Jay L Hess

Author PubWeight™ 85.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell 2002 8.17
2 Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 2005 6.12
3 Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell 2004 6.08
4 Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol 2004 3.62
5 A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood 2007 3.60
6 Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A 2005 3.37
7 Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol 2012 3.15
8 Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet 2012 2.94
9 MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A 2005 2.87
10 The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell 2010 2.50
11 Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications. Cancer Res 2005 2.45
12 CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell 2011 2.01
13 Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation. Blood 2011 1.99
14 The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol 2011 1.95
15 Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood 2009 1.90
16 Interaction of MLL amino terminal sequences with menin is required for transformation. Cancer Res 2007 1.82
17 Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J 2005 1.79
18 Dimerization of MLL fusion proteins immortalizes hematopoietic cells. Cancer Cell 2003 1.79
19 The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A 2006 1.67
20 The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin. Oncogene 2005 1.64
21 Identification and characterization of Hoxa9 binding sites in hematopoietic cells. Blood 2011 1.63
22 Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. J Virol 2005 1.46
23 The advent of targeted therapeutics and implications for pathologists. Am J Clin Pathol 2002 1.38
24 MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia. Exp Hematol 2010 1.35
25 MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription. Mol Cell Biol 2009 1.33
26 Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia. Int J Hematol 2007 1.26
27 The PHD fingers of MLL block MLL fusion protein-mediated transformation. Blood 2008 1.18
28 HOX proteins and leukemia. Int J Clin Exp Pathol 2008 1.14
29 Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins. Methods Mol Biol 2009 1.13
30 Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants. Blood 2004 1.09
31 ECSASB2 mediates MLL degradation during hematopoietic differentiation. Blood 2011 0.99
32 MLL core components give the green light to histone methylation. ACS Chem Biol 2006 0.99
33 Acute myeloid leukemia diagnosis in the 21st century. Arch Pathol Lab Med 2010 0.90
34 PAFc, a key player in MLL-rearranged leukemogenesis. Oncotarget 2010 0.89
35 A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity. J Biol Chem 2012 0.89
36 MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells. Cell Rep 2013 0.86
37 Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins. J Biol Chem 2013 0.83
38 Epigenetic dysregulation in cancer. Am J Pathol 2009 0.82
39 The role of menin in hematopoiesis. Adv Exp Med Biol 2009 0.82
40 The Cancer Genome Anatomy Project: power tools for cancer biologists. Cancer Invest 2003 0.80
41 MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction. Blood 2013 0.79
42 Significance of AF4-MLL reciprocal fusion in t(4;11) leukemias? Leuk Res 2010 0.77
43 Deregulation of the HOXA9/MEIS1 axis in acute leukemia. Curr Opin Hematol 2016 0.76
44 MLL-AF9 leukemia stem cells: hardwired or taking cues from the microenvironment? Cancer Cell 2008 0.76
45 Structural basis of multimer-mediated mayhem. Cancer Cell 2006 0.75
46 Twenty-first century pathology sign-out. Clin Lab Med 2012 0.75