Published in J Biol Chem on September 09, 2008
Targeting the interleukin-6/Jak/stat pathway in human malignancies. J Clin Oncol (2012) 2.46
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Regulation of STAT signaling by acetylation. Cell Signal (2013) 0.99
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Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer Res (2015) 0.97
The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proc Natl Acad Sci U S A (2012) 0.94
Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response. Mol Endocrinol (2009) 0.88
Pivotal Importance of STAT3 in Protecting the Heart from Acute and Chronic Stress: New Advancement and Unresolved Issues. Front Cardiovasc Med (2015) 0.85
Antitumor activity of IL-32β through the activation of lymphocytes, and the inactivation of NF-κB and STAT3 signals. Cell Death Dis (2013) 0.85
Differential STAT3 signaling in the heart: Impact of concurrent signals and oxidative stress. JAKSTAT (2012) 0.85
P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells. Acta Pharmacol Sin (2014) 0.83
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Deciphering STAT3 signaling in the heart: plasticity and vascular inflammation. Congest Heart Fail (2010) 0.83
Plumbagin promotes the generation of astrocytes from rat spinal cord neural progenitors via activation of the transcription factor Stat3. J Neurochem (2010) 0.83
Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart. JAKSTAT (2013) 0.82
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Cytokine amplification and macrophage effector functions in aortic inflammation and abdominal aortic aneurysm formation. J Thorac Dis (2016) 0.79
Inhibition of STAT3 acetylation is associated with angiotesin renal fibrosis in the obstructed kidney. Acta Pharmacol Sin (2014) 0.79
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Bromodomains: Translating the words of lysine acetylation into myelin injury and repair. Neurosci Lett (2015) 0.76
High-density P300 enhancers control cell state transitions. BMC Genomics (2015) 0.76
Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation. Mol Cell (2017) 0.75
TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression. Circ Res (2017) 0.75
Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score. Oncotarget (2017) 0.75
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STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. Gastroenterology (2005) 1.56
Interaction between acetylated MyoD and the bromodomain of CBP and/or p300. Mol Cell Biol (2001) 1.56
Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol Cell Biol (2000) 1.55
IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem (2006) 1.54
A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci (2003) 1.39
The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. J Biol Chem (2007) 1.36
A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors. J Biol Chem (2004) 1.34
p300 forms a stable, template-committed complex with chromatin: role for the bromodomain. Mol Cell Biol (2001) 1.34
Independent and cooperative activation of chromosomal c-fos promoter by STAT3. J Biol Chem (2003) 1.32
Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells. J Biol Chem (1998) 1.26
Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene. J Biol Chem (2001) 1.25
Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes. Mol Cell Biol (1999) 1.21
Cloning and characterization of a functional promoter of the human SOCS-3 gene. Biochem Biophys Res Commun (2003) 1.07
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Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization. Eur J Biochem (2000) 1.02
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Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL-6 signaling. FEBS Lett (2006) 0.93
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An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest (2009) 2.86
Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells. J Virol (2006) 2.76
Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling. J Biol Chem (2005) 2.43
Regulation of human airway epithelial cell IL-8 expression by MAP kinases. Am J Physiol Lung Cell Mol Physiol (2002) 2.19
MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II. Hum Mol Genet (2007) 2.17
Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells. J Virol (2002) 1.97
A TNF-induced gene expression program under oscillatory NF-kappaB control. BMC Genomics (2005) 1.92
RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes. Mol Cell Biol (2008) 1.91
Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. J Infect Dis (2002) 1.77
Identification of a nuclear factor kappa B-dependent gene network. Recent Prog Horm Res (2003) 1.68
Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection. Gastroenterology (2004) 1.59
STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen. Gastroenterology (2005) 1.56
TNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway. Cell Signal (2007) 1.47
Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells. J Virol (2003) 1.47
Single TNFalpha trimers mediating NF-kappaB activation: stochastic robustness of NF-kappaB signaling. BMC Bioinformatics (2007) 1.44
Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases. J Biol Chem (2003) 1.42
Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines. J Allergy Clin Immunol (2008) 1.42
Systemic cytokine response profiles associated with respiratory virus-induced acute otitis media. Pediatr Infect Dis J (2009) 1.42
The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. J Biol Chem (2007) 1.36
Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta. J Immunol (2003) 1.34
Stochastic regulation in early immune response. Biophys J (2005) 1.31
MAPK activation is involved in posttranscriptional regulation of RSV-induced RANTES gene expression. Am J Physiol Lung Cell Mol Physiol (2002) 1.25
Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex. Diabetes (2006) 1.25
Functional analysis of the nuclear proteome of human A549 alveolar epithelial cells by HPLC-high resolution 2-D gel electrophoresis. Proteomics (2006) 1.23
Regulation of RANTES promoter activation in alveolar epithelial cells after cytokine stimulation. Am J Physiol Lung Cell Mol Physiol (2002) 1.18
Respiratory syncytial virus induces RelA release from cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I{middle dot}NF- kappa B-inducing kinase signaling pathway. J Biol Chem (2008) 1.17
Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expression. J Virol (2009) 1.17
Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice. Atherosclerosis (2006) 1.15
The CTSA as an exemplar framework for developing multidisciplinary translational teams. Clin Transl Sci (2012) 1.14
Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry. Proteomics (2007) 1.13
Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent. J Biol Chem (2010) 1.13
Respiratory syncytial virus influences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14/NIK expression and nuclear complex formation with NF-kappaB2. J Virol (2005) 1.13
Sources of cell-to-cell variability in canonical nuclear factor-κB (NF-κB) signaling pathway inferred from single cell dynamic images. J Biol Chem (2011) 1.13
Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution. Nucleic Acids Res (2008) 1.12
How cytokines co-occur across asthma patients: from bipartite network analysis to a molecular-based classification. J Biomed Inform (2011) 1.12
Aortic adventitial fibroblasts participate in angiotensin-induced vascular wall inflammation and remodeling. J Vasc Res (2010) 1.10
RhoA mediates angiotensin II-induced phospho-Ser536 nuclear factor kappaB/RelA subunit exchange on the interleukin-6 promoter in VSMCs. Circ Res (2006) 1.10
IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. J Virol (2004) 1.09
Transcriptional stochasticity in gene expression. J Theor Biol (2005) 1.09
Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway. Physiol Genomics (2004) 1.08
Hyperspectral confocal fluorescence imaging: exploring alternative multivariate curve resolution approaches. Appl Spectrosc (2009) 1.08
Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity. Mol Endocrinol (2002) 1.07
Two-step cross-linking for analysis of protein-chromatin interactions. Methods Mol Biol (2012) 1.06
Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner. PLoS Negl Trop Dis (2012) 1.05
Roles of IL-6-gp130 Signaling in Vascular Inflammation. Curr Cardiol Rev (2008) 1.04
Quantification of activated NF-kappaB/RelA complexes using ssDNA aptamer affinity-stable isotope dilution-selected reaction monitoring-mass spectrometry. Mol Cell Proteomics (2011) 1.02
A syngeneic glioma model to assess the impact of neural progenitor target cell age on tumor malignancy. Aging Cell (2009) 1.01
Role of peroxiredoxin 1 and peroxiredoxin 4 in protection of respiratory syncytial virus-induced cysteinyl oxidation of nuclear cytoskeletal proteins. J Virol (2010) 0.99
Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway. Virology (2006) 0.99
Aortic remodeling after transverse aortic constriction in mice is attenuated with AT1 receptor blockade. Arterioscler Thromb Vasc Biol (2013) 0.99
Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. J Virol (2006) 0.99
Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. Am J Physiol Regul Integr Comp Physiol (2013) 0.99
Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation. Virology (2002) 0.98
Innate immune response to arenaviral infection: a focus on the highly pathogenic New World hemorrhagic arenaviruses. J Mol Biol (2013) 0.98
Examining troughs in the mass distribution of all theoretically possible tryptic peptides. J Proteome Res (2011) 0.97
Assessing and evaluating multidisciplinary translational teams: a mixed methods approach. Eval Health Prof (2013) 0.97
The IL-6 trans-signaling-STAT3 pathway mediates ECM and cellular proliferation in fibroblasts from hypertrophic scar. J Invest Dermatol (2013) 0.97
A probabilistic approach to learn chromatin architecture and accurate inference of the NF-κB/RelA regulatory network using ChIP-Seq. Nucleic Acids Res (2013) 0.96
Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis. J Biol Chem (2004) 0.96
Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology. Glia (2009) 0.96
Applications of selected reaction monitoring (SRM)-mass spectrometry (MS) for quantitative measurement of signaling pathways. Methods (2013) 0.94
Involvement of a novel Rac/RhoA guanosine triphosphatase-nuclear factor-kappaB inducing kinase signaling pathway mediating angiotensin II-induced RelA transactivation. Mol Endocrinol (2007) 0.94
CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells. J Virol (2013) 0.93
8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. J Immunol (2014) 0.92
Systems approaches to modeling chronic mucosal inflammation. Biomed Res Int (2013) 0.91
Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometer. Anal Chem (2014) 0.91
Expression of an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection. PLoS One (2009) 0.90
Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometry. Mol Cell Proteomics (2013) 0.90
Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway. Pediatr Res (2004) 0.90
Direct access to 1,4-dihydroxyanthraquinones: the Hauser annulation reexamined with p-quinones. J Org Chem (2007) 0.90
Proteomics improves the prediction of burns mortality: results from regression spline modeling. Clin Transl Sci (2012) 0.90
Modulation of gene expression regulated by the transcription factor NF-κB/RelA. J Biol Chem (2014) 0.90
Stochastic effects of multiple regulators on expression profiles in eukaryotes. J Theor Biol (2004) 0.89
Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. J Biol Chem (2003) 0.88
Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response. Mol Endocrinol (2009) 0.88
Efficacy and safety of lansoprazole in adolescents with symptomatic erosive and non-erosive gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr (2005) 0.88
Model-based analysis of interferon-beta induced signaling pathway. Bioinformatics (2008) 0.87
Improved mass defect model for theoretical tryptic peptides. Anal Chem (2012) 0.86
Variable selection methods for developing a biomarker panel for prediction of dengue hemorrhagic fever. BMC Res Notes (2013) 0.85
Inducible tumor necrosis factor (TNF) receptor-associated factor-1 expression couples the canonical to the non-canonical NF-κB pathway in TNF stimulation. J Biol Chem (2013) 0.85
IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR/mgR mouse model of severe Marfan syndrome. J Am Heart Assoc (2014) 0.84
Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice. Arterioscler Thromb Vasc Biol (2013) 0.84
High throughput short interfering RNA (siRNA) screening of the human kinome identifies novel kinases controlling the canonical nuclear factor-κB (NF-κB) activation pathway. J Biol Chem (2011) 0.82
IKKε modulates RSV-induced NF-κB-dependent gene transcription. Virology (2010) 0.82
A structured approach to predictive modeling of a two-class problem using multidimensional data sets. Methods (2013) 0.81
Unlocking proteomic heterogeneity in complex diseases through visual analytics. Proteomics (2015) 0.81
The dependence of expression of NF-κB-dependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3' UTR. BMC Genomics (2012) 0.79