Wnt signalling in stem cells and cancer.

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol (2009) 9.43

Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36

Interactions between cancer stem cells and their niche govern metastatic colonization. Nature (2011) 6.94

Regulation of bone mass by Wnt signaling. J Clin Invest (2006) 5.59

EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology (2008) 5.53

BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci U S A (2008) 4.79

Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev (2008) 4.77

Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43

Structural basis of Wnt recognition by Frizzled. Science (2012) 4.31

Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol (2010) 4.22

Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell (2007) 4.21

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov (2009) 4.12

Epithelial stem cells: turning over new leaves. Cell (2007) 4.10

Nuclear signalling by tumour-associated antigen EpCAM. Nat Cell Biol (2009) 4.05

Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96

The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96

Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev (2006) 3.85

Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol (2008) 3.84

Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev (2005) 3.67

Imaging hematopoietic precursor division in real time. Cell Stem Cell (2007) 3.62

A new description of cellular quiescence. PLoS Biol (2006) 3.56

Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis. Proc Natl Acad Sci U S A (2006) 3.54

Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties. PLoS One (2008) 3.36

Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol (2010) 3.22

Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res (2011) 3.18

The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol (2012) 3.16

Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06

Chromatin code, local non-equilibrium dynamics, and the emergence of transcription regulatory programs. Eur Phys J E Soft Matter (2006) 2.88

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A (2006) 2.83

Wnt signaling in cancer. Cold Spring Harb Perspect Biol (2012) 2.75

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell (2009) 2.74

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70

PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell (2010) 2.68

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet (2013) 2.59

Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11. Proc Natl Acad Sci U S A (2009) 2.56

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A (2007) 2.56

A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nat Rev Microbiol (2012) 2.56

SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood (2006) 2.53

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53

Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45

O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45

Retracted The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling. PLoS Biol (2006) 2.42

BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev (2008) 2.41

Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer. Clin Exp Metastasis (2007) 2.41

The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis. Eur J Immunol (2008) 2.37

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol (2010) 2.37

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell (2012) 2.36

An integrated, directed mass spectrometric approach for in-depth characterization of complex peptide mixtures. Mol Cell Proteomics (2008) 2.35

Liver stem cells and hepatocellular carcinoma. Hepatology (2009) 2.27

Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation. Proc Natl Acad Sci U S A (2007) 2.25

Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol (2008) 2.21

Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res (2008) 2.18

Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs. Genome Res (2007) 2.16

The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity (2012) 2.15

Wnt signal transduction pathways. Organogenesis (2008) 2.14

REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol (2008) 2.12

Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J (2007) 2.11

A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Proc Natl Acad Sci U S A (2008) 2.10

Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One (2007) 2.08

Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet (2009) 2.07

Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog (2009) 2.06

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proc Natl Acad Sci U S A (2010) 2.05

Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res (2009) 2.04

An integrated gene regulatory network controls stem cell proliferation in teeth. PLoS Biol (2007) 2.03

The contribution of bone to whole-organism physiology. Nature (2012) 2.03

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med (2012) 2.02

Apoptosis, stem cells, and tissue regeneration. Sci Signal (2010) 1.95

More than one way to skin . . . Genes Dev (2008) 1.95

Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell (2009) 1.92

Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans. Curr Biol (2006) 1.87

A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87

Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell (2007) 1.87

Cell-autonomous beta-catenin signaling regulates cortical precursor proliferation. J Neurosci (2006) 1.87

The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut (2006) 1.86

New molecularly targeted therapies for lung cancer. J Clin Invest (2007) 1.86

A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell (2013) 1.86

Modulation of canonical Wnt signaling by the extracellular matrix component biglycan. Proc Natl Acad Sci U S A (2011) 1.85

Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol Sin (2013) 1.83

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem (2008) 1.83

Pluripotency and nuclear reprogramming. Philos Trans R Soc Lond B Biol Sci (2008) 1.82

Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science (2008) 1.81

Stabilization of beta-catenin induces pancreas tumor formation. Gastroenterology (2008) 1.81

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci U S A (2012) 1.80

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.80

Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. Proc Natl Acad Sci U S A (2006) 1.77

Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma. Proc Natl Acad Sci U S A (2007) 1.77

Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev (2008) 1.74

Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov (2012) 1.71

Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget (2010) 1.71

Bone mass is inversely proportional to Dkk1 levels in mice. Bone (2007) 1.71

Nuclear lamins: key regulators of nuclear structure and activities. J Cell Mol Med (2009) 1.70

WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth. Breast Cancer Res (2009) 1.70

Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells. Circ Res (2012) 1.68

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat Struct Mol Biol (2011) 1.68

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med (2012) 1.66

Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res (2008) 1.65

Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92

A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell (2010) 12.23

Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08

Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85

Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64

Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55

Coexistence of quiescent and active adult stem cells in mammals. Science (2010) 7.54

Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol (2009) 7.29

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25

Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell (2009) 7.08

FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol (2005) 7.02

Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (2012) 6.55

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology (2011) 6.36

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature (2011) 6.09

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66

Self-renewal and cancer of the gut: two sides of a coin. Science (2005) 5.44

Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42

Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov (2006) 5.29

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell (2011) 4.79

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell (2012) 4.58

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52

The Intestinal Wnt/TCF Signature. Gastroenterology (2006) 4.48

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45

Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science (2004) 4.39

Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol (2005) 4.34

Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 4.27

The intestinal stem cell. Genes Dev (2008) 4.21

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17

Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology (2009) 4.16

Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology (2005) 4.09

Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol (2004) 4.00

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97

Transcriptome profile of human colorectal adenomas. Mol Cancer Res (2007) 3.82

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65

Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (2013) 3.43

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology (2009) 3.39

Strategies for homeostatic stem cell self-renewal in adult tissues. Cell (2011) 3.33

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol (2012) 3.30

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol (2004) 3.24

Isolation and in vitro expansion of human colonic stem cells. Nat Med (2011) 3.20

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci (2009) 3.18

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat Med (2012) 3.17

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell (2012) 3.03

Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol (2008) 3.02

The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89

EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature (2012) 2.76

Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast Cancer Res Treat (2009) 2.76

Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol (2011) 2.72

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology (2012) 2.57

Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology (2010) 2.55

beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci U S A (2002) 2.55

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature (2012) 2.53

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci U S A (2004) 2.46

Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell (2009) 2.40

Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology (2012) 2.31

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest (2009) 2.28

Survivin and molecular pathogenesis of colorectal cancer. Lancet (2003) 2.25

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol (2011) 2.21

Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell (2010) 2.15

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell (2010) 2.13

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10

Wnt control of stem cells and differentiation in the intestinal epithelium. Exp Cell Res (2005) 2.08

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. EMBO J (2011) 2.08

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology (2009) 2.01

T-cell factors: turn-ons and turn-offs. EMBO J (2002) 2.00

Controlled gene expression in primary Lgr5 organoid cultures. Nat Methods (2011) 1.98

TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. Biol Chem (2002) 1.95

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94

TCF transcription factors, mediators of Wnt-signaling in development and cancer. Dev Biol (2002) 1.93

LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol Rev (2009) 1.93

You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. Curr Opin Genet Dev (2003) 1.93

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol (2008) 1.90

Wnt signaling mediates regional specification in the vertebrate face. Development (2007) 1.89

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nat Commun (2010) 1.89

Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell (2012) 1.88

A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nat Med (2013) 1.87

Live and let die in the intestinal epithelium. Curr Opin Cell Biol (2003) 1.85

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS Biol (2010) 1.81

WNT signaling in the normal intestine and colorectal cancer. Front Biosci (2007) 1.79