Published in Nature on May 17, 2007
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell (2008) 9.92
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
The tortoise and the hair: slow-cycling cells in the stem cell race. Cell (2009) 3.90
Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Science (2012) 3.45
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell (2009) 3.44
Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature (2012) 3.34
Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res (2009) 3.25
Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip. Nature (2011) 3.03
A Wnt survival guide: from flies to human disease. J Invest Dermatol (2009) 2.91
Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis. Development (2009) 2.82
Skin stem cells: rising to the surface. J Cell Biol (2008) 2.66
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev (2011) 2.63
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Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet (2008) 2.45
Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell (2011) 2.36
Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature (2013) 2.29
Epidermal stem cell diversity and quiescence. EMBO Mol Med (2009) 2.14
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet (2009) 2.07
Regeneration of fat cells from myofibroblasts during wound healing. Science (2017) 2.07
Stem cells and the niche: a dynamic duo. Cell Stem Cell (2010) 2.06
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Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell (2011) 1.92
A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol (2012) 1.91
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Finding one's niche in the skin. Cell Stem Cell (2009) 1.77
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Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell (2015) 1.72
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest (2011) 1.65
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Paneth cells in intestinal homeostasis and tissue injury. PLoS One (2012) 1.57
Tracking adult stem cells. EMBO Rep (2011) 1.56
Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Proc Natl Acad Sci U S A (2013) 1.52
Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. J Invest Dermatol (2012) 1.48
Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J (2011) 1.47
Stem cells, their niches and the systemic environment: an aging network. Genetics (2008) 1.46
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin. Development (2011) 1.43
Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling. Semin Cell Dev Biol (2012) 1.41
A molecular wound response program associated with regeneration initiation in planarians. Genes Dev (2012) 1.41
Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell Mol Life Sci (2012) 1.40
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol (2011) 1.39
Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates. PLoS One (2012) 1.38
The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells. Nat Immunol (2013) 1.36
Epithelial stem cells and implications for wound repair. Semin Cell Dev Biol (2012) 1.35
In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nat Cell Biol (2014) 1.35
TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis. EMBO J (2011) 1.34
Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment. Cell Stem Cell (2011) 1.33
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nat Med (2013) 1.33
Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet (2009) 1.31
Wnt signaling and injury repair. Cold Spring Harb Perspect Biol (2012) 1.30
A matter of life and death: self-renewal in stem cells. EMBO Rep (2012) 1.30
Modulating the stem cell niche for tissue regeneration. Nat Biotechnol (2014) 1.28
Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing. Proc Natl Acad Sci U S A (2011) 1.24
Ultrafast mid-IR laser scalpel: protein signals of the fundamental limits to minimally invasive surgery. PLoS One (2010) 1.24
Physiological regeneration of skin appendages and implications for regenerative medicine. Physiology (Bethesda) (2012) 1.23
Extracellular matrix degradation products and low-oxygen conditions enhance the regenerative potential of perivascular stem cells. Tissue Eng Part A (2010) 1.21
Beta-catenin signaling increases in proliferating NG2+ progenitors and astrocytes during post-traumatic gliogenesis in the adult brain. Stem Cells (2010) 1.18
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development (2011) 1.15
Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling. Nat Med (2013) 1.15
Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice. J Invest Dermatol (2010) 1.15
Building epithelial tissues from skin stem cells. Cold Spring Harb Symp Quant Biol (2008) 1.12
DeltaNp63 regulates stem cell dynamics in the mammalian olfactory epithelium. J Neurosci (2011) 1.12
Sept4/ARTS regulates stem cell apoptosis and skin regeneration. Science (2013) 1.11
Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harb Perspect Biol (2013) 1.11
Regenerative biology: new hair from healing wounds. Nature (2007) 1.11
Liposomal packaging generates Wnt protein with in vivo biological activity. PLoS One (2008) 1.09
Retracted Tanshinone IIA pretreatment renders free flaps against hypoxic injury through activating Wnt signaling and upregulating stem cell-related biomarkers. Int J Mol Sci (2014) 1.09
Stem cell dynamics in the hair follicle niche. Semin Cell Dev Biol (2013) 1.08
Heterogeneity and plasticity of epidermal stem cells. Development (2014) 1.08
Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. J Clin Invest (2010) 1.08
Tanshinone IIA pretreatment protects free flaps against hypoxic injury by upregulating stem cell-related biomarkers in epithelial skin cells. BMC Complement Altern Med (2014) 1.08
Evidence for altered Wnt signaling in psoriatic skin. J Invest Dermatol (2010) 1.08
Retracted Ultrafast Mid-IR Laser Scalpel; Approaching to Scar-less Surgery. Int J Prev Med (2010) 1.07
Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation. Dev Biol (2010) 1.06
Basal cell carcinoma - molecular biology and potential new therapies. J Clin Invest (2012) 1.06
Macrophages modulate adult zebrafish tail fin regeneration. Development (2014) 1.05
Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Dev Biol (2008) 1.04
Making an epidermis. Ann N Y Acad Sci (2009) 1.04
Dissecting the bulge in hair regeneration. J Clin Invest (2012) 1.03
Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth. Proc Natl Acad Sci U S A (2013) 1.02
Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation. J Invest Dermatol (2015) 1.01
The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology. J Cell Mol Med (2007) 1.01
Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. J Invest Dermatol (2012) 1.01
Wnt signaling in skin organogenesis. Organogenesis (2008) 1.00
Module-based complexity formation: periodic patterning in feathers and hairs. Wiley Interdiscip Rev Dev Biol (2013) 1.00
dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration. Cell Stem Cell (2015) 0.99
DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration. PLoS One (2010) 0.99
p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network. J Biol Chem (2011) 0.98
Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. Nat Commun (2014) 0.98
Hardwiring Stem Cell Communication through Tissue Structure. Cell (2016) 0.97
Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling. Stem Cells (2014) 0.96
Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway. Nat Commun (2011) 0.95
Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering. Expert Opin Biol Ther (2013) 0.95
Animal models in burn research. Cell Mol Life Sci (2014) 0.95
Tuning Wnt signals for more or fewer hairs. J Invest Dermatol (2013) 0.93
Capturing and profiling adult hair follicle stem cells. Nat Biotechnol (2004) 10.35
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med (2005) 8.01
WNT signals are required for the initiation of hair follicle development. Dev Cell (2002) 6.63
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02
Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol (2003) 5.28
Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol (2005) 4.04
Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol (2003) 3.72
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet (2008) 2.45
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet (2006) 2.43
The longest telomeres: a general signature of adult stem cell compartments. Genes Dev (2008) 2.38
Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature (2005) 2.37
Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen. Differentiation (2004) 2.34
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (2004) 2.24
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science (2011) 1.96
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
Decreased serum ferritin is associated with alopecia in women. J Invest Dermatol (2003) 1.87
Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest (2011) 1.81
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell (2010) 1.75
Review of hair follicle dermal cells. J Dermatol Sci (2010) 1.72
The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem (2002) 1.59
CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res (2007) 1.55
Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem (2011) 1.51
4-Des-oxy-4β-[(5-meth-oxy-1H-indol-3-yl)oxalylamino]podophyllotoxin methanol solvate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.51
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 1.51
Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res (2013) 1.49
Summary of North American Hair Research Society (NAHRS)-sponsored Workshop on Cicatricial Alopecia, Duke University Medical Center, February 10 and 11, 2001. J Am Acad Dermatol (2003) 1.42
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell (2013) 1.41
The mammary bud as a skin appendage: unique and shared aspects of development. J Mammary Gland Biol Neoplasia (2006) 1.39
Epithelial stem cells and implications for wound repair. Semin Cell Dev Biol (2012) 1.35
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nat Med (2013) 1.33
Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development (2008) 1.32
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol (2006) 1.28
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med (2012) 1.22
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc Natl Acad Sci U S A (2012) 1.19
Wnt/β-catenin signaling regulates postnatal development and regeneration of the salivary gland. Stem Cells Dev (2010) 1.17
Vitiligo-like hypopigmentation associated with imiquimod treatment of genital warts. J Am Acad Dermatol (2005) 1.16
Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter. Mol Ther (2007) 1.12
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (2012) 1.11
Differential expression of cyclin D1 in the human hair follicle. Am J Pathol (2003) 1.10
Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. J Clin Invest (2010) 1.08
Bioengineering the hair follicle: fringe benefits of stem cell technology. Curr Opin Biotechnol (2005) 1.07
Defining hair follicles in the age of stem cell bioengineering. J Invest Dermatol (2007) 1.05
A deviant immune response to viral proteins and transgene product is generated on subretinal administration of adenovirus and adeno-associated virus. Mol Ther (2002) 1.04
Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation. Cancer Res (2009) 1.04
Expression of Frizzled genes in developing and postnatal hair follicles. J Invest Dermatol (2004) 1.04
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Development (2013) 1.02
Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. J Invest Dermatol (2003) 1.01
Conjunctival melanoma: bladder and upper urinary tract metastases. J Clin Oncol (2010) 0.99
DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration. PLoS One (2010) 0.99
Fox-Fordyce disease following axillary laser hair removal. Arch Dermatol (2011) 0.96
A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Hum Mol Genet (2005) 0.96
Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle. J Invest Dermatol (2004) 0.93
Hairy math: insights into hair-follicle spacing and orientation. Cell (2007) 0.91
A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse. Mol Carcinog (2012) 0.90
Control by a hair's breadth: the role of microRNAs in the skin. Cell Mol Life Sci (2012) 0.90
Is the hair follicle necessary for normal wound healing? J Invest Dermatol (2008) 0.89
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Phosphodiesterase 4-targeted treatments for autoimmune diseases. BMC Med (2013) 0.88
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Scarring alopecia associated with mastocytosis. J Cutan Pathol (2003) 0.84
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A novel podophyllotoxin derivative (YB-1EPN) induces apoptosis and down-regulates express of P-glycoprotein in multidrug resistance cell line KBV200. Eur J Pharmacol (2009) 0.82
Developmental biology. Rac1 up for epidermal stem cells. Science (2005) 0.82
MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer. J Clin Invest (2015) 0.81
Wnt signaling influences the development of murine epidermal Langerhans cells. J Invest Dermatol (2011) 0.78