Published in J Neurophysiol on September 10, 2008
Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood (2010) 2.45
Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation. AAPS J (2009) 1.36
Inflammatory signals enhance piezo2-mediated mechanosensitive currents. Cell Rep (2012) 1.32
Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy. J Neurosci (2012) 0.96
Mode of action of cannabinoids on nociceptive nerve endings. Exp Brain Res (2009) 0.90
Excitation of cutaneous C nociceptors by intraplantar administration of anandamide. Brain Res (2009) 0.87
Cannabinoid agonists inhibit neuropathic pain induced by brachial plexus avulsion in mice by affecting glial cells and MAP kinases. PLoS One (2011) 0.83
Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia. Neuroscience (2013) 0.82
Nociceptor Sensitization Depends on Age and Pain Chronicity(1,2,3). eNeuro (2016) 0.81
Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain. Neurobiol Dis (2013) 0.81
Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons. Brain Struct Funct (2012) 0.80
CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neurons. Neurosci Lett (2013) 0.80
Changes in response properties of rostral ventromedial medulla neurons during prolonged inflammation: modulation by neurokinin-1 receptors. Neuroscience (2012) 0.78
Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin. Neuropharmacology (2012) 0.77
Amplified Mechanically Gated Currents in Distinct Subsets of Myelinated Sensory Neurons following In Vivo Inflammation of Skin and Muscle. J Neurosci (2015) 0.76
The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain. Neuroscience (2013) 0.75
Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods (1994) 23.05
Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (1990) 13.60
Molecular characterization of a peripheral receptor for cannabinoids. Nature (1993) 13.45
Control of pain initiation by endogenous cannabinoids. Nature (1998) 4.73
Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol (1969) 4.68
The cannabinoid system and immune modulation. J Leukoc Biol (2003) 2.87
Peripheral and central mechanisms of cutaneous hyperalgesia. Prog Neurobiol (1992) 2.80
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci (2007) 2.78
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain (1998) 2.43
CB2 cannabinoid receptor-mediated peripheral antinociception. Pain (2001) 2.38
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A (2005) 2.36
Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors. J Neurosci (2006) 2.32
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A (2003) 2.29
Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology (2004) 2.18
Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain. Br J Pharmacol (2007) 2.01
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem (1994) 1.80
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors. Eur J Pharmacol (1996) 1.78
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain (2001) 1.76
Functional CB1 cannabinoid receptors in human vascular endothelial cells. Biochem J (2000) 1.75
Differential roles of CB1 and CB2 cannabinoid receptors in mast cells. J Immunol (2003) 1.75
Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study. Neuroscience (1999) 1.73
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J Pharmacol Exp Ther (1999) 1.67
Cutaneous sensory receptors in the rat foot. J Neurophysiol (1993) 1.64
Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain. Pain (2006) 1.61
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology (2003) 1.60
Morphine directly inhibits nociceptors in inflamed skin. J Neurophysiol (2005) 1.59
Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience (2000) 1.56
Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide. Br J Pharmacol (2004) 1.49
Peripheral mechanisms of somatic pain. Anesthesiology (1988) 1.48
CB2 cannabinoid receptor mediation of antinociception. Pain (2006) 1.47
AM630, a competitive cannabinoid receptor antagonist. Life Sci (1995) 1.46
Mechanical and heat sensitization of cutaneous nociceptors after peripheral inflammation in the rat. J Neurophysiol (1999) 1.45
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. Neuroscience (2003) 1.42
Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats. Eur J Neurosci (2005) 1.41
Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. Eur J Neurosci (2004) 1.40
Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception. Neuropharmacology (2001) 1.35
Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. J Neurophysiol (2004) 1.33
Characterization of Adelta- and C-fibers innervating the plantar rat hindpaw one day after an incision. J Neurophysiol (2002) 1.32
Activation of peripheral cannabinoid CB1 and CB2 receptors suppresses the maintenance of inflammatory nociception: a comparative analysis. Br J Pharmacol (2006) 1.32
Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry. Neuroscience (2003) 1.27
The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the rat. Pain (1987) 1.24
Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers. J Neurophysiol (1984) 1.24
Presence and regulation of the endocannabinoid system in human dendritic cells. Eur J Biochem (2002) 1.22
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin. J Pharmacol Exp Ther (2003) 1.20
Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand. Science (1981) 1.19
Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci (2005) 1.18
Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives. Chem Phys Lipids (2002) 1.17
Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin. Eur J Neurosci (1999) 1.17
Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. J Neurosci (1982) 1.16
Cannabinoid analgesia. Pharmacol Ther (2002) 1.15
Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. Pain (2005) 1.14
Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms. Pain (2001) 1.12
Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. Br J Pharmacol (2002) 1.11
Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons. Pain (2008) 1.10
Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur J Pharmacol (2001) 1.09
Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. Pain (2006) 1.09
Differential effects of CB1 and opioid agonists on two populations of adult rat dorsal root ganglion neurons. J Neurosci (2004) 1.06
AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. Life Sci (1997) 1.04
Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats. Neuropharmacology (2003) 1.04
Acute effect of an incision on mechanosensitive afferents in the plantar rat hindpaw. J Neurophysiol (2002) 1.03
Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist. Pain (2006) 1.03
The neurobiology of cannabinoid analgesia. Life Sci (1999) 1.02
Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. Neuropharmacology (2006) 0.99
Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human. J Neurophysiol (1983) 0.99
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats. Neuroscience (2002) 0.98
Kainate-induced excitation and sensitization of nociceptors in normal and inflamed rat glabrous skin. Neuroscience (2005) 0.97
Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury. Pain (2004) 0.96
Cannabinoids, immune system and cytokine network. Curr Pharm Des (2006) 0.96
Peripheral cannabinoids attenuate carcinoma-induced nociception in mice. Neurosci Lett (2008) 0.96
Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones. Br J Pharmacol (2001) 0.93
The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms. Brain Res (2008) 0.92
Presence and functional regulation of cannabinoid receptors in immune cells. Life Sci (1999) 0.91
Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. J Immunol (2001) 0.89
Cannabinoids in pain and inflammation. Inflammopharmacology (2004) 0.89
Carrageenan inflammation increases bradykinin sensitivity of rat cutaneous nociceptors. Neurosci Lett (1990) 0.88
ATP responses in human C nociceptors. Pain (2002) 0.86
Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo. Eur J Pharmacol (2008) 0.78
Additive interaction of the cannabinoid receptor I agonist arachidonyl-2-chloroethylamide with etomidate in a sedation model in mice. Anesthesiology (2008) 0.76
The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci (2007) 2.63
Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood (2010) 2.45
Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood (2013) 1.94
Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation. Circ Res (2012) 1.74
Variation in quantitative sensory testing and epidermal nerve fiber density in repeated measurements. Pain (2010) 1.58
Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons. Nat Neurosci (2009) 1.51
Hematopoietic colony-stimulating factors mediate tumor-nerve interactions and bone cancer pain. Nat Med (2009) 1.45
Spinal neurons that possess the substance P receptor are required for the development of central sensitization. J Neurosci (2002) 1.42
A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain. Pain (2003) 1.25
Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate. J Neurophysiol (2012) 1.18
A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain. J Neurosci (2008) 1.13
Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness. Br J Haematol (2011) 1.09
Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain. J Neurosci (2007) 1.06
Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia. Eur J Pharmacol (2006) 1.06
Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells. J Biol Chem (2011) 1.04
Mechanism of cancer pain. Mol Interv (2010) 1.00
Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain. Brain Res (2005) 1.00
Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease. Pain (2015) 0.98
NK-1 receptors modulate the excitability of ON cells in the rostral ventromedial medulla. J Neurophysiol (2006) 0.98
Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. Pharmacol Res (2011) 0.97
Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury. Pain (2004) 0.96
Use-dependent inhibition of P2X3 receptors by nanomolar agonist. J Neurosci (2005) 0.96
Cannabinoid type-1 receptor reduces pain and neurotoxicity produced by chemotherapy. J Neurosci (2012) 0.96
Roles for pain modulatory cells during micturition and continence. J Neurosci (2005) 0.95
Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer pain. Brain Res (2007) 0.93
The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms. Brain Res (2008) 0.92
Tumor-evoked sensitization of C nociceptors: a role for endothelin. J Neurophysiol (2008) 0.90
NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin. Pain (2008) 0.88
Excitation of cutaneous C nociceptors by intraplantar administration of anandamide. Brain Res (2009) 0.87
Analgesic effects of tramadol, tramadol-gabapentin, and buprenorphine in an incisional model of pain in rats (Rattus norvegicus). J Am Assoc Lab Anim Sci (2011) 0.87
Characterization of cutaneous primary afferent fibers excited by acetic acid in a model of nociception in frogs. J Neurophysiol (2003) 0.86
Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus. J Neurophysiol (2004) 0.85
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. Clin Cancer Res (2012) 0.85
Mouse anesthesia and analgesia. Curr Protoc Mouse Biol (2015) 0.83
Termination zones of functionally characterized spinothalamic tract neurons within the primate posterior thalamus. J Neurophysiol (2008) 0.83
Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors. J Neurophysiol (2011) 0.82
CB1 and CB2 receptor agonists promote analgesia through synergy in a murine model of tumor pain. Behav Pharmacol (2011) 0.82
Activity of murine raphe magnus cells predicts tachypnea and on-going nociceptive responsiveness. J Neurophysiol (2007) 0.81
Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons. J Neurophysiol (2004) 0.80
SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia. Brain Res (2003) 0.77
Endotracheal intubation in swine. Lab Anim (NY) (2012) 0.76
Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis. Pain (2017) 0.75
Taking the pain away. Lab Anim (NY) (2014) 0.75
A role for nk-1 neurons in the rostral ventromedial medulla in the development of chronic post-thoracotomy pain. Pain (2017) 0.75
Influence of Pain and Analgesia on Orthopedic and Wound-healing Models in Rats and Mice. Comp Med (2019) 0.75
A role for neurokinin-1 receptor neurons in the rostral ventromedial medulla in the development of chronic postthoracotomy pain. Pain (2017) 0.75