Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation.

PubWeight™: 1.41‹?› | Rank: Top 5%

🔗 View Article (PMID 19001367)

Published in J Biol Chem on November 10, 2008

Authors

Wen-Bing Yin1, Alexander Grundmann, Jun Cheng, Shu-Ming Li

Author Affiliations

1: Philipps-Universität Marburg, Institut für Pharmazeutische Biologie, Deutschhausstrasse 17A, D-35037 Marburg, Germany.

Articles citing this

Advances in Aspergillus secondary metabolite research in the post-genomic era. Nat Prod Rep (2012) 1.75

The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proc Natl Acad Sci U S A (2009) 1.48

Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41

Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis. Biochemistry (2010) 1.33

Anthranilate-activating modules from fungal nonribosomal peptide assembly lines. Biochemistry (2010) 1.25

Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. ACS Chem Biol (2013) 1.08

Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nat Chem Biol (2012) 1.04

A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum. PLoS One (2013) 0.99

Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus. Org Lett (2013) 0.96

Nonribosomal peptide synthetase genes pesL and pes1 are essential for Fumigaclavine C production in Aspergillus fumigatus. Appl Environ Microbiol (2012) 0.94

Biochemical characterization of indole prenyltransferases: filling the last gap of prenylation positions by a 5-dimethylallyltryptophan synthase from Aspergillus clavatus. J Biol Chem (2011) 0.92

Deletion and gene expression analyses define the paxilline biosynthetic gene cluster in Penicillium paxilli. Toxins (Basel) (2013) 0.88

Characterization of cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase in cyclopiazonic acid biosynthesis: substrate promiscuity and site directed mutagenesis studies. Biochemistry (2009) 0.88

A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines. Org Lett (2011) 0.87

Recent advances in genome mining of secondary metabolites in Aspergillus terreus. Front Microbiol (2014) 0.87

Among developmental regulators, StuA but not BrlA is essential for penicillin V production in Penicillium chrysogenum. Appl Environ Microbiol (2010) 0.87

Histone deacetylase inhibitors as a tool to up-regulate new fungal biosynthetic products: isolation of EGM-556, a cyclodepsipeptide, from Microascus sp. Org Lett (2010) 0.85

The tRNA-dependent biosynthesis of modified cyclic dipeptides. Int J Mol Sci (2014) 0.85

Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. ACS Chem Biol (2013) 0.85

Multisite prenylation of 4-substituted tryptophans by dimethylallyltryptophan synthase. J Am Chem Soc (2013) 0.85

Biosynthesis of fungal indole alkaloids. Nat Prod Rep (2014) 0.85

Structure-based engineering increased the catalytic turnover rate of a novel phenazine prenyltransferase. PLoS One (2012) 0.84

Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. J Am Chem Soc (2012) 0.84

Characterization and Engineering of the Adenylation Domain of a NRPS-Like Protein: A Potential Biocatalyst for Aldehyde Generation. ACS Catal (2014) 0.83

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones. Biochemistry (2013) 0.83

Extrolites of Aspergillus fumigatus and Other Pathogenic Species in Aspergillus Section Fumigati. Front Microbiol (2016) 0.81

Oxidative Cyclization in Natural Product Biosynthesis. Chem Rev (2016) 0.81

An iterative, bimodular nonribosomal peptide synthetase that converts anthranilate and tryptophan into tetracyclic asperlicins. Chem Biol (2013) 0.79

Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16. J Antibiot (Tokyo) (2015) 0.79

Tyrosine O-prenyltransferase SirD catalyzes S-, C-, and N-prenylations on tyrosine and tryptophan derivatives. ACS Chem Biol (2013) 0.78

Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biol (2017) 0.75

New Cyclotetrapeptides and a New Diketopiperzine Derivative from the Marine Sponge-Associated Fungus Neosartorya glabra KUFA 0702. Mar Drugs (2016) 0.75

Regiospecificities and prenylation mode specificities of the fungal indole diterpene prenyltransferases AtmD and PaxD. Appl Environ Microbiol (2013) 0.75

Articles by these authors

A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09

Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke (2008) 3.81

Microtubule assembly dynamics at the nanoscale. Curr Biol (2007) 3.02

Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity (2010) 3.00

Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med (2002) 2.90

Ice-shelf collapse from subsurface warming as a trigger for Heinrich events. Proc Natl Acad Sci U S A (2011) 2.83

Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice. Immunity (2011) 2.69

Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet (2003) 2.67

Future cardiovascular disease in china: markov model and risk factor scenario projections from the coronary heart disease policy model-china. Circ Cardiovasc Qual Outcomes (2010) 2.63

Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell (2003) 2.55

Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation (2006) 2.55

Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet (2002) 2.39

Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.28

Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol (2002) 1.94

Drosophila male germline stem cells do not asymmetrically segregate chromosome strands. J Cell Sci (2011) 1.83

Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development (2003) 1.64

Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus. Microbiology (2005) 1.60

CloQ, a prenyltransferase involved in clorobiocin biosynthesis. Proc Natl Acad Sci U S A (2003) 1.50

Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics. Microbiology (2002) 1.49

The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proc Natl Acad Sci U S A (2009) 1.48

The fumitremorgin gene cluster of Aspergillus fumigatus: identification of a gene encoding brevianamide F synthetase. Chembiochem (2006) 1.46

Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg (2004) 1.43

Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus. Chembiochem (2007) 1.42

Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes. Nat Prod Rep (2010) 1.40

Origin of additional capacities in metal oxide lithium-ion battery electrodes. Nat Mater (2013) 1.30

Extracellular matrix remodeling in oral submucous fibrosis: its stage-specific modes revealed by immunohistochemistry and in situ hybridization. J Oral Pathol Med (2005) 1.30

Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus: gene expression, purification, and characterization of fumigaclavine C synthase FGAPT1. Chembiochem (2006) 1.27

Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels. PLoS Genet (2011) 1.25

Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus. Microbiology (2005) 1.22

Fast spin state initialization in a singly charged InAs-GaAs quantum dot by optical cooling. Phys Rev Lett (2007) 1.22

Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J Clin Invest (2006) 1.22

Novel regional and developmental NMDA receptor expression patterns uncovered in NR2C subunit-beta-galactosidase knock-in mice. Mol Cell Neurosci (2007) 1.20

TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest (2009) 1.20

Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040. Arch Microbiol (2002) 1.19

The future impact of population growth and aging on coronary heart disease in China: projections from the Coronary Heart Disease Policy Model-China. BMC Public Health (2008) 1.18

Polarity in stem cell division: asymmetric stem cell division in tissue homeostasis. Cold Spring Harb Perspect Biol (2010) 1.17

Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure. J Biol Chem (2008) 1.16

A 7-dimethylallyltryptophan synthase from Aspergillus fumigatus: overproduction, purification and biochemical characterization. Microbiology (2007) 1.14

The distribution of polar ejection forces determines the amplitude of chromosome directional instability. Curr Biol (2009) 1.13

Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis. Antimicrob Agents Chemother (2004) 1.13

Biosynthesis and accumulation of ergoline alkaloids in a mutualistic association between Ipomoea asarifolia (Convolvulaceae) and a clavicipitalean fungus. Plant Physiol (2008) 1.12

Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells. Dev Biol (2011) 1.10

Tetracycline-regulated transactivators driven by the involucrin promoter to achieve epidermal conditional gene expression. J Invest Dermatol (2004) 1.08

Human Wharton's jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells. Stem Cell Res Ther (2013) 1.08

MicroRNA-503 inhibits the G1/S transition by downregulating cyclin D3 and E2F3 in hepatocellular carcinoma. J Transl Med (2013) 1.08

FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B. Chembiochem (2008) 1.07

Chemoenzymatic synthesis of prenylated indole derivatives by using a 4-dimethylallyltryptophan synthase from Aspergillus fumigatus. Chembiochem (2007) 1.06

Keratin pearl degradation in oral squamous cell carcinoma: reciprocal roles of neutrophils and macrophages. J Oral Pathol Med (2014) 1.06

TRIM29 negatively regulates p53 via inhibition of Tip60. Biochim Biophys Acta (2011) 1.06

Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis. Clin Chim Acta (2010) 1.06

SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines. Neurosci Lett (2012) 1.06

Structure-function analysis of an enzymatic prenyl transfer reaction identifies a reaction chamber with modifiable specificity. J Am Chem Soc (2010) 1.05

Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters. Appl Environ Microbiol (2005) 1.04

Deep RNA-Seq uncovers the peach transcriptome landscape. Plant Mol Biol (2013) 1.03

Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions. Hepatol Int (2010) 1.03

Emergence of keratin 17 vs. loss of keratin 13: their reciprocal immunohistochemical profiles in oral carcinoma in situ. Oral Oncol (2011) 1.01

The alleviation of acute and chronic kidney injury by human Wharton's jelly-derived mesenchymal stromal cells triggered by ischemia-reperfusion injury via an endocrine mechanism. Cytotherapy (2012) 1.00

Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice. Circ Res (2010) 1.00

Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3. Org Biomol Chem (2010) 1.00

Primary malignant melanoma of the esophagus with multiple esophageal lesions. Nat Clin Pract Gastroenterol Hepatol (2007) 1.00

Remodeling of early-phase repolarization: a mechanism of abnormal impulse conduction in heart failure. Circulation (2006) 0.99

A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis. Hum Mol Genet (2010) 0.99

A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin PL. Microbiology (2009) 0.99

Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol (2012) 0.99

Basement membrane-type heparan sulfate proteoglycan (perlecan) and low-density lipoprotein (LDL) are co-localized in granulation tissues: a possible pathogenesis of cholesterol granulomas in jaw cysts. J Oral Pathol Med (2004) 0.98

The 104-week efficacy and safety of telbivudine-based optimization strategy in chronic hepatitis B patients: a randomized, controlled study. Hepatology (2014) 0.98

Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1. Mol Med Rep (2013) 0.98

Microarray analysis of microRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1). BMC Infect Dis (2013) 0.98

CdpNPT, an N-prenyltransferase from Aspergillus fumigatus: overproduction, purification and biochemical characterisation. Chembiochem (2007) 0.97

Transient-outward K+ channel inhibition facilitates L-type Ca2+ current in heart. J Cardiovasc Electrophysiol (2006) 0.97

The surgical treatment and outcome for primary duodenal adenocarcinoma. J Gastrointest Cancer (2010) 0.96

CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. J Biol Chem (2003) 0.95

Remodeling of outward K+ currents in pressure-overload heart failure. J Cardiovasc Electrophysiol (2007) 0.95

Nucleotide sequences and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelial carcinomas. Virus Genes (2005) 0.95

Surgically treated primary malignant tumor of small bowel: a clinical analysis. World J Gastroenterol (2010) 0.95

Function of BKCa channels is reduced in human vascular smooth muscle cells from Han Chinese patients with hypertension. Hypertension (2012) 0.95

Vascular endothelial growth factor in salivary pleomorphic adenomas: one of the reasons for their poorly vascularized stroma. Virchows Arch (2005) 0.95

Preparation of pyrrolo[2,3-b]indoles carrying a beta-configured reverse C3-dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT. Org Biomol Chem (2010) 0.94

Cartilage hair hypoplasia mutations that lead to RMRP promoter inefficiency or RNA transcript instability. Am J Med Genet A (2007) 0.94

CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin. Chembiochem (2003) 0.93

RET proto-oncogene genetic screening of families with multiple endocrine neoplasia type 2 optimizes diagnostic and clinical management in China. Thyroid (2012) 0.93

High relative frequency of oral squamous cell carcinoma in Yemen: qat and tobacco chewing as its aetiological background. Int J Environ Health Res (2007) 0.93

An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. Eur J Biochem (2003) 0.93

Perlecan-rich epithelial linings as a background of proliferative potentials of keratocystic odontogenic tumor. J Oral Pathol Med (2008) 0.92

Biochemical characterization of indole prenyltransferases: filling the last gap of prenylation positions by a 5-dimethylallyltryptophan synthase from Aspergillus clavatus. J Biol Chem (2011) 0.92

Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. Antimicrob Agents Chemother (2003) 0.92

Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase. J Biol Chem (2008) 0.92

Enhanced expression of podoplanin in oral carcinomas in situ and squamous cell carcinomas. Pathobiology (2011) 0.92

Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus ( section sign). J Nat Prod (2009) 0.91

Audiometric findings in workers exposed to low levels of styrene and noise. J Occup Environ Med (2002) 0.91

Heterogeneity of bla(IND) metallo-beta-lactamase-producing Chryseobacterium indologenes isolates detected in Hefei, China. Int J Antimicrob Agents (2008) 0.91

Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489. Microbiology (2004) 0.91

Hepatitis B virus in tenofovir-naive Chinese patients with chronic hepatitis B contains no mutation of rtA194T conferring a reduced tenofovir susceptibility. Chin Med J (Engl) (2009) 0.91

A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol (2013) 0.91

[Study of serum Hcy and polymorphisms of Hcy metabolic enzymes in 192 families affected by congenital heart disease]. Beijing Da Xue Xue Bao (2005) 0.91

Podoplanin expression profiles characteristic of odontogenic tumor-specific tissue architectures. Pathol Res Pract (2012) 0.91