Published in Nat Genet on June 14, 2009
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature (2011) 9.30
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell (2013) 9.24
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature (2011) 7.92
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol (2012) 5.71
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature (2011) 5.28
Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. J Biol Chem (2011) 3.21
Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity. Hum Mol Genet (2009) 3.07
SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells. Retrovirology (2012) 2.92
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling. Nat Genet (2014) 2.88
The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe (2012) 2.79
Intrinsic antiviral immunity. Nat Immunol (2012) 2.71
Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein. Cell Host Microbe (2012) 2.66
SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection. PLoS Pathog (2011) 2.65
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. Nat Genet (2012) 2.63
Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell (2012) 2.62
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. Lancet Neurol (2013) 2.36
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nat Med (2014) 2.35
Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages. J Biol Chem (2012) 2.25
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood (2013) 2.18
Evolutionary conflicts between viruses and restriction factors shape immunity. Nat Rev Immunol (2012) 2.10
SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. Retrovirology (2012) 1.96
Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction. J Biol Chem (2013) 1.95
Studies of endogenous retroviruses reveal a continuing evolutionary saga. Nat Rev Microbiol (2012) 1.94
APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells. PLoS Pathog (2011) 1.90
Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac. Retrovirology (2012) 1.87
Aicardi-Goutières syndrome and the type I interferonopathies. Nat Rev Immunol (2015) 1.82
Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem (2013) 1.76
RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell (2012) 1.74
Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1. Virology (2012) 1.68
Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity. J Exp Med (2012) 1.62
Homozygous mutation in SAMHD1 gene causes cerebral vasculopathy and early onset stroke. Proc Natl Acad Sci U S A (2011) 1.62
The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.61
Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1. J Virol (2013) 1.58
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations. J Clin Invest (2014) 1.50
Mechanism of allosteric activation of SAMHD1 by dGTP. Nat Struct Mol Biol (2013) 1.49
Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx. Cell Host Microbe (2015) 1.48
Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance. Cell Host Microbe (2014) 1.47
The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus. J Virol (2012) 1.47
Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression. Hum Mutat (2010) 1.43
Aicardi-Goutières syndrome is caused by IFIH1 mutations. Am J Hum Genet (2014) 1.41
Neuroradiologic patterns and novel imaging findings in Aicardi-Goutières syndrome. Neurology (2015) 1.41
Adenosine-to-inosine RNA editing and human disease. Genome Med (2013) 1.40
The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation. Nat Immunol (2017) 1.38
Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells. PLoS Pathog (2013) 1.37
SAMHD1-dependent retroviral control and escape in mice. EMBO J (2013) 1.36
Innate immune sensing of HIV-1 by dendritic cells. Cell Host Microbe (2012) 1.35
Evolutionary genetic dissection of human interferons. J Exp Med (2011) 1.32
Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1. Clin Exp Immunol (2012) 1.30
Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep (2013) 1.28
The enemy within: endogenous retroelements and autoimmune disease. Nat Immunol (2014) 1.27
SAMHD1: a new insight into HIV-1 restriction in myeloid cells. Retrovirology (2011) 1.26
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity. J Clin Invest (2014) 1.25
SAMHD1 prevents autoimmunity by maintaining genome stability. Ann Rheum Dis (2014) 1.20
Intracellular nucleotide levels and the control of retroviral infections. Virology (2012) 1.19
RNase H2 roles in genome integrity revealed by unlinking its activities. Nucleic Acids Res (2013) 1.19
SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells. J Virol (2012) 1.18
Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1. Cell Rep (2013) 1.18
Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1. Am J Med Genet A (2015) 1.17
How SAMHD1 changes our view of viral restriction. Trends Immunol (2011) 1.15
Aicardi-Goutières syndrome: a model disease for systemic autoimmunity. Clin Exp Immunol (2014) 1.10
Restricting HIV the SAMHD1 way: through nucleotide starvation. Nat Rev Microbiol (2012) 1.10
SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. J Virol (2013) 1.09
Innate immune sensing of DNA. PLoS Pathog (2011) 1.08
Cerebral vasculopathy is a common feature in Aicardi-Goutieres syndrome associated with SAMHD1 mutations. Proc Natl Acad Sci U S A (2011) 1.08
Mutations in CECR1 associated with a neutrophil signature in peripheral blood. Pediatr Rheumatol Online J (2014) 1.07
Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor. PLoS One (2012) 1.07
Intracellular nucleic acid sensors and autoimmunity. J Interferon Cytokine Res (2011) 1.07
Therapies in Aicardi-Goutières syndrome. Clin Exp Immunol (2014) 1.07
Endogenous retroelements and autoimmune disease. Curr Opin Immunol (2012) 1.06
Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase. Curr Opin Virol (2012) 1.06
Temporal genomewide expression profiling of DSS colitis reveals novel inflammatory and angiogenesis genes similar to ulcerative colitis. Physiol Genomics (2010) 1.06
Structural basis of cellular dNTP regulation by SAMHD1. Proc Natl Acad Sci U S A (2014) 1.06
Host restriction factors in retroviral infection: promises in virus-host interaction. Retrovirology (2012) 1.05
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection. Viruses (2012) 1.05
Promoter methylation regulates SAMHD1 gene expression in human CD4+ T cells. J Biol Chem (2013) 1.05
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response. EMBO J (2016) 1.04
Identification and characterization of naturally occurring splice variants of SAMHD1. Retrovirology (2012) 1.02
rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proc Natl Acad Sci U S A (2011) 1.02
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol (2012) 1.02
RNA degradation in antiviral immunity and autoimmunity. Trends Immunol (2015) 1.01
SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity. Nucleic Acids Res (2015) 1.01
Detection of selective sweeps in cattle using genome-wide SNP data. BMC Genomics (2013) 1.01
SAMHD1: a new contributor to HIV-1 restriction in resting CD4+ T-cells. Retrovirology (2012) 1.00
Sensors of the innate immune system: their link to rheumatic diseases. Nat Rev Rheumatol (2010) 1.00
Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates. J Biol Chem (2014) 0.97
A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1. Antimicrob Agents Chemother (2014) 0.97
Out of balance: R-loops in human disease. PLoS Genet (2014) 0.97
Polymorphisms of the SAMHD1 gene are not associated with the infection and natural control of HIV type 1 in Europeans and African-Americans. AIDS Res Hum Retroviruses (2012) 0.96
Early-Onset Aicardi-Goutières Syndrome: Magnetic Resonance Imaging (MRI) Pattern Recognition. J Child Neurol (2014) 0.96
The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes. Microbiol Spectr (2015) 0.96
Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. Elife (2015) 0.96
Transcriptional profiling of polycythemia vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F. Clin Cancer Res (2010) 0.95
How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells. Nucleic Acids Res (2014) 0.95
Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply. Retrovirology (2013) 0.94
SAMHD1 specifically restricts retroviruses through its RNase activity. Retrovirology (2015) 0.94
The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents. Mol Biol Int (2012) 0.93
A large homozygous deletion in the SAMHD1 gene causes atypical Aicardi-Goutiéres syndrome associated with mtDNA deletions. Eur J Hum Genet (2010) 0.93
dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages. Retrovirology (2014) 0.92
Functional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome. J Biol Chem (2011) 0.92
Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus. Nat Genet (2006) 6.15
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat Genet (2006) 5.26
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet (2007) 4.76
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Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell (2007) 3.93
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The many faces of SAM. Sci STKE (2005) 2.87
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Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. Am J Hum Genet (2007) 2.73
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Cerebral thrombotic microangiopathy and antiphospholipid antibodies in Aicardi-Goutieres syndrome--report of two sisters. Neuropediatrics (2005) 2.44
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Microarray analysis of interferon-regulated genes in SLE. Autoimmunity (2003) 2.24
Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli. J Mol Biol (2008) 2.19
Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. J Virol (2006) 2.16
Type I interferon in systemic lupus erythematosus. Curr Top Microbiol Immunol (2007) 1.96
Shape-specific recognition in the structure of the Vts1p SAM domain with RNA. Nat Struct Mol Biol (2006) 1.61
Inhibition of G1P3 expression found in the differential display study on respiratory syncytial virus infection. Virol J (2008) 1.60
Cree encephalitis is allelic with Aicardi-Goutiéres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolism. J Med Genet (2003) 1.53
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Systemic lupus erythematosus or Aicardi-Goutières syndrome? Neuropediatrics (2000) 1.37
Intrathecal synthesis of different alpha-interferons in patients with various neurological diseases. Acta Neurol Scand (1985) 1.34
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Linking retroelements to autoimmunity. Cell (2008) 1.16
DNA mismanagement leads to immune system oversight. Cell (2007) 1.12
Molecular genetics of tetrahydrobiopterin (BH4) deficiency in the Maltese population. Mol Genet Metab (2006) 0.98
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55
A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N Engl J Med (2011) 8.26
Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum (2004) 7.07
Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nat Genet (2004) 6.90
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Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science (2011) 6.19
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus. Nat Genet (2006) 6.15
TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 5.86
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature (2011) 5.28
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat Genet (2006) 5.26
X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. Am J Hum Genet (2004) 5.15
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Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities. Nat Genet (2008) 4.87
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Herpes simplex virus encephalitis in human UNC-93B deficiency. Science (2006) 4.26
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Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation. Nat Genet (2007) 3.43
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Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. Nat Genet (2012) 2.63