Published in Science on March 01, 2002
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature (2005) 3.82
Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell (2008) 3.79
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem J (2003) 3.43
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest (2003) 3.15
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell (2005) 3.01
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep (2004) 2.98
The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol (2004) 2.70
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol (2009) 2.59
Correcting confocal acquisition to optimize imaging of fluorescence resonance energy transfer by sensitized emission. Biophys J (2004) 2.55
Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev (2009) 2.53
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. Proc Natl Acad Sci U S A (2003) 2.52
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab (2009) 2.45
Glutamate induces de novo growth of functional spines in developing cortex. Nature (2011) 2.24
Genetically encoded Ca2+ indicators: using genetics and molecular design to understand complex physiology. J Physiol (2006) 2.12
Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. J Physiol (2006) 2.06
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell (2006) 2.05
A-kinase anchoring proteins take shape. Curr Opin Cell Biol (2007) 2.03
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J (2006) 1.99
Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. J Biol Chem (2010) 1.94
Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chem Rev (2011) 1.88
Direct in vivo monitoring of sarcoplasmic reticulum Ca2+ and cytosolic cAMP dynamics in mouse skeletal muscle. J Cell Biol (2006) 1.82
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol (2006) 1.81
Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A (2003) 1.80
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. EMBO Rep (2007) 1.72
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol (2004) 1.68
Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J Cell Biol (2002) 1.67
Capturing adenylyl cyclases as potential drug targets. Nat Rev Drug Discov (2009) 1.66
Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci U S A (2005) 1.65
Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. Mol Microbiol (2008) 1.61
How does intracellular Ca2+ oscillate: by chance or by the clock? Biophys J (2007) 1.60
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci U S A (2006) 1.59
A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Circ Res (2006) 1.57
Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach. Biochem J (2011) 1.55
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50
Subcellular dynamics of type II PKA in neurons. Neuron (2009) 1.43
The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations. PLoS One (2010) 1.34
The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Proc Natl Acad Sci U S A (2003) 1.32
Quantification of high-specificity cyclic diguanylate signaling. Proc Natl Acad Sci U S A (2012) 1.31
AKAP18 contains a phosphoesterase domain that binds AMP. J Mol Biol (2007) 1.31
Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circ Res (2009) 1.31
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J Biol Chem (2006) 1.30
cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Circ Res (2011) 1.29
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol (2007) 1.29
The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Proc Natl Acad Sci U S A (2008) 1.27
Compartmentalized cyclic adenosine 3',5'-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains. Mol Biol Cell (2010) 1.25
cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies. Br J Pharmacol (2009) 1.25
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5. Heart Fail Rev (2010) 1.24
Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes. Immun Ageing (2013) 1.24
Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A (2011) 1.23
Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP. J Cell Biol (2008) 1.20
Spatial and temporal second messenger codes for growth cone turning. Proc Natl Acad Sci U S A (2011) 1.18
Calcium signals driven by single channel noise. PLoS Comput Biol (2010) 1.18
Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am J Physiol Cell Physiol (2006) 1.17
Ca2+ cycling and new therapeutic approaches for heart failure. Circulation (2010) 1.16
Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling. EMBO J (2009) 1.16
PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts. J Biol Chem (2011) 1.13
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol (2008) 1.13
Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart. Circ Res (2007) 1.13
Muscarinic regulation of cardiac ion channels. Br J Pharmacol (2003) 1.12
Kinetics of G-protein-coupled receptor signals in intact cells. Br J Pharmacol (2008) 1.12
Missense mutations in desmocollin-2 N-terminus, associated with arrhythmogenic right ventricular cardiomyopathy, affect intracellular localization of desmocollin-2 in vitro. BMC Med Genet (2007) 1.11
Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes. J Mol Cell Cardiol (2010) 1.11
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays. Biochem J (2007) 1.10
The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol (2010) 1.09
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. Am J Physiol Cell Physiol (2003) 1.09
Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes. Mol Pharmacol (2010) 1.08
Spatial distribution of protein kinase A activity during cell migration is mediated by A-kinase anchoring protein AKAP Lbc. J Biol Chem (2008) 1.08
Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes. J Biol Chem (2009) 1.08
Compartmentation of cAMP signaling in cardiac myocytes: a computational study. Biophys J (2007) 1.07
Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations. J Cell Biol (2005) 1.07
Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res (2011) 1.07
Cytoplasmic cAMP concentrations in intact cardiac myocytes. Am J Physiol Cell Physiol (2008) 1.07
Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells. J Cell Sci (2010) 1.06
Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes. J Physiol (2003) 1.05
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04
Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment. Proc Natl Acad Sci U S A (2010) 1.03
Cyclic AMP compartments and signaling specificity: role of cyclic nucleotide phosphodiesterases. J Gen Physiol (2014) 1.03
cAMP signaling in subcellular compartments. Pharmacol Ther (2014) 1.02
cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes. J Physiol (2007) 1.02
Metabolic compartmentation - a system level property of muscle cells: real problems of diffusion in living cells. Int J Mol Sci (2008) 1.01
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome. J Cell Biol (2012) 1.01
Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas. Future Med Chem (2012) 1.00
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. Mol Pharmacol (2008) 1.00
Mechanisms of cyclic AMP compartmentation revealed by computational models. J Gen Physiol (2014) 1.00
Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases. Proc Natl Acad Sci U S A (2009) 0.99
Optical molecular imaging for systems biology: from molecule to organism. Anal Bioanal Chem (2006) 0.99
Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts. Acta Pharmacol Sin (2008) 0.99
Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation. J Biol Chem (2010) 0.98
Spatial control of cAMP signalling in health and disease. Curr Opin Pharmacol (2011) 0.98
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway. J Biol Chem (2012) 0.98
Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool. PLoS One (2012) 0.97
A-kinase anchoring proteins: getting to the heart of the matter. Circulation (2010) 0.97
Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters. Annu Rev Pharmacol Toxicol (2012) 0.97
Spatially distributed cell signalling. FEBS Lett (2009) 0.97
G-protein-coupled receptors, Hedgehog signaling and primary cilia. Semin Cell Dev Biol (2014) 0.96
Mutations in the insulin-like factor 3 receptor are associated with osteoporosis. J Bone Miner Res (2008) 0.96
Phosphodiesterase inhibition in heart failure. Heart Fail Rev (2008) 0.95
Imaging second messenger dynamics in developing neural circuits. Dev Neurobiol (2008) 0.95
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science (2003) 9.55
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci (2003) 8.23
Microdomains of intracellular Ca2+: molecular determinants and functional consequences. Physiol Rev (2006) 4.87
Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron (2004) 4.35
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2004) 3.00
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J (2004) 2.77
Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness. Nat Cell Biol (2004) 2.70
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res (2004) 2.58
Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels. Mol Cell (2010) 2.48
Stable interactions between mitochondria and endoplasmic reticulum allow rapid accumulation of calcium in a subpopulation of mitochondria. J Biol Chem (2003) 2.28
Flirting in little space: the ER/mitochondria Ca2+ liaison. Sci STKE (2004) 2.22
Calcium and apoptosis: facts and hypotheses. Oncogene (2003) 2.12
Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circ Res (2005) 1.91
Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation. EMBO J (2009) 1.85
In vivo monitoring of Ca(2+) uptake into mitochondria of mouse skeletal muscle during contraction. J Cell Biol (2004) 1.85
High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc Natl Acad Sci U S A (2008) 1.84
Direct in vivo monitoring of sarcoplasmic reticulum Ca2+ and cytosolic cAMP dynamics in mouse skeletal muscle. J Cell Biol (2006) 1.82
Mitochondrial pH monitored by a new engineered green fluorescent protein mutant. J Biol Chem (2003) 1.74
Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. Trends Cell Biol (2007) 1.73
Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage. Proc Natl Acad Sci U S A (2008) 1.60
CXCR4-CCR5: a couple modulating T cell functions. Proc Natl Acad Sci U S A (2008) 1.47
Looking forward to seeing calcium. Nat Rev Mol Cell Biol (2003) 1.45
After half a century mitochondrial calcium in- and efflux machineries reveal themselves. EMBO J (2011) 1.38
An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol (2010) 1.35
Mitochondria: the calcium connection. Biochim Biophys Acta (2010) 1.35
Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: role of calcineurin/NFAT as Ca2+ signal integrators. Proc Natl Acad Sci U S A (2008) 1.34
Compartmentalisation of cAMP and Ca(2+) signals. Curr Opin Cell Biol (2002) 1.33
Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol (2003) 1.30
Calcium signaling in a low calcium environment: how the intracellular malaria parasite solves the problem. J Cell Biol (2003) 1.28
Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes. J Physiol (2003) 1.27
The inner side of T cell lipid rafts. Immunol Lett (2004) 1.26
Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes. Proc Natl Acad Sci U S A (2012) 1.25
Mitochondrial Ca²⁺ homeostasis: mechanism, role, and tissue specificities. Pflugers Arch (2012) 1.23
Improved strategies for the delivery of GFP-based Ca2+ sensors into the mitochondrial matrix. Cell Calcium (2005) 1.23
Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk. Proc Natl Acad Sci U S A (2011) 1.22
Purinergic receptors mediate two distinct glutamate release pathways in hippocampal astrocytes. J Biol Chem (2005) 1.21
CAMP and Ca2+ interplay: a matter of oscillation patterns. Trends Neurosci (2003) 1.20
Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells. J Biol Chem (2002) 1.19
Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores. J Invest Dermatol (2003) 1.19
Lipid rafts and T cell receptor signaling: a critical re-evaluation. Eur J Immunol (2002) 1.13
Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J Biol Chem (2009) 1.11
H2O2 in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging system. Plant J (2010) 1.10
Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes. Hepatology (2012) 1.09
Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor. Am J Physiol Cell Physiol (2005) 1.07
Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations. J Cell Biol (2005) 1.07
When calcium goes wrong: genetic alterations of a ubiquitous signaling route. Nat Genet (2003) 1.07
Mitochondrial matrix calcium is an activating signal for hormone secretion. Cell Metab (2011) 1.06
Synaptobrevin2-expressing vesicles in rat astrocytes: insights into molecular characterization, dynamics and exocytosis. J Physiol (2005) 1.06
Mitochondrial Ca²⁺ uptake induces cyclic AMP generation in the matrix and modulates organelle ATP levels. Cell Metab (2013) 1.04
Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment. Proc Natl Acad Sci U S A (2010) 1.03
Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo. Proc Natl Acad Sci U S A (2010) 1.03
Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake. J Cell Mol Med (2009) 1.01
Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases. Proc Natl Acad Sci U S A (2009) 0.99
Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells. FASEB J (2010) 0.94
Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia. Neurobiol Dis (2005) 0.93
Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1. J Gen Physiol (2012) 0.92
Targeting of Cameleons to various subcellular compartments reveals a strict cytoplasmic/mitochondrial Ca²⁺ handling relationship in plant cells. Plant J (2012) 0.91
A role for calcium in Bcl-2 action? Biochimie (2002) 0.90
Ca(2+) signalling in the Golgi apparatus. Cell Calcium (2011) 0.90
The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores. Neurobiol Dis (2004) 0.90
Calcium dynamics in the peroxisomal lumen of living cells. J Biol Chem (2008) 0.88
Ca2+ and cAMP cross-talk in mitochondria. J Physiol (2013) 0.87
Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism. Gastroenterology (2005) 0.86
Cardiac cell hypertrophy in vitro: role of calcineurin/NFAT as Ca2+ signal integrators. Ann N Y Acad Sci (2008) 0.86
Paradoxical Ca2+ rises induced by low external Ca2+ in rat hippocampal neurones. J Physiol (2003) 0.86
Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high-frequency hearing acquisition. Proc Natl Acad Sci U S A (2012) 0.85
No evidence for inositol 1,4,5-trisphosphate-dependent Ca2+ release in isolated fibers of adult mouse skeletal muscle. J Gen Physiol (2012) 0.85
Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis products. J Biol Chem (2007) 0.84
Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2. Aging Cell (2012) 0.83
Interplay among cGMP, cAMP, and Ca2+ in living olfactory sensory neurons in vitro and in vivo. J Neurosci (2011) 0.82
Actin reorganization is abnormal and cellular ATP is decreased in Hailey-Hailey keratinocytes. J Invest Dermatol (2003) 0.81
Heterogeneity of Ca2+ handling among and within Golgi compartments. J Mol Cell Biol (2013) 0.81
Presenilin-2 modulation of ER-mitochondria interactions: FAD mutations, mechanisms and pathological consequences. Commun Integr Biol (2011) 0.79
Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure. BMC Cell Biol (2011) 0.78
Ca2+ on the move: ways and means to translate a multifarious signal. Trends Pharmacol Sci (2002) 0.78
Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation. Biochem Biophys Res Commun (2009) 0.78
Peroxisome Ca(2+) homeostasis in animal and plant cells. Subcell Biochem (2013) 0.76
The trans-golgi compartment: A new distinct intracellular Ca store. Commun Integr Biol (2010) 0.76
Imaging calcium dynamics using targeted recombinant aequorins. CSH Protoc (2008) 0.75