PubRank

Roger P Simon

Author PubWeight™ 100.55‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell 2004 6.15
2 Ischemic tolerance and endogenous neuroprotection. Trends Neurosci 2003 3.44
3 Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet 2003 3.36
4 Mechanisms of ischemic brain damage. Neuropharmacology 2008 2.40
5 Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest 2008 1.86
6 In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning. J Cereb Blood Flow Metab 2007 1.82
7 Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain 2006 1.82
8 Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice. Stroke 2004 1.79
9 Toll-like receptor 9: a new target of ischemic preconditioning in the brain. J Cereb Blood Flow Metab 2008 1.79
10 Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases. Curr Opin Pharmacol 2007 1.68
11 Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis. Stroke 2007 1.64
12 CREB-mediated Bcl-2 protein expression after ischemic preconditioning. J Cereb Blood Flow Metab 2005 1.60
13 Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance. J Cereb Blood Flow Metab 2007 1.55
14 Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex. J Cereb Blood Flow Metab 2009 1.52
15 miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132. Am J Pathol 2011 1.52
16 Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain 2007 1.50
17 Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J Neurosci 2004 1.40
18 Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury. J Neurosci 2011 1.35
19 Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. J Clin Invest 2004 1.34
20 Neuroprotection by osteopontin in stroke. J Cereb Blood Flow Metab 2005 1.33
21 Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance. Sci Signal 2010 1.31
22 Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death. J Neurosci 2002 1.31
23 Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. J Cereb Blood Flow Metab 2006 1.30
24 Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control. Exp Neurol 2007 1.27
25 Adenosine dysfunction in astrogliosis: cause for seizure generation? Neuron Glia Biol 2007 1.23
26 Ischemia-induced neurogenesis is preserved but reduced in the aged rodent brain. Aging Cell 2004 1.21
27 Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism. J Cereb Blood Flow Metab 2007 1.18
28 Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke. J Cereb Blood Flow Metab 2008 1.16
29 Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways. Neurobiol Dis 2008 1.16
30 Acid sensing ion channels--novel therapeutic targets for ischemic brain injury. Front Biosci 2007 1.13
31 A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J Biol Chem 2007 1.13
32 A new model of cortical stroke in the rhesus macaque. J Cereb Blood Flow Metab 2009 1.13
33 Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci 2011 1.12
34 Epilepsy and apoptosis pathways. J Cereb Blood Flow Metab 2005 1.11
35 Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis. PLoS One 2012 1.10
36 Proton-gated channels in PC12 cells. J Neurophysiol 2002 1.10
37 Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH. J Biol Chem 2006 1.09
38 Proliferating progenitor cells: a required cellular element for induction of ischemic tolerance in the brain. J Cereb Blood Flow Metab 2008 1.08
39 Cloning of a novel Apaf-1-interacting protein: a potent suppressor of apoptosis and ischemic neuronal cell death. J Neurosci 2004 1.07
40 Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death. Exp Neurol 2012 1.07
41 Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Eur J Neurosci 2003 1.07
42 Activation of acid-sensing ion channel 1a (ASIC1a) by surface trafficking. J Biol Chem 2010 1.05
43 Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse. J Neurosci Res 2002 1.05
44 Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance. Brain Res 2009 1.05
45 Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants. J Cereb Blood Flow Metab 2006 1.04
46 Genomics of preconditioning. Stroke 2004 1.04
47 Toll-like receptor 7 preconditioning induces robust neuroprotection against stroke by a novel type I interferon-mediated mechanism. Stroke 2012 1.00
48 Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. J Neurochem 2003 0.98
49 Ischemic preconditioning in the rat brain enhances the repair of endogenous oxidative DNA damage by activating the base-excision repair pathway. J Cereb Blood Flow Metab 2006 0.97
50 Acid-sensing ion channels in acidosis-induced injury of human brain neurons. J Cereb Blood Flow Metab 2010 0.96
51 Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication. J Cereb Blood Flow Metab 2004 0.95
52 Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse. J Neurosci Res 2004 0.94
53 Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy. Exp Neurol 2006 0.91
54 Acidosis decreases low Ca(2+)-induced neuronal excitation by inhibiting the activity of calcium-sensing cation channels in cultured mouse hippocampal neurons. J Physiol 2003 0.90
55 Tolerance to ischemia - an increasingly complex biology. Transl Stroke Res 2013 0.89
56 Developmental change in the electrophysiological and pharmacological properties of acid-sensing ion channels in CNS neurons. J Physiol 2010 0.89
57 Death-associated protein kinase expression in human temporal lobe epilepsy. Ann Neurol 2004 0.88
58 Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis. Neurosci Lett 2002 0.88
59 Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. J Cereb Blood Flow Metab 2006 0.88
60 Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels. Stroke 2007 0.87
61 Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. Neurobiol Dis 2002 0.86
62 Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat. Neurosci Lett 2004 0.85
63 Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. J Biol Chem 2011 0.85
64 Racial and sex differences in associations between activities of daily living and cognition in community-dwelling older adults. J Am Geriatr Soc 2013 0.85
65 Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia. J Cereb Blood Flow Metab 2003 0.84
66 Nascent proteomes of ischemic-injured and ischemic-tolerant neuronal cells. Int J Comput Biol Drug Des 2011 0.84
67 Cell cycle arrest associated with anoxia-induced quiescence, anoxic preconditioning, and embryonic diapause in embryos of the annual killifish Austrofundulus limnaeus. J Comp Physiol B 2012 0.84
68 Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures. Hippocampus 2004 0.81
69 Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. J Cereb Blood Flow Metab 2009 0.81
70 Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels. Antioxid Redox Signal 2011 0.80
71 Interaction of 14-3-3 with Bid during seizure-induced neuronal death. J Neurochem 2003 0.80
72 Inhibition of acid sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesth Analg 2011 0.79
73 Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism. J Neurochem 2003 0.79
74 Modeling neural injury in organotypic cultures by application of inertia-driven shear strain. J Neurotrauma 2007 0.79
75 Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia. J Neurochem 2002 0.79
76 Expression of neurogenesis genes in human temporal lobe epilepsy with hippocampal sclerosis. Int J Physiol Pathophysiol Pharmacol 2010 0.78
77 Working with GFP in the brain. Biotechniques 2003 0.78
78 Nascent proteomes in peripheral blood mononuclear cells as a novel source for biomarker discovery in human stroke. Stroke 2014 0.78
79 Explicit consideration of baseline factors to assess recombinant tissue-type plasminogen activator response with respect to race and sex. Stroke 2013 0.78
80 Stereo-selective neuroprotection against stroke with vitamin A derivatives. Brain Res 2008 0.77
81 Endogenous neuroprotective mechanisms in the brain. Epilepsia 2009 0.77
82 Suppression of TNF receptor-1 signaling in an in vitro model of epileptic tolerance. Int J Physiol Pathophysiol Pharmacol 2011 0.76
83 Why pus is bad for the brain. Neurology 2002 0.75