Published in J Med Chem on June 10, 1994
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol Rev (2010) 4.31
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci U S A (1999) 3.54
The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication. J Physiol (1999) 1.69
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc Natl Acad Sci U S A (1998) 1.53
Structural determinants for recognition and translocation by the anandamide transporter. Proc Natl Acad Sci U S A (1999) 1.51
Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists. Curr Med Chem (2010) 1.49
Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. Br J Pharmacol (2001) 1.35
Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol (2012) 1.31
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Br J Pharmacol (2007) 1.25
The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys. J Neurosci (2005) 1.20
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. Proc Natl Acad Sci U S A (1998) 1.18
Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice. Psychopharmacology (Berl) (2007) 1.18
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats. Psychopharmacology (Berl) (2005) 1.16
Cardiovascular pharmacology of cannabinoids. Handb Exp Pharmacol (2005) 1.14
2012 Division of medicinal chemistry award address. Trekking the cannabinoid road: a personal perspective. J Med Chem (2014) 1.05
Cannabinoids as therapeutic agents in cancer: current status and future implications. Oncotarget (2014) 1.05
Discriminative stimulus functions of methanandamide and delta(9)-THC in rats: tests with aminoalkylindoles (WIN55,212-2 and AM678) and ethanol. Psychopharmacology (Berl) (2009) 1.02
Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinol. Psychopharmacology (Berl) (2008) 1.00
Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand. AAPS PharmSci (1999) 1.00
Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents. Neuroimage (2008) 0.99
Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS One (2007) 0.99
Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation. J Neurophysiol (2008) 0.98
Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. J Neurochem (2010) 0.97
Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes. Br J Pharmacol (2014) 0.96
Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice. Behav Pharmacol (2008) 0.96
The therapeutic potential of novel cannabinoid receptors. Pharmacol Ther (2009) 0.95
Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. Curr Med Chem (2010) 0.95
Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. Br J Pharmacol (2005) 0.95
The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. J Neurosci (2011) 0.94
Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction. Pharmacol Ther (2013) 0.92
Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Delta9-THC or (R)-methanandamide (AM-356). Psychopharmacology (Berl) (2006) 0.92
Design and synthesis of (13S)-methyl-substituted arachidonic acid analogues: templates for novel endocannabinoids. Chemistry (2010) 0.90
Diuretic effects of cannabinoids. J Pharmacol Exp Ther (2012) 0.89
Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog. Psychopharmacology (Berl) (2008) 0.88
Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats. Psychopharmacology (Berl) (2008) 0.88
Emerging drugs of abuse: current perspectives on synthetic cannabinoids. Subst Abuse Rehabil (2015) 0.88
Development of novel tail-modified anandamide analogs. Bioorg Med Chem Lett (2008) 0.87
Dissimilar cannabinoid substitution patterns in mice trained to discriminate Δ(9)-tetrahydrocannabinol or methanandamide from vehicle. Behav Pharmacol (2011) 0.86
Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats. Psychopharmacology (Berl) (2013) 0.85
Production and actions of the anandamide metabolite prostamide E2 in the renal medulla. J Pharmacol Exp Ther (2012) 0.85
The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice. Eur J Pharmacol (2011) 0.85
The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism. J Neurochem (2009) 0.85
Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain. Eur J Neurosci (2006) 0.83
Modulation of sensory neuron potassium conductances by anandamide indicates roles for metabolites. Br J Pharmacol (2008) 0.83
In vivo pharmacology of endocannabinoids and their metabolic inhibitors: therapeutic implications in Parkinson's disease and abuse liability. Prostaglandins Other Lipid Mediat (2009) 0.81
Factors influencing the regional haemodynamic responses to methanandamide and anandamide in conscious rats. Br J Pharmacol (2009) 0.81
Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation. Curr Neuropharmacol (2016) 0.80
The role of sensory nerve endings in nerve growth factor-induced airway hyperresponsiveness to histamine in guinea-pigs. Br J Pharmacol (2001) 0.79
Long-term treatment with methanandamide attenuates LPS-induced periodontitis in rats. Inflamm Res (2012) 0.79
Methanandamide attenuates cocaine-induced hyperthermia in rats by a cannabinoid CB1-dopamine D2 receptor mechanism. Brain Res (2009) 0.78
Novel, potent THC/anandamide (hybrid) analogs. Bioorg Med Chem (2007) 0.78
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells. Br J Pharmacol (2013) 0.78
Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium. Br J Pharmacol (2011) 0.78
Enantioselective synthesis of (10S)- and (10R)-methyl-anandamides. Tetrahedron (2012) 0.77
Endocannabinoid system in cardiovascular disorders - new pharmacotherapeutic opportunities. J Pharm Bioallied Sci (2011) 0.77
Terpenes and lipids of the endocannabinoid and transient-receptor-potential-channel biosignaling systems. ACS Chem Neurosci (2014) 0.77
Acute Immobilization Stress Modulate GABA Release from Rat Olfactory Bulb: Involvement of Endocannabinoids-Cannabinoids and Acute Stress Modulate GABA Release. Int J Cell Biol (2011) 0.75
Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters. Tetrahedron Lett (2012) 0.75
Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity. Life Sci (2012) 0.75
Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (1992) 16.31
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev (2002) 8.50
Evaluation of coliform tests for chlorinated secondary effluents. J Water Pollut Control Fed (1973) 5.51
Synthetic lac operator DNA is functional in vivo. Nature (1976) 5.36
The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J Immunol (1989) 4.30
HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J (2000) 4.11
Presence of an SH2 domain in the actin-binding protein tensin. Science (1991) 4.03
Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nat Cell Biol (2000) 3.99
The general affinity of lac repressor for E. coli DNA: implications for gene regulation in procaryotes and eucaryotes. Cell (1975) 3.73
Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry (1996) 3.65
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem (1996) 3.63
T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci U S A (1998) 3.61
Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem (1980) 3.49
Preliminary experiments on the chemistry and pharmacology of cannabis. Nature (1970) 3.41
Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science (1997) 3.16
Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J Cell Biol (2000) 3.13
Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids. Toxicol In Vitro (2014) 3.10
Beta-galactosidase. Rates of synthesis and degradation of incomplete chains. J Biol Chem (1972) 3.06
Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome. Exp Neurol (1989) 3.00
An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. J Biol Chem (2001) 2.95
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci U S A (2001) 2.95
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med (1999) 2.92
Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongation. J Cell Biol (1980) 2.74
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem (1999) 2.73
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science (1996) 2.71
Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement-microfilaments-rabbit striated muscle). Proc Natl Acad Sci U S A (1972) 2.68
Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change. Nature (1981) 2.63
The effect of hiatus hernia on gastro-oesophageal junction pressure. Gut (1999) 2.60
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. Br J Pharmacol (1999) 2.56
Lipid A modifications characteristic of Salmonella typhimurium are induced by NH4VO3 in Escherichia coli K12. Detection of 4-amino-4-deoxy-L-arabinose, phosphoethanolamine and palmitate. J Biol Chem (1999) 2.56
CB2 cannabinoid receptor-mediated peripheral antinociception. Pain (2001) 2.38
GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development (1997) 2.38
Specific interaction of vinculin with alpha-actinin. Biochem Biophys Res Commun (1987) 2.34
HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. Proc Natl Acad Sci U S A (1999) 2.32
A comparison of lac repressor binding to operator and to nonoperator DNA. Biochem Biophys Res Commun (1975) 2.32
Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation. J Biol Chem (2001) 2.30
A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data. Pharmacogenomics J (2010) 2.30
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J (1998) 2.29
Bacterial activity in South Pole snow. Appl Environ Microbiol (2000) 2.28
Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor. EMBO J (1997) 2.26
Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. Mol Pharmacol (2001) 2.22
Toward a resolution of the introns early/late debate: only phase zero introns are correlated with the structure of ancient proteins. Proc Natl Acad Sci U S A (1998) 2.16
The cellular metabolism and systemic toxicity of arsenic. Toxicol Appl Pharmacol (2001) 2.15
Zebrafish pigmentation mutations and the processes of neural crest development. Development (1996) 2.14
Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett (2000) 2.11
Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion. Mol Biol Cell (1999) 2.10
Purification and initial characterization of a protein from skeletal muscle that caps the barbed ends of actin filaments. J Biol Chem (1986) 2.08
Neurological impairment in violent schizophrenic inpatients. Am J Psychiatry (1989) 2.07
Neuropathology in mice expressing human alpha-synuclein. J Neurosci (2000) 2.06
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity (1997) 2.04
Actin polymerization induced by a motility-related high-affinity cytochalasin binding complex from human erythrocyte membrane. Proc Natl Acad Sci U S A (1979) 1.99
Motivations and perceptions of early adopters of personalized genomics: perspectives from research participants. Public Health Genomics (2011) 1.96
Timing, propagation, coordination, and effect of esophageal shortening during peristalsis. Gastroenterology (1997) 1.94
The RAD50 gene, a member of the double strand break repair epistasis group, is not required for spontaneous mitotic recombination in yeast. Curr Genet (1990) 1.93
Identification of a calcium channel modulator using a high throughput yeast two-hybrid screen. Nat Biotechnol (1998) 1.92
Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Clin Cancer Res (1996) 1.88
Instant MR labeling of stem cells using magnetoelectroporation. Magn Reson Med (2005) 1.88
Biochemical studies on the mode of action of cytochalasin B. Cytochalasin B binding to red cell membrane in relation to glucose transport. J Biol Chem (1974) 1.86
The ring test: a quantitative method for assessing the 'cataleptic' effect of cannabis in mice. Br J Pharmacol (1972) 1.86
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol (2007) 1.85
High-affinity interaction of vinculin with actin filaments in vitro. Cell (1982) 1.83
Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J Immunol (1997) 1.80
Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis. Nat Med (2001) 1.80
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors. Eur J Pharmacol (1996) 1.78
Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature (2000) 1.77
Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A. Function of LpxO, A new Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue. J Biol Chem (2000) 1.76
Functional CB1 cannabinoid receptors in human vascular endothelial cells. Biochem J (2000) 1.75
The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization. Med Phys (1995) 1.75
Biphasic calcium phosphate bioceramics: preparation, properties and applications. J Mater Sci Mater Med (2003) 1.74
Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2. Curr Opin Lipidol (2001) 1.70
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J Pharmacol Exp Ther (1999) 1.67
Closure mechanisms of laryngeal vestibule during swallow. Am J Physiol (1992) 1.67
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci U S A (2004) 1.66
An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy. Nature (2001) 1.65
Outcome in schizophrenia and related disorders compared between developing and developed countries. A recursive partitioning re-analysis of the WHO DOSMD data. Br J Psychiatry (1997) 1.65
Hormonal regulation of protein degradation and synthesis in skeletal muscle. Fed Proc (1980) 1.65
Experimental characterization and physical modelling of the dose distribution of scanned proton pencil beams. Phys Med Biol (2005) 1.64
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. Mol Psychiatry (2012) 1.63
Shape, volume, and content of the deglutitive pharyngeal chamber imaged by ultrafast computerized tomography. Gastroenterology (1993) 1.63
A zebrafish model for hepatoerythropoietic porphyria. Nat Genet (1998) 1.62
Specificity of the effects of cytochalasin B on transport and motile processes. Proc Natl Acad Sci U S A (1978) 1.61
Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals. Eur J Pharmacol (1997) 1.61
Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. J Biol Chem (2001) 1.60
Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons. J Neurosci (2001) 1.58
Reduced levels of amyloid beta-peptide antibody in Alzheimer disease. Neurology (2001) 1.58
Synthesis of Sch 29482--a novel penem antibiotic. J Antimicrob Chemother (1982) 1.57
Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism. Br J Pharmacol (1972) 1.56
Pharyngeal clearance during swallowing: a combined manometric and videofluoroscopic study. Gastroenterology (1992) 1.56
Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding. Drug Alcohol Depend (2000) 1.55
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br J Pharmacol (2001) 1.54
Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes. J Biol Chem (1995) 1.52
Structural determinants for recognition and translocation by the anandamide transporter. Proc Natl Acad Sci U S A (1999) 1.51
Vascular endothelial growth factor (VEGF) expression and the effect of exogenous VEGF on survival of a random flap in the rat. Br J Plast Surg (2003) 1.50
Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc Natl Acad Sci U S A (1998) 1.49