PubRank

Thomas M Roberts

Author PubWeight™ 129.97‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 2010 14.62
2 Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 2009 10.59
3 Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 2007 7.60
4 A histone H3 lysine 27 demethylase regulates animal posterior development. Nature 2007 6.57
5 Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature 2008 6.04
6 The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 2007 6.04
7 A genetic screen for candidate tumor suppressors identifies REST. Cell 2005 5.61
8 Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 2012 5.23
9 The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A 2005 3.72
10 Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell 2003 3.33
11 A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell 2003 3.29
12 An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). Cancer Discov 2013 2.52
13 Human tumor mutants in the p110alpha subunit of PI3K. Cell Cycle 2006 2.39
14 Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res 2004 2.32
15 The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A 2006 2.23
16 Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature 2010 2.20
17 PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis. Proc Natl Acad Sci U S A 2011 2.14
18 Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nat Chem Biol 2006 2.08
19 Retraction in amoeboid cell motility powered by cytoskeletal dynamics. Science 2003 1.89
20 Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell 2002 1.86
21 Should individual PI3 kinase isoforms be targeted in cancer? Curr Opin Cell Biol 2009 1.47
22 Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc Natl Acad Sci U S A 2004 1.42
23 Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol 2008 1.35
24 The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. Genes Dev 2012 1.32
25 The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet 2008 1.30
26 Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology 2011 1.22
27 Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discov 2012 1.22
28 Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci U S A 2007 1.20
29 Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology 2008 1.20
30 Functional genetics and experimental models of human cancer. Trends Mol Med 2004 1.17
31 Surveillance mechanism linking Bub1 loss to the p53 pathway. Proc Natl Acad Sci U S A 2007 1.17
32 K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo. PLoS One 2012 1.16
33 PI3 kinases in cancer: from oncogene artifact to leading cancer target. Sci STKE 2006 1.15
34 The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A 2004 1.14
35 DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. J Biol Chem 2001 1.13
36 PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem 2006 1.13
37 A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One 2008 1.08
38 Dissection of the Ascaris sperm motility machinery identifies key proteins involved in major sperm protein-based amoeboid locomotion. Mol Biol Cell 2003 1.03
39 A 48 kDa integral membrane phosphoprotein orchestrates the cytoskeletal dynamics that generate amoeboid cell motility in Ascaris sperm. J Cell Sci 2003 1.02
40 The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol 2007 1.01
41 A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc Natl Acad Sci U S A 2010 1.01
42 Bub1: escapades in a cellular world. Cell Cycle 2007 0.99
43 A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris. Mol Biol Cell 2007 0.95
44 Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α. J Clin Invest 2014 0.94
45 Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of Ascaris sperm. Mol Biol Cell 2009 0.93
46 PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context. Proc Natl Acad Sci U S A 2014 0.93
47 Comparing the roles of the p110α and p110β isoforms of PI3K in signaling and cancer. Curr Top Microbiol Immunol 2010 0.89
48 Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility. J Mol Biol 2005 0.87
49 Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function. J Virol 2011 0.87
50 Membrane insertion by anthrax protective antigen in cultured cells. Mol Cell Biol 2005 0.87
51 The role of filament-packing dynamics in powering amoeboid cell motility. Proc Natl Acad Sci U S A 2008 0.86
52 2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans. J Mol Biol 2002 0.85
53 Cytoskeleton dynamics powers nematode sperm motility. Adv Protein Chem 2005 0.84
54 Reconstitution of amoeboid motility in vitro identifies a motor-independent mechanism for cell body retraction. Curr Biol 2011 0.84
55 Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma. J Virol 2011 0.81
56 A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proc Natl Acad Sci U S A 2003 0.78
57 Reconstitution in vitro of MSP-based filopodium extension in nematode sperm. Cell Motil Cytoskeleton 2007 0.77
58 Comment on "observation of optical precursors in water". Phys Rev Lett 2004 0.75
59 Preparing to move: assembly of the MSP amoeboid motility apparatus during spermiogenesis in Ascaris. Cell Motil Cytoskeleton 2005 0.75
60 Corrigendum: Essential roles of PI(3)K-p110β in cell growth, metabolism and tumorigenesis. Nature 2016 0.75