Published in Cell on August 22, 2008
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Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell (2005) 20.30
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (2012) 10.47
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell (2009) 10.11
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell (2006) 7.32
The specific and essential role of MAVS in antiviral innate immune responses. Immunity (2006) 6.74
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell (2004) 6.00
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell (2011) 5.91
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Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci U S A (2005) 5.31
Peroxisomes are signaling platforms for antiviral innate immunity. Cell (2010) 5.24
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell (2004) 5.08
Direct activation of protein kinases by unanchored polyubiquitin chains. Nature (2009) 4.65
Ubiquitylation in innate and adaptive immunity. Nature (2009) 4.60
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Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science (2013) 3.61
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal (2012) 3.59
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol (2008) 3.45
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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med (2009) 2.92
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NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell (2010) 2.49
Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell (2012) 2.38
Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell (2011) 2.32
Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol Cell (2009) 2.27
Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J Clin Invest (2008) 2.24
Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A (2006) 2.19
Emerging role of ISG15 in antiviral immunity. Cell (2010) 2.19
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NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. Immunity (2011) 2.10
Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci Signal (2009) 2.05
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MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci U S A (2008) 1.74
A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells. Blood (2014) 1.68
Activation of the interferon-beta promoter during hepatitis C virus RNA replication. Viral Immunol (2002) 1.68
MAVS-mediated apoptosis and its inhibition by viral proteins. PLoS One (2009) 1.67
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Elife (2013) 1.63
E1-L2 activates both ubiquitin and FAT10. Mol Cell (2007) 1.60
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Cell (2013) 1.56
Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production. J Gen Virol (2009) 1.56
Structural basis for the prion-like MAVS filaments in antiviral innate immunity. Elife (2014) 1.56
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Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell (2013) 1.32
The role of ubiquitination in Drosophila innate immunity. J Biol Chem (2005) 1.32
TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. Proc Natl Acad Sci U S A (2004) 1.28
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6. PLoS Pathog (2011) 1.26
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Ubiquitin in NF-kappaB signaling. Chem Rev (2009) 1.20
Endocytic pathway is required for Drosophila Toll innate immune signaling. Proc Natl Acad Sci U S A (2010) 1.18
Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction. Circulation (2003) 1.18
Regulation of NF-κB by ubiquitination. Curr Opin Immunol (2013) 1.17
Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication. PLoS Pathog (2010) 1.14
Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science (2002) 1.13
Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1. Mol Cell Biol (2004) 1.12
Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation. J Biol Chem (2008) 1.10
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood (2009) 1.07
Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis. Proc Natl Acad Sci U S A (2011) 1.04
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SnapShot: pathways of antiviral innate immunity. Cell (2010) 1.00
Human metapneumovirus M2-2 protein inhibits innate cellular signaling by targeting MAVS. J Virol (2012) 1.00
Structural insights into the activation of RIG-I, a nanosensor for viral RNAs. EMBO Rep (2011) 0.97
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Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection. J Immunol (2012) 0.93
RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge. J Virol (2013) 0.92
Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor. J Lipid Res (2013) 0.92
IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. Cell Rep (2013) 0.87
A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis. J Immunol (2014) 0.85
Protein ubiquitination: CHIPping away the symmetry. Mol Cell (2005) 0.81
Smads keep TABs on inflammation. Nat Immunol (2007) 0.80
Viperin links lipid bodies to immune defense. Immunity (2011) 0.79
MITAgating viral infection. Immunity (2008) 0.78
Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. Nucleic Acids Res (2003) 0.78
SUMO, Ubiquitin, UBL Proteins: Implications For Human Diseases - Fifth International Conference. IDrugs (2010) 0.77
Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress. J Nutr (2004) 0.76
K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping. Mol Cell (2016) 0.75