1
|
The diploid genome sequence of an Asian individual.
|
Nature
|
2008
|
46.29
|
2
|
A human gut microbial gene catalogue established by metagenomic sequencing.
|
Nature
|
2010
|
43.63
|
3
|
A draft sequence of the rice genome (Oryza sativa L. ssp. indica).
|
Science
|
2002
|
42.78
|
4
|
International network of cancer genome projects.
|
Nature
|
2010
|
20.35
|
5
|
The sequence and de novo assembly of the giant panda genome.
|
Nature
|
2009
|
15.76
|
6
|
Sequencing of 50 human exomes reveals adaptation to high altitude.
|
Science
|
2010
|
11.27
|
7
|
The genome of the cucumber, Cucumis sativus L.
|
Nat Genet
|
2009
|
8.19
|
8
|
Ancient human genome sequence of an extinct Palaeo-Eskimo.
|
Nature
|
2010
|
7.51
|
9
|
Rapid, low-input, low-bias construction of shotgun fragment libraries by high-density in vitro transposition.
|
Genome Biol
|
2010
|
6.07
|
10
|
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder.
|
Nat Genet
|
2011
|
5.73
|
11
|
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor.
|
Cell
|
2012
|
5.62
|
12
|
Building the sequence map of the human pan-genome.
|
Nat Biotechnol
|
2009
|
5.53
|
13
|
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants.
|
Nat Genet
|
2010
|
5.44
|
14
|
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm.
|
Cell
|
2012
|
5.16
|
15
|
Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes.
|
Nat Biotechnol
|
2011
|
4.84
|
16
|
Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study.
|
BMJ
|
2011
|
4.50
|
17
|
The DNA methylome of human peripheral blood mononuclear cells.
|
PLoS Biol
|
2010
|
4.25
|
18
|
Genome-wide patterns of genetic variation among elite maize inbred lines.
|
Nat Genet
|
2010
|
4.06
|
19
|
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation.
|
Nat Genet
|
2013
|
3.87
|
20
|
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
|
Nat Genet
|
2011
|
3.66
|
21
|
Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors.
|
Prenat Diagn
|
2012
|
3.54
|
22
|
Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome.
|
Genome Res
|
2010
|
3.34
|
23
|
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx).
|
Science
|
2009
|
2.68
|
24
|
Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly.
|
Nat Biotechnol
|
2011
|
2.45
|
25
|
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques.
|
Nat Biotechnol
|
2011
|
2.37
|
26
|
Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing.
|
PLoS One
|
2011
|
2.29
|
27
|
Whole genome DNA methylation analysis based on high throughput sequencing technology.
|
Methods
|
2010
|
2.17
|
28
|
Comprehensive comparison of three commercial human whole-exome capture platforms.
|
Genome Biol
|
2011
|
2.15
|
29
|
Single base-resolution methylome of the silkworm reveals a sparse epigenomic map.
|
Nat Biotechnol
|
2010
|
2.03
|
30
|
A comparison of rice chloroplast genomes.
|
Plant Physiol
|
2004
|
1.85
|
31
|
Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma.
|
PLoS One
|
2010
|
1.82
|
32
|
A microarray analysis of the rice transcriptome and its comparison to Arabidopsis.
|
Genome Res
|
2005
|
1.71
|
33
|
DNA microarray analysis of genome dynamics in Yersinia pestis: insights into bacterial genome microevolution and niche adaptation.
|
J Bacteriol
|
2004
|
1.52
|
34
|
High-resolution mapping of genotype-phenotype relationships in cri du chat syndrome using array comparative genomic hybridization.
|
Am J Hum Genet
|
2005
|
1.51
|
35
|
Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies.
|
BMC Med Genomics
|
2012
|
1.45
|
36
|
Noninvasive prenatal diagnosis of common fetal chromosomal aneuploidies by maternal plasma DNA sequencing.
|
J Matern Fetal Neonatal Med
|
2012
|
1.38
|
37
|
Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias.
|
Cancer Res
|
2009
|
1.35
|
38
|
Microarray analysis of temperature-induced transcriptome of Yersinia pestis.
|
Microbiol Immunol
|
2004
|
1.28
|
39
|
An atlas of DNA methylomes in porcine adipose and muscle tissues.
|
Nat Commun
|
2012
|
1.28
|
40
|
The YH database: the first Asian diploid genome database.
|
Nucleic Acids Res
|
2009
|
1.22
|
41
|
A method for noninvasive detection of fetal large deletions/duplications by low coverage massively parallel sequencing.
|
Prenat Diagn
|
2013
|
1.22
|
42
|
Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing.
|
BMC Genomics
|
2013
|
1.18
|
43
|
Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer.
|
Gigascience
|
2012
|
1.18
|
44
|
The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1.
|
PLoS One
|
2011
|
1.17
|
45
|
Differential DNA methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis.
|
Genome Biol
|
2012
|
1.16
|
46
|
A single cell level based method for copy number variation analysis by low coverage massively parallel sequencing.
|
PLoS One
|
2013
|
1.15
|
47
|
Comparative mRNA and microRNA expression profiling of three genitourinary cancers reveals common hallmarks and cancer-specific molecular events.
|
PLoS One
|
2011
|
1.15
|
48
|
Prenatal detection of aneuploidy and imbalanced chromosomal arrangements by massively parallel sequencing.
|
PLoS One
|
2012
|
1.06
|
49
|
A genome sequence of novel SARS-CoV isolates: the genotype, GD-Ins29, leads to a hypothesis of viral transmission in South China.
|
Genomics Proteomics Bioinformatics
|
2003
|
1.06
|
50
|
Systematic assessment of reduced representation bisulfite sequencing to human blood samples: A promising method for large-sample-scale epigenomic studies.
|
J Biotechnol
|
2011
|
1.05
|
51
|
HIVID: an efficient method to detect HBV integration using low coverage sequencing.
|
Genomics
|
2013
|
1.02
|
52
|
Detecting novel low-abundant transcripts in Drosophila.
|
RNA
|
2005
|
1.02
|
53
|
Gene identification and expression analysis of 86,136 Expressed Sequence Tags (EST) from the rice genome.
|
Genomics Proteomics Bioinformatics
|
2003
|
0.95
|
54
|
Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology.
|
Methods Mol Biol
|
2009
|
0.95
|
55
|
Omics-based profiling of carcinoma of the breast and matched regional lymph node metastasis.
|
Proteomics
|
2008
|
0.95
|
56
|
An improved method for genome wide DNA methylation profiling correlated to transcription and genomic instability in two breast cancer cell lines.
|
BMC Genomics
|
2009
|
0.95
|
57
|
High resolution profiling of human exon methylation by liquid hybridization capture-based bisulfite sequencing.
|
BMC Genomics
|
2011
|
0.94
|
58
|
Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPP1R13L/iASPP.
|
BMC Med Genet
|
2008
|
0.92
|
59
|
A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancer.
|
PLoS One
|
2011
|
0.91
|
60
|
Rapid detection of aneuploidies on a benchtop sequencing platform.
|
Prenat Diagn
|
2013
|
0.87
|
61
|
Multilayered molecular profiling supported the monoclonal origin of metastatic renal cell carcinoma.
|
Int J Cancer
|
2013
|
0.86
|
62
|
High-performance single-chip exon capture allows accurate whole exome sequencing using the Illumina Genome Analyzer.
|
Sci China Life Sci
|
2011
|
0.86
|
63
|
Deep sequencing reveals small RNA characterization of invasive micropapillary carcinomas of the breast.
|
Breast Cancer Res Treat
|
2012
|
0.85
|
64
|
Rare inborn errors associated with chronic hepatitis B virus infection.
|
Hepatology
|
2012
|
0.84
|
65
|
A short-read multiplex sequencing method for reliable, cost-effective and high-throughput genotyping in large-scale studies.
|
Hum Mutat
|
2013
|
0.84
|
66
|
Comprehensive evaluation of SNP identification with the Restriction Enzyme-based Reduced Representation Library (RRL) method.
|
BMC Genomics
|
2012
|
0.82
|
67
|
3D genome tuner: compare multiple circular genomes in a 3D context.
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Genomics Proteomics Bioinformatics
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2009
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0.82
|
68
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Paired-end sequencing of long-range DNA fragments for de novo assembly of large, complex Mammalian genomes by direct intra-molecule ligation.
|
PLoS One
|
2012
|
0.82
|
69
|
High hydrostatic pressure treatment of porcine oocytes before handmade cloning improves developmental competence and cryosurvival.
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Cloning Stem Cells
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2008
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0.81
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70
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Depletion of GRIM-19 accelerates hepatocellular carcinoma invasion via inducing EMT and loss of contact inhibition.
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J Cell Physiol
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2012
|
0.80
|
71
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DNA copy number aberrations in breast cancer by array comparative genomic hybridization.
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Genomics Proteomics Bioinformatics
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2009
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0.80
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72
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Non-invasive fetal sex determination by maternal plasma sequencing and application in X-linked disorder counseling.
|
J Matern Fetal Neonatal Med
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2014
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0.80
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73
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HLA-A gene polymorphism defined by high-resolution sequence-based typing in 161 Northern Chinese Han people.
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Genomics Proteomics Bioinformatics
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2003
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0.80
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74
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Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma.
|
Genome Biol
|
2014
|
0.80
|
75
|
Gene expression profiling in rice young panicle and vegetative organs and identification of panicle-specific genes through known gene functions.
|
Mol Genet Genomics
|
2005
|
0.80
|
76
|
Identification of somatic alterations in stage I lung adenocarcinomas by next-generation sequencing.
|
Genes Chromosomes Cancer
|
2014
|
0.79
|
77
|
A novel approach for identifying the heme-binding proteins from mouse tissues.
|
Genomics Proteomics Bioinformatics
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2003
|
0.79
|
78
|
A novel strategy of natural plant ferritin to protect DNA from oxidative damage during iron oxidation.
|
Free Radic Biol Med
|
2012
|
0.79
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79
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Piglets born from vitrified cloned blastocysts produced with a simplified method of delipation and nuclear transfer.
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Cloning Stem Cells
|
2007
|
0.78
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80
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The DNA sequence, annotation and analysis of human chromosome 3.
|
Nature
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2006
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0.78
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81
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Comparison of gene expression and genome-wide DNA methylation profiling between phenotypically normal cloned pigs and conventionally bred controls.
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PLoS One
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2011
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0.78
|
82
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Osmotic stress induced by sodium chloride, sucrose or trehalose improves cryotolerance and developmental competence of porcine oocytes.
|
Reprod Fertil Dev
|
2009
|
0.78
|
83
|
The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae).
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Peptides
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2008
|
0.76
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84
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Preparing a re-sequencing DNA library of 2 cancer candidate genes using the ligation-by-amplification protocol by two PCR reactions.
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Sci China C Life Sci
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2009
|
0.75
|
85
|
Aseptic minimum volume vitrification technique for porcine parthenogenetically activated blastocyst.
|
Cryo Letters
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2011
|
0.75
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86
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[Correlations between atopy and airway hyperresponsiveness].
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Wei Sheng Yan Jiu
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2002
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0.75
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87
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Flow-through pretreatment with strongly acidic electrolyzed water for hemicellulose removal and enzymatic hydrolysis of corn stover.
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Bioresour Technol
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2012
|
0.75
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88
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Identification of prostate cancer hub genes and therapeutic agents using bioinformatics approach.
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Cancer Biomark
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2017
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0.75
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89
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Mesoscopic simulation studies on micellar phases of Pluronic P103 solution.
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J Mol Model
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2008
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0.75
|
90
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Replication study of RAD54B and GREB1 polymorphisms and risk of PCOS in Han Chinese.
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Reprod Biomed Online
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2013
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0.75
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91
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DNA methylation in peripheral blood cells of pigs cloned by somatic cell nuclear transfer.
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Cell Reprogram
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2011
|
0.75
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92
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High hydrostatic pressure treatment of porcine oocytes induces parthenogenetic activation.
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Cell Reprogram
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2010
|
0.75
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93
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Elevated NaCl concentration improves cryotolerance and developmental competence of porcine oocytes.
|
Reprod Biomed Online
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2009
|
0.75
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