Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization.

PubWeight™: 0.99‹?› | Rank: Top 15%

🔗 View Article (PMC 3756152)

Published in Exp Eye Res on August 06, 2008

Authors

Sergio Caballero1, James Swaney, Kelli Moreno, Aqeela Afzal, Jennifer Kielczewski, Glenn Stoller, Amy Cavalli, William Garland, Geneviève Hansen, Roger Sabbadini, Maria B Grant

Author Affiliations

1: Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL, USA.

Associated clinical trials:

Safety Study of iSONEP (Sonepcizumab/LT1009) to Treat Neovascular Age-related Macular Degeneration | NCT00767949

Articles citing this

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov (2013) 1.66

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma. Nat Rev Drug Discov (2012) 1.52

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J Lipid Res (2009) 1.29

Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. Am J Respir Cell Mol Biol (2010) 1.27

Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. Br J Pharmacol (2011) 1.16

Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art. Fibrogenesis Tissue Repair (2009) 1.07

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. EMBO Mol Med (2012) 1.05

Regulating survival and development in the retina: key roles for simple sphingolipids. J Lipid Res (2010) 1.02

Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders. Surv Ophthalmol (2013) 0.96

Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. Crit Rev Biochem Mol Biol (2011) 0.91

Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system. Br J Pharmacol (2011) 0.90

Examining the role of lipid mediators in diabetic retinopathy. Clin Lipidol (2012) 0.86

Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. Acta Pharmacol Sin (2010) 0.86

Molecular mechanisms of subretinal fibrosis in age-related macular degeneration. Exp Eye Res (2015) 0.86

γ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines. Invest Ophthalmol Vis Sci (2012) 0.85

Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. Vision Res (2009) 0.85

Selective blockade of cytoskeletal actin remodeling reduces experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2011) 0.83

Sphingolipids in pulmonary fibrosis. Adv Biol Regul (2014) 0.83

G-protein-coupled receptors in adult neurogenesis. Pharmacol Rev (2012) 0.83

Sphingolipid regulation of tissue fibrosis. Open Rheumatol J (2012) 0.82

Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. J Biol Chem (2013) 0.78

Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? Invest Ophthalmol Vis Sci (2015) 0.76

Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. PLoS One (2017) 0.75

Articles cited by this

Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol (2003) 9.29

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol (2005) 5.10

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest (2001) 5.05

Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina (2006) 4.40

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell (2006) 4.13

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol (1999) 2.87

Structural and functional characteristics of S1P receptors. J Cell Biochem (2004) 2.75

Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res (2000) 2.63

Increased expression of angiogenic growth factors in age-related maculopathy. Br J Ophthalmol (1997) 2.28

Ranibizumab: Phase III clinical trial results. Ophthalmol Clin North Am (2006) 2.25

Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science (2001) 2.17

Emerging medicinal roles for lysophospholipid signaling. Trends Mol Med (2006) 2.01

Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes (2007) 2.01

Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol (2007) 1.91

Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest (2007) 1.89

Lysophospholipid G protein-coupled receptors. J Biol Chem (2004) 1.88

Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. Arterioscler Thromb Vasc Biol (2006) 1.80

IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc Natl Acad Sci U S A (2007) 1.77

Growth factors in age-related macular degeneration: pathogenic and therapeutic implications. Ophthalmic Res (1997) 1.68

G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem (2004) 1.65

VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors. Proc Natl Acad Sci U S A (2003) 1.64

Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J Biol Chem (2002) 1.57

Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF. J Cell Physiol (2001) 1.56

Sphingosine-1-phosphate markedly induces matrix metalloproteinase and integrin-dependent human endothelial cell invasion and lumen formation in three-dimensional collagen and fibrin matrices. Biochem Biophys Res Commun (2003) 1.55

The role of adult bone marrow-derived stem cells in choroidal neovascularization. Invest Ophthalmol Vis Sci (2003) 1.52

Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood (2005) 1.47

Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. Am J Physiol Cell Physiol (2000) 1.42

Choroidal neovascularization: a wound healing perspective. Mol Vis (2003) 1.37

Constitutive expression of the S1P1 receptor in adult tissues. Prostaglandins Other Lipid Mediat (2004) 1.35

Sphingolipids and the balancing of immune cell function: lessons from the mast cell. J Immunol (2005) 1.28

Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing. Wound Repair Regen (2007) 1.23

Vascular endothelial growth factor family and receptor expression in human choroidal neovascular membranes. Microvasc Res (2002) 1.21

Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling. Am J Pathol (2007) 1.17

Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. Exp Eye Res (2008) 1.17

Insulin-like growth factor binding protein-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms. J Thromb Haemost (2007) 1.16

Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. Blood (2003) 1.15

Targeting sphingosine-1-phosphate for cancer therapy. Br J Cancer (2006) 1.11

Sphingosine-1-phosphate signaling in endothelial activation. J Atheroscler Thromb (2003) 1.03

Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. Biochem J (1997) 1.02

Plasminogen activator production by human retinal endothelial cells of nondiabetic and diabetic origin. Invest Ophthalmol Vis Sci (1991) 1.02

Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. Invest Ophthalmol Vis Sci (2006) 0.99

Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase. Kobe J Med Sci (2005) 0.99

Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells. Biochemistry (2003) 0.87

Emerging drugs for age-related macular degeneration. Expert Opin Emerg Drugs (2006) 0.85

Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. Exp Cell Res (2004) 0.85

Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. J Cell Biochem (2003) 0.85

Sphingosine kinase signalling in immune cells. Clin Exp Pharmacol Physiol (2005) 0.82

Functionalizing cell-based therapy for age-related macular degeneration. Am J Ophthalmol (2007) 0.77

Articles by these authors

Generation of functional hemangioblasts from human embryonic stem cells. Nat Methods (2007) 2.06

Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes (2007) 2.01

Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. Diabetes (2008) 1.97

Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes. Diabetes (2006) 1.96

Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1. J Biol Chem (2005) 1.90

SDF-1 is both necessary and sufficient to promote proliferative retinopathy. J Clin Invest (2005) 1.84

Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model. Invest Ophthalmol Vis Sci (2003) 1.83

Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis. Circ Res (2012) 1.78

The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells. Blood (2004) 1.77

IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc Natl Acad Sci U S A (2007) 1.77

Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. Am J Respir Crit Care Med (2013) 1.71

Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock. J Exp Med (2009) 1.68

Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism. J Exp Med (2007) 1.67

Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice. Blood (2011) 1.56

Surgical hypothesis: inner retinal fenestration as a treatment for optic disc pit maculopathy. Retina (2006) 1.55

The role of adult bone marrow-derived stem cells in choroidal neovascularization. Invest Ophthalmol Vis Sci (2003) 1.52

The promise of cell-based therapies for diabetic complications: challenges and solutions. Circ Res (2010) 1.46

Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat Rev Nephrol (2010) 1.43

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. J Cell Biol (2011) 1.42

ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Mol Ther (2011) 1.32

Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation. Circ Res (2009) 1.31

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J Lipid Res (2009) 1.29

The role of growth factors in the pathogenesis of diabetic retinopathy. Expert Opin Investig Drugs (2004) 1.26

Inflammation in the pathogenesis of microvascular complications in diabetes. Front Endocrinol (Lausanne) (2012) 1.24

Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice. Am J Pathol (2009) 1.19

Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci (2010) 1.18

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med (2012) 1.16

Dyslipidemia, but not hyperglycemia, induces inflammatory adhesion molecules in human retinal vascular endothelial cells. Invest Ophthalmol Vis Sci (2003) 1.16

Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury. Am J Pathol (2011) 1.12

Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide. Endocrinology (2011) 1.11

Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. Arch Ophthalmol (2004) 1.11

Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol (2006) 1.10

Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors. Invest Ophthalmol Vis Sci (2005) 1.10

Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis (2006) 1.10

Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma. Exp Eye Res (2006) 1.09

Time course of NADH oxidase, inducible nitric oxide synthase and peroxynitrite in diabetic retinopathy in the BBZ/WOR rat. Nitric Oxide (2002) 1.08

EPCs and pathological angiogenesis: when good cells go bad. Microvasc Res (2010) 1.07

Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization. Invest Ophthalmol Vis Sci (2004) 1.06

Myogenic tone and reactivity of cerebral arteries in type II diabetic BBZDR/Wor rat. Eur J Pharmacol (2007) 1.06

Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells. Invest Ophthalmol Vis Sci (2011) 1.06

Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair. Mol Ther (2009) 1.05

Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes. Diabetes (2008) 1.05

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. EMBO Mol Med (2012) 1.05

PEDF regulates vascular permeability by a γ-secretase-mediated pathway. PLoS One (2011) 1.05

Lentivirus-mediated overexpression of angiotensin-(1-7) attenuated ischaemia-induced cardiac pathophysiology. Exp Physiol (2011) 1.04

Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke. Neuropharmacology (2013) 1.04

Autophagy in the retina: a potential role in age-related macular degeneration. Adv Exp Med Biol (2012) 1.02

Neutralization of Clostridium difficile toxin A using antibody combinations. MAbs (2011) 1.01

Bone marrow-CNS connections: implications in the pathogenesis of diabetic retinopathy. Prog Retin Eye Res (2012) 1.01

Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury. Invest Ophthalmol Vis Sci (2006) 1.00

Anatomical benefit from ranibizumab treatment of predominantly classic neovascular age-related macular degeneration in the 2-year anchor study. Retina (2010) 1.00

Placenta growth factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeability. PLoS One (2011) 1.00

Effects of tenascin-C on normal and diabetic retinal endothelial cells in culture. Invest Ophthalmol Vis Sci (2002) 1.00

Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase). Invest Ophthalmol Vis Sci (2011) 1.00

gamma-Secretase: a multifaceted regulator of angiogenesis. J Cell Mol Med (2008) 0.99

Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors. Diabetes (2012) 0.98

γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. J Biol Chem (2011) 0.98

The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy. Lab Invest (2008) 0.98

Hematopoietic stem cells provide repair functions after laser-induced Bruch's membrane rupture model of choroidal neovascularization. Am J Pathol (2006) 0.98

Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization. J Cell Physiol (2009) 0.97

The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. Diabetes (2011) 0.97

Molecular targeting of antiangiogenic factor 16K hPRL inhibits oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci (2004) 0.96

Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization. Invest Ophthalmol Vis Sci (2009) 0.96

The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci (2006) 0.95

Brain-mediated dysregulation of the bone marrow activity in angiotensin II-induced hypertension. Hypertension (2012) 0.95

Effect of glatiramer acetate on primary and secondary degeneration of retinal ganglion cells in the rat. Invest Ophthalmol Vis Sci (2005) 0.95

Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc Natl Acad Sci U S A (2002) 0.95

Transient inhibition of transforming growth factor-beta1 in human diabetic CD34+ cells enhances vascular reparative functions. Diabetes (2010) 0.95

Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrow. Diabetes (2012) 0.95

Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes. Diabetes (2012) 0.94

The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy. J Biol Chem (2011) 0.94

Engineering stability into Escherichia coli secreted Fabs leads to increased functional expression. Protein Eng Des Sel (2006) 0.94

Fibronectin fragments promote human retinal endothelial cell adhesion and proliferation and ERK activation through alpha5beta1 integrin and PI 3-kinase. Invest Ophthalmol Vis Sci (2003) 0.94

Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene. J Biol Chem (2012) 0.93

Altered inflammatory response is associated with an impaired autonomic input to the bone marrow in the spontaneously hypertensive rat. Hypertension (2013) 0.93

Focal adhesion kinase overexpression induces enhanced pathological retinal angiogenesis. Invest Ophthalmol Vis Sci (2004) 0.93

Long-term effects of intravitreal injection of GMP-grade bone-marrow-derived CD34+ cells in NOD-SCID mice with acute ischemia-reperfusion injury. Invest Ophthalmol Vis Sci (2012) 0.93

The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen. Proc Natl Acad Sci U S A (2009) 0.92

CNS inflammation and bone marrow neuropathy in type 1 diabetes. Am J Pathol (2013) 0.92

Endothelial progenitor dysfunction in the pathogenesis of diabetic retinopathy: treatment concept to correct diabetes-associated deficits. EPMA J (2010) 0.92

The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens. Mol Vis (2008) 0.91