Published in Eukaryot Cell on August 22, 2008
Cryptococcal cell morphology affects host cell interactions and pathogenicity. PLoS Pathog (2010) 2.28
The evolution of sex: a perspective from the fungal kingdom. Microbiol Mol Biol Rev (2010) 2.24
Asymmetry in sexual pheromones is not required for ascomycete mating. Curr Biol (2011) 1.46
Sex in fungi. Annu Rev Genet (2011) 1.45
A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients. PLoS Pathog (2011) 1.38
Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi. Genes Dev (2010) 1.35
The mating type locus (MAT) and sexual reproduction of Cryptococcus heveanensis: insights into the evolution of sex and sex-determining chromosomal regions in fungi. PLoS Genet (2010) 1.08
Orchestration of sexual reproduction and virulence by the fungal mating-type locus. Curr Opin Microbiol (2008) 1.08
A deviation from the bipolar-tetrapolar mating paradigm in an early diverged basidiomycete. PLoS Genet (2010) 1.07
Profiling a killer, the development of Cryptococcus neoformans. FEMS Microbiol Rev (2011) 1.06
Fungal mating pheromones: choreographing the dating game. Fungal Genet Biol (2011) 1.04
Interspecific sex in grass smuts and the genetic diversity of their pheromone-receptor system. PLoS Genet (2011) 0.94
Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii. PLoS Genet (2013) 0.94
The cryptic sexual strategies of human fungal pathogens. Nat Rev Microbiol (2014) 0.91
Discovery of a modified tetrapolar sexual cycle in Cryptococcus amylolentus and the evolution of MAT in the Cryptococcus species complex. PLoS Genet (2012) 0.91
Allelic exchange of pheromones and their receptors reprograms sexual identity in Cryptococcus neoformans. PLoS Genet (2010) 0.90
Morphological and genomic characterization of Filobasidiella depauperata: a homothallic sibling species of the pathogenic cryptococcus species complex. PLoS One (2010) 0.89
Evolution of uni- and bifactorial sexual compatibility systems in fungi. Heredity (Edinb) (2013) 0.86
Sex-determination system in the diploid yeast Zygosaccharomyces sapae. G3 (Bethesda) (2014) 0.85
Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination. PLoS Biol (2017) 0.75
A regulatory hierarchy for cell specialization in yeast. Nature (1989) 5.68
Genetic association of mating types and virulence in Cryptococcus neoformans. Infect Immun (1992) 5.27
The evolution of sex chromosomes. Science (1991) 4.08
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infect Immun (2003) 3.61
Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada. Eukaryot Cell (2003) 3.25
Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes. Eukaryot Cell (2002) 3.12
Deciphering the model pathogenic fungus Cryptococcus neoformans. Nat Rev Microbiol (2005) 2.63
Karyotyping of Cryptococcus neoformans as an epidemiological tool. J Clin Microbiol (1993) 2.50
Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms. PLoS Biol (2004) 2.22
Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Proc Natl Acad Sci U S A (2007) 2.18
Light controls growth and development via a conserved pathway in the fungal kingdom. PLoS Biol (2005) 2.15
Mating type in filamentous fungi. Annu Rev Genet (1997) 2.12
Sex determination: insights from the chicken. Bioessays (2004) 1.91
Identification of the sex genes in an early diverged fungus. Nature (2008) 1.75
Temperature sex reversal implies sex gene dosage in a reptile. Science (2007) 1.73
Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha. Genes Dev (2002) 1.68
The mating-type and pathogenicity locus of the fungus Ustilago hordei spans a 500-kb region. Proc Natl Acad Sci U S A (1999) 1.55
Sex in smut fungi: Structure, function and evolution of mating-type complexes. Fungal Genet Biol (2008) 1.51
Linkage of mating-type loci distinguishes bipolar from tetrapolar mating in basidiomycetous smut fungi. Proc Natl Acad Sci U S A (1994) 1.46
Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. Eukaryot Cell (2005) 1.37
Sex determination and dosage compensation: lessons from flies and worms. Science (1994) 1.32
Recombination hotspots flank the Cryptococcus mating-type locus: implications for the evolution of a fungal sex chromosome. PLoS Genet (2006) 1.24
A constitutively active G-protein-coupled receptor causes mating self-compatibility in the mushroom Coprinus. EMBO J (1999) 1.23
Evolution of the bipolar mating system of the mushroom Coprinellus disseminatus from its tetrapolar ancestors involves loss of mating-type-specific pheromone receptor function. Genetics (2006) 1.20
A role for heterodimerization in nuclear localization of a homeodomain protein. Proc Natl Acad Sci U S A (1998) 1.18
Sex in the 90s: SRY and the switch to the male pathway. Annu Rev Physiol (1998) 1.13
Mating factor linkage and genome evolution in basidiomycetous pathogens of cereals. Fungal Genet Biol (2006) 1.13
Changes in mate recognition through alterations of pheromones and receptors in the multisexual mushroom fungus Schizophyllum commune. Genetics (2001) 1.11
Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence. Curr Genet (2004) 1.06
The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans. Curr Genet (2007) 0.95
Disentangling genetic vs. environmental causes of sex determination in the common frog, Rana temporaria. BMC Genet (2008) 0.94
Heterozygosity at the b mating-type locus attenuates fusion in Ustilago maydis. Curr Genet (1995) 0.93
Kwoniella mangroviensis gen. nov., sp.nov. (Tremellales, Basidiomycota), a teleomorphic yeast from mangrove habitats in the Florida Everglades and Bahamas. FEMS Yeast Res (2007) 0.92
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res (2003) 7.56
Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature (2009) 5.90
Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature (2005) 5.11
The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes. Science (2012) 4.93
The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science (2005) 4.74
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infect Immun (2003) 3.61
A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology (2002) 3.58
Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada. Eukaryot Cell (2003) 3.25
Sexual reproduction between partners of the same mating type in Cryptococcus neoformans. Nature (2005) 3.22
Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect Immun (2005) 3.13
Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes. Eukaryot Cell (2002) 3.12
Calcineurin is essential for survival during membrane stress in Candida albicans. EMBO J (2002) 2.81
The human fungal pathogen Cryptococcus can complete its sexual cycle during a pathogenic association with plants. Cell Host Microbe (2007) 2.75
Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States. PLoS Pathog (2010) 2.67
Deciphering the model pathogenic fungus Cryptococcus neoformans. Nat Rev Microbiol (2005) 2.63
Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat Rev Microbiol (2007) 2.60
The cyclophilins. Genome Biol (2005) 2.58
Genetics of Cryptococcus neoformans. Annu Rev Genet (2002) 2.57
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. Curr Biol (2009) 2.50
Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States. J Infect Dis (2009) 2.37
Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. Eukaryot Cell (2006) 2.35
The biology of the Cryptococcus neoformans species complex. Annu Rev Microbiol (2006) 2.31
Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J (2007) 2.30
Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. Proc Natl Acad Sci U S A (2002) 2.29
Cryptococcal cell morphology affects host cell interactions and pathogenicity. PLoS Pathog (2010) 2.28
Mechanistic plasticity of sexual reproduction and meiosis in the Candida pathogenic species complex. Curr Biol (2009) 2.25
The evolution of sex: a perspective from the fungal kingdom. Microbiol Mol Biol Rev (2010) 2.24
Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms. PLoS Biol (2004) 2.22
Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryot Cell (2002) 2.21
Spread of Cryptococcus gattii into Pacific Northwest region of the United States. Emerg Infect Dis (2009) 2.19
Light controls growth and development via a conserved pathway in the fungal kingdom. PLoS Biol (2005) 2.15
Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Mol Biol Cell (2005) 2.12
Microsporidia evolved from ancestral sexual fungi. Curr Biol (2008) 2.11
Sensing the environment: lessons from fungi. Nat Rev Microbiol (2007) 2.10
Calcineurin is essential for Candida albicans survival in serum and virulence. Eukaryot Cell (2003) 1.98
Cryptococcus neoformans gene expression during murine macrophage infection. Eukaryot Cell (2005) 1.89
Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans. PLoS Biol (2013) 1.88
A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Mol Biol Cell (2006) 1.86
Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. Mol Cell Biol (2002) 1.84
The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Mol Microbiol (2003) 1.81
Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Antimicrob Agents Chemother (2003) 1.80
Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality. J Infect Dis (2007) 1.78
Enzymes that counteract nitrosative stress promote fungal virulence. Curr Biol (2003) 1.75
Identification of the sex genes in an early diverged fungus. Nature (2008) 1.75
Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade. Eukaryot Cell (2005) 1.75
Spores as infectious propagules of Cryptococcus neoformans. Infect Immun (2009) 1.72
Evolution of fungal sex chromosomes. Mol Microbiol (2004) 1.71
Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa. Eukaryot Cell (2003) 1.71
First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak. J Clin Microbiol (2007) 1.70
A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans. EMBO J (2009) 1.68
Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. Eukaryot Cell (2004) 1.68
Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha. Genes Dev (2002) 1.68
Calcineurin: a central controller of signalling in eukaryotes. EMBO Rep (2004) 1.65
Good fungi gone bad: the corruption of calcineurin. Bioessays (2002) 1.64
Sex and virulence of human pathogenic fungi. Adv Genet (2007) 1.63
Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence. Curr Biol (2005) 1.62
Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. Antimicrob Agents Chemother (2008) 1.62
Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. Biochem Biophys Res Commun (2003) 1.61
Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans. Mol Microbiol (2005) 1.59
Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Eukaryot Cell (2004) 1.59
A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans. Mol Microbiol (2003) 1.55
Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. Eukaryot Cell (2002) 1.55
Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. MBio (2012) 1.55
Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Antimicrob Agents Chemother (2007) 1.54
Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray. Eukaryot Cell (2004) 1.54
Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts. J Cardiovasc Electrophysiol (2012) 1.53
Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. PLoS One (2011) 1.52
alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness. PLoS Genet (2007) 1.52
Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans. Microbiology (2002) 1.51
G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Mol Biol Cell (2005) 1.50
Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology (2006) 1.49
Clonality and recombination in genetically differentiated subgroups of Cryptococcus gattii. Eukaryot Cell (2005) 1.48
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrob Agents Chemother (2004) 1.46
Chromosomal sex-determining regions in animals, plants and fungi. Curr Opin Genet Dev (2005) 1.45
Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. Eukaryot Cell (2004) 1.45
Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. Cell Host Microbe (2013) 1.45
Sex in fungi. Annu Rev Genet (2011) 1.45
The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infect Immun (2004) 1.44
The protein kinase Tor1 regulates adhesin gene expression in Candida albicans. PLoS Pathog (2009) 1.44
Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. Eukaryot Cell (2004) 1.42
The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell (2002) 1.41
Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. PLoS Genet (2006) 1.40
Cryptococcal osteomyelitis in an adolescent survivor of T-cell acute lymphoblastic leukemia. Pediatr Infect Dis J (2015) 1.40
Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryot Cell (2009) 1.40
Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. Mol Microbiol (2004) 1.39
A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients. PLoS Pathog (2011) 1.38
Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. Eukaryot Cell (2005) 1.37
Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell (2008) 1.37
Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating. PLoS Pathog (2009) 1.35
Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi. Genes Dev (2010) 1.35
Evolution of the mating type locus: insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii. Eukaryot Cell (2007) 1.34
Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol (2011) 1.34
First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen. PLoS One (2009) 1.34
Cryptococcus neoformans mates on pigeon guano: implications for the realized ecological niche and globalization. Eukaryot Cell (2007) 1.33
Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiol Rev (2008) 1.33