Published in PLoS One on May 19, 2010
Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med (2011) 1.77
Statin use and the risk of Clostridium difficile in academic medical centres. Gut (2012) 1.55
Studies on the antibacterial effects of statins--in vitro and in vivo. PLoS One (2011) 1.00
The role of statins in prevention and treatment of community acquired pneumonia: a systematic review and meta-analysis. PLoS One (2013) 0.96
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Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent. Sci Rep (2015) 0.89
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Risk of severe upper gastrointestinal complications among oral bisphosphonate users. PLoS One (2013) 0.75
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Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins. Chest (2007) 4.96
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Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis. Lancet (2006) 4.42
Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat Rev Drug Discov (2005) 3.92
Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study. BMJ (2006) 3.62
Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med (1995) 3.11
Preadmission use of statins and outcomes after hospitalization with pneumonia: population-based cohort study of 29,900 patients. Arch Intern Med (2008) 3.10
The effect of statins on mortality in patients with bacteremia. Clin Infect Dis (2001) 3.02
Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation (2004) 2.82
Statin therapy is associated with fewer deaths in patients with bacteraemia. Intensive Care Med (2005) 2.81
Statin use and sepsis events [corrected] in patients with chronic kidney disease. JAMA (2007) 2.69
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The effect of statin therapy on infection-related mortality in patients with atherosclerotic diseases. Crit Care Med (2007) 2.42
The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia. Respir Res (2005) 2.18
Statin use and mortality within 180 days after bacteremia: a population-based cohort study. Crit Care Med (2006) 2.16
Statins and cancer: A systematic review and meta-analysis. Eur J Cancer (2008) 2.15
Prior statin use is associated with improved outcomes in community-acquired pneumonia. Am J Med (2008) 2.14
Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials. Br J Clin Pharmacol (2008) 2.03
Statin therapy prior to ICU admission: protection against infection or a severity marker? Intensive Care Med (2005) 1.86
Impact of statins and angiotensin-converting enzyme inhibitors on mortality of subjects hospitalised with pneumonia. Eur Respir J (2007) 1.80
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. J Exp Med (2006) 1.69
The impact of statins, ACE inhibitors and gastric acid suppressants on pneumonia mortality in a UK general practice population cohort. Pharmacoepidemiol Drug Saf (2009) 1.69
Statins and the risk of pneumonia: a population-based, nested case-control study. Pharmacotherapy (2007) 1.61
Statin treatment and reduced risk of pneumonia in patients with diabetes. Thorax (2006) 1.60
Preoperative statin intake and morbid events after isolated coronary artery bypass grafting. J Clin Anesth (2008) 1.53
The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis. Atherosclerosis (2008) 1.52
Statins for sepsis: a critical and updated review. Clin Microbiol Infect (2009) 1.43
Risk of community-acquired pneumonia and the use of statins, ace inhibitors and gastric acid suppressants: a population-based case-control study. Pharmacoepidemiol Drug Saf (2009) 1.37
Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial. Eur J Neurol (2007) 1.32
Statin use and risk of community acquired pneumonia in older people: population based case-control study. BMJ (2009) 1.30
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol (2008) 1.27
Association of statin therapy and increased survival in patients with multiple organ dysfunction syndrome. Intensive Care Med (2006) 1.15
Reduction in mortality associated with statin therapy in patients with severe sepsis. Pharmacotherapy (2009) 1.15
Influenza morbidity and mortality in elderly patients receiving statins: a cohort study. PLoS One (2009) 1.11
Preoperative statins and infectious complications following cardiac surgery. Curr Med Res Opin (2007) 1.09
Statin therapy is associated with decreased mortality in patients with infection. Acad Emerg Med (2009) 1.07
Effectiveness of statins in reducing the rate of severe sepsis: a retrospective evaluation. Pharmacotherapy (2007) 1.05
Graft-versus-host disease: suppression by statins. Nat Med (2008) 1.05
Decrease in mortality rate of chronic obstructive pulmonary disease (COPD) with statin use: a population-based analysis in Japan. Tohoku J Exp Med (2007) 1.04
Impact of previous statin and angiotensin II receptor blocker use on mortality in patients hospitalized with sepsis. Pharmacotherapy (2007) 0.99
Effects of acute pravastatin treatment on intensity of rescue therapy, length of inpatient stay, and 6-month outcome in patients after aneurysmal subarachnoid hemorrhage. Stroke (2007) 0.96
An assessment of the effect of statin use on the incidence of acute respiratory infections in England during winters 1998-1999 to 2005-2006. Epidemiol Infect (2010) 0.93
Effect of atorvastatin versus rosuvastatin on levels of serum lipids, inflammatory markers and adiponectin in patients with hypercholesterolemia. Pharm Res (2008) 0.93
Statins are associated with improved outcomes of bloodstream infection in solid-organ transplant recipients. Eur J Clin Microbiol Infect Dis (2009) 0.93
Preoperative statin use and infection after cardiac surgery: a cohort study. Clin Infect Dis (2009) 0.91
Statins do not improve short-term survival in an oriental population with sepsis. Am J Emerg Med (2007) 0.91
Achieving and maintaining National Cholesterol Education Program low-density lipoprotein cholesterol goals with five statins. Am J Med (2001) 0.89
Statin use and the risk of surgical site infections in elderly patients undergoing elective surgery. Arch Surg (2009) 0.87
Statin use does not affect the outcome of acute infection: a prospective cohort study. Presse Med (2010) 0.87
HMG CoA reductase inhibitors (statins) for kidney transplant recipients. Cochrane Database Syst Rev (2009) 0.85
Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis. J Trauma (2009) 0.83
Influence of statins on postoperative wound complications after inguinal or ventral herniorrhaphy. Hernia (2005) 0.82
Chromatography-tandem mass spectrometry method for the simultaneous quantitation of metoprolol succinate and simvastatin in human plasma. J Pharm Biomed Anal (2008) 0.76
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med (2006) 5.20
Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock. Crit Care Med (2005) 3.58
HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood (2006) 2.95
The largest prospective warfarin-treated cohort supports genetic forecasting. Blood (2008) 2.79
Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. Clin Infect Dis (2003) 2.54
Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients. Proc Natl Acad Sci U S A (2006) 2.08
Impact of cytochrome P450 2C19 polymorphisms on citalopram/escitalopram exposure: a systematic review and meta-analysis. Clin Pharmacokinet (2014) 2.08
Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells. J Virol (2005) 1.97
CD46 in meningococcal disease. Science (2003) 1.84
Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. J Infect Dis (2005) 1.80
Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci U S A (2006) 1.75
Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood (2012) 1.69
Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection. AIDS (2002) 1.67
Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One (2013) 1.53
Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection. J Immunol (2004) 1.46
Immunoglobulin G treatment of postcardiac surgery patients with score-identified severe systemic inflammatory response syndrome--the ESSICS study. Crit Care Med (2008) 1.42
A clinically significant interaction between warfarin and simvastatin is unique to carriers of the CYP2C9*3 allele. Pharmacogenomics (2012) 1.42
HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation. Blood (2004) 1.42
The development of autoimmune features in aging mice is closely associated with alterations of the peripheral CD4⁺ T-cell compartment. Eur J Immunol (2014) 1.40
Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock. Crit Care Med (2007) 1.39
Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy. Thromb Haemost (2011) 1.35
Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open (2012) 1.34
Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection. J Virol (2007) 1.32
rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector. PLoS One (2008) 1.31
Early immune activation in gut-associated and peripheral lymphoid tissue during acute HIV infection. AIDS (2007) 1.28
Local immune responses in human tuberculosis: learning from the site of infection. J Infect Dis (2012) 1.27
Antimicrobial peptides in the first line defence of human colon mucosa. Peptides (2003) 1.24
Metformin for weight reduction in non-diabetic patients on antipsychotic drugs: a systematic review and meta-analysis. J Psychopharmacol (2010) 1.22
Mobius sequence--a Swedish multidiscipline study. Eur J Paediatr Neurol (2002) 1.20
CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. Eur J Immunol (2007) 1.20
Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions. Am J Pathol (2009) 1.17
Parallel decline of CD8+/CD38++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection. AIDS (2002) 1.14
Abundant expression of HIV target cells and C-type lectin receptors in the foreskin tissue of young Kenyan men. Am J Pathol (2010) 1.13
Upregulation of interferon-alpha and RANTES in the cervix of HIV-1-seronegative women with high-risk behavior. J Acquir Immune Defic Syndr (2006) 1.09
Problematic interpersonal relationships at work and depression: a Swedish prospective cohort study. J Occup Health (2009) 1.09
Abundant and superficial expression of C-type lectin receptors in ectocervix of women at risk of HIV infection. J Acquir Immune Defic Syndr (2009) 1.05
Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy. PLoS One (2011) 1.04
Rapid diagnosis of active tuberculosis by detecting antibodies from lymphocyte secretions. J Infect Dis (2003) 1.02
Studies on the antibacterial effects of statins--in vitro and in vivo. PLoS One (2011) 1.00
Detection of antibodies secreted from circulating Mycobacterium tuberculosis-specific plasma cells in the diagnosis of pediatric tuberculosis. Clin Vaccine Immunol (2009) 1.00
Human-like immune responses in CD46 transgenic mice. J Immunol (2005) 1.00
What is a relevant statin concentration in cell experiments claiming pleiotropic effects? Br J Clin Pharmacol (2011) 1.00
Pattern recognition in pulmonary tuberculosis defined by high content peptide microarray chip analysis representing 61 proteins from M. tuberculosis. PLoS One (2008) 1.00
Adjunct immunotherapies for tuberculosis. J Infect Dis (2012) 0.99
Do regulatory T-cells play a role in AIDS pathogenesis? AIDS Rev (2006) 0.99
Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections. J Leukoc Biol (2012) 0.99
Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner. Virology (2003) 0.98
ELISpot analysis of LPS-stimulated leukocytes: human granulocytes selectively secrete IL-8, MIP-1beta and TNF-alpha. J Immunol Methods (2009) 0.98
Effect of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis. Am J Clin Nutr (2004) 0.97
Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184. Eur J Nucl Med Mol Imaging (2009) 0.97
Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2. Infect Immun (2002) 0.97
HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques. AIDS (2009) 0.97
Human monocytes promote Th1 and Th17 responses to Streptococcus pneumoniae. Infect Immun (2011) 0.96
Antiviral therapy in children with hydroa vacciniforme. Acta Derm Venereol (2009) 0.95
Therapeutic drug monitoring for tomorrow. Eur J Clin Pharmacol (2013) 0.95
Identification of clinical Pasteurella isolates by MALDI-TOF -- a comparison with VITEK 2 and conventional microbiological methods. Diagn Microbiol Infect Dis (2013) 0.95
Molecular mechanisms guiding late stages of B-cell development. Immunol Rev (2004) 0.95
Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity. J Immunol Methods (2009) 0.95
Endogenous inhibitors of HIV: potent anti-HIV activity of leukemia inhibitory factor. Curr Mol Med (2002) 0.95
Association between tuberculin skin test reactivity, the memory CD4 cell subset, and circulating FoxP3-expressing cells in HIV-infected persons. J Infect Dis (2009) 0.94
Use of antibodies in lymphocyte secretions for detection of subclinical tuberculosis infection in asymptomatic contacts. Clin Diagn Lab Immunol (2004) 0.93
Preclinical characterization of a novel class of 18F-labeled PET tracers for amyloid-β. J Nucl Med (2012) 0.93
[11C]AZ10419369: a selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain. Neuroimage (2008) 0.93
Persistence of mucosal mast cells and eosinophils in Shigella-infected children. Infect Immun (2003) 0.92
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Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects. EJNMMI Res (2012) 0.91
Proinflammatory and type 1 cytokine expression in cervical mucosa during HIV-1 and human papillomavirus infection. J Acquir Immune Defic Syndr (2007) 0.91
Discovery and labeling of high-affinity 3,4-diarylpyrazolines as candidate radioligands for in vivo imaging of cannabinoid subtype-1 (CB1) receptors. J Med Chem (2008) 0.91
Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain. J Cereb Blood Flow Metab (2010) 0.89
Specificity in killing pathogens is mediated by distinct repertoires of human neutrophil peptides. J Innate Immun (2010) 0.89
A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties. Eur J Immunol (2010) 0.89
HMGB1 activates replication of latent HIV-1 in a monocytic cell-line, but inhibits HIV-1 replication in primary macrophages. Cytokine (2006) 0.88
Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial. BMC Infect Dis (2012) 0.88
Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells. J Immunol (2002) 0.88
CMV-associated encephalitis and antineuronal autoantibodies--a case report. BMC Neurol (2012) 0.87
Compensating strategies in collaborative remembering in very old couples. Scand J Psychol (2005) 0.87
Validation of the ALS assay in adult patients with culture confirmed pulmonary tuberculosis. PLoS One (2011) 0.86
BCG-specific IgG-secreting peripheral plasmablasts as a potential biomarker of active tuberculosis in HIV negative and HIV positive patients. Thorax (2012) 0.86
Prime-boost vaccination with rBCG/rAd35 enhances CD8⁺ cytolytic T-cell responses in lesions from Mycobacterium tuberculosis-infected primates. Mol Med (2012) 0.85
Developmental disorders in larvae of eelpout (Zoarces viviparus) from German and Swedish Baltic coastal waters. Mar Pollut Bull (2005) 0.85
Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. Genomics (2005) 0.84
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Immunomodulatory effects of vitamin D on innate and adaptive immune responses to Streptococcus pneumoniae. J Infect Dis (2013) 0.84
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Battle and balance at mucosal surfaces--the story of Shigella and antimicrobial peptides. Biochem Biophys Res Commun (2010) 0.84
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A new potential biomarker for childhood tuberculosis. Thorax (2011) 0.83
Plasma levels of 25-hydroxyvitamin D3 and in vivo markers of cytochrome P450 3A activity in Swedes and Koreans: effects of a genetic polymorphism and oral contraceptives. Basic Clin Pharmacol Toxicol (2014) 0.82
Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosis. Am J Clin Nutr (2005) 0.82
In interleukin-7-transgenic mice, increasing B lymphopoiesis increases follicular but not marginal zone B cell numbers. Eur J Immunol (2003) 0.81
Determination of cytomegalovirus DNA load for monitoring of cytomegalovirus disease and antiviral treatment in solid organ transplant patients, comparing limiting-dilution PCR and hybrid capture assay with cytomegalovirus isolation. Clin Microbiol Infect (1999) 0.81