Published in Eur J Endocrinol on September 01, 2008
Lipodystrophy: pathophysiology and advances in treatment. Nat Rev Endocrinol (2010) 1.34
State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS). Int J Pediatr Endocrinol (2011) 0.90
Familial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution. Cell Cycle (2012) 0.83
Genetics in endocrinology: genetic forms of severe insulin resistance: what endocrinologists should know. Eur J Endocrinol (2013) 0.80
The role of genetic variation in the lamin a/c gene in the etiology of polycystic ovary syndrome. J Clin Endocrinol Metab (2009) 0.78
Complications and challenges associated with polycystic ovary syndrome: current perspectives. Int J Womens Health (2015) 0.77
Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes (2001) 9.67
Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature (1997) 7.33
Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med (1999) 6.94
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature (2000) 5.86
Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med (1999) 5.65
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet (1997) 4.77
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature (2010) 4.52
A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet (1998) 4.06
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Nat Genet (2000) 3.73
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet (2001) 3.50
A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet (2001) 3.26
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest (2000) 3.10
The perils of portliness: causes and consequences of visceral adiposity. Diabetes (2000) 2.96
Genetics of body-weight regulation. Nature (2000) 2.84
Moderate alcohol use and health: a consensus document. Nutr Metab Cardiovasc Dis (2013) 2.77
Linkage of type 2 diabetes to the glucokinase gene. Lancet (1992) 2.64
An activating mutation of AKT2 and human hypoglycemia. Science (2011) 2.60
Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes (2001) 2.43
Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med (1998) 2.04
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci U S A (2004) 2.03
Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection. Hepatology (1999) 2.02
Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent. Int J Obes (Lond) (2009) 1.98
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. J Clin Invest (1997) 1.95
Genotype-phenotype relationships in Berardinelli-Seip congenital lipodystrophy. J Med Genet (2002) 1.84
Partial leptin deficiency and human adiposity. Nature (2001) 1.83
Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia (2009) 1.81
Obesity and the polycystic ovary syndrome. Int J Obes Relat Metab Disord (2002) 1.77
Endogenous cannabinoid system as a modulator of food intake. Int J Obes Relat Metab Disord (2003) 1.74
Genetic factors in human obesity. Obes Rev (2007) 1.72
Regulation of adipose cell number in man. Clin Sci (Lond) (1997) 1.72
Elevated plasma adiponectin in humans with genetically defective insulin receptors. J Clin Endocrinol Metab (2006) 1.71
Testosterone levels in obese male patients with obstructive sleep apnea syndrome: relation to oxygen desaturation, body weight, fat distribution and the metabolic parameters. J Endocrinol Invest (2003) 1.71
Homozygous nonsense mutation in the insulin receptor gene in infant with leprechaunism. Lancet (1993) 1.65
Evidence for gene-nutrient interaction at the PPARgamma locus. Diabetes (2001) 1.54
Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes (1997) 1.52
Triple H syndrome: a novel autoimmune endocrinopathy characterized by dysfunction of the hippocampus, hair follicle, and hypothalamic-pituitary adrenal axis. J Clin Endocrinol Metab (2000) 1.48
Expression of the thermogenic nuclear hormone receptor coactivator PGC-1alpha is reduced in the adipose tissue of morbidly obese subjects. Int J Obes Relat Metab Disord (2004) 1.46
The impact of obesity on reproduction in women with polycystic ovary syndrome. BJOG (2006) 1.44
A gene for congenital generalized lipodystrophy maps to human chromosome 9q34. J Clin Endocrinol Metab (1999) 1.44
[The role of diffusion 3-Tesla MRI in detecting prostate cancer before needle biopsy: multiparametric study of 111 patients]. J Radiol (2010) 1.43
Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes (1998) 1.43
Type II diabetes of early onset: a distinct clinical and genetic syndrome? Br Med J (Clin Res Ed) (1987) 1.39
Severe insulin resistance, diabetes mellitus, hypertriglyceridemia, and pseudoacromegaly. J Clin Endocrinol Metab (1996) 1.39
Is the defect in pro-hormone processing in Type 2 diabetes mellitus restricted to the beta cell? Diabet Med (2001) 1.39
Potentiation of glucose uptake in 3T3-L1 adipocytes by PPAR gamma agonists is maintained in cells expressing a PPAR gamma dominant-negative mutant: evidence for selectivity in the downstream responses to PPAR gamma activation. Mol Endocrinol (2001) 1.36
Monogenic human obesity syndromes. Recent Prog Horm Res (2004) 1.33
WNT10B mutations in human obesity. Diabetologia (2006) 1.29
Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies. J Clin Endocrinol Metab (2010) 1.29
Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes. Diabetologia (2006) 1.27
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am J Hum Genet (2001) 1.26
Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes. Diabetes (1998) 1.25
The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation. Cell Death Differ (2009) 1.24
WHO and ATPIII proposals for the definition of the metabolic syndrome in patients with Type 2 diabetes. Diabet Med (2004) 1.24
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. J Clin Endocrinol Metab (1993) 1.22
The effects of neurokinin B upon gonadotrophin release in male rodents. J Neuroendocrinol (2009) 1.22
Tumor necrosis factor-alpha induces apoptosis of human adipose cells. Diabetes (1997) 1.21
Recent advances in the genetics of severe childhood obesity. Arch Dis Child (2000) 1.21
Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochem Biophys Res Commun (2003) 1.17
The direct economic cost of pharmacologically-treated diabetes in Italy-2006. The ARNO observatory. Nutr Metab Cardiovasc Dis (2010) 1.15
High prevalence of hepatitis C infection in Afro-Caribbean patients with type 2 diabetes and abnormal liver function tests. Diabet Med (1995) 1.12
Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes. Diabetologia (2005) 1.11
Mutant insulin receptors in syndromes of insulin resistance. Baillieres Clin Endocrinol Metab (1996) 1.08
Molecular scanning of the insulin receptor gene in syndromes of insulin resistance. Diabetes (1994) 1.08
Expression of epidermal growth factor receptor in neoplastic pituitary cells: evidence for a role in corticotropinoma cells. J Endocrinol (2004) 1.08
Interrelationships between body weight, body fat distribution and insulin in obese women before and after hypocaloric feeding and weight loss. Ann Nutr Metab (1989) 1.06
Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects. Mol Psychiatry (2012) 1.06
Retinoic acid prevents experimental Cushing syndrome. J Clin Invest (2001) 1.05
Regulation of tumour necrosis factor-alpha release from human adipose tissue in vitro. J Endocrinol (1999) 1.04
The changing classification and diagnosis of diabetes. New classification is based on pathogenesis, not insulin dependence. BMJ (1998) 1.02
FTO expression is regulated by availability of essential amino acids. Int J Obes (Lond) (2012) 1.02
Studies of the SIM1 gene in relation to human obesity and obesity-related traits. Int J Obes (Lond) (2006) 1.01
Laminopathies: many diseases, one gene. Report of the first Italian Meeting Course on Laminopathies. Acta Myol (2011) 1.01
The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models. QJM (2000) 1.00
WHO and ADA criteria for the diagnosis of diabetes mellitus in relation to body mass index. Insulin sensitivity and secretion in resulting subcategories of glucose tolerance. Int J Obes Relat Metab Disord (2002) 1.00
New advances in the genetics of early onset obesity. Int J Obes (Lond) (2005) 1.00
Hypoketotic hypofattyacidaemic hypoinsulinaemic hypoglycaemia in a child with hemihypertrophy? A new syndrome. Horm Res (2004) 1.00
Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II. Biosci Rep (1998) 0.99
Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats. J Endocrinol Invest (2006) 0.99
Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: evidence for a central and a peripheral alteration. J Clin Endocrinol Metab (2000) 0.99
Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes. J Biol Chem (1999) 0.98
Cannabinoid type 1 receptor: another arrow in the adipocytes' bow. J Neuroendocrinol (2008) 0.98
Insulin-dependent metabolism of branched-chain amino acids in obesity. Metabolism (1984) 0.98
Sex-dependent role of glucocorticoids and androgens in the pathophysiology of human obesity. Int J Obes (Lond) (2008) 0.98
Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity. Diabetologia (2000) 0.97
A dominant negative human peroxisome proliferator-activated receptor (PPAR){alpha} is a constitutive transcriptional corepressor and inhibits signaling through all PPAR isoforms. Endocrinology (2005) 0.97
The unliganded estrogen receptor (ER) transduces growth factor signals. J Steroid Biochem Mol Biol (1994) 0.97
Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin. J Neuroendocrinol (2010) 0.96
Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level? Metabolism (2004) 0.96
Pathophysiological role of the cytokine network in the anterior pituitary gland. Front Neuroendocrinol (1999) 0.96
Mitochondrial DNA, diabetes and pancreatic pathology in Kearns-Sayre syndrome. Diabetologia (1995) 0.96
Molecular mechanisms of inherited insulin resistance. QJM (1997) 0.96