Published in FASEB J on October 21, 2008
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 2.28
Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr (2005) 2.21
Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J (2007) 2.17
Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J (2003) 2.14
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr (2007) 2.05
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proc Natl Acad Sci U S A (2002) 1.93
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell (2013) 1.71
Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci U S A (2002) 1.54
gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci U S A (2004) 1.52
Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free Radic Biol Med (2002) 1.46
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 1.46
Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB J (2007) 1.44
Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci (2002) 1.42
Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Natl Acad Sci U S A (2002) 1.41
Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci (2002) 1.36
Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci U S A (2002) 1.29
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J Nutr (2003) 1.25
Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol (2004) 1.24
The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr (2005) 1.24
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci (2007) 1.24
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr (2009) 1.20
The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age. Arch Biochem Biophys (2002) 1.18
An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring. Neurosci Biobehav Rev (2006) 1.12
Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease. Nutr Neurosci (2005) 1.10
(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci (2005) 1.06
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. J Neurol Sci (2009) 1.04
Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol. Free Radic Biol Med (2007) 1.00
Analysis of plasma tocopherols alpha, gamma, and 5-nitro-gamma in rats with inflammation by HPLC coulometric detection. J Lipid Res (2002) 0.98
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. J Cell Mol Med (2008) 0.98
Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms. Ann N Y Acad Sci (2004) 0.96
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res (2008) 0.96
Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proc Natl Acad Sci U S A (2008) 0.95
Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes. Anal Biochem (2004) 0.94
Enough is enough. Ann Intern Med (2014) 0.94
Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats. Toxicol Pathol (2009) 0.94
5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay. J Biol Chem (2003) 0.91
Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging. FASEB J (2011) 0.90
Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. FASEB J (2003) 0.89
A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes. FASEB J (2004) 0.89
Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci (2004) 0.89
Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxid Redox Signal (2003) 0.89
Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells. J Nutr Biochem (2011) 0.89
Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts. J Nutr (2007) 0.88
Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes. J Nutr (2003) 0.87
A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial. FASEB J (2012) 0.86
Iron accumulation during cellular senescence. Ann N Y Acad Sci (2004) 0.86
An assay for uracil in human DNA at baseline: effect of marginal vitamin B6 deficiency. Anal Biochem (2007) 0.85
A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects. J Nutr Biochem (2008) 0.84
Daily supplementation with iron increases lipid peroxidation in young women with low iron stores. Exp Biol Med (Maywood) (2008) 0.83
N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration. FASEB J (2007) 0.83
Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status. Mutagenesis (2011) 0.83
The role of Fe2+-induced lipid peroxidation in the initiation of the mitochondrial permeability transition. Arch Biochem Biophys (2003) 0.82
Measuring chromosome breaks in patients with thalassemia. Ann N Y Acad Sci (2005) 0.81
Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.81
Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough. Am J Clin Nutr (2007) 0.80
Fe(2+) induces a transient Ca(2+) release from rat liver mitochondria. Arch Biochem Biophys (2002) 0.80
Chronic ethanol perturbs testicular folate metabolism and dietary folate deficiency reduces sex hormone levels in the Yucatan micropig. Biol Reprod (2006) 0.79
5-Methyltetrahydrofolate inhibits photosensitization reactions and strand breaks in DNA. FASEB J (2007) 0.78
Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. Redox Rep (2008) 0.76