Published in Oncogene on September 18, 2008
Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med (2009) 10.01
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell (2009) 4.47
A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. J Biol Chem (2009) 2.40
Role and regulation of autophagy in cancer. Biochim Biophys Acta (2009) 2.00
PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. Cancer Res (2010) 1.84
Autophagy as a therapeutic target in cancer. Cancer Biol Ther (2011) 1.84
The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma. Pigment Cell Melanoma Res (2009) 1.62
PTEN interacts with histone H1 and controls chromatin condensation. Cell Rep (2014) 1.60
Risk factors for autism: translating genomic discoveries into diagnostics. Hum Genet (2011) 1.46
Genetic alterations in colorectal cancer. Gastrointest Cancer Res (2012) 1.44
Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes. PLoS One (2015) 1.44
CREB is a novel nuclear target of PTEN phosphatase. Cancer Res (2011) 1.27
The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology (2011) 1.19
Synthetic lethal approaches to breast cancer therapy. Nat Rev Clin Oncol (2010) 1.17
Akt and PTEN: beta-cell mass and pancreas plasticity. Trends Endocrinol Metab (2009) 1.13
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Sci Signal (2009) 1.11
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha. J Clin Invest (2010) 1.09
Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells. Proc Natl Acad Sci U S A (2011) 1.09
Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis. Aging (Albany NY) (2010) 1.08
Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle. J Biol Chem (2014) 1.07
Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS Biol (2010) 1.07
Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. PLoS One (2010) 1.00
Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds. Int J Mol Sci (2013) 0.98
Regulation of PTEN stability and activity by Plk3. J Biol Chem (2010) 0.98
Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer. Oncogene (2015) 0.97
Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency. Nat Commun (2015) 0.96
Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome. PLoS One (2011) 0.94
Therapeutic targeting of cancers with loss of PTEN function. Curr Drug Targets (2014) 0.93
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells. Breast Cancer (Dove Med Press) (2009) 0.93
Carney complex and lentiginosis. Pigment Cell Melanoma Res (2009) 0.93
The emerging role of pseudogene expressed non-coding RNAs in cellular functions. Int J Biochem Cell Biol (2014) 0.92
Genetics of melanoma. Front Genet (2013) 0.91
The PI3K-PTEN tug-of-war, oxidative stress and retinal degeneration. Trends Mol Med (2009) 0.91
PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation. Carcinogenesis (2010) 0.91
HOXA10 is associated with temozolomide resistance through regulation of the homologous recombinant DNA repair pathway in glioblastoma cell lines. Genes Cancer (2014) 0.91
Obesity and colorectal cancer: molecular features of adipose tissue. J Transl Med (2016) 0.90
RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. Cell Cycle (2009) 0.90
PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle. Am J Pathol (2009) 0.89
The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer. Br J Cancer (2010) 0.89
Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin. J Biol Chem (2014) 0.89
Autophagy: cancer's friend or foe? Adv Cancer Res (2013) 0.89
Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol (2012) 0.86
Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response. Br J Cancer (2015) 0.86
The expression of PTEN is associated with improved prognosis in patients with ampullary adenocarcinoma after pancreaticoduodenectomy. Arch Pathol Lab Med (2013) 0.85
A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapy. Mol Cell Ther (2014) 0.85
Therapeutic Implications of Targeting AKT Signaling in Melanoma. Enzyme Res (2011) 0.85
Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers. Oncotarget (2014) 0.85
PTEN regulates PLK1 and controls chromosomal stability during cell division. Cell Cycle (2016) 0.85
Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression Pathways. Front Oncol (2016) 0.84
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis. Nat Commun (2016) 0.84
Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress. J Biol Chem (2011) 0.84
High-resolution analysis of aberrant regions in autosomal chromosomes in human leukemia THP-1 cell line. BMC Res Notes (2009) 0.84
The mTOR signaling pathway as a treatment target for intracranial neoplasms. Neuro Oncol (2014) 0.84
Tumor Suppressor Inactivation in the Pathogenesis of Adult T-Cell Leukemia. J Oncol (2015) 0.84
Killing me softly--future challenges in apoptosis research. Int J Mol Sci (2014) 0.83
Shifting the balance of mitochondrial apoptosis: therapeutic perspectives. Front Oncol (2012) 0.83
Cell cycle arrest induced by engagement of B7-H4 on Epstein-Barr virus-positive B-cell lymphoma cell lines. Immunology (2009) 0.83
Targeting SRC and tubulin in mucinous ovarian carcinoma. Clin Cancer Res (2013) 0.83
Sapacitabine for cancer. Expert Opin Investig Drugs (2012) 0.81
The emerging role of RNA polymerase I transcription machinery in human malignancy: a clinical perspective. Onco Targets Ther (2013) 0.80
Clinical and molecular heterogeneity in brazilian patients with sotos syndrome. Mol Syndromol (2015) 0.79
Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL. Cancer Immunol Res (2013) 0.79
PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells. Oncotarget (2016) 0.79
Secreted factors derived from obese visceral adipose tissue regulate the expression of breast malignant transformation genes. Int J Obes (Lond) (2015) 0.78
MCT-1 expression and PTEN deficiency synergistically promote neoplastic multinucleation through the Src/p190B signaling activation. Oncogene (2014) 0.78
Protein tyrosine phosphatases PTP-1B, SHP-2, and PTEN facilitate Rb/E2F-associated apoptotic signaling. PLoS One (2014) 0.78
In human retinoblastoma Y79 cells okadaic acid-parthenolide co-treatment induces synergistic apoptotic effects, with PTEN as a key player. Cancer Biol Ther (2013) 0.77
Proteins interaction network and modeling of IGVH mutational status in chronic lymphocytic leukemia. Theor Biol Med Model (2015) 0.77
Regional differences in gallbladder cancer pathogenesis: insights from a comparison of cell cycle-regulatory, PI3K, and pro-angiogenic protein expression. Ann Surg Oncol (2012) 0.77
No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer. World J Gastroenterol (2009) 0.77
AML sensitivity to YM155 is modulated through AKT and Mcl-1. Cancer Lett (2015) 0.77
Computer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunities. Int J Mol Sci (2014) 0.77
Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer. Carcinogenesis (2016) 0.77
Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1. Oncotarget (2016) 0.77
Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. Biomed Res Int (2015) 0.77
Analysis of PTEN expression in large intestine polyps and its relation to the recognized histopathological and clinical risk factors for cancer development in this location. Contemp Oncol (Pozn) (2012) 0.77
Chemoresistance and targeted therapies in ovarian and endometrial cancers. Oncotarget (2017) 0.75
Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase. Mol Cancer Ther (2013) 0.75
Does PTEN gene mutation play any role in Li-Fraumeni syndrome. Med J Islam Repub Iran (2016) 0.75
Phosphatase and Tensin Homolog Is a Growth Repressor of Both Rhizoid and Gametophore Development in the Moss Physcomitrella patens. Plant Physiol (2015) 0.75
Synthetic lethality in lung cancer and translation to clinical therapies. Mol Cancer (2016) 0.75
Association between PTEN Gene IVS4 polymorphism and risk of cancer: a meta-analysis. PLoS One (2014) 0.75
Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis. Thorac Cancer (2017) 0.75
Apoptosis-induced effects of extract from Artemisia annua Linné by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells. BMC Complement Altern Med (2017) 0.75
The Optimization of Soluble PTEN Expression in Escherichia coli. Open Biochem J (2015) 0.75
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. Nat Genet (2017) 0.75
Hereditary syndromes predisposing to endocrine tumors and their skin manifestations. Rev Endocr Metab Disord (2016) 0.75
PTEN is a negative regulator of mitotic checkpoint complex during the cell cycle. Exp Hematol Oncol (2017) 0.75
[Precursor lesions of endometrial carcinoma: diagnostic approach and molecular pathology]. Pathologe (2011) 0.75
Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis. PLoS One (2017) 0.75
Tumour heterogeneity poses a significant challenge to cancer biomarker research. Br J Cancer (2017) 0.75
A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel. Invest New Drugs (2017) 0.75
Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases. Mol Endocrinol (1994) 2.00
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