Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes.

PubWeight™: 1.50‹?› | Rank: Top 4%

🔗 View Article (PMC 3314446)

Published in J Clin Invest on March 19, 2012

Authors

Nicolas Skuli1, Amar J Majmundar, Bryan L Krock, Rickson C Mesquita, Lijoy K Mathew, Zachary L Quinn, Anja Runge, Liping Liu, Meeri N Kim, Jiaming Liang, Steven Schenkel, Arjun G Yodh, Brian Keith, M Celeste Simon

Author Affiliations

1: Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.

Articles citing this

HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. PLoS One (2016) 1.40

Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell Rep (2015) 1.17

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J Clin Invest (2014) 1.16

Angiogenesis in the infarcted myocardium. Antioxid Redox Signal (2012) 1.15

Human high-altitude adaptation: forward genetics meets the HIF pathway. Genes Dev (2014) 1.09

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development (2013) 1.07

Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation (2012) 1.06

miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proc Natl Acad Sci U S A (2013) 1.06

Endothelial cell-dependent regulation of arteriogenesis. Circ Res (2013) 1.00

Vascular endothelial growth factor signaling in hypoxia and inflammation. J Neuroimmune Pharmacol (2014) 0.99

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching. Proc Natl Acad Sci U S A (2013) 0.94

RSUME inhibits VHL and regulates its tumor suppressor function. Oncogene (2014) 0.94

Peritubular capillary rarefaction: a new therapeutic target in chronic kidney disease. Pediatr Nephrol (2013) 0.93

Molecular controls of arterial morphogenesis. Circ Res (2015) 0.91

Obstructive sleep apnea and cognitive impairment: addressing the blood-brain barrier. Sleep Med Rev (2013) 0.91

The ever-expanding role of HIF in tumour and stromal biology. Nat Cell Biol (2016) 0.89

A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism. J Biol Chem (2013) 0.89

Oxygen sensing mesenchymal progenitors promote neo-vasculogenesis in a humanized mouse model in vivo. PLoS One (2012) 0.87

Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells. Int J Mol Sci (2014) 0.87

Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2α activity. Cancer Discov (2013) 0.87

Systemic and Cerebral Vascular Endothelial Growth Factor Levels Increase in Murine Cerebral Malaria along with Increased Calpain and Caspase Activity and Can be Reduced by Erythropoietin Treatment. Front Immunol (2014) 0.84

Hypoxic signaling during tissue repair and regenerative medicine. Int J Mol Sci (2014) 0.84

CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J Am Soc Nephrol (2013) 0.82

ATP-binding cassette transporter Abcg2 lineage contributes to the cardiac vasculature after oxidative stress. Am J Physiol Heart Circ Physiol (2014) 0.81

Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation. Mol Cell Biol (2015) 0.81

HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo. Development (2015) 0.81

Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus. J Mol Med (Berl) (2013) 0.81

Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease. Sci Rep (2014) 0.81

Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model. J Clin Invest (2015) 0.81

Cells of renin lineage express hypoxia inducible factor 2α following experimental ureteral obstruction. BMC Nephrol (2016) 0.81

Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features. Adv Pharmacol (2013) 0.80

Despite normal arteriogenic and angiogenic responses, hind limb perfusion recovery and necrotic and fibroadipose tissue clearance are impaired in matrix metalloproteinase 9-deficient mice. J Vasc Surg (2014) 0.80

Overexpressed HIF-2α in Endothelial Cells Promotes Vascularization and Improves Random Pattern Skin Flap Survival. Plast Reconstr Surg Glob Open (2014) 0.79

Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer. PLoS Comput Biol (2015) 0.79

Tongxinluo inhibits cyclooxygenase-2, inducible nitric oxide synthase, hypoxia-inducible factor-2α/vascular endothelial growth factor to antagonize injury in hypoxia-stimulated cardiac microvascular endothelial cells. Chin Med J (Engl) (2015) 0.79

HIF-1α and HIF-2α: siblings in promoting angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation. PLoS One (2014) 0.79

Temporal cardiac remodeling post-myocardial infarction: dynamics and prognostic implications in personalized medicine. Heart Fail Rev (2015) 0.78

HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide. Sci Rep (2016) 0.78

Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model. PLoS One (2013) 0.77

When it is better to regress: dynamics of vascular pruning. PLoS Biol (2015) 0.77

Mechanisms of adaptation of the hepatic vasculature to the deteriorating conditions of blood circulation in liver cirrhosis. World J Hepatol (2016) 0.77

Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). J Clin Endocrinol Metab (2015) 0.76

The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. High Alt Med Biol (2015) 0.76

Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors. PLoS One (2014) 0.76

Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro. Angiogenesis (2016) 0.75

The role of endothelial HIF-1 αin the response to sublethal hypoxia in C57BL/6 mouse pups. Lab Invest (2017) 0.75

Loss of endothelial-ARNT in adult mice contributes to dampened circulating proangiogenic cells and delayed wound healing. Vasc Med (2014) 0.75

Endothelial hypoxic metabolism in carcinogenesis and dissemination: HIF-A isoforms are a NO metastatic phenomenon. Oncotarget (2013) 0.75

Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model. Sci Rep (2017) 0.75

Hypoxia and Dysregulated Angiogenesis in Kidney Disease. Kidney Dis (Basel) (2015) 0.75

Restructuring of the vascular bed in response to hemodynamic disturbances in portal hypertension. World J Hepatol (2016) 0.75

Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling. Oncotarget (2017) 0.75

Cyclosporin A promotes tumor angiogenesis in a calcineurin-independent manner by increasing mitochondrial reactive oxygen species. Mol Cancer Res (2014) 0.75

HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver. JCI Insight (2016) 0.75

Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic. Oncogene (2016) 0.75

Endothelial cell metabolism in health and disease: impact of hypoxia. EMBO J (2017) 0.75

Hypoxia-induced suppression of c-Myc by HIF-2α in human pulmonary endothelial cells attenuates TFAM expression. Cell Signal (2017) 0.75

Articles cited by this

Angiogenesis in life, disease and medicine. Nature (2005) 15.36

Purification and characterization of hypoxia-inducible factor 1. J Biol Chem (1995) 8.53

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev (1997) 8.51

Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000. Circulation (2004) 7.30

Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20

Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell (2005) 7.07

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature (2006) 7.01

The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 6.84

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell (2007) 6.16

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell (2009) 5.91

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet (2008) 3.94

Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature (2005) 3.67

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol (2010) 3.61

Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51

VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn (2006) 3.38

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell (2004) 3.28

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer (2007) 2.96

Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev (2007) 2.69

Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest (2010) 2.48

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature (2011) 2.47

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res (2007) 2.43

Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Nat Protoc (2009) 2.34

Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev (2010) 2.26

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? Angiogenesis (2009) 2.15

Blood monocyte concentration is critical for enhancement of collateral artery growth. Am J Physiol Heart Circ Physiol (2002) 1.99

Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest (2008) 1.89

Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr Top Dev Biol (2006) 1.87

Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol (2006) 1.86

Murine model of hindlimb ischemia. J Vis Exp (2009) 1.82

Isolation of endothelial cells from murine tissue. J Immunol Methods (2000) 1.81

Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood (2009) 1.81

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res (2006) 1.77

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. J Biol Chem (2003) 1.60

HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A (2009) 1.59

Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. Circ Res (2007) 1.54

Hypoxia-induced angiogenesis: good and evil. Genes Cancer (2011) 1.52

Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A (2009) 1.43

Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proc Natl Acad Sci U S A (2009) 1.41

Inhibition of myogenesis by Notch: evidence for multiple pathways. J Cell Physiol (2009) 1.28

Anti-VEGF compounds in the treatment of neovascular age related macular degeneration. Curr Drug Targets (2011) 1.27

Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Lab Invest (2005) 1.26

Hypoxia-inducible transcription factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin A1. J Biol Chem (2008) 1.24

Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice. Hepatology (2006) 1.24

Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis. Arterioscler Thromb Vasc Biol (2008) 1.19

Direct isolation, culture and transplant of mouse skeletal muscle derived endothelial cells with angiogenic potential. PLoS One (2008) 1.19

Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia. Biomed Opt Express (2010) 1.18

Novel insights into the differential functions of Notch ligands in vascular formation. J Angiogenes Res (2009) 1.16

Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects. Heart (2010) 1.15

Oxygen-induced retinopathy: a model for vascular pathology in the retina. Eye (Lond) (2009) 1.13

Conditional activation of FGFR1 in the prostate epithelium induces angiogenesis with concomitant differential regulation of Ang-1 and Ang-2. Oncogene (2007) 1.13

Targeted therapies of cancer: angiogenesis inhibition seems not enough. Cancer Lett (2010) 1.12

Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia. Circ Res (2010) 1.10

Regulation of skeletal myogenesis by Notch. Exp Cell Res (2010) 1.08

Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model. Cancer Res (2009) 1.08

Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses. Carcinogenesis (2010) 1.07

Promoting angiogenesis via manipulation of VEGF responsiveness with notch signaling. Biomaterials (2009) 1.00

Adrenomedullin stimulates angiogenic response in cultured human vascular endothelial cells: involvement of the vascular endothelial growth factor receptor 2. Peptides (2008) 0.96

HIF-1alpha versus HIF-2alpha in endothelial cells and vascular functions: is there a master in angiogenesis regulation? Cell Cycle (2009) 0.93

Therapeutic neovascularization for peripheral arterial diseases: advances and perspectives. Histol Histopathol (2007) 0.81

Articles by these authors

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33

Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med (2013) 8.76

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol (2003) 8.12

Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85

The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 6.84

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer (2011) 6.32

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature (2011) 6.21

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell (2007) 6.16

Hypoxia-inducible factors, stem cells, and cancer. Cell (2007) 5.96

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev (2006) 5.15

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell (2008) 4.84

Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev (2007) 4.46

The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol (2008) 4.43

Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev (2007) 4.13

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10

Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology (2008) 3.99

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab (2005) 3.94

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem (2003) 3.88

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest (2007) 3.61

Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation (2013) 3.57

Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A (2007) 3.51

Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat Immunol (2003) 3.24

Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science (2014) 3.19

Assessing the future of diffuse optical imaging technologies for breast cancer management. Med Phys (2008) 3.02

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature (2006) 3.01

Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans. Opt Express (2007) 2.84

The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev (2004) 2.77

Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI. Med Phys (2005) 2.76

Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell (2005) 2.67

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell (2007) 2.58

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood (2010) 2.57

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol (2006) 2.56

Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54

Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.53

Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest (2010) 2.48

HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest (2009) 2.47

O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45

Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest (2003) 2.37

An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature (2002) 2.33

Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy. Clin Cancer Res (2005) 2.33

Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity (2010) 2.32

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol (2006) 2.27

Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults. Neurocrit Care (2010) 2.26

Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev (2010) 2.26

Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood (2008) 2.26

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes. Nature (2009) 2.23

Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation. Opt Lett (2004) 2.12

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets. J Clin Invest (2012) 2.10

Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth. Cancer Res (2005) 2.07

Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy. J Biomed Opt (2007) 2.01

Diffuse optical tomography with spectral constraints and wavelength optimization. Appl Opt (2005) 2.00

Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI. Opt Express (2007) 1.93

Diabetes and poor outcomes within 6 months after acute ischemic stroke: the China National Stroke Registry. Stroke (2011) 1.91

The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. Int J Stroke (2011) 1.90

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol Cell Biol (2009) 1.88

Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr Top Dev Biol (2006) 1.87

HIF-2alpha deletion promotes Kras-driven lung tumor development. Proc Natl Acad Sci U S A (2010) 1.86

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell (2003) 1.85

Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell (2009) 1.84

Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography. J Biomed Opt (2009) 1.82

Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. J Biomed Opt (2009) 1.82

Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood (2009) 1.81

Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement. Neuroimage (2013) 1.77

Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science (2010) 1.77

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects. J Biomed Opt (2010) 1.75

Regulation of transcription and translation by hypoxia. Cancer Biol Ther (2004) 1.74

Regenerative growth is impacted by TCDD: gene expression analysis reveals extracellular matrix modulation. Toxicol Sci (2006) 1.74

Structure of a Shigella effector reveals a new class of ubiquitin ligases. Nat Struct Mol Biol (2008) 1.71

ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell (2012) 1.71

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood (2009) 1.70

Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem (2002) 1.70

Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol (2005) 1.67

Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography. Opt Lett (2003) 1.67

Diffuse optical measurement of blood flow in breast tumors. Opt Lett (2005) 1.65

Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry. J Cereb Blood Flow Metab (2004) 1.64

Genotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cells. Behav Genet (2003) 1.64

Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies. J Biomed Opt (2005) 1.63

Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation. Stroke (2014) 1.62

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene (2008) 1.61