Published in Mol Biol Cell on August 20, 2008
The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96
Snail family regulation and epithelial mesenchymal transitions in breast cancer progression. J Mammary Gland Biol Neoplasia (2010) 1.76
Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition. Curr Opin Cell Biol (2014) 1.55
MEK5/ERK5 pathway: the first fifteen years. Biochim Biophys Acta (2011) 1.39
Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks. J Clin Med (2016) 1.07
The skinny on Slug. Mol Carcinog (2010) 1.06
A comparison of epithelial-to-mesenchymal transition and re-epithelialization. Semin Cancer Biol (2012) 1.00
Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms. J Biol Chem (2014) 0.99
A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nat Chem Biol (2010) 0.98
Slug controls stem/progenitor cell growth dynamics during mammary gland morphogenesis. PLoS One (2012) 0.98
MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover. J Biol Chem (2009) 0.95
Epithelial Mesenchymal Transition: a double-edged sword. Clin Transl Med (2015) 0.92
Tie1 deficiency induces endothelial-mesenchymal transition. EMBO Rep (2012) 0.89
The translational significance of epithelial-mesenchymal transition in head and neck cancer. Clin Transl Med (2014) 0.86
Mechanisms of action of topical corticosteroids in psoriasis. Int J Endocrinol (2012) 0.84
Live imaging and gene expression analysis in zebrafish identifies a link between neutrophils and epithelial to mesenchymal transition. PLoS One (2014) 0.82
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer. Cancers (Basel) (2014) 0.82
Glioblastoma Circulating Cells: Reality, Trap or Illusion? Stem Cells Int (2015) 0.81
Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly. Dev Dyn (2011) 0.81
Slug is associated with poor survival in squamous cell carcinoma of the lung. Int J Clin Exp Pathol (2014) 0.80
Cardiac explant-derived cells are regulated by Notch-modulated mesenchymal transition. PLoS One (2012) 0.80
Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction. PLoS One (2010) 0.80
Dedifferentiation of foetal CNS stem cells to mesendoderm-like cells through an EMT process. PLoS One (2012) 0.80
Epithelial-mesenchymal transition in tissue repair and fibrosis. Cell Tissue Res (2016) 0.79
Epithelial topography for repetitive tooth formation. Biol Open (2015) 0.79
Loss of the desmosomal component perp impairs wound healing in vivo. Dermatol Res Pract (2010) 0.78
MAPK7 Regulates EMT Features and Modulates the Generation of CTCs. Mol Cancer Res (2015) 0.77
Estrogen Upregulates Slug to Enhance the Migration of Keratinocytes. J Invest Dermatol (2015) 0.77
ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial-mesenchymal transition. Oncotarget (2015) 0.77
EMT and MET: necessary or permissive for metastasis? Mol Oncol (2017) 0.77
Environmental particulate (PM2.5) augments stiffness-induced alveolar epithelial cell mechanoactivation of transforming growth factor beta. PLoS One (2014) 0.76
Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors. Carcinogenesis (2015) 0.75
Identification of biomechanical force as a novel inducer of epithelial-mesenchymal transition features in mechanical stretched skin. Am J Transl Res (2015) 0.75
Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness. Int J Mol Sci (2016) 0.75
The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol (2002) 10.59
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem (1996) 5.42
Functional correlation between cell adhesive properties and some cell surface proteins. J Cell Biol (1977) 4.97
MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell (2003) 4.52
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J (1997) 4.51
The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol (1997) 3.52
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol (2006) 3.44
Enhancement of wound healing by topical treatment with epidermal growth factor. N Engl J Med (1989) 3.39
Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer (2005) 3.26
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol (2003) 3.09
Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J Cell Physiol (2005) 2.91
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature (1998) 2.62
Snail and slug play distinct roles during breast carcinoma progression. Clin Cancer Res (2006) 2.57
Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16. J Cell Biol (1996) 2.49
The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol (1998) 2.13
Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts. Oncogene (1994) 2.03
ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing. Curr Biol (2004) 2.00
Slug is an essential target of TGFbeta2 signaling in the developing chicken heart. Dev Biol (2000) 1.91
Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma. Clin Cancer Res (2005) 1.84
Human Slug is a repressor that localizes to sites of active transcription. Mol Cell Biol (2000) 1.63
Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. J Cell Biol (2003) 1.62
Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase. Mol Cell Biol (2005) 1.38
Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. J Biol Chem (2006) 1.30
MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src. Mol Cell Biol (2003) 1.29
A pattern of epidermal cell migration during wound healing. J Cell Biol (1971) 1.26
Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways. J Cell Sci (2002) 1.17
Activation of cyclin D1 expression by the ERK5 cascade. Oncogene (2003) 1.14
A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway. Mol Cell Biol (2005) 1.12
Induction-independent recruitment of CREB-binding protein to the c-fos serum response element through interactions between the bromodomain and Elk-1. J Biol Chem (2000) 1.11
Differential MAPK pathways utilized for HGF- and EGF-dependent renal epithelial morphogenesis. J Biol Chem (2000) 1.11
An ex vivo assay to assess the potential of skin keratinocytes for wound epithelialization. J Invest Dermatol (2002) 1.11
Activation of either ERK1/2 or ERK5 MAP kinase pathways can lead to disruption of the actin cytoskeleton. J Cell Sci (2005) 1.08
Growth factors and cutaneous wound repair. Prog Growth Factor Res (1992) 1.01
In vivo transfer and expression of a human epidermal growth factor gene accelerates wound repair. Proc Natl Acad Sci U S A (1994) 0.99
Contributions of the epidermal growth factor receptor to keratinocyte motility. Microsc Res Tech (1998) 0.98
Epidermal growth factor and the onset of epithelial epidermal wound healing. Tissue Cell (1990) 0.84
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38
Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol (2009) 3.09
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol (2003) 3.09
Snail and slug play distinct roles during breast carcinoma progression. Clin Cancer Res (2006) 2.57
Snail family regulation and epithelial mesenchymal transitions in breast cancer progression. J Mammary Gland Biol Neoplasia (2010) 1.76
Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation. J Neurosci (2002) 1.54
Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression. J Mammary Gland Biol Neoplasia (2004) 1.33
Infection with influenza virus induces IL-33 in murine lungs. Am J Respir Cell Mol Biol (2011) 1.29
CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells. Eur J Cancer (2011) 1.26
SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. J Cell Biol (2004) 1.24
Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J Biol Chem (2003) 1.15
Activation of cyclin D1 expression by the ERK5 cascade. Oncogene (2003) 1.14
Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. J Hepatol (2005) 1.12
Aberrant fibroblast growth factor receptor signaling in bladder and other cancers. Differentiation (2007) 1.08
ERK5 activates NF-kappaB in leukemic T cells and is essential for their growth in vivo. J Immunol (2006) 1.06
SUMOylation regulates the transcriptional activity of JunB in T lymphocytes. J Immunol (2008) 1.03
Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway. Eur J Immunol (2004) 1.03
Transforming growth factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression. Am J Pathol (2008) 1.01
Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. Oncogene (2003) 0.98
Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism. Mol Cell Biol (2002) 0.98
Slug controls stem/progenitor cell growth dynamics during mammary gland morphogenesis. PLoS One (2012) 0.98
Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasion. Mol Cancer Ther (2013) 0.93
TRAIL but not FasL and TNFα, regulates IL-33 expression in murine hepatocytes during acute hepatitis. Hepatology (2012) 0.92
Regulation of p63 isoforms by snail and slug transcription factors in human squamous cell carcinoma. Am J Pathol (2010) 0.92
ERK5 knockdown generates mouse leukemia cells with low MHC class I levels that activate NK cells and block tumorigenesis. J Immunol (2009) 0.90
Oxidative phosphorylation induces de novo expression of the MHC class I in tumor cells through the ERK5 pathway. J Immunol (2010) 0.89
Impaired anti-leukemic immune response in PKCtheta-deficient mice. Mol Immunol (2008) 0.89
RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. J Biol Chem (2008) 0.87
P2 receptors in bone--modulation of osteoclast formation and activity via P2X7 activation. Crit Rev Eukaryot Gene Expr (2003) 0.87
TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin. J Cell Sci (2009) 0.87
Chemical metabolic inhibitors for the treatment of blood-borne cancers. Anticancer Agents Med Chem (2014) 0.87
Invariant natural killer T-cell-deficient mice display increased CCl₄ -induced hepatitis associated with CXCL1 over-expression and neutrophil infiltration. Eur J Immunol (2011) 0.85
Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1. Nucleic Acids Res (2011) 0.82
Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis. Hepatology (2006) 0.80
The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver. J Mol Med (Berl) (2015) 0.80
An in situ hybridization technique to detect low-abundance slug mRNA in adherent cultured cells. Methods Mol Biol (2006) 0.75
[SUMO pins Elk-1 in the nucleus]. Med Sci (Paris) (2005) 0.75
Out of the desert: the 4th TEMTIA Meeting on new advances in development, fibrosis and cancer. Cells Tissues Organs (2010) 0.75