Published in Arch Intern Med on October 27, 2008
Effect of Simvastatin on Pneumonia Prognosis in Elderly Patients | NCT01651728
Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med (2009) 2.52
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med (2011) 2.40
Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe (2010) 2.28
Risk factors for community-acquired pneumonia in adults in Europe: a literature review. Thorax (2013) 1.92
Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv (2010) 1.78
Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. J Clin Invest (2010) 1.44
Sterols and oxysterols in immune cell function. Nat Immunol (2013) 1.41
Beneficial effects of perioperative statins for major pulmonary resection. J Thorac Cardiovasc Surg (2014) 1.38
The effect of rosuvastatin on incident pneumonia: results from the JUPITER trial. CMAJ (2012) 1.36
Marked reduction in 30-day mortality among elderly patients with community-acquired pneumonia. Am J Med (2011) 1.36
Simvastatin attenuates ventilator-induced lung injury in mice. Crit Care (2010) 1.34
Statin use and risk of community acquired pneumonia in older people: population based case-control study. BMJ (2009) 1.30
Mechanisms of neutrophil accumulation in the lungs against bacteria. Am J Respir Cell Mol Biol (2009) 1.28
Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis. Crit Care (2011) 1.23
Meeting the challenge of influenza pandemic preparedness in developing countries. Emerg Infect Dis (2009) 1.22
Neutrophil extracellular traps - the dark side of neutrophils. J Clin Invest (2016) 1.19
Association between use of HMG CoA reductase inhibitors and mortality in HIV-infected patients. PLoS One (2011) 1.12
Influenza morbidity and mortality in elderly patients receiving statins: a cohort study. PLoS One (2009) 1.11
Association between statins given in hospital and mortality in pneumonia patients. J Gen Intern Med (2011) 1.08
Preadmission statin use and one-year mortality among patients in intensive care - a cohort study. Crit Care (2010) 1.07
Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure. Crit Care (2012) 1.07
Statin treatment and mortality in bacterial infections--a systematic review and meta-analysis. PLoS One (2010) 1.05
Statins for community-acquired pneumonia: current state of the science. Eur J Clin Microbiol Infect Dis (2009) 0.99
The impact of statin use on pneumonia risk and outcome: a combined population-based case-control and cohort study. Crit Care (2012) 0.99
Emerging roles for cholesterol and lipoproteins in lung disease. Pulm Pharmacol Ther (2012) 0.97
The role of statins in prevention and treatment of community acquired pneumonia: a systematic review and meta-analysis. PLoS One (2013) 0.96
Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality. PLoS One (2012) 0.95
Effect of statin therapy on mortality from infection and sepsis: a meta-analysis of randomized and observational studies. Crit Care (2014) 0.92
Risk of pneumonia in patients taking statins: population-based nested case-control study. Br J Gen Pract (2011) 0.90
Statins in the critically ill. Ann Intensive Care (2012) 0.90
The effect of rosuvastatin in a murine model of influenza A infection. PLoS One (2012) 0.89
Community-acquired pneumonia in elderly patients. Aging health (2009) 0.88
Statin therapy as prevention against development of acute respiratory distress syndrome: an observational study. Crit Care Med (2012) 0.86
Pre-existing atrial fibrillation and risk of arterial thromboembolism and death following pneumonia: a population-based cohort study. BMJ Open (2014) 0.86
Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells. Clin Exp Immunol (2012) 0.85
Statins in candidemia: clinical outcomes from a matched cohort study. BMC Infect Dis (2010) 0.83
Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis. BMC Med (2016) 0.83
Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target. Elife (2014) 0.82
Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study. Eur J Clin Microbiol Infect Dis (2014) 0.81
The effect of simvastatin on inflammatory cytokines in community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. BMJ Open (2015) 0.80
Effect of statin use on outcomes of adults with candidemia. PLoS One (2013) 0.79
Targeting the host to control an infection disorder. Arch Intern Med (2008) 0.77
Preadmission use of statins in patients with pneumonia. Arch Intern Med (2009) 0.75
The association of prior statin use in septic shock treated with early goal directed therapy. Eur J Emerg Med (2012) 0.75
Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia: a pilot study. Univ Louisville J Respir Infect (2017) 0.75
Statin Potency and the Risk of Hospitalization for Community-Acquired Pneumonia. Br J Clin Pharmacol (2016) 0.75
Year in review 2012: Critical Care--management. Crit Care (2013) 0.75
The best of respiratory infections from the 2015 European Respiratory Society International Congress. ERJ Open Res (2016) 0.75
Pediatric Statin Administration: Navigating a Frontier with Limited Data. J Pediatr Pharmacol Ther (2016) 0.75
The Effect of Simvastatin on Pulmonary Damage in Experimental Peritonitis in Rats. Indian J Surg (2013) 0.75
The role of statins in the setting of HIV infection. Curr HIV/AIDS Rep (2015) 0.75
Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target? Intensive Care Med Exp (2014) 0.75
Pleiotropic effects of statins on acute kidney injury: involvement of Krüppel-like factor 4. Clin Exp Nephrol (2016) 0.75
The predictive value of ICD-10 diagnostic coding used to assess Charlson comorbidity index conditions in the population-based Danish National Registry of Patients. BMC Med Res Methodol (2011) 4.54
Cancer risk among statin users: a population-based cohort study. Int J Cancer (2005) 3.50
Ischemic heart disease in HIV-infected and HIV-uninfected individuals: a population-based cohort study. Clin Infect Dis (2007) 2.69
Statin use and mortality within 180 days after bacteremia: a population-based cohort study. Crit Care Med (2006) 2.16
Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study. PLoS Med (2009) 2.13
Registration in the danish hip arthroplasty registry: completeness of total hip arthroplasties and positive predictive value of registered diagnosis and postoperative complications. Acta Orthop Scand (2004) 2.07
Diabetes mellitus and pyogenic liver abscess: risk and prognosis. Clin Infect Dis (2007) 2.01
Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention. Eur Heart J (2013) 2.00
Risk of hospitalization for myocardial infarction among users of rofecoxib, celecoxib, and other NSAIDs: a population-based case-control study. Arch Intern Med (2005) 1.98
Diabetes, glycemic control, and risk of hospitalization with pneumonia: a population-based case-control study. Diabetes Care (2008) 1.97
Therapeutic drug use in women with Crohn's disease and birth outcomes: a Danish nationwide cohort study. Am J Gastroenterol (2007) 1.95
Socioeconomic gradient in use of statins among Danish patients: population-based cross-sectional study. Br J Clin Pharmacol (2005) 1.89
Predictive value and completeness of the registration of congenital abnormalities in three Danish population-based registries. Scand J Public Health (2003) 1.82
Nontuberculous pulmonary mycobacteriosis in Denmark: incidence and prognostic factors. Am J Respir Crit Care Med (2009) 1.73
Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. Gut (2011) 1.70
Type 2 diabetes and pneumonia outcomes: a population-based cohort study. Diabetes Care (2007) 1.64
An internet-based prospective study of body size and time-to-pregnancy. Hum Reprod (2009) 1.64
Short-term mortality in relation to age and comorbidity in older adults with community-acquired bacteremia: a population-based cohort study. J Am Geriatr Soc (2008) 1.63
Cohort profile: the Danish Web-based Pregnancy Planning Study--'Snart-Gravid'. Int J Epidemiol (2008) 1.62
Risk of congenital abnormalities in children born to women with ulcerative colitis: a population-based, case-control study. Am J Gastroenterol (2003) 1.60
Cohort profile: the Danish HIV cohort study. Int J Epidemiol (2008) 1.59
Chronic diseases requiring hospitalization and risk of non-melanoma skin cancers--a population based study from Denmark. J Invest Dermatol (2007) 1.57
Use of bisphosphonates among women and risk of atrial fibrillation and flutter: population based case-control study. BMJ (2008) 1.54
Fever of unknown origin and cancer: a population-based study. Lancet Oncol (2005) 1.52
Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drug Use and Colorectal Cancer Risk: A Population-Based, Case-Control Study. Ann Intern Med (2015) 1.50
Fish intake and acute coronary syndrome. Eur Heart J (2009) 1.48
Sex- and age-related differences in clinical outcome after primary percutaneous coronary intervention. EuroIntervention (2012) 1.42
Lack of observed association between high plasma osteoprotegerin concentrations and ischemic stroke risk in a healthy population. Clin Chem (2008) 1.41
Nonaspirin nonsteroidal anti-inflammatory drugs and risk of hospitalization for intracerebral hemorrhage: a population-based case-control study. Stroke (2003) 1.40
Preadmission metformin use and mortality among intensive care patients with diabetes: a cohort study. Crit Care (2013) 1.40
The impact of comorbidity on survival of Danish colorectal cancer patients from 1995 to 2006--a population-based cohort study. Dis Colon Rectum (2009) 1.39
Incidence of bone metastases and skeletal-related events in breast cancer patients: a population-based cohort study in Denmark. BMC Cancer (2011) 1.38
Desmopressin in the treatment of nocturia: a double-blind, placebo-controlled study. Eur Urol (2007) 1.30
Total hip arthroplasty in Denmark: incidence of primary operations and revisions during 1996-2002 and estimated future demands. Acta Orthop (2005) 1.29
Randomized trial of questionnaire length. Epidemiology (2009) 1.27
Diabetes mellitus as a risk and prognostic factor for community-acquired bacteremia due to enterobacteria: a 10-year, population-based study among adults. Clin Infect Dis (2005) 1.27
Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source. BMC Genet (2011) 1.25
Low mortality in HIV-infected patients starting highly active antiretroviral therapy: a comparison with the general population. AIDS (2004) 1.24
The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) study: expected outcome from the DD2 project and two intervention studies. Clin Epidemiol (2012) 1.24
Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study. Int J Epidemiol (2008) 1.22
Risk factors for revision due to infection after primary total hip arthroplasty. A population-based study of 80,756 primary procedures in the Danish Hip Arthroplasty Registry. Acta Orthop (2010) 1.21
Comparison of stent thrombosis, myocardial infarction, and mortality following drug-eluting versus bare-metal stent coronary intervention in patients with diabetes mellitus. Am J Cardiol (2008) 1.20
Self-management of oral anticoagulant therapy: a systematic review and meta-analysis. Int J Cardiol (2006) 1.19
In-hospital medical complications, length of stay, and mortality among stroke unit patients. Stroke (2011) 1.18
Nonsteroidal anti-inflammatory drug use and breast cancer risk: a Danish cohort study. Eur J Cancer Prev (2008) 1.18
Comorbidity and mortality following hip fracture: a population-based cohort study. Aging Clin Exp Res (2008) 1.15
Implant survival after primary total hip arthroplasty due to childhood hip disorders: results from the Danish Hip Arthroplasty Registry. Acta Orthop (2008) 1.14
Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study. Gastroenterology (2007) 1.13
Predictors for pathologically confirmed aortitis after resection of the ascending aorta: a 12-year Danish nationwide population-based cross-sectional study. Arthritis Res Ther (2011) 1.12
Diabetes, glycemic control, and risk of tuberculosis: a population-based case-control study. Diabetes Care (2011) 1.11
Glucocorticoid use and risk of atrial fibrillation or flutter: a population-based, case-control study. Arch Intern Med (2009) 1.11
Has directly observed treatment improved outcomes for patients with tuberculosis in southern Thailand? Trop Med Int Health (2002) 1.10
Antidepressants and risk of first-time hospitalization for myocardial infarction: a population-based case-control study. Am J Med (2004) 1.10
Guidelines: From artificial evolution to computational evolution: a research agenda. Nat Rev Genet (2006) 1.09
Quality of care and mortality among patients with stroke: a nationwide follow-up study. Med Care (2008) 1.09
Diabetes and 30-day mortality from peptic ulcer bleeding and perforation: a Danish population-based cohort study. Diabetes Care (2006) 1.08
Diabetes and outcome of community-acquired pneumococcal bacteremia: a 10-year population-based cohort study. Diabetes Care (2004) 1.08
SSRIs and upper gastrointestinal bleeding: what is known and how should it influence prescribing? CNS Drugs (2006) 1.08
Alcoholic cirrhosis in Denmark - population-based incidence, prevalence, and hospitalization rates between 1988 and 2005: a descriptive cohort study. BMC Gastroenterol (2008) 1.08
HbA1c in early diabetic pregnancy and pregnancy outcomes: a Danish population-based cohort study of 573 pregnancies in women with type 1 diabetes. Diabetes Care (2006) 1.07
Digoxin treatment is associated with an increased incidence of breast cancer: a population-based case-control study. Breast Cancer Res (2008) 1.07
Eighteen-year trends in stroke mortality and the prognostic influence of comorbidity. Neurology (2013) 1.07
Intake of fruit and vegetables and the risk of ischemic stroke in a cohort of Danish men and women. Am J Clin Nutr (2003) 1.05
Postterm delivery and risk for epilepsy in childhood. Pediatrics (2007) 1.04
Risk for hospital contact with infection in patients with splenectomy: a population-based cohort study. Ann Intern Med (2009) 1.04
Increase in incidence and prevalence of inflammatory bowel disease in northern Denmark: a population-based study, 1978-2002. Eur J Gastroenterol Hepatol (2006) 1.03
Socioeconomic differences in quality of care and clinical outcome after stroke: a nationwide population-based study. Stroke (2011) 1.03
Acetaminophen use during pregnancy: effects on risk for congenital abnormalities. Am J Obstet Gynecol (2008) 1.03
Patients' answers to simple questions about treatment satisfaction and adherence and depression are associated with failure of HAART: a cross-sectional survey. AIDS Patient Care STDS (2005) 1.02
Postoperative use of bisphosphonates and risk of revision after primary total hip arthroplasty: a nationwide population-based study. Bone (2010) 1.02
Risk of arterial cardiovascular diseases in patients with multiple sclerosis: a population-based cohort study. Neuroepidemiology (2010) 1.02
Quality of care and 30 day mortality among patients with hip fractures: a nationwide cohort study. BMC Health Serv Res (2009) 1.00
Use of acetaminophen during pregnancy and risk of adverse pregnancy outcomes. Int J Epidemiol (2009) 1.00
Short-term mortality after perforated or bleeding peptic ulcer among elderly patients: a population-based cohort study. BMC Geriatr (2007) 0.99
Effect of hydroxyapatite coating on risk of revision after primary total hip arthroplasty in younger patients: findings from the Danish Hip Arthroplasty Registry. Acta Orthop (2007) 0.99
A prospective study found impaired left ventricular function predicted job retirement after acute myocardial infarction. J Clin Epidemiol (2004) 0.99
Survival in Danish patients with breast cancer and inflammatory bowel disease: a nationwide cohort study. Inflamm Bowel Dis (2008) 0.99
Seasonal variation in meningococcal disease in Denmark: relation to age and meningococcal phenotype. Scand J Infect Dis (2003) 0.98
Gender differences in hospitalization rates for respiratory tract infections in Danish youth. Scand J Infect Dis (2004) 0.98