Published in Cancer Res on October 01, 2008
The Beclin 1 interactome. Curr Opin Cell Biol (2010) 4.13
Autophagy as a therapeutic target in cancer. Cancer Biol Ther (2011) 1.84
Estrogen regulation of apoptosis: how can one hormone stimulate and inhibit? Breast Cancer Res (2009) 1.75
Autophagy and endocrine resistance in breast cancer. Expert Rev Anticancer Ther (2011) 1.29
Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Carcinogenesis (2011) 1.10
A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes. Br J Cancer (2012) 1.05
Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis (2013) 0.99
Interaction between Her2 and Beclin-1 proteins underlies a new mechanism of reciprocal regulation. J Biol Chem (2013) 0.96
Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and JNK activation. BMC Cancer (2012) 0.91
Sex differences in constitutive autophagy. Biomed Res Int (2014) 0.90
The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast cancer. J Biol Chem (2010) 0.87
Autophagy signal transduction by ATG proteins: from hierarchies to networks. Cell Mol Life Sci (2015) 0.83
mTOR: An attractive therapeutic target for osteosarcoma? Oncotarget (2016) 0.81
Tamoxifen resistance in breast cancer. Biomol Ther (Seoul) (2012) 0.81
Inhibition of the mammalian target of rapamycin leads to autophagy activation and cell death of MG63 osteosarcoma cells. Oncol Lett (2013) 0.78
Blockade of irradiation-induced autophagosome formation impairs proliferation but does not enhance cell death in HCT-116 human colorectal carcinoma cells. Int J Oncol (2012) 0.77
Galectin-3 and Beclin1/Atg6 genes in human cancers: using cDNA tissue panel, qRT-PCR, and logistic regression model to identify cancer cell biomarkers. PLoS One (2011) 0.76
Autophagic regulation of cell growth by altered expression of Beclin 1 in triple-negative breast cancer. Int J Clin Exp Med (2015) 0.75
Is BECN1 a Target Gene of Chromosome 17q21 Alteration in Breast Cancer? EBioMedicine (2015) 0.75
Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer. Oncotarget (2016) 0.75
Lower Beclin 1 downregulates HER2 expression to enhance tamoxifen sensitivity and predicts a favorable outcome for ER positive breast cancer. Oncotarget (2016) 0.75
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol (2007) 6.67
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology (2013) 3.50
Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci (2001) 2.99
Polyamine metabolism and cancer. J Cell Mol Med (2003) 1.91
Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis. Arthritis Rheum (2005) 1.79
Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors. Cancer Biol Ther (2005) 1.64
Ionic and structural specificity effects of natural and synthetic polyamines on the aggregation and resolubilization of single-, double-, and triple-stranded DNA. Biochemistry (1999) 1.53
Regulation of apoptosis proteins in cancer cells by ubiquitin. Oncogene (2004) 1.46
Serologic evaluation of patients receiving procainamide. Arthritis Rheum (1992) 1.45
Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function. J Biol Chem (2006) 1.44
DNA nanoparticles and development of DNA delivery vehicles for gene therapy. Biochemistry (2002) 1.42
Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis. Cancer Res (2007) 1.42
Attractive forces between cation condensed DNA double helices. Biophys J (2008) 1.40
Determination of specific CD4 and CD8 T cell epitopes after AAV2- and AAV8-hF.IX gene therapy. Mol Ther (2006) 1.34
Ionic and structural effects on the thermal helix-coil transition of DNA complexed with natural and synthetic polyamines. Biopolymers (1984) 1.33
Novel tumor necrosis factor alpha-regulated genes in rheumatoid arthritis. Arthritis Rheum (2004) 1.33
IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16. J Immunol (2010) 1.21
Chain flexibility and hydrodynamics of the B and Z forms of poly(dG-dC).poly(dG-dC). Nucleic Acids Res (1983) 1.20
Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis. Arthritis Rheum (2006) 1.20
Managing macrophages in rheumatoid arthritis by reform or removal. Curr Rheumatol Rep (2012) 1.17
DNA condensation by polyamines: a laser light scattering study of structural effects. Biochemistry (2001) 1.17
Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin. Clin Cancer Res (2006) 1.14
Role of alcohol metabolism in non-alcoholic steatohepatitis. PLoS One (2010) 1.13
Selectivity of polyamines in triplex DNA stabilization. Biochemistry (1993) 1.12
CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis. J Clin Invest (2003) 1.10
Cigarette smoke condensate-induced transformation of normal human breast epithelial cells in vitro. Oncogene (2004) 1.09
Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation. Proc Natl Acad Sci U S A (2010) 1.07
Toroidal condensation of Z DNA and identification of an intermediate in the B to Z transition of poly(dG-m5dC) X poly(dG-m5dC). Biochemistry (1985) 1.05
Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model. Arthritis Rheum (2011) 1.03
Collapse of DNA caused by trivalent cations: pH and ionic specificity effects. Biopolymers (1983) 1.03
Radiation-induced hepatitis B virus reactivation in liver mediated by the bystander effect from irradiated endothelial cells. Clin Cancer Res (2007) 1.03
Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach. Virol J (2008) 1.03
Doxorubicin activates hepatitis B virus (HBV) replication in HBV-harboring hepatoblastoma cells. A possible novel mechanism of HBV reactivation in HBV carriers receiving systemic chemotherapy. Anticancer Res (2004) 1.02
Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity. J Immunol (2009) 1.02
Formation of DNA nanoparticles in the presence of novel polyamine analogues: a laser light scattering and atomic force microscopic study. Nucleic Acids Res (2004) 1.02
IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells. J Immunol (2013) 0.99
Development of polyamine analogs as cancer therapeutic agents. Oncol Res (2002) 0.96
A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling. J Cell Physiol (2009) 0.96
Disruption of estrogen receptor alpha-p53 interaction in breast tumors: a novel mechanism underlying the anti-tumor effect of radiation therapy. Breast Cancer Res Treat (2008) 0.96
Estrogen-mediated downregulation of CD24 in breast cancer cells. Int J Cancer (2008) 0.95
Activation of nuclear factor kappaB by polyamines in breast cancer cells. Biochemistry (1999) 0.95
Lipid in the livers of adolescents with nonalcoholic steatohepatitis: combined effects of pathways on steatosis. Metabolism (2010) 0.94
A molecular beacon strategy for the thermodynamic characterization of triplex DNA: triplex formation at the promoter region of cyclin D1. Biochemistry (2001) 0.94
Triptolide binds covalently to a 90 kDa nuclear protein. Role of epoxides in binding and activity. Immunobiology (2007) 0.93
Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells. Oncol Rep (2000) 0.93
Successful treatment of lupus nephritis in MRL-lpr/lpr mice by inhibiting ornithine decarboxylase. Kidney Int (1991) 0.92
Differential effects on the B-to-Z transition of poly(dG-me5dC).poly(dG-me5dC) produced by N1- and N8-acetyl spermidine. Biopolymers (1985) 0.92
Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3. Mech Ageing Dev (2009) 0.92
Regulation of estrogenic and nuclear factor kappa B functions by polyamines and their role in polyamine analog-induced apoptosis of breast cancer cells. Oncogene (2001) 0.91
Type I interferon-dependent CD86(high) marginal zone precursor B cells are potent T cell costimulators in mice. Arthritis Rheum (2011) 0.91
Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice. Arthritis Rheumatol (2014) 0.91
Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics. Nucleic Acids Res (2002) 0.91
IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation. J Immunol (2004) 0.91
Facilitation of the cellular uptake of a triplex-forming oligonucleotide by novel polyamine analogues: structure-activity relationships. Biochemistry (1999) 0.91
Testing hypotheses on the rate of molecular evolution in relation to gene expression using microRNAs. Proc Natl Acad Sci U S A (2011) 0.90
Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver. J Virol (2002) 0.90
Genetic analysis of the antibody response to AAV2 and factor IX. Mol Ther (2005) 0.90
BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model. Int J Cancer (2002) 0.90
Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications. Breast Cancer Res Treat (1994) 0.90
Inhibition of calcium signalling in murine splenocytes by polyamines: differential effects on CD4 and CD8 T-cells. Biochem J (1993) 0.89
Labile catalytic packaging of DNA/siRNA: control of gold nanoparticles "out" of DNA/siRNA complexes. ACS Nano (2010) 0.89
Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice. Arthritis Rheum (2013) 0.89
Inhibition of calcification of glutaraldehyde pretreated porcine aortic valve cusps with sodium dodecyl sulfate: preincubation and controlled release studies. J Biomed Mater Res (1993) 0.89
Effect of dietary advanced glycation end products on mouse liver. PLoS One (2012) 0.89
CD8 T-cell immune phenotype of successful aging. Mech Ageing Dev (2005) 0.88
Yohimbine elimination in normal volunteers is characterized by both one- and two-compartment behavior. J Cardiovasc Pharmacol (1997) 0.88
Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells. PLoS One (2011) 0.88
Direct measurement of the association constant of HER2/neu antisense oligonucleotide to its target RNA sequence using a molecular beacon. Antisense Nucleic Acid Drug Dev (2002) 0.88
Increase in the stability and helical content of estrogen receptor alpha in the presence of the estrogen response element: analysis by circular dichroism spectroscopy. Biochemistry (2001) 0.88
Selectivity of polyamines on the stability of RNA-DNA hybrids containing phosphodiester and phosphorothioate oligodeoxyribonucleotides. Biochemistry (1999) 0.87
Biogenic and synthetic polyamines bind bovine serum albumin. Biomacromolecules (2010) 0.87
Regulation of cyclin B1 by estradiol and polyamines in MCF-7 breast cancer cells. Cancer Res (1994) 0.87
Quasielastic laser light scattering and electron microscopy studies of the conformational transitions and condensation of poly(dA-dT).poly(dA-dT). Biopolymers (1985) 0.87
Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives as high-affinity ligands of the alpha(2)delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett (2004) 0.87
Antioxidant Mechanisms in Nonalcoholic Fatty Liver Disease. Curr Drug Targets (2015) 0.86
Endotoxemia unrequired in the pathogenesis of pediatric nonalcoholic steatohepatitis. J Gastroenterol Hepatol (2014) 0.86
Addition of six-His-tagged peptide to the C terminus of adeno-associated virus VP3 does not affect viral tropism or production. J Virol (2002) 0.86
Cytokine regulation of B-cell migratory behavior favors formation of germinal centers in autoimmune disease. Discov Med (2011) 0.86
Stabilization of p53 and transactivation of its target genes in response to replication blockade. Oncogene (2002) 0.86
A left-handed (Z) conformation of poly(dA-dC).poly(dG-dT) induced by polyamines. Nucleic Acids Res (1986) 0.86
Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. J Mol Endocrinol (2005) 0.86