Published in Proc Natl Acad Sci U S A on December 12, 2002
The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Invest (2003) 1.82
Antimetastatic Potentials of Dioscorea nipponica on Melanoma In Vitro and In Vivo. Evid Based Complement Alternat Med (2011) 1.56
Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci U S A (2006) 1.48
A tautomeric zinc sensor for ratiometric fluorescence imaging: application to nitric oxide-induced release of intracellular zinc. Proc Natl Acad Sci U S A (2004) 1.27
Zinc and the modulation of redox homeostasis. Free Radic Biol Med (2012) 1.23
Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr (2009) 1.21
QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II). J Am Chem Soc (2005) 1.14
MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy. Oncogene (2010) 1.00
Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature. Oncogene (2011) 1.00
Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. J Nutr (2008) 0.96
Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair. Toxicol Appl Pharmacol (2013) 0.96
Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency. J Biol Chem (2009) 0.96
Zinc and the liver: an active interaction. Dig Dis Sci (2007) 0.95
Matrix metalloproteinase-9 inhibition down-regulates radiation-induced nuclear factor-kappa B activity leading to apoptosis in breast tumors. Clin Cancer Res (2008) 0.95
Gastroprotection studies of Schiff base zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats. PLoS One (2013) 0.94
Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation. J Nutr Biochem (2012) 0.94
Zinc and prostatic cancer. Curr Opin Clin Nutr Metab Care (2009) 0.94
Zinc and cancer: implications for LIV-1 in breast cancer. Nutrients (2012) 0.91
Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function. Nutrients (2015) 0.90
Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc Natl Acad Sci U S A (2013) 0.90
Dietary zinc restriction and repletion affects DNA integrity in healthy men. Am J Clin Nutr (2009) 0.88
Altered antioxidant status and increased lipid per-oxidation in seminal plasma of tunisian infertile men. Int J Biol Sci (2011) 0.88
Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exercise. Free Radic Biol Med (2009) 0.88
Dietary regulation of Keap1/Nrf2/ARE pathway: focus on plant-derived compounds and trace minerals. Nutrients (2014) 0.87
Plasma copper and zinc concentration in individuals with autism correlate with selected symptom severity. Nutr Metab Insights (2012) 0.86
Cellular mechanisms of zinc dysregulation: a perspective on zinc homeostasis as an etiological factor in the development and progression of breast cancer. Nutrients (2012) 0.86
Low extracellular zinc increases neuronal oxidant production through nadph oxidase and nitric oxide synthase activation. Free Radic Biol Med (2010) 0.85
Cytosolic superoxide dismutase (SOD1) is critical for tolerating the oxidative stress of zinc deficiency in yeast. PLoS One (2009) 0.84
Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa. PLoS Genet (2014) 0.84
Hibiscus sabdariffa Leaf Extract Inhibits Human Prostate Cancer Cell Invasion via Down-Regulation of Akt/NF-kB/MMP-9 Pathway. Nutrients (2015) 0.83
Increasing longevity by tuning up metabolism. To maximize human health and lifespan, scientists must abandon outdated models of micronutrients. EMBO Rep (2005) 0.83
Trace elements in diabetic cardiomyopathy: An electrophysiological overview. World J Diabetes (2013) 0.83
Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake. J Nucleic Acids (2010) 0.82
Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc. Eur J Nutr (2011) 0.82
The immunological contribution of NF-κB within the tumor microenvironment: a potential protective role of zinc as an anti-tumor agent. Biochim Biophys Acta (2011) 0.82
Zinc and gastrointestinal disease. World J Gastrointest Pathophysiol (2014) 0.82
Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism. Biomark Insights (2011) 0.82
Zinc distribution within breast cancer tissue: A possible marker for histological grading? J Cancer Res Clin Oncol (2015) 0.81
Decreased zinc and increased copper in individuals with anxiety. Nutr Metab Insights (2011) 0.81
Toenail zinc level and gastric cancer risk in Cali, Colombia. J Cancer Res Clin Oncol (2007) 0.80
Comparative genomic analysis of slc39a12/ZIP12: insight into a zinc transporter required for vertebrate nervous system development. PLoS One (2014) 0.80
Zinc deficiency and neurodevelopment: the case of neurons. Biofactors (2010) 0.80
The influence of micronutrients in cell culture: a reflection on viability and genomic stability. Biomed Res Int (2013) 0.80
Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease. Nutr Metab Insights (2011) 0.80
A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations. Am J Clin Nutr (2016) 0.80
Zinc: a promising agent in dietary chemoprevention of cancer. Indian J Med Res (2010) 0.79
Gene expression profiling in hepatic tissue of newly weaned pigs fed pharmacological zinc and phytase supplemented diets. BMC Genomics (2008) 0.79
Zinc supplementation reduced DNA breaks in Ethiopian women. Nutr Res (2014) 0.79
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. Carcinogenesis (2012) 0.79
Zinc in Early Life: A Key Element in the Fetus and Preterm Neonate. Nutrients (2015) 0.78
Prediction of Zn concentration in human seminal plasma of Normospermia samples by Artificial Neural Networks (ANN). J Assist Reprod Genet (2013) 0.78
Analysis of plasma zinc and copper concentration, and perceived symptoms, in individuals with depression, post zinc and anti-oxidant therapy. Nutr Metab Insights (2011) 0.78
Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control. Genome Integr (2010) 0.78
Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis. Sci Rep (2016) 0.78
Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells. DNA Repair (Amst) (2011) 0.77
Burn-induced oxidative stress is altered by a low zinc status: kinetic study in burned rats fed a low zinc diet. Biol Trace Elem Res (2008) 0.77
Zinc deficiency or excess within the physiological range increases genome instability and cytotoxicity, respectively, in human oral keratinocyte cells. Genes Nutr (2011) 0.77
Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets. PLoS One (2017) 0.75
Zinc transporters are differentially expressed in human non-small cell lung cancer. Oncotarget (2016) 0.75
Zinc Transport Differs in Rat Spermatogenic Cell Types and Is Affected by Treatment with Cyclophosphamide. Biol Reprod (2016) 0.75
Zinc transporters and dysregulated channels in cancers. Front Biosci (Landmark Ed) (2017) 0.75
Genomic instability related to zinc deficiency and excess in an in vitro model: is the upper estimate of the physiological requirements recommended for children safe? In Vitro Cell Dev Biol Anim (2017) 0.75
p53 mutations in human cancers. Science (1991) 31.96
p53, the cellular gatekeeper for growth and division. Cell (1997) 31.04
A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res (1988) 17.88
Cancer. p53, guardian of the genome. Nature (1992) 16.36
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science (1994) 13.51
Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol (1994) 8.98
AP-1 in cell proliferation and survival. Oncogene (2001) 6.07
Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase. J Biol Chem (1970) 4.85
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A (1997) 4.38
The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots. Genes Dev (1993) 3.99
Going APE over ref-1. Mutat Res (2000) 3.63
ALS, SOD and peroxynitrite. Nature (1993) 2.64
The antioxidant properties of zinc. J Nutr (2000) 2.51
Nitric-oxide synthase assays. Methods Enzymol (1994) 2.19
Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite. J Neurochem (1997) 2.13
DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res (2001) 2.09
Zinc homeostasis in humans. J Nutr (2000) 2.03
Dietary intake, dietary patterns, and changes with age: an epidemiological perspective. J Gerontol A Biol Sci Med Sci (2001) 1.67
Adenocarcinomas of the esophagus and gastric cardia: the role of diet. Nutr Cancer (1997) 1.59
Superoxide dismutase and the death of motoneurons in ALS. Trends Neurosci (2001) 1.58
Zinc: health effects and research priorities for the 1990s. Environ Health Perspect (1994) 1.42
Are vitamin and mineral deficiencies a major cancer risk? Nat Rev Cancer (2002) 1.34
Zinc deficiency and child development. Am J Clin Nutr (1998) 1.28
Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. J Nutr (1995) 1.24
Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells. Oncogene (2000) 1.21
Dietary zinc deficiency enhances esophageal cell proliferation and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in C57BL/6 mouse. Cancer Lett (1999) 1.17
Zinc and cognitive development. Br J Nutr (2001) 1.15
Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc. J Natl Cancer Inst (2001) 1.14
The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer. Anticancer Res (1998) 1.13
Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells. Free Radic Biol Med (2000) 1.08
Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas. Oncol Rep (2001) 1.08
History of zinc as related to brain function. J Nutr (2000) 1.08
Zinc binding and redox control of p53 structure and function. Antioxid Redox Signal (2001) 1.05
Determination of standard zinc values in the intact tissues of mice by ICP spectrometry. Biol Trace Elem Res (1997) 1.01
Nutritional and zinc status of head and neck cancer patients: an interpretive review. J Am Coll Nutr (1998) 1.01
Low intracellular zinc impairs the translocation of activated NF-kappa B to the nuclei in human neuroblastoma IMR-32 cells. J Biol Chem (2002) 0.99
Breast carcinoma and the role of iron metabolism. A cytochemical, tissue culture, and ultrastructural study. Ann N Y Acad Sci (1993) 0.97
Effects of zinc and nutritional status on clinical outcomes in head and neck cancer. Nutrition (1998) 0.97
Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation, and mutations in H-ras and p53 genes. Carcinogenesis (1997) 0.96
Zinc status affects p53, gadd45, and c-fos expression and caspase-3 activity in human bronchial epithelial cells. Am J Physiol Cell Physiol (2001) 0.94
Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract. Eur J Clin Nutr (2001) 0.93
Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas. J Pediatr Hematol Oncol (2001) 0.93
Copper and zinc deficiencies in association with depression and neurological findings. Biol Psychiatry (1983) 0.92
Oxidant defense systems in testes from zinc-deficient rats. Proc Soc Exp Biol Med (1996) 0.92
Human APE/Ref-1 protein. Int J Biochem Cell Biol (2000) 0.92
Paracelsus to parascience: the environmental cancer distraction. Mutat Res (2000) 0.91
The role of zinc in the growth and development of children. Nutrition (2002) 0.87
Maternal dietary zinc influences DNA strand break and 8-hydroxy-2'-deoxyguanosine levels in infant rhesus monkey liver. Proc Soc Exp Biol Med (1993) 0.84
Esophageal zinc content in human squamous esophageal cancer. J Am Coll Nutr (1987) 0.83
Zinc deficiency exacerbates loss in blood-brain barrier integrity induced by hyperoxia measured by dynamic MRI. Proc Soc Exp Biol Med (2000) 0.80
Esophageal carcinogenesis in the rat: zinc deficiency, DNA methylation and alkyltransferase activity. Pathobiology (1997) 0.78
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 2.28
Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr (2005) 2.21
Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J (2007) 2.17
Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J (2003) 2.14
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr (2007) 2.05
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proc Natl Acad Sci U S A (2002) 1.93
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell (2013) 1.71
gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci U S A (2004) 1.52
Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free Radic Biol Med (2002) 1.46
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A (2002) 1.46
Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB J (2007) 1.44
Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci (2002) 1.42
Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Natl Acad Sci U S A (2002) 1.41
Unusual clustering of coefficients of variation in published articles from a medical biochemistry department in India. FASEB J (2008) 1.39
Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann N Y Acad Sci (2002) 1.36
Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci U S A (2002) 1.29
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J Nutr (2003) 1.25
Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol (2004) 1.24
The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr (2005) 1.24
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci (2007) 1.24
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr (2009) 1.20
The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age. Arch Biochem Biophys (2002) 1.18
An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring. Neurosci Biobehav Rev (2006) 1.12
Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease. Nutr Neurosci (2005) 1.10
(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci (2005) 1.06
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. J Neurol Sci (2009) 1.04
Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol. Free Radic Biol Med (2007) 1.00
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. J Cell Mol Med (2008) 0.98
Analysis of plasma tocopherols alpha, gamma, and 5-nitro-gamma in rats with inflammation by HPLC coulometric detection. J Lipid Res (2002) 0.98
Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms. Ann N Y Acad Sci (2004) 0.96
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res (2008) 0.96
Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proc Natl Acad Sci U S A (2008) 0.95
Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes. Anal Biochem (2004) 0.94
Enough is enough. Ann Intern Med (2014) 0.94
Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats. Toxicol Pathol (2009) 0.94
5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay. J Biol Chem (2003) 0.91
Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging. FASEB J (2011) 0.90
Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. FASEB J (2003) 0.89
Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxid Redox Signal (2003) 0.89
Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells. J Nutr Biochem (2011) 0.89
Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci (2004) 0.89
A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes. FASEB J (2004) 0.89
Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts. J Nutr (2007) 0.88
Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes. J Nutr (2003) 0.87
A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial. FASEB J (2012) 0.86
Iron accumulation during cellular senescence. Ann N Y Acad Sci (2004) 0.86
An assay for uracil in human DNA at baseline: effect of marginal vitamin B6 deficiency. Anal Biochem (2007) 0.85
A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects. J Nutr Biochem (2008) 0.84
Daily supplementation with iron increases lipid peroxidation in young women with low iron stores. Exp Biol Med (Maywood) (2008) 0.83
N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration. FASEB J (2007) 0.83
Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status. Mutagenesis (2011) 0.83
The role of Fe2+-induced lipid peroxidation in the initiation of the mitochondrial permeability transition. Arch Biochem Biophys (2003) 0.82
Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.81
Measuring chromosome breaks in patients with thalassemia. Ann N Y Acad Sci (2005) 0.81
Fe(2+) induces a transient Ca(2+) release from rat liver mitochondria. Arch Biochem Biophys (2002) 0.80
Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough. Am J Clin Nutr (2007) 0.80
Chronic ethanol perturbs testicular folate metabolism and dietary folate deficiency reduces sex hormone levels in the Yucatan micropig. Biol Reprod (2006) 0.79
5-Methyltetrahydrofolate inhibits photosensitization reactions and strand breaks in DNA. FASEB J (2007) 0.78
Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. Redox Rep (2008) 0.76