Published in Nat Struct Mol Biol on November 09, 2008
Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov (2010) 2.90
Common themes in the design and function of bacterial effectors. Cell Host Microbe (2009) 2.50
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Nat Commun (2013) 2.10
Legionella metaeffector exploits host proteasome to temporally regulate cognate effector. PLoS Pathog (2010) 2.09
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science (2010) 1.77
The role of ubiquitylation in immune defence and pathogen evasion. Nat Rev Immunol (2011) 1.76
A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases. Proc Natl Acad Sci U S A (2009) 1.70
A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. Nat Cell Biol (2009) 1.60
Epigenetics and bacterial infections. Cold Spring Harb Perspect Med (2012) 1.56
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism. Structure (2013) 1.48
Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligases. Curr Opin Microbiol (2009) 1.23
Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase. Proc Natl Acad Sci U S A (2010) 1.20
Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxin. J Biol Chem (2009) 1.16
NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases. PLoS Pathog (2010) 1.16
The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence. Infect Immun (2010) 1.14
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis. EMBO J (2010) 1.14
Subversion of cell signaling by pathogens. Cold Spring Harb Perspect Biol (2012) 1.08
The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3. J Biol Chem (2010) 1.04
The Shigella type three secretion system effector OspG directly and specifically binds to host ubiquitin for activation. PLoS One (2013) 1.04
Yersinia virulence factor YopM induces sustained RSK activation by interfering with dephosphorylation. PLoS One (2010) 1.02
A pathogen type III effector with a novel E3 ubiquitin ligase architecture. PLoS Pathog (2013) 0.99
BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300. Cancer Res (2012) 0.97
Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7. J Biol Chem (2010) 0.96
Shigella IpaH0722 E3 ubiquitin ligase effector targets TRAF2 to inhibit PKC-NF-κB activity in invaded epithelial cells. PLoS Pathog (2013) 0.95
Exploitation of the ubiquitin system by invading bacteria. Traffic (2010) 0.95
Five mechanisms of manipulation by bacterial effectors: a ubiquitous theme. PLoS Pathog (2012) 0.94
Middle-down mass spectrometry enables characterization of branched ubiquitin chains. Biochemistry (2014) 0.92
Bacteria-host relationship: ubiquitin ligases as weapons of invasion. Cell Res (2016) 0.92
The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. PLoS One (2011) 0.91
Stability of thioester intermediates in ubiquitin-like modifications. Protein Sci (2009) 0.91
Amoebal endosymbiont Neochlamydia genome sequence illuminates the bacterial role in the defense of the host amoebae against Legionella pneumophila. PLoS One (2014) 0.91
Conserved structural mechanisms for autoinhibition in IpaH ubiquitin ligases. J Biol Chem (2011) 0.89
Phylogenomic network and comparative genomics reveal a diverged member of the ΦKZ-related group, marine vibrio phage ΦJM-2012. J Virol (2013) 0.88
Functional analysis of NopM, a novel E3 ubiquitin ligase (NEL) domain effector of Rhizobium sp. strain NGR234. PLoS Pathog (2012) 0.86
Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc Natl Acad Sci U S A (2014) 0.86
Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligation. Nat Microbiol (2016) 0.86
Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase. Mol Cell Biol (2013) 0.85
Interactions of bacterial proteins with host eukaryotic ubiquitin pathways. Front Microbiol (2011) 0.84
Hell's BELs: bacterial E3 ligases that exploit the eukaryotic ubiquitin machinery. PLoS Pathog (2014) 0.83
Bacterial effector-involved temporal and spatial regulation by hijack of the host ubiquitin pathway. Front Microbiol (2011) 0.80
Complex structure of OspI and Ubc13: the molecular basis of Ubc13 deamidation and convergence of bacterial and host E2 recognition. PLoS Pathog (2013) 0.79
Bacterial effectors and their functions in the ubiquitin-proteasome system: insight from the modes of substrate recognition. Cells (2014) 0.79
Patterns of expression and translocation of the ubiquitin ligase SlrP in Salmonella enterica serovar Typhimurium. J Bacteriol (2014) 0.78
IS3 profiling identifies the enterohaemorrhagic Escherichia coli O-island 62 in a distinct enteroaggregative E. coli lineage. Gut Pathog (2011) 0.78
Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila. Structure (2015) 0.77
Shigella IpaH Family Effectors as a Versatile Model for Studying Pathogenic Bacteria. Front Cell Infect Microbiol (2016) 0.77
The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3. Cell Death Dis (2016) 0.76
Convergent evolution in the assembly of polyubiquitin degradation signals by the Shigella flexneri IpaH9.8 ligase. J Biol Chem (2014) 0.75
Implications of Spatiotemporal Regulation of Shigella flexneri Type Three Secretion Activity on Effector Functions: Think Globally, Act Locally. Front Cell Infect Microbiol (2016) 0.75
Distribution and Evolution of Yersinia Leucine-Rich Repeat Proteins. Infect Immun (2016) 0.75
Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases. Proc Natl Acad Sci U S A (2017) 0.75
GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8. Cell Host Microbe (2017) 0.75
Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Mediates Ubiquitination-Dependent STAT3 Activation upon Salmonella enterica Serovar Typhimurium Infection. Infect Immun (2017) 0.75
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell (2006) 10.10
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med (2013) 8.76
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature (2011) 6.21
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology (2008) 3.99
Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res (2005) 3.79
Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons. Nat Protoc (2007) 3.74
Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation (2013) 3.57
Identification of a bacterial type III effector family with G protein mimicry functions. Cell (2006) 3.47
Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs. Nat Med (2008) 3.28
Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors. Mol Pharmacol (2003) 3.22
The HBV drug entecavir - effects on HIV-1 replication and resistance. N Engl J Med (2007) 3.20
The phosphothreonine lyase activity of a bacterial type III effector family. Science (2007) 3.18
A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. Cell Host Microbe (2007) 3.15
Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1. J Virol (2004) 3.13
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest (2004) 2.95
Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection. J Virol (2002) 2.89
Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo. J Virol (2003) 2.78
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. J Clin Invest (2009) 2.75
Pore-forming activity and structural autoinhibition of the gasdermin family. Nature (2016) 2.71
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68
The multifactorial nature of HIV-1 latency. Trends Mol Med (2004) 2.68
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A (2011) 2.64
Mixture of new sulfated steroids functions as a migratory pheromone in the sea lamprey. Nat Chem Biol (2005) 2.34
Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. J Hepatol (2010) 2.33
Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity (2010) 2.32
Lithium diaqua-magnesium catena-borodiphosphate(V) monohydrate, LiMg(H(2)O)(2)[BP(2)O(8)]·H(2)O, at 173 K. Acta Crystallogr Sect E Struct Rep Online (2008) 2.28
The analysis of large-scale gene expression correlated to the phase changes of the migratory locust. Proc Natl Acad Sci U S A (2004) 2.26
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood (2008) 2.26
Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem (2003) 2.19
TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets. J Clin Invest (2012) 2.10
Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells. PLoS Pathog (2006) 2.08
An empirical assessment of long-branch attraction artefacts in deep eukaryotic phylogenomics. Syst Biol (2005) 2.02
Intranasal vaccination induces protective immunity against intranasal infection with virulent Francisella tularensis biovar A. Infect Immun (2005) 1.98
Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation. Proc Natl Acad Sci U S A (2013) 1.97
Characterization of a novicida-like subspecies of Francisella tularensis isolated in Australia. J Med Microbiol (2003) 1.97
Diabetes and poor outcomes within 6 months after acute ischemic stroke: the China National Stroke Registry. Stroke (2011) 1.91
The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. Int J Stroke (2011) 1.90
Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest (2006) 1.88
Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism. Blood (2008) 1.86
Heterotachy and long-branch attraction in phylogenetics. BMC Evol Biol (2005) 1.86
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell (2009) 1.84
Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K. J Gen Virol (2007) 1.84
Latency in human immunodeficiency virus type 1 infection: no easy answers. J Virol (2003) 1.83
Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood (2009) 1.81
Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res (Phila) (2010) 1.80
Lineage specification and plasticity in CD19- early B cell precursors. J Exp Med (2006) 1.80
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science (2010) 1.77
K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Res (2011) 1.72
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature (2013) 1.70
Laboratory analysis of tularemia in wild-trapped, commercially traded prairie dogs, Texas, 2002. Emerg Infect Dis (2004) 1.70
Synthetic lethal screen of an EGFR-centered network to improve targeted therapies. Sci Signal (2010) 1.64
Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem (2005) 1.64
Genotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cells. Behav Genet (2003) 1.64
Characterization of function and regulation of miR-24-1 and miR-31. Biochem Biophys Res Commun (2009) 1.60
Intrauterine growth restriction caused by underlying congenital cytomegalovirus infection. J Infect Dis (2014) 1.59
Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury. Hepatology (2003) 1.59
Chemokines and chemokine receptors: multipurpose players in neuroinflammation. Int Rev Neurobiol (2007) 1.56
Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing. Biochemistry (2004) 1.56
Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study. Stroke (2014) 1.53
High-performance, all-solution-processed organic nanowire transistor arrays with inkjet-printing patterned electrodes. Langmuir (2011) 1.52
Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Nature (2011) 1.50
Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer. BMC Cancer (2008) 1.50
Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J Clin Invest (2012) 1.50
Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Synapse (2003) 1.50
Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population. Int J Cancer (2010) 1.49
Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses. Cell (2012) 1.49
Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem (2011) 1.48
A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors. Proc Natl Acad Sci U S A (2009) 1.48
A pair of allelic WRKY genes play opposite roles in rice-bacteria interactions. Plant Physiol (2009) 1.47
Evaluation of GO-based functional similarity measures using S. cerevisiae protein interaction and expression profile data. BMC Bioinformatics (2008) 1.47
SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation. J Virol (2007) 1.47
Role of gamma-glutamyl transpeptidase in redox regulation of K+ channel remodeling in postmyocardial infarction rat hearts. Am J Physiol Cell Physiol (2009) 1.45
Bacterial expression of mutant argininosuccinate lyase reveals imperfect correlation of in-vitro enzyme activity with clinical phenotype in argininosuccinic aciduria. J Inherit Metab Dis (2011) 1.44
Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional Chinese medicine. Genome Biol (2011) 1.42
The association between IGF1 CA repeat polymorphisms and breast cancer risk: a meta-analysis. Breast Cancer Res Treat (2011) 1.42
miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β. Biochem Biophys Res Commun (2010) 1.42
Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism. Cancer Res (2009) 1.42
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev (2013) 1.40
Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. J Clin Invest (2009) 1.39
Permanent Genetic Resources added to Molecular Ecology Resources Database 1 August 2009-30 September 2009. Mol Ecol Resour (2010) 1.39