Helicobacter pylori activate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3beta phosphorylation.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMC 2827479)

Published in Cell Microbiol on September 08, 2008

Authors

Fazal H Tabassam1, David Y Graham, Yoshio Yamaoka

Author Affiliations

1: Department of Medicine-Gastroenterology, Michael DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA.

Articles citing this

Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev (2010) 3.41

Mechanisms of disease: Helicobacter pylori virulence factors. Nat Rev Gastroenterol Hepatol (2010) 2.56

Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. Gastroenterology (2010) 1.45

Helicobacter pylori virulence and cancer pathogenesis. Future Oncol (2014) 1.21

Pathogenesis of Helicobacter pylori-Related Gastroduodenal Diseases from Molecular Epidemiological Studies. Gastroenterol Res Pract (2012) 1.17

The significance of virulence factors in Helicobacter pylori. J Dig Dis (2013) 1.16

Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis. Future Oncol (2010) 1.14

The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Commun Signal (2013) 1.11

A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease. Front Microbiol (2010) 1.00

Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Mol Cancer (2010) 0.97

Phylogeographic origin of Helicobacter pylori determines host-adaptive responses upon coculture with gastric epithelial cells. Infect Immun (2013) 0.95

Helicobacter pylori infection: host immune response, implications on gene expression and microRNAs. World J Gastroenterol (2014) 0.93

Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways. Cell Commun Signal (2015) 0.92

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. PLoS One (2013) 0.91

Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer. Oncogene (2011) 0.90

Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis. Oncotarget (2015) 0.89

Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation. Cancer Immunol Immunother (2012) 0.88

H. pylori virulence factors: influence on immune system and pathology. Mediators Inflamm (2014) 0.88

Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam. Eur J Clin Microbiol Infect Dis (2010) 0.86

Helicobacter pylori-associated regulation of forkhead transcription factors FoxO1/3a in human gastric cells. Helicobacter (2012) 0.86

H. pylori CagL-Y58/E59 prime higher integrin α5β1 in adverse pH condition to enhance hypochlorhydria vicious cycle for gastric carcinogenesis. PLoS One (2013) 0.84

Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection. Gut (2012) 0.82

Role of epidermal growth factor receptor signaling in the interaction of Neisseria meningitidis with endothelial cells. Infect Immun (2013) 0.82

Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer. Nat Rev Microbiol (2017) 0.81

Activation of EGFR-PI3K-AKT signaling is required for Mycoplasma hyorhinis-promoted gastric cancer cell migration. Cancer Cell Int (2014) 0.80

Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling. Am J Physiol Gastrointest Liver Physiol (2011) 0.79

Association of MTOR and AKT Gene Polymorphisms with Susceptibility and Survival of Gastric Cancer. PLoS One (2015) 0.78

What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases. World J Gastroenterol (2015) 0.78

Epigenetic modifications induced by Helicobacter pylori infection through a direct microbe-gastric epithelial cells cross-talk. Med Microbiol Immunol (2013) 0.77

The Effect of Helicobacter pylori on Epidermal Growth Factor Receptor-Induced Signal Transduction and the Preventive Effect of Celecoxib in Gastric Cancer Cells. Gut Liver (2013) 0.76

Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation. Biomed Res Int (2015) 0.76

Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells. Front Cell Infect Microbiol (2017) 0.75

STAT3 activation in infection and infection-associated cancer. Mol Cell Endocrinol (2017) 0.75

Effects of EGFR Inhibitor on Helicobacter pylori Induced Gastric Epithelial Pathology in Vivo. Pathogens (2013) 0.75

Helicobacter pylori CagA Protein Negatively Regulates Autophagy and Promotes Inflammatory Response via c-Met-PI3K/Akt-mTOR Signaling Pathway. Front Cell Infect Microbiol (2017) 0.75

Articles cited by this

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99

AKT/PKB signaling: navigating downstream. Cell (2007) 31.26

The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer (2002) 28.11

The phosphoinositide 3-kinase pathway. Science (2002) 24.72

Mammalian MAP kinase signalling cascades. Nature (2001) 18.89

GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci (2003) 10.89

The renaissance of GSK3. Nat Rev Mol Cell Biol (2001) 7.99

GSK3 takes centre stage more than 20 years after its discovery. Biochem J (2001) 7.74

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell (1998) 7.03

Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci (2001) 6.66

Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res (2003) 6.43

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A (1998) 5.98

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science (2001) 5.49

Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology (1998) 5.15

Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev (1998) 4.22

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia (2003) 3.89

A M(r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori. Proc Natl Acad Sci U S A (2000) 3.66

Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production. Gastroenterology (2002) 3.27

Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res (2006) 3.12

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol (1999) 2.86

Recent advances in the protein kinase B signaling pathway. Curr Opin Cell Biol (2005) 2.71

Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans (2007) 2.70

The role of the EGFR signaling in tumor microenvironment. J Cell Physiol (2008) 2.34

Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem (2000) 2.20

Role of type IV secretion in Helicobacter pylori pathogenesis. Cell Microbiol (2008) 2.18

Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res (2008) 2.08

Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis (2005) 2.01

Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration. Trends Cell Biol (2006) 1.86

Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J Biol Chem (2001) 1.65

Helicobacter pylori outer membrane proteins and gastroduodenal disease. Gut (2005) 1.62

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia (2005) 1.61

Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis (2007) 1.60

Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection. Gastroenterology (2004) 1.59

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. J Biol Chem (2004) 1.49

Transcriptional activation of interleukin-8 by beta-catenin-Tcf4. J Biol Chem (2002) 1.40

Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. Int J Cancer (2005) 1.39

Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori. Mol Biol Cell (2005) 1.37

Correlation between Helicobacter pylori OipA protein expression and oipA gene switch status. J Clin Microbiol (2004) 1.27

Regulation of RANTES promoter activation in gastric epithelial cells infected with Helicobacter pylori. Infect Immun (2005) 1.12

Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cells. Dig Liver Dis (2006) 1.07

Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapy. Gastric Cancer (2007) 1.06

Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains. J Biol Chem (2007) 1.06

OipA plays a role in Helicobacter pylori-induced focal adhesion kinase activation and cytoskeletal re-organization. Cell Microbiol (2007) 1.03

Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention. Cancer Lett (2004) 0.89

Helicobacter pylori environmental interactions: effect of acidic conditions on H. pylori-induced gastric mucosal interleukin-8 production. Cell Microbiol (2007) 0.89

Overexpression of cyclin D1 is associated with elevated levels of MAP kinases, Akt and Pak1 during diethylnitrosamine-induced progressive liver carcinogenesis. Cell Biol Int (2006) 0.86

Involvement of ERK1/2 in invasiveness and metastatic development of rat prostatic adenocarcinoma. Oncol Res (2003) 0.85

Reversal of multidrug resistance of gastric cancer cells by downregulation of Akt1 with Akt1 siRNA. J Exp Clin Cancer Res (2006) 0.84

Transactivation of the EGFR by AP-1 is induced by Helicobacter pylori in gastric cancer. Am J Gastroenterol (2007) 0.83

Articles by these authors

Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut (2012) 12.62

Traces of human migrations in Helicobacter pylori populations. Science (2003) 11.92

Norwalk virus infection and disease is associated with ABO histo-blood group type. J Infect Dis (2002) 5.09

Norovirus vaccine against experimental human Norwalk Virus illness. N Engl J Med (2011) 3.78

Norwalk virus shedding after experimental human infection. Emerg Infect Dis (2008) 3.70

Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients. Gastroenterology (2006) 3.68

Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol (2005) 3.34

Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production. Gastroenterology (2002) 3.27

The peopling of the Pacific from a bacterial perspective. Science (2009) 3.14

Proton pump inhibitor use and recurrent Clostridium difficile-associated disease: a case-control analysis matched by propensity score. J Clin Gastroenterol (2012) 2.99

Gastroesophageal reflux among different racial groups in the United States. Gastroenterology (2004) 2.87

Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood. Lancet (2002) 2.71

Gain and loss of multiple genes during the evolution of Helicobacter pylori. PLoS Genet (2005) 2.61

Helicobacter pylori in North and South America before Columbus. FEBS Lett (2002) 2.57

Determination of the 50% human infectious dose for Norwalk virus. J Infect Dis (2013) 2.50

Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma. Liver Transpl (2005) 2.43

A report card to grade Helicobacter pylori therapy. Helicobacter (2007) 2.41

Prevalence of Helicobacter pylori infection in long-term hemodialysis patients. Kidney Int (2008) 2.39

Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection. Gastroenterology (2002) 2.32

Serological correlate of protection against norovirus-induced gastroenteritis. J Infect Dis (2010) 2.21

Sequential and concomitant therapy with four drugs is equally effective for eradication of H pylori infection. Clin Gastroenterol Hepatol (2009) 2.15

Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res (2008) 2.08

Comparing the Blatchford and pre-endoscopic Rockall score in predicting the need for endoscopic therapy in patients with upper GI hemorrhage. Gastrointest Endosc (2010) 2.04

Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology (2005) 2.03

Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese nationwide survey. Cancer (2004) 2.03

Meta-analysis: four-drug, three-antibiotic, non-bismuth-containing "concomitant therapy" versus triple therapy for Helicobacter pylori eradication. Helicobacter (2009) 2.02

Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter (2011) 2.00

Optimal therapy for Helicobacter pylori infections. Nat Rev Gastroenterol Hepatol (2011) 1.98

Development of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan. Hepatol Res (2008) 1.91

Contribution of bone marrow cells to liver regeneration after partial hepatectomy in mice. J Hepatol (2002) 1.91

Gastritis staging in clinical practice: the OLGA staging system. Gut (2006) 1.90

Staging of hepatocellular carcinoma: assessment of the Japanese TNM and AJCC/UICC TNM systems in a cohort of 13,772 patients in Japan. Ann Surg (2007) 1.82

Effects of Helicobacter pylori eradication on methylation status of E-cadherin gene in noncancerous stomach. Clin Cancer Res (2006) 1.79

A prospective randomized trial of esomeprazole- versus pantoprazole-based triple therapy for Helicobacter pylori eradication. Am J Gastroenterol (2005) 1.79

Report of the 15th follow-up survey of primary liver cancer. Hepatol Res (2004) 1.78

Risk factors for immediate and delayed bleeding associated with endoscopic submucosal dissection of gastric neoplastic lesions. Scand J Gastroenterol (2009) 1.75

NSAIDs, Helicobacter pylori, and Pandora's Box. N Engl J Med (2002) 1.75

Modified sequential Helicobacter pylori therapy: proton pump inhibitor and amoxicillin for 14 days with clarithromycin and metronidazole added as a quadruple (hybrid) therapy for the final 7 days. Helicobacter (2011) 1.73

Discrimination between cases of duodenal ulcer and gastritis on the basis of putative virulence factors of Helicobacter pylori. J Clin Microbiol (2002) 1.72

Patterns of gastric atrophy in intestinal type gastric carcinoma. Cancer (2002) 1.69

Biliary stenting in the management of large or multiple common bile duct stones. Gastrointest Endosc (2010) 1.68

Management of gastric polyps: a pathology-based guide for gastroenterologists. Nat Rev Gastroenterol Hepatol (2009) 1.62

Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes. Cancer Res (2004) 1.60

Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection. Gastroenterology (2004) 1.59

Helicobacter pylori infection in mice: Role of outer membrane proteins in colonization and inflammation. Gastroenterology (2002) 1.58

Iron deficiency and Helicobacter pylori infection in the United States. Am J Epidemiol (2005) 1.57

Endoscopic demonstration of transient small bowel intussusception in a patient with adult celiac disease. Gastrointest Endosc (2003) 1.55

Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: results of a multicenter study. Surgery (2005) 1.54

Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database. Ann Surg Oncol (2005) 1.53

c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains. J Clin Invest (2012) 1.53

Helicobacter pylori-negative gastritis: prevalence and risk factors. Am J Gastroenterol (2012) 1.51

Therapy for Helicobacter pylori infection can be improved: sequential therapy and beyond. Drugs (2008) 1.48

Horizontal versus familial transmission of Helicobacter pylori. PLoS Pathog (2008) 1.48

Helicobacter pylori eradication and change in markers of iron stores among non-iron-deficient children in El Paso, Texas: an etiologic intervention study. J Pediatr Gastroenterol Nutr (2011) 1.47

Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation. J Gastrointest Surg (2002) 1.47

Genome-wide analysis of gene expression in intestinal-type gastric cancers using a complementary DNA microarray representing 23,040 genes. Cancer Res (2002) 1.46

Helicobacter pylori virulence factors: facts and fantasies. Curr Opin Gastroenterol (2005) 1.44

The relationship between Helicobacter pylori infection and Alzheimer's disease in Japan. J Neurol (2011) 1.44

Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. Arch Surg (2005) 1.44

Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori. Infect Genet Evol (2011) 1.44

Etest for metronidazole susceptibility in H. pylori: use of the wrong standard may have led to the wrong conclusion. Am J Gastroenterol (2004) 1.43

Perioperative changes in carbonylhemoglobin and methemoglobin during abdominal surgery: alteration in endogenous generation of carbon monoxide. J Gastroenterol Hepatol (2002) 1.43

Effect of the carbonic anhydrase inhibitor, acetazolamide, on Helicobacter pylori infection in vivo: a pilot study. Helicobacter (2005) 1.42

Analysis of Helicobacter pylori genotypes and correlation with clinical outcome in Turkey. J Clin Microbiol (2004) 1.42

Waist-to-hip ratio, but not body mass index, is associated with an increased risk of Barrett's esophagus in white men. Clin Gastroenterol Hepatol (2012) 1.41

Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection. J Immunol (2006) 1.41

Double-blind randomized trial of quadruple sequential Helicobacter pylori eradication therapy in asymptomatic infected children in El Paso, Texas. J Pediatr Gastroenterol Nutr (2011) 1.40

Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer. Gastroenterology (2002) 1.39

Helicobacter pylori infection--a boon or a bane: lessons from studies in a low-prevalence population. Helicobacter (2013) 1.38

Association between Helicobacter pylori virulence factors and gastroduodenal diseases in Okinawa, Japan. J Clin Microbiol (2011) 1.37

Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori. Mol Biol Cell (2005) 1.37

Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events. Arch Intern Med (2002) 1.35

Preoperative predictors of survival after resection of small hepatocellular carcinomas. Ann Surg (2002) 1.35

Molecular epidemiology and outcome of Helicobacter pylori infection in Thailand: a cultural cross roads. Helicobacter (2004) 1.35

Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology (2003) 1.34

Clinical presentation in relation to diversity within the Helicobacter pylori cag pathogenicity island. Am J Gastroenterol (2002) 1.34

A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori. PLoS One (2009) 1.34

Antimicrobial activity of essential oils against Helicobacter pylori. Helicobacter (2003) 1.31

Diagnosis and management of iron deficiency anemia in the 21st century. Therap Adv Gastroenterol (2011) 1.30

Helicobacter pylori infection in Kazakhstan: effect of water source and household hygiene. Am J Trop Med Hyg (2002) 1.29

Eradication of gastric cancer is now both possible and practical. Semin Cancer Biol (2013) 1.28

Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1. Cancer Res (2003) 1.28

Correlation between Helicobacter pylori OipA protein expression and oipA gene switch status. J Clin Microbiol (2004) 1.27

Pharmacologic aspects of eradication therapy for Helicobacter pylori Infection. Gastroenterol Clin North Am (2010) 1.26

Helicobacter pylori and hetertopic gastric mucosa in the upper esophagus (the inlet patch). Am J Gastroenterol (2003) 1.25

Report of the 16th follow-up survey of primary liver cancer. Hepatol Res (2005) 1.25

Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis. Am Heart J (2009) 1.24

Population-based strategies for Helicobacter pylori-associated disease management: a Japanese perspective. Expert Rev Gastroenterol Hepatol (2010) 1.24

Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: results of a multicenter study. J Surg Oncol (2004) 1.23