Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28806736)

Published in PLoS One on August 14, 2017

Authors

Sarah E Nicholas1, Tyler G Rowsey1,2, Shrestha Priyadarsini1, Nawajes A Mandal3,4, Dimitrios Karamichos5,6

Author Affiliations

1: Department of Ophthalmology/ Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America.
2: University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, United States of America.
3: Department of Ophthalmology /University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
4: Department of Anatomy and Neurobiology /University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
5: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America.
6: Department of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America.

Articles cited by this

In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc (2007) 12.39

Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res (2003) 3.71

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J Cell Biol (1991) 2.57

Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res (1999) 2.24

Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. J Biol Chem (1999) 2.22

Keratocyte phenotype mediates proteoglycan structure: a role for fibroblasts in corneal fibrosis. J Biol Chem (2003) 2.14

Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: maintenance of the keratocyte phenotype in culture. Invest Ophthalmol Vis Sci (1999) 1.95

Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells. Biochem Biophys Res Commun (1999) 1.90

Endothelial cell barrier regulation by sphingosine 1-phosphate. J Cell Biochem (2004) 1.71

Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. J Biol Chem (2001) 1.70

Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J Biol Chem (2005) 1.67

Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest (2004) 1.67

Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophthalmol Vis Sci (2007) 1.56

Sphingosine-1-phosphate: signaling inside and out. FEBS Lett (2000) 1.53

Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochem Biophys Res Commun (2002) 1.53

Sphingosine-1-phosphate receptor signalling in the heart. Cardiovasc Res (2009) 1.53

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. Biochem J (2000) 1.51

Cell surface receptors in lysophospholipid signaling. Semin Cell Dev Biol (2004) 1.49

Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. Br J Pharmacol (2004) 1.48

Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses. J Biol Chem (2004) 1.48

Sphingosine-1-phosphate: dual messenger functions. FEBS Lett (2002) 1.44

Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. J Biol Chem (2003) 1.43

Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. J Biol Chem (1999) 1.41

Human corneal fibrosis: an in vitro model. Invest Ophthalmol Vis Sci (2009) 1.40

Corneal myofibroblast biology and pathobiology: generation, persistence, and transparency. Exp Eye Res (2012) 1.34

An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application. Biomaterials (2001) 1.31

Pleiotropic actions of sphingosine-1-phosphate. Prog Lipid Res (2003) 1.27

Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. Am J Respir Cell Mol Biol (2010) 1.27

The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J (2007) 1.25

S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res (2009) 1.25

The immune privilege of corneal grafts. J Leukoc Biol (2003) 1.25

Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing. Wound Repair Regen (2007) 1.23

Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model. J Tissue Eng Regen Med (2011) 1.22

Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration. Mol Cell Biol (2008) 1.22

Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. J Surg Res (2005) 1.19

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. J Lipid Res (2008) 1.18

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem (2004) 1.18

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. Cardiovasc Res (2009) 1.18

Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. Exp Eye Res (2008) 1.17

Extracellular matrix and wound healing. Curr Opin Ophthalmol (2001) 1.17

Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. Br J Pharmacol (2011) 1.16

Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. Blood (2003) 1.15

Ceramide levels are inversely associated with malignant progression of human glial tumors. Glia (2002) 1.11

Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. J Hepatol (2010) 1.09

Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. J Biol Chem (2008) 1.06

Ceramide in apoptosis: a revisited role. Neurochem Res (2002) 1.06

Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. J Biol Chem (2004) 1.06

Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res (2008) 1.06

The roles of ceramide and complex sphingolipids in neuronal cell function. Pharmacol Res (2003) 1.04

Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells. Biochem J (2006) 1.03

Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors. Biochim Biophys Acta (2011) 1.02

Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells. Blood (1999) 1.02

Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. Am J Pathol (2009) 1.01

Inhibition of chemotactic motility and trans-endothelial migration of human neutrophils by sphingosine 1-phosphate. FEBS Lett (1997) 1.00

Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization. Exp Eye Res (2008) 0.99

An experimental model for assessing fibroblast migration in 3-D collagen matrices. Cell Motil Cytoskeleton (2009) 0.98

Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development. Dev Biol (2006) 0.98

Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. J Biol Chem (2000) 0.98

Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. J Immunol (2005) 0.97

Sphingosine-1-phosphate signaling in physiology and diseases. Biofactors (2012) 0.97

Novel in Vitro Model for Keratoconus Disease. J Funct Biomater (2012) 0.96

New insights into the mechanism of fibroblast to myofibroblast transformation and associated pathologies. Int Rev Cell Mol Biol (2010) 0.94

Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts. J Biol Chem (2002) 0.93

Retinal sphingolipids and their very-long-chain fatty acid-containing species. Invest Ophthalmol Vis Sci (2010) 0.92

Lipid receptors in cardiovascular development. Annu Rev Physiol (2002) 0.89

Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. Cell Signal (2004) 0.88

Reversal of fibrosis by TGF-β3 in a 3D in vitro model. Exp Eye Res (2014) 0.87

Sphingosine 1-phosphate inhibits cell migration in C2C12 myoblasts. Biochim Biophys Acta (2006) 0.84

Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation. J Cell Physiol (2011) 0.84

Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. J Gastrointest Surg (2003) 0.83

Sphingolipid regulation of tissue fibrosis. Open Rheumatol J (2012) 0.82

Metabolic formation of ceramide-1-phosphate in cerebellar granule cells: evidence for the phosphorylation of ceramide by different metabolic pathways. Neurochem Res (2002) 0.81

Regulation of cancer cell migration and invasion by sphingosine-1-phosphate. World J Biol Chem (2010) 0.81

Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases. Biochim Biophys Acta (2012) 0.81

Mechanisms of corneal allograft rejection and regional immunosuppression. Eye (Lond) (2009) 0.80

Sphingolipids inhibit vimentin-dependent cell migration. J Cell Sci (2015) 0.80

Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. J Ocul Pharmacol Ther (2013) 0.78

Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma. Exp Eye Res (2016) 0.78

Signalling of sphingosine-1-phosphate in Müller glial cells via the S1P/EDG-family of G-protein-coupled receptors. Neurosci Lett (2010) 0.76

Human corneal fibroblast migration and ECM synthesis during stromal repair: Role played by PDGF-BB, bFGF, and TGFβ1. J Tissue Eng Regen Med (2016) 0.76

Sphingosine-1-Phosphate Is a Crucial Signal for Migration of Retina Müller Glial Cells. Invest Ophthalmol Vis Sci (2015) 0.76

Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. J Lipid Res (2017) 0.75