Published in Cytotechnology on July 01, 2004
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry. PLoS One (2016) 1.44
Liver tissue engineering in the evaluation of drug safety. Expert Opin Drug Metab Toxicol (2009) 1.17
Heparin-based hydrogel as a matrix for encapsulation and cultivation of primary hepatocytes. Biomaterials (2010) 1.07
Plasmin triggers a switch-like decrease in thrombospondin-dependent activation of TGF-β1. Biophys J (2012) 0.88
Hepatospheres: Three dimensional cell cultures resemble physiological conditions of the liver. World J Hepatol (2010) 0.88
Layered long-term co-culture of hepatocytes and endothelial cells on a transwell membrane: toward engineering the liver sinusoid. Biofabrication (2013) 0.81
Mesenchymal stromal cells as supportive cells for hepatocytes. Mol Ther (2009) 0.81
Rapid formation of size-controlled three dimensional hetero-cell aggregates using micro-rotation flow for spheroid study. Biomicrofluidics (2011) 0.81
The multi-organ chip--a microfluidic platform for long-term multi-tissue coculture. J Vis Exp (2015) 0.80
Establishment and characterization of an immortalized human hepatic stellate cell line for applications in co-culturing with immortalized human hepatocytes. Int J Med Sci (2015) 0.79
Multiscale tissue engineering for liver reconstruction. Organogenesis (2014) 0.78
Functional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures. Toxicol Res (Camb) (2015) 0.78
Experimental models of liver fibrosis. Arch Toxicol (2015) 0.78
Engraftment of human induced pluripotent stem cell-derived hepatocytes in immunocompetent mice via 3D co-aggregation and encapsulation. Sci Rep (2015) 0.76
Preparation of isolated rat liver cells. Methods Cell Biol (1976) 17.96
Modified reagents for determination of urea and ammonia. Clin Chem (1962) 11.76
A rapid and precise method for the determination of urea. J Clin Pathol (1960) 9.07
An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J Lipid Res (2000) 2.36
Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities. J Cell Biol (1985) 1.90
Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor. Hepatology (1999) 1.72
Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Exp Cell Res (1983) 1.68
Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments. Exp Cell Res (1990) 1.66
The extracellular matrix in hepatic regeneration. FASEB J (1995) 1.65
Liver specification and early morphogenesis. Mech Dev (2000) 1.60
The story of the myofibroblasts. Am J Surg Pathol (1979) 1.53
Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43. Lab Invest (1993) 1.36
Structural polarity and functional bile canaliculi in rat hepatocyte spheroids. Exp Cell Res (2002) 1.33
Hepatic stellate cells. Prog Liver Dis (1996) 1.29
Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels. Ann Surg (1998) 1.29
Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells. Hepatology (1992) 1.27
Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures. J Biomater Sci Polym Ed (1998) 1.26
Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells. Hepatology (2000) 1.21
Oxygen consumption characteristics of porcine hepatocytes. Metab Eng (1999) 1.15
Liver tissue engineering: a role for co-culture systems in modifying hepatocyte function and viability. Tissue Eng (2001) 1.14
Mechanistics of formation and ultrastructural evaluation of hepatocyte spheroids. In Vitro Cell Dev Biol Anim (1996) 1.11
In vitro organogenesis of liver tissue. Ann N Y Acad Sci (1997) 1.07
Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system. Am J Pathol (1995) 1.04
The role of actin filaments and microtubules in hepatocyte spheroid self-assembly. Cell Motil Cytoskeleton (2001) 1.03
Efficient assembly of rat hepatocyte spheroids for tissue engineering applications. Biotechnol Bioeng (1996) 0.99
Identification and partial characterization of a hepatocyte-derived factor promoting proliferation of cultured fat-storing cells (parasinusoidal lipocytes). Hepatology (1992) 0.97
Long-term culture of rat liver cell spheroids in hormonally defined media. Exp Cell Res (1990) 0.97
Molecular mechanisms in the reversible regulation of morphology, proliferation and collagen metabolism in hepatic stellate cells by the three-dimensional structure of the extracellular matrix. J Gastroenterol Hepatol (1998) 0.95
Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s. J Pharmacol Exp Ther (1990) 0.92
Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells. Hepatology (1995) 0.91
Prolonged maintenance of active cytochrome P-450 in adult rat hepatocytes co-cultured with another liver cell type. Hepatology (1984) 0.89
Enhanced cytochrome P450 IA1 activity of self-assembled rat hepatocyte spheroids. Cell Transplant (1999) 0.88
Extended liver-specific functions of porcine hepatocyte spheroids entrapped in collagen gel. In Vitro Cell Dev Biol Anim (1995) 0.88
Evaluation of the function of primary human hepatocytes co-cultured with the human hepatic stellate cell (HSC) line LI90. Int J Artif Organs (1998) 0.84
Metabolic interactions of parenchymal hepatocytes and dividing epithelial cells in co-culture. Biochem J (1988) 0.83
Receding cytochrome P450 activity in disassembling hepatocyte spheroids. Tissue Eng (1999) 0.79
Formation of multicellular spheroids composed of rat hepatocytes. Res Commun Chem Pathol Pharmacol (1992) 0.78
Co-cultures of hepatocytes with epithelial-like cell lines: expression of drug-biotransformation activities by hepatocytes. Cell Biol Toxicol (1991) 0.78
Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Biochem Pharmacol (1996) 0.77
Partial cloning of the M subunit of laminin from adult rat lipocytes: expression of the M subunit by cells isolated from normal and injured liver. Hepatology (1994) 0.77
Reciprocal regulation of prothrombin secretion and tyrosine aminotransferase induction in hepatocytes. Eur J Biochem (1995) 0.77
Rapid formation of multicellular spheroids composed of Propionibacterium acnes pretreated adult rat liver cells by rotary culture and their immunological properties. Res Commun Mol Pathol Pharmacol (1995) 0.77
Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest (2002) 3.90
A kinetic model of quantitative real-time polymerase chain reaction. Biotechnol Bioeng (2005) 1.75
Ovarian carcinoma spheroids disaggregate on type I collagen and invade live human mesothelial cell monolayers. Clin Exp Metastasis (2004) 1.60
Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PLoS One (2008) 1.46
Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity. Genome Biol (2007) 1.41
Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation. Biotechnol Bioeng (2006) 1.40
Engineering cell metabolism for high-density cell culture via manipulation of sugar transport. J Biotechnol (2007) 1.34
Structural polarity and functional bile canaliculi in rat hepatocyte spheroids. Exp Cell Res (2002) 1.33
Convergent transcription confers a bistable switch in Enterococcus faecalis conjugation. Proc Natl Acad Sci U S A (2011) 1.30
Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes. J Biol Chem (2002) 1.29
Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide. J Neurobiol (2005) 1.26
Endothelium-mediated hepatocyte recruitment in the establishment of liver-like tissue in vitro. Tissue Eng (2006) 1.23
Extracellular matrix- and cytoskeleton-dependent changes in cell shape and stiffness. Exp Cell Res (2002) 1.22
Culture systems for pluripotent stem cells. J Biosci Bioeng (2005) 1.19
Defined conditions for development of functional hepatic cells from human embryonic stem cells. Stem Cells Dev (2005) 1.16
Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology (2002) 1.13
Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2). BMC Genomics (2008) 1.12
An auxin surge following fertilization in carrots: a mechanism for regulating plant totipotency. Planta (2002) 1.11
A diffusion-reaction model for DNA microarray assays. J Biotechnol (2004) 1.07
Tweaking biological switches through a better understanding of bistability behavior. Curr Opin Biotechnol (2008) 1.06
Type I collagen structure regulates cell morphology and EGF signaling in primary rat hepatocytes through cAMP-dependent protein kinase A. Mol Biol Cell (2005) 1.06
Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems. J Proteome Res (2010) 1.06
A framework to analyze multiple time series data: a case study with Streptomyces coelicolor. J Ind Microbiol Biotechnol (2005) 1.05
Transcriptome and proteome profiling to understanding the biology of high productivity CHO cells. Mol Biotechnol (2006) 1.05
Systems analysis of N-glycan processing in mammalian cells. PLoS One (2007) 1.03
Transcriptional response of Escherichia coli to temperature shift. Biotechnol Prog (2005) 1.03
Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer. Proc Natl Acad Sci U S A (2013) 1.03
Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment. J Biotechnol (2009) 1.03
Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans. BMC Genomics (2007) 1.02
Non-linear reduction for kinetic models of metabolic reaction networks. Metab Eng (2004) 1.02
Transcriptome dynamics-based operon prediction and verification in Streptomyces coelicolor. Nucleic Acids Res (2007) 1.00
Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS One (2010) 0.99
On metabolic shift to lactate consumption in fed-batch culture of mammalian cells. Metab Eng (2012) 0.99
Fedbatch culture and dynamic nutrient feeding. Adv Biochem Eng Biotechnol (2006) 0.99
A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor. PLoS One (2008) 0.97
Analysis of cellular metabolism of hybridoma cells at distinct physiological states. J Biosci Bioeng (2003) 0.97
Genomic and proteomic exploration of CHO and hybridoma cells under sodium butyrate treatment. Biotechnol Bioeng (2008) 0.97
Mining manufacturing data for discovery of high productivity process characteristics. J Biotechnol (2010) 0.96
In pursuit of a super producer-alternative paths to high producing recombinant mammalian cells. Curr Opin Biotechnol (2007) 0.96
Reaching the depth of the Chinese hamster ovary cell transcriptome. Biotechnol Bioeng (2010) 0.96
Conserved microRNAs in Chinese hamster ovary cell lines. Biotechnol Bioeng (2011) 0.95
Isolation and characterization of a novel population of progenitor cells from unmanipulated rat liver. Liver Transpl (2008) 0.94
An analysis of the use of genomic DNA as a universal reference in two channel DNA microarrays. BMC Genomics (2005) 0.94
Mining bioprocess data: opportunities and challenges. Trends Biotechnol (2008) 0.94
Spheroid culture for enhanced differentiation of human embryonic stem cells to hepatocyte-like cells. Stem Cells Dev (2013) 0.93
Amino acids regulate hepatocyte proliferation through modulation of cyclin D1 expression. J Biol Chem (2003) 0.93
Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2). Microb Biotechnol (2010) 0.93
Molecular portrait of high productivity in recombinant NS0 cells. Biotechnol Bioeng (2007) 0.93
Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways. Trends Biotechnol (2010) 0.92
Engineering cells for cell culture bioprocessing--physiological fundamentals. Adv Biochem Eng Biotechnol (2006) 0.91
Biofilm growth alters regulation of conjugation by a bacterial pheromone. Mol Microbiol (2011) 0.91
Large scale gene expression profiling of metabolic shift of mammalian cells in culture. J Biotechnol (2004) 0.91
Activation of hypoxic response in human embryonic stem cell-derived embryoid bodies. Exp Biol Med (Maywood) (2008) 0.91
Isolation procedure and characterization of multipotent adult progenitor cells from rat bone marrow. Methods Mol Biol (2010) 0.90
Extracellular matrix-dependent myosin dynamics during G1-S phase cell cycle progression in hepatocytes. Exp Cell Res (2004) 0.90
EST sequencing for gene discovery in Chinese hamster ovary cells. Biotechnol Bioeng (2005) 0.90
Advancing mammalian cell culture engineering using genome-scale technologies. Trends Biotechnol (2007) 0.89
Low-glutamine fed-batch cultures of 293-HEK serum-free suspension cells for adenovirus production. Biotechnol Prog (2003) 0.88
A mathematical model for suppression subtractive hybridization. Comp Funct Genomics (2002) 0.88
Comparative transcriptional analysis of mouse hybridoma and recombinant Chinese hamster ovary cells undergoing butyrate treatment. J Biosci Bioeng (2007) 0.88
Bistability versus bimodal distributions in gene regulatory processes from population balance. PLoS Comput Biol (2011) 0.88
Genome-wide inference of regulatory networks in Streptomyces coelicolor. BMC Genomics (2010) 0.88
The role of collagen structure in mitogen stimulation of ERK, cyclin D1 expression, and G1-S progression in rat hepatocytes. J Biol Chem (2003) 0.88
Developing genomic platforms for Chinese hamster ovary cells. Biotechnol Adv (2009) 0.87
A scaffold for the Chinese hamster genome. Biotechnol Bioeng (2007) 0.86
Quality assessment of cross-species hybridization of CHO transcriptome on a mouse DNA oligo microarray. Biotechnol Bioeng (2008) 0.85
A Boolean algorithm for reconstructing the structure of regulatory networks. Metab Eng (2004) 0.85
Stem cell culture engineering - process scale up and beyond. Biotechnol J (2011) 0.85
Global assessment of protein turnover in recombinant antibody producing myeloma cells. J Biotechnol (2010) 0.84
MAPC culture conditions support the derivation of cells with nascent hypoblast features from bone marrow and blastocysts. J Mol Cell Biol (2012) 0.84
Multivariate analysis of cell culture bioprocess data--lactate consumption as process indicator. J Biotechnol (2012) 0.83
Titanium-enriched hydroxyapatite-gelatin scaffolds with osteogenically differentiated progenitor cell aggregates for calvaria bone regeneration. Tissue Eng Part A (2013) 0.82
Global insights into the Chinese hamster and CHO cell transcriptomes. Biotechnol Bioeng (2015) 0.82
A scalable approach for discovering conserved active subnetworks across species. PLoS Comput Biol (2010) 0.82
Reverting cholesterol auxotrophy of NS0 cells by altering epigenetic gene silencing. Biotechnol Bioeng (2006) 0.82
GlycoVis: visualizing glycan distribution in the protein N-glycosylation pathway in mammalian cells. Biotechnol Bioeng (2006) 0.81
Enhanced differentiation of adult bone marrow-derived stem cells to liver lineage in aggregate culture. Tissue Eng Part A (2011) 0.81
Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells. Biotechnol Bioeng (2009) 0.81
Genome sequence of the curdlan-producing Agrobacterium sp. strain ATCC 31749. J Bacteriol (2011) 0.81
17Beta-hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells. J Biotechnol (2005) 0.80
Hypothermic maintenance of hepatocyte spheroids. Cell Transplant (2005) 0.80
Convergent transcription in the butyrolactone regulon in Streptomyces coelicolor confers a bistable genetic switch for antibiotic biosynthesis. PLoS One (2011) 0.80
Dexamethasone effects on rat hepatocyte spheroid formation and function. Tissue Eng (2005) 0.79
Role of intracellular stochasticity in biofilm growth. Insights from population balance modeling. PLoS One (2013) 0.79
The road to regenerative liver therapies: the triumphs, trials and tribulations. Biotechnol Adv (2013) 0.78
Toward genomic cell culture engineering. Cytotechnology (2006) 0.78
MODELING OF GENE REGULATORY PROCESSES BY POPULATION MEDIATED SIGNALING. NEW APPLICATIONS OF POPULATION BALANCES. Chem Eng Sci (2011) 0.78
Large-scale gene expression analysis of cholesterol dependence in NS0 cells. Biotechnol Bioeng (2005) 0.78
Dynamic gene expression for metabolic engineering of mammalian cells in culture. Metab Eng (2013) 0.77
Transcriptome dynamics of transgene amplification in Chinese hamster ovary cells. Biotechnol Bioeng (2013) 0.77
Differential gene expression analysis during porcine hepatocyte spheroid formation. Mamm Genome (2002) 0.76
Mining transcriptome data for function-trait relationship of hyper productivity of recombinant antibody. Biotechnol Bioeng (2009) 0.76
Exploring the transcriptome space of a recombinant BHK cell line through next generation sequencing. Biotechnol Bioeng (2013) 0.76
Characterization of a hollow fiber bioartificial liver device. Artif Organs (2005) 0.76
Unveiling steady-state multiplicity in hybridoma cultures: the cybernetic approach. Biotechnol Bioeng (2003) 0.76
TimeView: for comparative gene expression analysis. Appl Bioinformatics (2006) 0.75
Cell line development for biomanufacturing processes: recent advances and an outlook. Biotechnol Lett (2015) 0.75
Transcriptome data analysis for cell culture processes. Adv Biochem Eng Biotechnol (2012) 0.75