Obesity and colorectal cancer: molecular features of adipose tissue.

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Published in J Transl Med on January 22, 2016

Authors

Javier Martinez-Useros1, Jesus Garcia-Foncillas2

Author Affiliations

1: Translational Oncology Division, Oncohealth Institute, FIIS-Fundacion Jimenez Diaz, Av. Reyes Catolicos 2, 28040, Madrid, Spain. javier.museros@oncohealth.eu.
2: Translational Oncology Division, Oncohealth Institute, FIIS-Fundacion Jimenez Diaz, Av. Reyes Catolicos 2, 28040, Madrid, Spain. jesus.garciafoncillas@oncohealth.eu.

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Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser (1995) 57.68

Cancer statistics, 2015. CA Cancer J Clin (2015) 57.51

A genetic model for colorectal tumorigenesis. Cell (1990) 44.37

Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA (2014) 36.94

Cancer-related inflammation. Nature (2008) 34.21

High frequency of mutations of the PIK3CA gene in human cancers. Science (2004) 27.94

Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82

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NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol (2005) 13.98

Effects of the obese gene product on body weight regulation in ob/ob mice. Science (1995) 13.57

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Inflammatory mechanisms in obesity. Annu Rev Immunol (2011) 9.83

Prevalence of ras gene mutations in human colorectal cancers. Nature (1987) 9.23

Mutation of a mutL homolog in hereditary colon cancer. Science (1994) 9.04

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (1994) 8.04

Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature (2002) 7.46

Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J (2003) 7.21

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res (2011) 5.97

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res (1990) 5.70

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science (2005) 5.68

Accuracy of body mass index in diagnosing obesity in the adult general population. Int J Obes (Lond) (2008) 5.03

PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol (2009) 4.83

The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer (2012) 4.72

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell (2005) 4.48

Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors. J Natl Cancer Inst (2000) 4.39

Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol (2012) 4.22

Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis. Obes Rev (2011) 4.07

Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut (2010) 4.01

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci U S A (1998) 3.90

Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res (2010) 3.71

PPARγ signaling and metabolism: the good, the bad and the future. Nat Med (2013) 3.71

Molecular mechanisms of cancer development in obesity. Nat Rev Cancer (2011) 3.65

Insulin and colon cancer. Cancer Causes Control (1995) 3.48

Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med (2002) 3.47

Impact of EGFR expression on colorectal cancer patient prognosis and survival. Ann Oncol (2005) 3.34

Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism (1987) 3.32

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Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol (2013) 2.92

Overweight as an avoidable cause of cancer in Europe. Int J Cancer (2001) 2.88

Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer. Gut (2009) 2.62

Minireview: Obesity and breast cancer: the estrogen connection. Endocrinology (2009) 2.57

Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One (2011) 2.55

Obesity and cancer risk: the role of the insulin-IGF axis. Trends Endocrinol Metab (2006) 2.52

AP-1--The Jun proteins: Oncogenes or tumor suppressors in disguise? Cell Signal (2010) 2.49

Increased blood glucose and insulin, body size, and incident colorectal cancer. J Natl Cancer Inst (1999) 2.40

PTEN: a new guardian of the genome. Oncogene (2008) 2.37

Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol (2014) 2.35

16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer (2011) 2.32

Macrophage polarization to a unique phenotype driven by B cells. Eur J Immunol (2010) 2.25

NSAIDs and cancer prevention: targets downstream of COX-2. Annu Rev Med (2007) 2.19

Free radical lipid peroxidation: mechanisms and analysis. Chem Rev (2011) 2.17

The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis. Acta Oncol (2014) 2.14

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Biology of the adenomatous polyposis coli tumor suppressor. J Clin Oncol (2000) 2.03

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Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci (2013) 2.00

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BRAFV600E: implications for carcinogenesis and molecular therapy. Mol Cancer Ther (2011) 1.77

Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo. Proc Natl Acad Sci U S A (2005) 1.72

Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression. Annu Rev Med (2012) 1.70

SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology (2011) 1.67

Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res (2006) 1.64

Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterology (2005) 1.58

Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution. Proc Natl Acad Sci U S A (2000) 1.55

Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. Am J Pathol (1998) 1.55

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas. Cancer Res (1986) 1.55

Adipocyte-derived endotrophin promotes malignant tumor progression. J Clin Invest (2012) 1.55

CXCL10 and autoimmune diseases. Autoimmun Rev (2008) 1.49

4-hydroxynonenal as a bioactive marker of pathophysiological processes. Mol Aspects Med (2003) 1.49

Oxidized phospholipids: from molecular properties to disease. Biochim Biophys Acta (2007) 1.47

Diet, lifestyle, and genomic instability in the North Carolina Colon Cancer Study. Cancer Epidemiol Biomarkers Prev (2005) 1.45

Body size and the risk of colon cancer in a large case-control study. Int J Obes Relat Metab Disord (1998) 1.41

Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer. Cancer Immunol Immunother (2014) 1.39

Aromatase: biologic relevance of tissue-specific expression. Semin Reprod Med (2004) 1.38

Possible mutagens derived from lipids and lipid precursors. Mutat Res (1990) 1.38

Adipokines linking obesity with colorectal cancer risk in postmenopausal women. Cancer Res (2012) 1.35

Body size and colorectal-cancer risk. Int J Cancer (1998) 1.34

Assessing body composition with DXA and bioimpedance: effects of obesity, physical activity, and age. Obesity (Silver Spring) (2008) 1.32

EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. Cancer Res (2007) 1.32

DNA adducts with lipid peroxidation products. J Biol Chem (2008) 1.32

Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res (2014) 1.30

Regulation of macrophage phenotype by long-term exposure to IL-10. Immunobiology (2005) 1.27

Insulin and insulin-like growth factor 1 stimulate proliferation of metastatic variants of colon carcinoma 26. Jpn J Cancer Res (1989) 1.26

Interaction between adiponectin and leptin influences the risk of colorectal adenoma. Cancer Res (2010) 1.26