Published in Proc Natl Acad Sci U S A on April 04, 2006
Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev (2008) 2.98
Thyroid and the heart. Am J Med (2014) 2.31
Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology. J Mol Cell Cardiol (2007) 1.55
Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility. Proc Natl Acad Sci U S A (2007) 1.46
American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid (2013) 1.41
Cardiac hypertrophy and thyroid hormone signaling. Heart Fail Rev (2009) 1.27
Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes. Stem Cell Reports (2014) 1.12
Short term triiodo-L-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. J Mol Cell Cardiol (2007) 1.11
Selenium and its supplementation in cardiovascular disease--what do we know? Nutrients (2015) 1.06
Threonine-5 at the N-terminus can modulate sarcolipin function in cardiac myocytes. J Mol Cell Cardiol (2009) 0.98
The role of thyroid hormone in the pathophysiology of heart failure: clinical evidence. Heart Fail Rev (2008) 0.93
Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci (2014) 0.92
Role of inotropic agents in the treatment of heart failure. Circulation (2010) 0.88
Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice. Mol Endocrinol (2012) 0.84
New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider? Heart Fail Rev (2011) 0.84
Thyroid hormone and cardiac disease: from basic concepts to clinical application. J Thyroid Res (2011) 0.82
Essential role of TEA domain transcription factors in the negative regulation of the MYH 7 gene by thyroid hormone and its receptors. PLoS One (2014) 0.82
Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem? Heart Fail Rev (2010) 0.81
Thyroid Hormone-Regulated Cardiac microRNAs are Predicted to Suppress Pathological Hypertrophic Signaling. Front Endocrinol (Lausanne) (2014) 0.79
Decreased cardiac SERCA2 expression, SR Ca uptake, and contractile function in hypothyroidism are attenuated in SERCA2 overexpressing transgenic rats. Am J Physiol Heart Circ Physiol (2011) 0.79
MicroRNA 214 Is a Potential Regulator of Thyroid Hormone Levels in the Mouse Heart Following Myocardial Infarction, by Targeting the Thyroid-Hormone-Inactivating Enzyme Deiodinase Type III. Front Endocrinol (Lausanne) (2016) 0.76
Cardiac Thyroid Hormone Metabolism and Heart Failure. Eur Thyroid J (2017) 0.75
Thyroid hormone and the cardiovascular system. N Engl J Med (2001) 5.56
Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol (2003) 5.05
Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res (2003) 3.16
Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease. Circulation (2003) 2.95
Toward transcriptional therapies for the failing heart: chemical screens to modulate genes. J Clin Invest (2005) 2.65
Recognition and management of cardiovascular disease related to thyroid dysfunction. Am J Med (1990) 2.54
Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium. Circulation (1999) 2.45
Myosin heavy chain gene expression in human heart failure. J Clin Invest (1997) 2.39
Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. J Clin Invest (1996) 2.21
Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol (2003) 2.19
Transgenic remodeling of the contractile apparatus in the mammalian heart. Circ Res (1996) 2.05
Conditional transgene expression in the heart. Circ Res (1996) 1.79
Safety and hemodynamic effects of intravenous triiodothyronine in advanced congestive heart failure. Am J Cardiol (1998) 1.70
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A (2004) 1.63
Expression of the beta (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects. Am J Physiol Heart Circ Physiol (2000) 1.60
The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium. J Mol Cell Cardiol (2001) 1.54
Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban. Proc Natl Acad Sci U S A (2003) 1.48
Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or beta. Endocrinology (2001) 1.37
Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs). J Biol Chem (2002) 1.32
Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circ Res (2001) 1.30
Measurement of intraventricular pressure and cardiac performance in the intact closed-chest anesthetized mouse. Am J Physiol (1997) 1.27
Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure. Endocrinology (2002) 1.25
Overexpression of sarcolipin decreases myocyte contractility and calcium transient. Cardiovasc Res (2005) 1.25
Myocyte-specific enhancer factor 2 and thyroid hormone receptor associate and synergistically activate the alpha-cardiac myosin heavy-chain gene. Mol Cell Biol (1997) 1.21
Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expression. Circulation (2001) 1.17
Nongenomic actions of thyroid hormone on the heart. Thyroid (2002) 1.11
Expression profiles of the three iodothyronine deiodinases, D1, D2, and D3, in the developing rat. Endocrinology (1999) 1.08
Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle. J Physiol (1997) 1.08
Regulation of sarco(endo)plasmic reticulum Ca2+ adenosine triphosphatase by phospholamban and sarcolipin: implication for cardiac hypertrophy and failure. Trends Cardiovasc Med (2003) 1.03
The different cardiac expression of the type 2 iodothyronine deiodinase gene between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors. Mol Endocrinol (2003) 1.02
Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics (2005) 1.02
Relevance of Na+-Ca2+ exchange in heart failure. Cardiovasc Res (2003) 1.00
Clinical and experimental studies on the use of 3,5-diiodothyropropionic acid, a thyroid hormone analogue, in heart failure. Thyroid (2002) 1.00
The expression of SR calcium transport ATPase and the Na(+)/Ca(2+)Exchanger are antithetically regulated during mouse cardiac development and in Hypo/hyperthyroidism. J Mol Cell Cardiol (2000) 0.99
Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat. Am J Physiol Endocrinol Metab (2000) 0.97
Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circ Res (2005) 0.94
Thyroid control of sarcolemmal Na+/Ca2+ exchanger and SR Ca2+-ATPase in developing rat heart. Am J Physiol (1998) 0.89
Thyroxine-induced cardiac hypertrophy: influence of adrenergic nervous system versus renin-angiotensin system on myocyte remodeling. Am J Physiol Regul Integr Comp Physiol (2003) 0.88
Functional and metabolic adaptation of the heart to prolonged thyroid hormone treatment. Am J Physiol Heart Circ Physiol (2002) 0.88
Thyroxine-induced cardiac hypertrophy: time course of development and inhibition by propranolol. Endocrinology (1988) 0.86
Dynamic study of post-natal thyroid function in the rat. Acta Endocrinol (Copenh) (1976) 0.84
Functional consequences of Na/Ca exchanger overexpression in cardiac myocytes. Ann N Y Acad Sci (2002) 0.77
VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med (2008) 9.87
Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid. Nat Genet (2004) 8.60
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature (2003) 5.94
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science (2006) 5.67
Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature (2002) 5.02
The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes. Science (2012) 4.93
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell (2009) 4.71
Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell (2005) 4.51
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science (2007) 3.73
The DNA sequence of human chromosome 7. Nature (2003) 3.18
Metamaterials application in sensing. Sensors (Basel) (2012) 3.09
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol (2004) 2.90
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci (2006) 2.85
Early pottery at 20,000 years ago in Xianrendong Cave, China. Science (2012) 2.73
Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr Relat Cancer (2013) 2.69
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters. Am J Physiol Regul Integr Comp Physiol (2008) 2.62
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest (2003) 2.56
Glutamate receptors: RNA editing and death of motor neurons. Nature (2004) 2.53
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
Genome-wide and organ-specific landscapes of epigenetic modifications and their relationships to mRNA and small RNA transcriptomes in maize. Plant Cell (2009) 2.39
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat Med (2003) 2.38
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med (2013) 2.31
The Arabidopsis heterochronic gene ZIPPY is an ARGONAUTE family member. Curr Biol (2003) 2.31
Structure-function analysis of the bestrophin family of anion channels. J Biol Chem (2003) 2.30
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature (2005) 2.27
Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol (2003) 2.19
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell (2005) 2.19
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J Comp Neurol (2007) 2.17
Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat Methods (2013) 2.14
Gaussian Bare-Bones Differential Evolution. IEEE Trans Cybern (2013) 2.08
Activation of STAT6 by STING is critical for antiviral innate immunity. Cell (2011) 2.08
Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerg Infect Dis (2006) 2.07
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat Immunol (2009) 2.07
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proc Natl Acad Sci U S A (2006) 2.05
Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med (2003) 2.04
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
The DNA sequence and analysis of human chromosome 14. Nature (2003) 2.02
Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int (2008) 1.99
Hyperoxic resuscitation improves survival but worsens neurologic outcome in a rat polytrauma model of traumatic brain injury plus hemorrhagic shock. J Trauma Acute Care Surg (2015) 1.97
The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry. PLoS Genet (2012) 1.95
Type 3 deiodinase is critical for the maturation and function of the thyroid axis. J Clin Invest (2006) 1.95
Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. J Clin Endocrinol Metab (2004) 1.95
Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. Clin Cancer Res (2008) 1.94
Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A (2011) 1.92
Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem (2006) 1.92
Sequence and comparative analysis of the maize NB mitochondrial genome. Plant Physiol (2004) 1.83
Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology (2009) 1.83
Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii. PLoS One (2009) 1.83
MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2. Biochem Biophys Res Commun (2010) 1.80
Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation (2010) 1.77
Three-column fixation for complex tibial plateau fractures. J Orthop Trauma (2010) 1.73
Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling. Circ Res (2002) 1.71
Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circ Res (2006) 1.71
Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retina. Proc Natl Acad Sci U S A (2006) 1.70
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proc Natl Acad Sci U S A (2003) 1.69
Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia. J Biol Chem (2012) 1.66
Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity. Am J Physiol Renal Physiol (2014) 1.64
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A (2004) 1.63
RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res (2008) 1.61
A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans. Genome Biol (2008) 1.60
Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension (2010) 1.59
Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol (2005) 1.58
Retracted Predicting new molecular targets for rhein using network pharmacology. BMC Syst Biol (2012) 1.55
Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol (2007) 1.55
Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells (2008) 1.54
Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regul Pept (2013) 1.54
Loss of p47phox subunit enhances susceptibility to biomechanical stress and heart failure because of dysregulation of cortactin and actin filaments. Circ Res (2013) 1.54
Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. J Clin Invest (2003) 1.54
Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q. Heart Rhythm (2012) 1.53
Comparisons among two fertile and three male-sterile mitochondrial genomes of maize. Genetics (2007) 1.53
TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer. J Clin Endocrinol Metab (2014) 1.52
Modern analytical techniques in metabolomics analysis. Analyst (2011) 1.52
The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice. Exp Neurol (2009) 1.50
A novel mutation in the RYR2 gene leading to catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation: dose-dependent arrhythmia-event suppression by β-blocker therapy. Can J Cardiol (2011) 1.50
Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches. J Mass Spectrom (2008) 1.49
Ryanodine receptor type 1 gene mutations found in the Canadian malignant hyperthermia population. Can J Anaesth (2011) 1.48
Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium. J Neurosci (2003) 1.47
Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy. J Mol Med (Berl) (2006) 1.46
Do mesenchymal stromal cells transdifferentiate into functional cardiomyocytes? Circ Res (2008) 1.46
The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy. J Am Coll Cardiol (2011) 1.46