PubRank

Raju Kucherlapati

Author PubWeight™ 174.53‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Integrated genomic characterization of endometrial carcinoma. Nature 2013 14.29
2 The somatic genomic landscape of glioblastoma. Cell 2013 11.73
3 Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data. Bioinformatics 2005 6.44
4 Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med 2015 5.71
5 Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 2002 5.08
6 Landscape of somatic retrotransposition in human cancers. Science 2012 4.37
7 Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell 2011 3.88
8 Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol 2006 3.75
9 Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature 2002 3.05
10 Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. Proc Natl Acad Sci U S A 2007 2.81
11 Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion. Proc Natl Acad Sci U S A 2011 2.72
12 Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection. Nat Methods 2009 2.71
13 (CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat Struct Mol Biol 2005 2.71
14 Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system. Proc Natl Acad Sci U S A 2005 2.65
15 Differential gene expression following early renal ischemia/reperfusion. Kidney Int 2003 2.60
16 Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A 2003 2.37
17 Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Res 2006 2.26
18 Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. Proc Natl Acad Sci U S A 2010 2.20
19 Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci U S A 2002 2.17
20 Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc Natl Acad Sci U S A 2002 2.15
21 Shared genetic causes of cardiac hypertrophy in children and adults. N Engl J Med 2008 2.12
22 In vivo wide-area cellular imaging by side-view endomicroscopy. Nat Methods 2010 2.10
23 A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science 2009 2.02
24 Diverse mechanisms of somatic structural variations in human cancer genomes. Cell 2013 2.00
25 APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A 2002 1.89
26 Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet 2006 1.86
27 Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Nat Genet 2005 1.84
28 Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol 2006 1.82
29 An Msh2 point mutation uncouples DNA mismatch repair and apoptosis. Cancer Res 2004 1.81
30 Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility. Cancer Cell 2004 1.81
31 Response to treatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing. Oncologist 2007 1.75
32 Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. Cancer Res 2002 1.64
33 Spectrum of somatic mitochondrial mutations in five cancers. Proc Natl Acad Sci U S A 2012 1.63
34 Genetic variation in DTNBP1 influences general cognitive ability. Hum Mol Genet 2006 1.61
35 Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res 2007 1.60
36 Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res 2006 1.60
37 Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development 2009 1.59
38 Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes. Neurobiol Dis 2008 1.58
39 Mouse models for human DNA mismatch-repair gene defects. Trends Mol Med 2002 1.49
40 Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet 2004 1.45
41 Epidermal growth factor receptor mutation testing in the care of lung cancer patients. Clin Cancer Res 2006 1.40
42 Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer. Proc Natl Acad Sci U S A 2006 1.40
43 A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet 2010 1.39
44 Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis. Cancer Prev Res (Phila) 2009 1.27
45 Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. J Clin Invest 2010 1.21
46 Low-volume, high-throughput sandwich immunoassays for profiling plasma proteins in mice: identification of early-stage systemic inflammation in a mouse model of intestinal cancer. Mol Oncol 2007 1.21
47 Genetic mechanisms in Apc-mediated mammary tumorigenesis. PLoS Genet 2009 1.21
48 DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophr Res 2006 1.20
49 Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model. Cancer Prev Res (Phila) 2011 1.19
50 A gender-moderated effect of a functional COMT polymorphism on prefrontal brain morphology and function in velo-cardio-facial syndrome (22q11.2 deletion syndrome). Am J Med Genet B Neuropsychiatr Genet 2006 1.19
51 Dysbindin genotype and negative symptoms in schizophrenia. Am J Psychiatry 2006 1.17
52 Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice. Cancer Res 2006 1.16
53 Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome. Neurogenetics 2006 1.14
54 COMT genetic variation confers risk for psychotic and affective disorders: a case control study. Behav Brain Funct 2005 1.14
55 DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice. Am J Pathol 2002 1.12
56 An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology 2009 1.11
57 The finished DNA sequence of human chromosome 12. Nature 2006 1.08
58 COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disord 2007 1.08
59 Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model. Hum Mol Genet 2011 1.04
60 The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev Biol 2002 1.04
61 Rb and N-ras function together to control differentiation in the mouse. Mol Cell Biol 2003 1.03
62 Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice. Int J Cancer 2005 1.01
63 Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. Cancer Prev Res (Phila) 2012 0.99
64 A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice. Proc Natl Acad Sci U S A 2005 0.99
65 Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. Carcinogenesis 2003 0.98
66 A suggested role for mitochondria in Noonan syndrome. Biochim Biophys Acta 2009 0.97
67 Mlh1 mediates tissue-specific regulation of mitotic recombination. Oncogene 2004 0.96
68 A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biol 2008 0.96
69 Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry. JAMA Oncol 2015 0.96
70 Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis. Proc Natl Acad Sci U S A 2008 0.94
71 Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. J Nutr 2008 0.94
72 B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate. J Immunol 2006 0.93
73 Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon. Proc Natl Acad Sci U S A 2008 0.93
74 Mass spectrometry-based study of the plasma proteome in a mouse intestinal tumor model. J Proteome Res 2006 0.92
75 Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. PLoS Genet 2008 0.91
76 COMT genotype and manic symptoms in schizophrenia. Schizophr Res 2006 0.89
77 DTNBP1 is associated with imaging phenotypes in schizophrenia. Hum Brain Mapp 2009 0.89
78 A panel of repeat markers for detection of microsatellite instability in murine tumors. Mol Carcinog 2003 0.89
79 PolyPhred analysis software for mutation detection from fluorescence-based sequence data. Curr Protoc Hum Genet 2008 0.89
80 Cis lethal genetic interactions attenuate and alter p53 tumorigenesis. Proc Natl Acad Sci U S A 2010 0.88
81 SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients. Genes Chromosomes Cancer 2008 0.87
82 DNA mismatch repair protein Msh6 is required for optimal levels of ultraviolet-B-induced apoptosis in primary mouse fibroblasts. J Invest Dermatol 2003 0.87
83 Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia. Hum Mol Genet 2005 0.86
84 Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia. Cancer Epidemiol Biomarkers Prev 2010 0.85
85 Impaired hippocampal long-term potentiation in microtubule-associated protein 1B-deficient mice. J Neurosci Res 2005 0.85
86 Analysis of TBX1 variation in patients with psychotic and affective disorders. Mol Med 2007 0.85
87 Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice. Hum Mol Genet 2009 0.84
88 Mutation frequencies and spectra in DNA polymerase eta-deficient mice. Cancer Res 2008 0.84
89 Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele. Am J Pathol 2003 0.83
90 Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice. PLoS One 2012 0.83
91 The Creating an Optimal Warfarin Nomogram (CROWN) Study. Thromb Haemost 2011 0.82
92 Mutation detection using automated fluorescence-based sequencing. Curr Protoc Hum Genet 2008 0.81
93 Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations. Carcinogenesis 2009 0.81
94 Genetics and genomics in the practice of medicine. Gastroenterology 2008 0.80
95 Genetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndrome. Brain Imaging Behav 2013 0.80
96 Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice. J Cell Physiol 2009 0.80
97 In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer. Mol Imaging 2012 0.79
98 The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration. PLoS One 2013 0.78
99 Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice. Anticancer Res 2003 0.76
100 Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations. Mutat Res 2008 0.76
101 Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling. Dev Biol 2013 0.75
102 Introduction for: frontiers of personalized cancer medicine. Cancer J 2011 0.75
103 Raju Kucherlapati talks about personalised medicine: breathing new life into old drugs. Interview by Steve Carney. Drug Discov Today 2007 0.75
104 A novel, single nucleotide polymorphism-based assay to detect 22q11 deletions. Genet Test 2007 0.75
105 Pharmacogenomics of lung cancer: with a view to address EGFR-targeted therapies. Pharmacogenomics 2007 0.75