Published in Diabetes on October 01, 2008
Molecular mechanisms of diabetic cardiomyopathy. Diabetologia (2014) 1.53
Mitochondria in the diabetic heart. Cardiovasc Res (2010) 1.50
Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats. J Mol Cell Cardiol (2013) 1.49
Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension (2009) 1.30
G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function. J Physiol (2011) 1.27
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Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J Biol Chem (2010) 1.24
Thioredoxin-1 gene therapy enhances angiogenic signaling and reduces ventricular remodeling in infarcted myocardium of diabetic rats. Circulation (2010) 1.16
Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. Diabetes (2013) 1.14
Lessons from in vitro studies and a related intracellular angiotensin II transgenic mouse model. Am J Physiol Regul Integr Comp Physiol (2011) 1.08
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The renin-angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studies. Mediators Inflamm (2009) 1.05
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Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phases of diabetic cardiomyopathy. PLoS One (2013) 1.01
The intracrine renin-angiotensin system. Clin Sci (Lond) (2012) 1.01
Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS One (2011) 1.00
Vascular dysfunction in the diabetic placenta: causes and consequences. J Anat (2009) 0.98
Mitochondrial morphology in metabolic diseases. Antioxid Redox Signal (2012) 0.98
Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney. Am J Physiol Regul Integr Comp Physiol (2011) 0.97
Network modeling reveals steps in angiotensin peptide processing. Hypertension (2013) 0.95
Subcellular characteristics of functional intracellular renin-angiotensin systems. Peptides (2012) 0.93
Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction. Regul Pept (2012) 0.93
Direct renin inhibition exerts an anti-hypertrophic effect associated with improved mitochondrial function in post-infarction heart failure in diabetic rats. Cell Physiol Biochem (2012) 0.89
Cardiac-specific suppression of NF-κB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system. Am J Physiol Heart Circ Physiol (2014) 0.88
Angiotensin II and oxidative stress in the failing heart. Antioxid Redox Signal (2012) 0.88
EPC-derived microvesicles protect cardiomyocytes from Ang II-induced hypertrophy and apoptosis. PLoS One (2014) 0.85
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Combination of angiotensin-(1-7) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy. Sci Rep (2015) 0.82
Glutaredoxin-1 overexpression enhances neovascularization and diminishes ventricular remodeling in chronic myocardial infarction. PLoS One (2012) 0.82
Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors. Cardiovasc Diabetol (2013) 0.82
Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.82
Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor. Clin Sci (Lond) (2013) 0.81
Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy. World J Diabetes (2015) 0.80
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Knocking out angiotensin II in the heart. Curr Hypertens Rep (2011) 0.80
Intracellular Enhanced Cyan Fluorescent Protein/Angiotensin II Does Not Modify Angiotensinogen Accumulation in Transgenic Mice. Ochsner J (2013) 0.79
Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. Am J Physiol Heart Circ Physiol (2016) 0.79
The renin-angiotensin system and prevention of age-related functional decline: where are we now? Age (Dordr) (2015) 0.78
The role of local renin-angiotensin system on high glucose-induced cell toxicity, apoptosis and reactive oxygen species production in PC12 cells. Iran J Basic Med Sci (2014) 0.78
Novel mechanism of blood pressure regulation by forkhead box class O1-mediated transcriptional control of hepatic angiotensinogen. Hypertension (2014) 0.78
Update on RAAS Modulation for the Treatment of Diabetic Cardiovascular Disease. J Diabetes Res (2016) 0.78
Anti-fibrotic effect of Aliskiren in rats with deoxycorticosterone induced myocardial fibrosis and its potential mechanism. Bosn J Basic Med Sci (2012) 0.77
Rapid induction of aldosterone synthesis in cultured neonatal rat cardiomyocytes under high glucose conditions. Biomed Res Int (2013) 0.77
Renin inhibition improves the survival of mesenchymal stromal cells in a mouse model of myocardial infarction. J Cardiovasc Transl Res (2014) 0.76
Aliskiren suppresses atrial electrical and structural remodeling in a canine model of atrial fibrillation. Heart Vessels (2016) 0.76
Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk. Am J Physiol Endocrinol Metab (2016) 0.76
Maternal high-salt intake during pregnancy reprogrammed renin-angiotensin system-mediated cardiomyocyte apoptosis in the adult offspring heart. Reprod Sci (2013) 0.76
Chronic NF-κB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats. Cardiovasc Diabetol (2015) 0.75
The Cooperative Effect of Local Angiotensin-II in Liver with Adriamycin Hepatotoxicity on Mitochondria. Med Sci Monit (2016) 0.75
Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue. PLoS One (2015) 0.75
The Interplay between the Renin Angiotensin System and Pacing Postconditioning Induced Cardiac Protection. PLoS One (2016) 0.75
Aliskiren prevents the toxic effects of peritoneal dialysis fluids during chronic dialysis in rats. PLoS One (2012) 0.75
Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus. Obstet Gynecol Int (2015) 0.75
Photoreleasable ligands to study intracrine angiotensin II signalling. J Physiol (2015) 0.75
Angiotensin-converting enzyme inhibitors reduce oxidative stress intensity in hyperglicemic conditions in rats independently from bradykinin receptor inhibitors. Croat Med J (2016) 0.75
Association of polymorphisms of angiotensin I converting enzyme 2 with retinopathy in type 2 diabetes mellitus among Chinese individuals. Eye (Lond) (2014) 0.75
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Physiology of local renin-angiotensin systems. Physiol Rev (2006) 5.77
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High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. Am J Physiol Renal Physiol (2004) 2.75
Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation (2004) 2.64
Impact of new-onset diabetes mellitus on cardiac outcomes in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial population. Hypertension (2007) 2.44
Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension (2006) 2.39
Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. J Clin Invest (2006) 2.25
Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension (2008) 2.21
High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes. Am J Physiol Heart Circ Physiol (2007) 2.18
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IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes (2001) 1.92
The collecting duct is the major source of prorenin in diabetes. Hypertension (2008) 1.78
Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun (2003) 1.74
Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril. Hypertension (2002) 1.71
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Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest (2008) 1.70
Myocyte death in streptozotocin-induced diabetes in rats in angiotensin II- dependent. Lab Invest (2000) 1.51
Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension (2008) 1.48
Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int (1996) 1.45
Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy. Regul Pept (2004) 1.30
Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus. Diabetologia (2006) 1.29
Determinants of angiotensin II generation during converting enzyme inhibition. Hypertension (1990) 1.23
Determinants of increased angiotensin II levels in severe chronic heart failure patients despite ACE inhibition. Int J Cardiol (2006) 1.20
The intracellular renin-angiotensin system: a new paradigm. Trends Endocrinol Metab (2007) 1.19
Involvement of chymase-mediated angiotensin II generation in blood pressure regulation. J Clin Invest (2004) 1.18
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Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production. Am J Physiol Heart Circ Physiol (2008) 1.15
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Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J Hypertens (2005) 1.10
Intracellular angiotensin II induces cell proliferation independent of AT1 receptor. Am J Physiol Cell Physiol (2006) 1.09
Mechanism of high glucose induced angiotensin II production in rat vascular smooth muscle cells. Circ Res (2007) 1.09
Functional significance of prorenin internalization in the rat heart. Circ Res (2002) 1.08
Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications. Circulation (2006) 1.03
ACE-dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells. Exp Biol Med (Maywood) (2008) 0.95
Circulating versus tissue renin-angiotensin system: on the origin of (pro)renin. Curr Hypertens Rep (2008) 0.95
Intracellular sorting of renin: cell type specific differences and their consequences. J Mol Cell Cardiol (2002) 0.94
Restoration of cardiomyocyte functional properties by angiotensin II receptor blockade in diabetic rats. Diabetes (2004) 0.94
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Angiotensin converting enzyme inhibitor prevents left ventricular remodelling after myocardial infarction in angiotensin II type 1 receptor knockout mice. Heart (2005) 0.88
Inhibiting the renin-angiotensin system to prevent cardiovascular diseases: do we need a more comprehensive strategy? Rev Cardiovasc Med (2006) 0.87
Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes. J Renin Angiotensin Aldosterone Syst (2007) 0.86
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Secretory and cytosolic (pro)renin in kidney, heart, and adrenal gland. J Mol Med (Berl) (2008) 0.81
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Pharmacokinetic/pharmacodynamic modeling of renin biomarkers in subjects treated with the renin inhibitor aliskiren. Clin Pharmacol Ther (2008) 0.78
A nationally representative case-control study of smoking and death in India. N Engl J Med (2008) 10.21
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HIV mortality and infection in India: estimates from nationally representative mortality survey of 1.1 million homes. BMJ (2010) 2.19
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Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol (2012) 1.54
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Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy. Regul Pept (2004) 1.30
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Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. Diabetes (2013) 1.14
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Willingness of healthcare workers to accept voluntary stockpiled H5N1 vaccine in advance of pandemic activity. Vaccine (2008) 1.12
User charges in health care: evidence of effect on service utilization & equity from north India. Indian J Med Res (2012) 1.12
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High diversity of group A Streptococcal emm types in an Indian community: the need to tailor multivalent vaccines. Clin Infect Dis (2004) 1.08
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Feasibility of expanding the medication abortion provider base in India to include ayurvedic physicians and nurses. Int Perspect Sex Reprod Health (2012) 1.08
African ancestry is associated with asthma risk in African Americans. PLoS One (2012) 1.07
Biomass fuel and risk of tuberculosis: a case-control study from Northern India. J Epidemiol Community Health (2010) 1.07
High prevalence of bacteriuria in pregnancy and its screening methods in north India. J Indian Med Assoc (2005) 1.06
Target foil rupture scenario and provision for handling different models of medical cyclotrons used in India. J Med Phys (2009) 1.06
Sex differences in white matter alterations accompanying obstructive sleep apnea. Sleep (2012) 1.06
Functional abnormalities in brain areas that mediate autonomic nervous system control in advanced heart failure. J Card Fail (2005) 1.05
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