Published in Stem Cells on September 01, 2009
Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (2010) 3.36
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev (2009) 2.70
Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell (2012) 2.33
Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell (2012) 2.02
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science (2011) 1.70
Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell (2010) 1.13
An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling. Stem Cells (2011) 1.03
Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. J Clin Invest (2011) 1.01
NANOG reporter cell lines generated by gene targeting in human embryonic stem cells. PLoS One (2010) 0.95
Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification. EMBO J (2014) 0.94
Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol (2011) 0.93
Hypoxia enhances differentiation of mouse embryonic stem cells into definitive endoderm and distal lung cells. Stem Cells Dev (2014) 0.82
Generation of functional hepatic cells from pluripotent stem cells. J Stem Cell Res Ther (2012) 0.82
A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev (2012) 0.81
New markers for tracking endoderm induction and hepatocyte differentiation from human pluripotent stem cells. Development (2015) 0.79
Multiplexing SERS nanotags for the imaging of differentiated mouse embryonic stem cells (mESC) and detection of teratoma in vivo. Am J Nucl Med Mol Imaging (2014) 0.76
Late stage definitive endodermal differentiation can be defined by Daf1 expression. BMC Dev Biol (2016) 0.75
Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton's jelly mesenchymal stem cells. Stem Cell Res Ther (2016) 0.75
Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (1975) 83.56
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47
Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol (2005) 9.58
Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev (2005) 7.27
Development of definitive endoderm from embryonic stem cells in culture. Development (2004) 4.61
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A (2006) 3.85
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development (1993) 3.63
Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat Biotechnol (2005) 3.55
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development (1993) 3.25
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development (1994) 3.12
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat Biotechnol (2006) 3.02
Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development (2005) 2.98
A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development (2001) 2.85
Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood. Cell Stem Cell (2008) 2.77
Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development (1998) 2.59
Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol (1999) 2.52
Inductive interactions direct early regionalization of the mouse forebrain. Development (1997) 2.43
The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain. Nat Genet (2001) 2.34
Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci (2006) 2.05
Anterior definitive endoderm from ESCs reveals a role for FGF signaling. Cell Stem Cell (2008) 1.88
Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol (2007) 1.75
Gene expression pattern and progression of embryogenesis in the immediate post-implantation period of mouse development. Gene Expr Patterns (2007) 1.45
Distinct roles for visceral endoderm during embryonic mouse development. Int J Dev Biol (1999) 1.44
The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. Blood (2005) 1.21
A simple, single-step technique for selecting and cloning hybridomas for the production of monoclonal antibodies. J Immunol Methods (1982) 1.18
A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). BMC Dev Biol (2007) 1.06
Subtractive immunization techniques for the production of monoclonal antibodies to rare antigens. Biotechniques (1992) 0.95
Strategies to generate antibodies capable of distinguishing between proteins with >90% amino acid identity. J Immunol Methods (2001) 0.93
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature (2008) 10.27
Biallelic inactivation of BRCA2 in Fanconi anemia. Science (2002) 9.31
Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol Cell (2002) 8.59
Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature (2003) 6.92
miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. RNA Biol (2004) 6.44
Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell (2006) 6.19
The Fanconi anaemia/BRCA pathway. Nat Rev Cancer (2003) 5.89
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nat Biotechnol (2007) 5.04
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development (2004) 4.72
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27
Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell (2012) 4.22
Generation and regeneration of cells of the liver and pancreas. Science (2008) 4.21
Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet (2003) 3.91
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A (2006) 3.85
Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. Cell (2012) 3.80
Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nat Med (2004) 3.77
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev (2003) 3.58
Stem cells and liver regeneration. Gastroenterology (2009) 3.40
The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature (2010) 3.27
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci U S A (2003) 2.99
AAV serotype 2 vectors preferentially integrate into active genes in mice. Nat Genet (2003) 2.81
Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood. Cell Stem Cell (2008) 2.77
Liver development update: new embryo models, cell lineage control, and morphogenesis. Curr Opin Genet Dev (2004) 2.71
The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. Cell (2003) 2.71
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev (2009) 2.70
Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes Dev (2011) 2.53
Epigenomic plasticity enables human pancreatic α to β cell reprogramming. J Clin Invest (2013) 2.38
The macrophage growth factor CSF-1 in mammary gland development and tumor progression. J Mammary Gland Biol Neoplasia (2002) 2.37
Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Dev Dyn (2006) 2.35
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell (2012) 2.26
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol (2011) 2.22
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Mol Cell Biol (2004) 2.20
Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev (2011) 2.17
Myeloid lineage progenitors give rise to vascular endothelium. Proc Natl Acad Sci U S A (2006) 2.13
Repression by Groucho/TLE/Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo. Mol Cell (2007) 2.12
Dynamic signaling network for the specification of embryonic pancreas and liver progenitors. Science (2009) 2.12
Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver. J Virol (2005) 2.09
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. Blood (2004) 2.08
Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes. Genes Dev (2013) 2.08
Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Dev Biol (2005) 1.94
Kinetics of liver repopulation after bone marrow transplantation. Am J Pathol (2002) 1.85
The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. Am J Sports Med (2010) 1.83
Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity (2013) 1.83
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc Natl Acad Sci U S A (2006) 1.82
Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA. Genes Dev (2009) 1.82
Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells. Proc Natl Acad Sci U S A (2007) 1.81
Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev Biol (2005) 1.80
Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development (2004) 1.80
Therapeutic liver reconstitution with murine cells isolated long after death. Gastroenterology (2010) 1.78
Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis. Cancer Cell (2008) 1.75
Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell (2012) 1.74
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med (2011) 1.74
Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3. J Pathol (2011) 1.70
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science (2011) 1.70
Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype. Am J Hum Genet (2007) 1.67
Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells. Blood (2010) 1.66
Surface markers for the murine oval cell response. Hepatology (2008) 1.65
Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One (2010) 1.60
Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes Dev (2008) 1.59
In vivo correction of murine hereditary tyrosinemia type I by phiC31 integrase-mediated gene delivery. Mol Ther (2005) 1.59
Preseismic velocity changes observed from active source monitoring at the Parkfield SAFOD drill site. Nature (2008) 1.58
Production of pluripotent stem cells by oocyte-assisted reprogramming: joint statement with signatories. Natl Cathol Bioeth Q (2005) 1.57
Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome. Nat Genet (2002) 1.57
Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice. J Clin Invest (2006) 1.54
Effect of a novel inhibitory mAb against beta-subunit of F1F0 ATPase on HCC. Cancer Biol Ther (2008) 1.54
Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. J Clin Invest (2012) 1.52
Efficient three-component one-pot synthesis of fully substituted pyridin-2(1H)-ones via tandem Knoevenagel condensation-ring-opening of cyclopropane-intramolecular cyclization. Chem Commun (Camb) (2009) 1.52
An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Dev Cell (2006) 1.50
Germ layer induction from embryonic stem cells. Exp Hematol (2005) 1.48
Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation. Hepatology (2009) 1.48
Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. Stem Cell Res (2008) 1.45
Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency. Hum Mutat (2003) 1.42
Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo. Hepatology (2010) 1.41
In vivo correction of murine tyrosinemia type I by DNA-mediated transposition. Mol Ther (2002) 1.39
An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev Biol (2006) 1.39
Seeking consensus: a clarification and defense of altered nuclear transfer. Hastings Cent Rep (2006) 1.39
New long-tailed pterosaurs (Wukongopteridae) from western Liaoning, China. An Acad Bras Cienc (2010) 1.38
Site-specific integration of adeno-associated virus involves partial duplication of the target locus. Proc Natl Acad Sci U S A (2009) 1.35
New toothed flying reptile from Asia: close similarities between early Cretaceous pterosaur faunas from China and Brazil. Naturwissenschaften (2012) 1.35
Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury. Hepatology (2014) 1.32
Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development. Trends Cardiovasc Med (2007) 1.31
Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro. J Virol (2004) 1.31
Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol (2007) 1.31
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development (2008) 1.30
Frequent aneuploidy among normal human hepatocytes. Gastroenterology (2011) 1.30
Observation of an evolving magnetic flux rope before and during a solar eruption. Nat Commun (2012) 1.29
Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proc Natl Acad Sci U S A (2013) 1.29
Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol. Blood (2010) 1.29
Ploidy reductions in murine fusion-derived hepatocytes. PLoS Genet (2009) 1.28
Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. Cancer Res (2010) 1.26
Committing embryonic stem cells to differentiate into thyrocyte-like cells in vitro. Endocrinology (2003) 1.25