plane illumination microscopy techniques in developmental biology. Development (2009) 5.07
Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development (2005) 5.06
Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature (2002) 5.02
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
Haematopoietic stem cells derive directly from aortic endothelium during development. Nature (2010) 4.42
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell (2012) 4.22
Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell (2009) 4.21
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature (2004) 4.09
Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry (2004) 3.85
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nat Genet (2002) 3.81
Mutations in SUFU predispose to medulloblastoma. Nat Genet (2002) 3.78
Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature (2009) 3.70
Mesodermal Wnt2b signalling positively regulates liver specification. Nature (2006) 3.69
Behavioral phenotypes of Disc1 missense mutations in mice. Neuron (2007) 3.68
Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell (2009) 3.50
Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies. Dev Dyn (2007) 3.44
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
The perivascular niche regulates breast tumour dormancy. Nat Cell Biol (2013) 3.36
Fibronectin regulates epithelial organization during myocardial migration in zebrafish. Dev Cell (2004) 3.34
Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol (2011) 3.25
Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM). Opt Lett (2007) 3.16
Genetic control of single lumen formation in the zebrafish gut. Nat Cell Biol (2007) 3.07
Targeting neural circuitry in zebrafish using GAL4 enhancer trapping. Nat Methods (2007) 3.00
Gay men who look for sex on the Internet: is there more HIV/STI risk with online partners? AIDS (2005) 2.99
The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature (2004) 2.95
Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell (2010) 2.91
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol (2004) 2.90
Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science (2009) 2.82
Web-based behavioral surveillance among men who have sex with men: a comparison of online and offline samples in London, UK. J Acquir Immune Defic Syndr (2004) 2.63
Optogenetic control of cardiac function. Science (2010) 2.63
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters. Am J Physiol Regul Integr Comp Physiol (2008) 2.62
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development (2004) 2.62
Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell (2008) 2.60
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev (2009) 2.59
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes (2009) 2.58
Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev (2006) 2.56
Malignant hyperthermia. Orphanet J Rare Dis (2007) 2.56
Formation of the digestive system in zebrafish. I. Liver morphogenesis. Dev Biol (2003) 2.48
Myofilament length dependent activation. J Mol Cell Cardiol (2010) 2.47
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet (2007) 2.47
Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev (2008) 2.44
A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula. Nature (2006) 2.42
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet (2012) 2.39
Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Dev Biol (2005) 2.38
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat Med (2003) 2.38
BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol (2010) 2.34
Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (2005) 2.32
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med (2013) 2.31
Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R. J Biol Chem (2003) 2.26
Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol (2003) 2.24
Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nat Genet (2009) 2.23
Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development (2003) 2.22
Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol (2003) 2.19
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell (2005) 2.19
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J (2004) 2.18
Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nat Genet (2005) 2.15
Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat Methods (2013) 2.14
Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nat Genet (2007) 2.14
Zebrafish model for human long QT syndrome. Proc Natl Acad Sci U S A (2007) 2.13
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev (2003) 2.12
Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Dev Biol (2003) 2.10
Multiple-mouse MRI. Magn Reson Med (2003) 2.10
Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol (2008) 2.08
The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci Signal (2009) 2.05
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05
Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J Clin Invest (2009) 1.98
Default mode network connectivity encodes clinical pain: an arterial spin labeling study. Pain (2012) 1.97
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development (2005) 1.93