Published in Cardiovasc Res on August 12, 2008
Signaling effectors underlying pathologic growth and remodeling of the heart. J Clin Invest (2013) 2.06
Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes. J Mol Cell Cardiol (2013) 1.70
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol (2009) 1.53
Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats. Br J Pharmacol (2010) 1.16
Roles and targets of class I and IIa histone deacetylases in cardiac hypertrophy. J Biomed Biotechnol (2010) 1.14
Targeting inflammation in heart failure with histone deacetylase inhibitors. Mol Med (2011) 1.11
Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition. Am J Physiol Heart Circ Physiol (2010) 1.06
gp-91 mediates histone deacetylase inhibition-induced cardioprotection. Biochim Biophys Acta (2010) 1.01
Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs. J Mol Cell Cardiol (2014) 1.00
Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab (2012) 0.98
Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure. J Am Heart Assoc (2013) 0.94
Epigenetics: a new mechanism of regulation of heart failure? Basic Res Cardiol (2013) 0.94
Transcriptional coregulators: fine-tuning metabolism. Cell Metab (2014) 0.93
HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases. Chonnam Med J (2016) 0.93
Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. FASEB J (2009) 0.90
Readers, writers, and erasers: chromatin as the whiteboard of heart disease. Circ Res (2015) 0.90
HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. Epigenetics (2015) 0.89
Pharmacoepigenetics in heart failure. Curr Heart Fail Rep (2010) 0.86
On the epigenetics of vascular regulation and disease. Clin Epigenetics (2012) 0.85
HDAC6 deacetylase activity is critical for lipopolysaccharide-induced activation of macrophages. PLoS One (2014) 0.85
Histone deacetylase activity selectively regulates notch-mediated smooth muscle differentiation in human vascular cells. J Am Heart Assoc (2012) 0.84
Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy. Physiol Genomics (2011) 0.84
Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms. J Physiol (2014) 0.82
Cardiac CD47 drives left ventricular heart failure through Ca2+-CaMKII-regulated induction of HDAC3. J Am Heart Assoc (2014) 0.81
Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure. Nat Rev Cardiol (2015) 0.81
Transradial approach for the endovascular treatment of type I endoleak after aortic aneurysm repair: a case report. BMC Surg (2013) 0.81
Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy. BMB Rep (2015) 0.78
4-PBA prevents pressure overload-induced myocardial hypertrophy and interstitial fibrosis by attenuating endoplasmic reticulum stress. Chem Biol Interact (2015) 0.78
Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression. Sci Signal (2016) 0.77
Novel epigenetic-based therapies useful in cardiovascular medicine. World J Cardiol (2016) 0.77
MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification. Nat Commun (2016) 0.76
Augmentation of Cationic Antimicrobial Peptide Production with Histone Deacetylase Inhibitors as a Novel Epigenetic Therapy for Bacterial Infections. Antibiotics (Basel) (2015) 0.76
Epigenetic mechanisms in heart failure pathogenesis. Circ Heart Fail (2014) 0.76
The expanding role of epigenetics. Glob Cardiol Sci Pract (2012) 0.76
Sodium Butyrate Protects Against High Fat Diet-induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice. J Cell Biochem (2017) 0.75
Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts. J Pharmacol Exp Ther (2017) 0.75
It's Time for An Epigenomics Roadmap of Heart Failure. Curr Genomics (2015) 0.75
Pressure overload-induced cardiac hypertrophy response requires janus kinase 2-histone deacetylase 2 signaling. Int J Mol Sci (2014) 0.75
New Aspects of Vascular Calcification: Histone Deacetylases and Beyond. J Korean Med Sci (2017) 0.75
Epigallocatechin gallate reverses cTnI-low expression-induced age-related heart diastolic dysfunction through histone acetylation modification. J Cell Mol Med (2017) 0.75
Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med (2010) 13.82
InterPro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res (2011) 13.45
MicroRNA-133 controls cardiac hypertrophy. Nat Med (2007) 11.68
The Ontology Lookup Service, a lightweight cross-platform tool for controlled vocabulary queries. BMC Bioinformatics (2006) 8.68
Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res (2004) 8.41
Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med (2009) 7.82
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol (2010) 7.73
PRIDE: the proteomics identifications database. Proteomics (2005) 7.52
Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA (2005) 7.41
Integrating biological data--the Distributed Annotation System. BMC Bioinformatics (2008) 6.56
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature (2010) 6.13
Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. Cell (2013) 4.99
The Ontology Lookup Service: more data and better tools for controlled vocabulary queries. Nucleic Acids Res (2008) 4.73
Bivalirudin or Unfractionated Heparin in Acute Coronary Syndromes. N Engl J Med (2015) 4.68
Health status predicts long-term outcome in outpatients with coronary disease. Circulation (2002) 4.10
The Protein Identifier Cross-Referencing (PICR) service: reconciling protein identifiers across multiple source databases. BMC Bioinformatics (2007) 3.97
ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med (2002) 3.36
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. Proc Natl Acad Sci U S A (2004) 3.27
Monitoring clinical changes in patients with heart failure: a comparison of methods. Am Heart J (2005) 3.26
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A (2002) 3.18
IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B. Hepatology (2012) 3.12
The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA. EMBO J (2002) 3.11
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem (2008) 3.09
No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. Ann Neurol (2011) 3.07
BioMart Central Portal: an open database network for the biological community. Database (Oxford) (2011) 3.03
Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro. J Biol Chem (2003) 2.82
Submit your interaction data the IMEx way: a step by step guide to trouble-free deposition. Proteomics (2007) 2.74
Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem (2003) 2.72
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science (2012) 2.65
Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. J Virol (2003) 2.63
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J Virol (2002) 2.61
HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics. Cell Res (2007) 2.60
In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor. J Virol (2003) 2.55
Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme. Clin Cancer Res (2008) 2.52
MicroRNAs and cardiac pathology. Nat Rev Cardiol (2009) 2.50
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron (2012) 2.49
Emerging role of microRNAs in cardiovascular biology. Circ Res (2007) 2.41
MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Circ Res (2009) 2.40
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med (2009) 2.38
Comprehensive use of cardiopulmonary exercise testing identifies adults with congenital heart disease at increased mortality risk in the medium term. Circulation (2011) 2.32
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nat Cell Biol (2010) 2.25
Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation Res (2009) 2.24
Differentiation, phenotype, and function of interleukin-17-producing human Vγ9Vδ2 T cells. Blood (2011) 2.20
Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis. Arch Neurol (2009) 2.20
Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease. Eur J Nucl Med Mol Imaging (2012) 2.17
Relation of various plasma growth factor levels in patients with stable angina pectoris and total occlusion of a coronary artery to the degree of coronary collaterals. Am J Cardiol (2005) 2.14
CaMK4 Gene Deletion Induces Hypertension. J Am Heart Assoc (2012) 2.14
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b. Nat Immunol (2011) 2.11
Routine assessment of on-clopidogrel platelet reactivity and gene polymorphisms in predicting clinical outcome following drug-eluting stent implantation in patients with stable coronary artery disease. JACC Cardiovasc Interv (2013) 2.11
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain. J Biol Chem (2008) 2.09
Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circ Res (2004) 2.08
Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis. Arch Neurol (2007) 2.07
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04
Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusion. J Mol Biol (2003) 2.03
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex. EMBO Rep (2007) 2.01
Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation (2011) 1.99
Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation (2009) 1.92
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation. J Biol Chem (2007) 1.92
IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A (2011) 1.87
Identification of genes selectively regulated by IFNs in endothelial cells. J Immunol (2007) 1.87
Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure. J Am Coll Cardiol (2003) 1.85
HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment. Proc Natl Acad Sci U S A (2008) 1.80
MicroRNAs: components of an integrated system controlling cardiac development, physiology, and disease pathogenesis. Cardiovasc Res (2008) 1.75
Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging. Stem Cells (2015) 1.75
A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope. Proc Natl Acad Sci U S A (2005) 1.74
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. Nat Cell Biol (2010) 1.74
Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication? Virology (2007) 1.74
EBI metagenomics--a new resource for the analysis and archiving of metagenomic data. Nucleic Acids Res (2013) 1.74
Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res (2013) 1.72
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture. J Virol (2004) 1.71
Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides. J Virol (2004) 1.71
MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo. Circ Res (2011) 1.67
Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin: a complex arrhythmogenic cascade in a knock in mouse model. Circ Res (2008) 1.67
MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J Cell Biol (2010) 1.64
Prognostic value of health status in patients with heart failure after acute myocardial infarction. Circulation (2004) 1.63
Direct intramyocardial percutaneous delivery of autologous bone marrow in patients with refractory myocardial angina. Am Heart J (2006) 1.59
Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation (2012) 1.56
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site. J Biol Chem (2005) 1.54
MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr-/-mice. Thromb Haemost (2014) 1.53
Nephrotoxicity of low-osmolality versus iso-osmolality contrast agents: impact of N-acetylcysteine. Kidney Int (2005) 1.52
Cortical atrophy is relevant in multiple sclerosis at clinical onset. J Neurol (2007) 1.51
Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. J Natl Cancer Inst (2006) 1.51
Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators. Hum Gene Ther (2002) 1.50
Abnormal lung function in adults with congenital heart disease: prevalence, relation to cardiac anatomy, and association with survival. Circulation (2013) 1.49
Genetic vaccines against Ep-CAM break tolerance to self in a limited subset of subjects: initial identification of predictive biomarkers. Eur J Immunol (2006) 1.49
Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. J Cell Physiol (2008) 1.48