Published in PLoS One on August 13, 2008
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J Biol Chem (2010) 1.63
Wnt3a reestablishes osteogenic capacity to bone grafts from aged animals. J Bone Joint Surg Am (2013) 1.52
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. Nat Med (2014) 1.39
Wnt signaling and injury repair. Cold Spring Harb Perspect Biol (2012) 1.30
Drugging a stem cell compartment using Wnt3a protein as a therapeutic. PLoS One (2014) 0.95
Targeting the Wnt signaling pathways in pulmonary arterial hypertension. Drug Discov Today (2014) 0.90
Wnt signaling in bone and muscle. Bone (2015) 0.86
Rescuing failed oral implants via Wnt activation. J Clin Periodontol (2016) 0.83
The pharmacology of regenerative medicine. Pharmacol Rev (2013) 0.83
Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin. Elife (2016) 0.80
Wnt3a protein reduces growth factor-driven expansion of human hematopoietic stem and progenitor cells in serum-free cultures. PLoS One (2015) 0.80
Isolation and characterization of recombinant murine Wnt3a. Protein Expr Purif (2014) 0.77
Structural dynamics and inhibitor searching for Wnt-4 protein using comparative computational studies. Drug Des Devel Ther (2015) 0.76
Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells. Nat Commun (2017) 0.76
Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth. J Biol Chem (2016) 0.75
Gelatin device for the delivery of growth factors involved in endochondral ossification. PLoS One (2017) 0.75
Wnt3a nanodisks promote ex vivo expansion of hematopoietic stem and progenitor cells. J Nanobiotechnology (2016) 0.75
Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81
Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol (2002) 10.95
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature (2007) 5.19
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell (2006) 4.89
Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature (2005) 4.38
Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci (2004) 3.05
Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell (2005) 2.71
Argosomes: a potential vehicle for the spread of morphogens through epithelia. Cell (2001) 2.48
Novel lipid modifications of secreted protein signals. Annu Rev Biochem (2004) 2.37
Wnt signaling promotes regeneration in the retina of adult mammals. J Neurosci (2007) 2.29
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J (1993) 2.12
The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv Drug Deliv Rev (2001) 2.01
Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis. Arthritis Rheum (2006) 1.98
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development (2003) 1.98
Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry (2005) 1.92
The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res (2007) 1.90
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev (1996) 1.87
Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine. J Biol Chem (2004) 1.85
Bone regeneration is regulated by wnt signaling. J Bone Miner Res (2007) 1.63
Liposome-based drug delivery in breast cancer treatment. Breast Cancer Res (2002) 1.55
Wnt signaling and human diseases: what are the therapeutic implications? Lab Invest (2007) 1.51
Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Dev Cell (2006) 1.47
A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl (2005) 1.44
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A (2007) 1.39
Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies. J Antimicrob Chemother (2001) 1.03
Liposomes: applications in medicine. J Biomater Appl (2001) 0.97
From conventional to stealth liposomes: a new Frontier in cancer chemotherapy. J Chemother (2004) 0.90
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
Wnt/β-catenin signaling and disease. Cell (2012) 16.05
Convergence of Wnt, beta-catenin, and cadherin pathways. Science (2004) 13.13
A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81
Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature (2011) 11.59
Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics (2004) 9.98
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science (2002) 6.35
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem (2006) 6.32
Towards an integrated view of Wnt signaling in development. Development (2009) 6.07
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol (2008) 5.54
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A (2003) 4.76
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell (2010) 4.25
Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96
Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature (2008) 3.87
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol (2002) 3.85
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron (2003) 3.76
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science (2003) 3.52
Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell (2012) 3.17
A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol (2002) 3.09
A localized Wnt signal orients asymmetric stem cell division in vitro. Science (2013) 2.82
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64
Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell (2008) 2.64
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci (2011) 2.61
Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A (2007) 2.61
TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Cell (2009) 2.53
Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science (2013) 2.52
Alternative wnt signaling is initiated by distinct receptors. Sci Signal (2008) 2.52
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci U S A (2004) 2.46
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Nat Biotechnol (2012) 2.43
Altered fracture repair in the absence of MMP9. Development (2003) 2.41
Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell (2008) 2.37
Lentiviral vectors to probe and manipulate the Wnt signaling pathway. PLoS One (2010) 2.28
Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15
Molecular interactions coordinating the development of the forebrain and face. Dev Biol (2005) 2.12
A critical role for endocytosis in Wnt signaling. BMC Cell Biol (2006) 2.09
A zone of frontonasal ectoderm regulates patterning and growth in the face. Development (2003) 2.04
The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res (2007) 1.90
Wnt signaling mediates regional specification in the vertebrate face. Development (2007) 1.89
Targeted disruption of Hotair leads to homeotic transformation and gene derepression. Cell Rep (2013) 1.89
Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development (2008) 1.87
A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev (2008) 1.85
Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci U S A (2012) 1.85
Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem (2002) 1.84
A model for intramembranous ossification during fracture healing. J Orthop Res (2002) 1.82
Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration. Development (2008) 1.82
Wnt proteins promote bone regeneration. Sci Transl Med (2010) 1.80
Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis (2011) 1.78
Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development (2002) 1.78
WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature (2005) 1.75
Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. J Clin Invest (2004) 1.74
Wnt proteins. Cold Spring Harb Perspect Biol (2012) 1.70
Identification and immunotherapeutic targeting of antigens induced by chemotherapy. Nat Biotechnol (2006) 1.68
Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology (2007) 1.66
Differentiation of multipotent vascular stem cells contributes to vascular diseases. Nat Commun (2012) 1.66
Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nat Chem Biol (2009) 1.65
Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development. Dev Biol (2004) 1.64
Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. Nat Commun (2012) 1.63
Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer. Clin Cancer Res (2010) 1.63
Bone regeneration is regulated by wnt signaling. J Bone Miner Res (2007) 1.63
Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J Biol Chem (2010) 1.63
Wnt signaling promotes Müller cell proliferation and survival after injury. Invest Ophthalmol Vis Sci (2013) 1.60
Initiation of proximal-distal patterning in the vertebrate limb by signals and growth. Science (2011) 1.58
rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair. J Bone Miner Res (2010) 1.56
Cranial neural crest cells on the move: their roles in craniofacial development. Am J Med Genet A (2010) 1.55
Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem (2007) 1.55
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells. Cancer Res (2004) 1.53
Wnt3a reestablishes osteogenic capacity to bone grafts from aged animals. J Bone Joint Surg Am (2013) 1.52
Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem (2009) 1.52
Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. PLoS One (2007) 1.50
Temporal gene expression during differentiation of human embryonic stem cells and embryoid bodies. Hum Reprod (2004) 1.49
Lipid-independent secretion of a Drosophila Wnt protein. J Biol Chem (2008) 1.48
Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid. Nat Protoc (2007) 1.47
Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. PLoS One (2011) 1.46
LRP5 and Wnt signaling: a union made for bone. J Bone Miner Res (2004) 1.45
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol (2012) 1.39
A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin. Genetics (2002) 1.39
Differential inhibition of Wnt-3a by Sfrp-1, Sfrp-2, and Sfrp-3. Dev Dyn (2006) 1.38
Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Cancer Res (2004) 1.38
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res (2013) 1.38