Published in Mol Pharmacol on August 13, 2008
Revealing the structural basis of action of hERG potassium channel activators and blockers. J Physiol (2010) 1.37
Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel. Nat Struct Mol Biol (2010) 1.16
Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening. PLoS One (2010) 1.02
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol (2011) 1.00
Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block. J Chem Inf Model (2014) 0.88
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J Mol Cell Cardiol (2014) 0.86
In silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K+ channel. PLoS One (2011) 0.85
Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway. J Biol Chem (2011) 0.85
hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine. J Am Heart Assoc (2015) 0.85
Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition. Physiol Rep (2013) 0.84
KCNH2 pharmacogenomics summary. Pharmacogenet Genomics (2010) 0.84
Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century. J Physiol (2016) 0.83
Ether-à-gogo-related gene (erg1) potassium channels shape the dark response of horizontal cells in the mammalian retina. Pflugers Arch (2008) 0.82
Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants. J Mol Cell Cardiol (2014) 0.81
Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide. J Mol Cell Cardiol (2015) 0.79
The Link between Inactivation and High-Affinity Block of hERG1 Channels. Mol Pharmacol (2015) 0.78
Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel. PLoS One (2012) 0.78
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias. J Biol Chem (2012) 0.78
Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology. Card Electrophysiol Clin (2016) 0.78
Genetics of inherited primary arrhythmia disorders. Appl Clin Genet (2015) 0.77
Role of the pH in state-dependent blockade of hERG currents. Sci Rep (2016) 0.77
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J Mol Cell Cardiol (2015) 0.76
Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. Biochem Pharmacol (2016) 0.75
A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias. J Physiol (2017) 0.75
Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A (2002) 3.59
Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels. Cell (2010) 2.50
Off-label use of medicines: consensus recommendations for evaluating appropriateness. Med J Aust (2006) 2.29
Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation? J Am Coll Cardiol (2007) 1.67
The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. J Biol Chem (2003) 1.64
Defensins and the convergent evolution of platypus and reptile venom genes. Genome Res (2008) 1.37
The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation. PLoS One (2011) 1.35
Genes and atrial fibrillation: a new look at an old problem. Circulation (2007) 1.33
Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction. Prog Biophys Mol Biol (2008) 1.31
Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a. J Physiol (2005) 1.27
AAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal Spf(ash) mice. Mol Ther (2009) 1.22
Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1. J Physiol (2003) 1.21
Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI. J Cereb Blood Flow Metab (2013) 1.21
Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel. J Physiol (2004) 1.18
Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood. Blood (2009) 1.18
Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel. Nat Struct Mol Biol (2010) 1.16
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics. Eur Biophys J (2003) 1.11
Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed. J Physiol (2005) 1.10
Glutathione synthesis and turnover in the human erythrocyte: alignment of a model based on detailed enzyme kinetics with experimental data. J Biol Chem (2010) 1.08
Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation. J Biol Chem (2003) 1.08
R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy. J Am Coll Cardiol (2012) 1.07
Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6. J Physiol (2003) 1.06
The Gárdos channel: a review of the Ca2+-activated K+ channel in human erythrocytes. Int J Biochem Cell Biol (2003) 1.03
The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel. J Biol Chem (2008) 1.03
Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype. J Cardiovasc Electrophysiol (2009) 1.02
Lentiviral vectors for delivery of genes into neonatal and adult ventricular cardiac myocytes in vitro and in vivo. Basic Res Cardiol (2002) 1.00
Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk. J Am Coll Cardiol (2012) 1.00
The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating. PLoS One (2012) 0.97
Rapid simulation and analysis of isotopomer distributions using constraints based on enzyme mechanisms: an example from HT29 cancer cells. Bioinformatics (2005) 0.97
The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function. J Biol Chem (2008) 0.96
Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12. Proteins (2008) 0.95
Kinetics of uptake and deacetylation of N-acetylcysteine by human erythrocytes. Int J Biochem Cell Biol (2007) 0.95
Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels. J Gen Physiol (2012) 0.95
D-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus. FEBS Lett (2002) 0.94
Role of N-acetylcysteine and cystine in glutathione synthesis in human erythrocytes. Redox Rep (2009) 0.94
Novel venom gene discovery in the platypus. Genome Biol (2010) 0.94
Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery. Mol Ther (2011) 0.93
Sensitivity limits for voltage control of P2Y receptor-evoked Ca2+ mobilization in the rat megakaryocyte. J Physiol (2003) 0.92
The beta-defensin-fold family of polypeptides. Toxicon (2004) 0.91
Glutamine and α-ketoglutarate as glutamate sources for glutathione synthesis in human erythrocytes. FEBS J (2011) 0.90
Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin. FEBS Lett (2003) 0.90
Chemical shift and magnetic susceptibility contributions to the separation of intracellular and supernatant resonances in variable angle spinning NMR spectra of erythrocyte suspensions. Magn Reson Med (2004) 0.89
Substrate specificity of platypus venom L-to-D-peptide isomerase. J Biol Chem (2007) 0.89
Effect of pravastatin compared with placebo initiated within 24 hours of onset of acute myocardial infarction or unstable angina: the Pravastatin in Acute Coronary Treatment (PACT) trial. Am Heart J (2004) 0.89
NMR studies of exchange between intra- and extracellular glutathione in human erythrocytes. Redox Rep (2005) 0.88
Identification of a novel family of proteins in snake venoms. Purification and structural characterization of nawaprin from Naja nigricollis snake venom. J Biol Chem (2003) 0.88
D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties. Biochem J (2005) 0.88
Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis. Clin Infect Dis (2005) 0.88
Simultaneous estimation of T₁ and the flip angle in hyperpolarized NMR experiments using acquisition at non-regular time intervals. J Magn Reson (2012) 0.86
The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations. PLoS One (2012) 0.86
Mammalian l-to-d-amino-acid-residue isomerase from platypus venom. FEBS Lett (2006) 0.86
Adeno-associated virus-mediated rescue of neonatal lethality in argininosuccinate synthetase-deficient mice. Mol Ther (2013) 0.86
Investigation of methaemoglobin reduction by extracellular NADH in mammalian erythrocytes. Int J Biochem Cell Biol (2005) 0.86
z-Spectra of 23Na+ in stretched gels: quantitative multiple quantum analysis. J Magn Reson (2010) 0.86
Mathematical modelling of the urea cycle. A numerical investigation into substrate channelling. Eur J Biochem (2003) 0.85
Redox reactions and electron transfer across the red cell membrane. IUBMB Life (2003) 0.85
Cardiac expression of the cystic fibrosis transmembrane conductance regulator involves novel exon 1 usage to produce a unique amino-terminal protein. J Biol Chem (2004) 0.85
The effects of long-term storage of human red blood cells on the glutathione synthesis rate and steady-state concentration. Transfusion (2011) 0.85
Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram. J Physiol (2013) 0.85
Double quantum transition as the origin of the central dip in the z-spectrum of HDO in variably stretched gel. J Magn Reson (2009) 0.84
Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions. Biochem J (2013) 0.84
Understanding and utilising mammalian venom via a platypus venom transcriptome. J Proteomics (2008) 0.84
Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating. J Biol Chem (2013) 0.83
Transmembrane exchange of hyperpolarized 13C-urea in human erythrocytes: subminute timescale kinetic analysis. Biophys J (2013) 0.83
Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected. Toxicon (2008) 0.83
Prochiral and chiral resolution in 2H NMR spectra: solutes in stretched and compressed gelatin gels. J Phys Chem A (2008) 0.83
1H and 13C NMR studies of glycine in anisotropic media: double-quantum transitions and the effects of chiral interactions. J Magn Reson (2011) 0.82
Simulations of NMR-detected diffusion in suspensions of red cells: the effects of variation in membrane permeability and observation time. Eur Biophys J (2003) 0.82
Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization. Endocrinology (2015) 0.82
Erythrocyte-shape evolution recorded with fast-measurement NMR diffusion-diffraction. J Magn Reson Imaging (2008) 0.82
Convection-compensating PGSE experiment incorporating excitation-sculpting water suppression (CONVEX). J Magn Reson (2004) 0.81
Human erythrocyte flickering: temperature, ATP concentration, water transport, and cell aging, plus a computer simulation. Eur Biophys J (2009) 0.81
Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel. J Phys Chem B (2007) 0.81
Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels. J Gen Physiol (2013) 0.81
Simulations of molecular diffusion in lattices of cells: insights for NMR of red blood cells. Biophys J (2002) 0.81
Erythrocyte orientational and cell volume effects on NMR q-space analysis: simulations of restricted diffusion. Eur Biophys J (2009) 0.80
Conformations of platypus venom C-type natriuretic peptide in aqueous solution and sodium dodecyl sulfate micelles. Toxicon (2002) 0.80
Cardiac function and lipid distribution in rats fed a high-fat diet: in vivo magnetic resonance imaging and spectroscopy. Am J Physiol Heart Circ Physiol (2013) 0.80
C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. PLoS One (2013) 0.80
Fermentative glycolysis with purified Escherichia coli enzymes for in vitro ATP production and evaluating an engineered enzyme. J Biotechnol (2011) 0.80
Cytoskeletal rearrangements in human red blood cells induced by snake venoms: light microscopy of shapes and NMR studies of membrane function. Cell Biol Int (2012) 0.80
Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy. Antimicrob Agents Chemother (2006) 0.79
pH and cell volume effects on H2O and phosphoryl resonance splitting in rapid-spinning NMR of red cells. Biophys J (2006) 0.79
Simulations of NMR-detected diffusion in suspensions of red cells: the "signatures" in q-space plots of various lattice arrangements. Eur Biophys J (2002) 0.79
Insights into hERG K+ channel structure and function from NMR studies. Eur Biophys J (2012) 0.79
Plasma membrane oxidoreductases: effects on erythrocyte metabolism and redox homeostasis. Antioxid Redox Signal (2006) 0.78
Rapid exchange of fluoroethylamine via the Rhesus complex in human erythrocytes: 19F NMR magnetization transfer analysis showing competition by ammonia and ammonia analogues. Biochemistry (2006) 0.78