Published in Hepatology on December 01, 2008
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Hepatocyte death: a clear and present danger. Physiol Rev (2010) 2.18
ON/OFF and beyond--a boolean model of apoptosis. PLoS Comput Biol (2009) 1.53
Intracellular localization of the BCL-2 family member BOK and functional implications. Cell Death Differ (2013) 1.40
X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists. J Biol Chem (2009) 1.08
Apoptosis and necrosis in the liver. Compr Physiol (2013) 1.05
Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? J Biol Chem (2012) 0.97
Modeling the TNFα-induced apoptosis pathway in hepatocytes. PLoS One (2011) 0.92
Experimental models of hepatotoxicity related to acute liver failure. Toxicol Appl Pharmacol (2015) 0.88
Primary hepatocytes and their cultures in liver apoptosis research. Arch Toxicol (2013) 0.88
Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes. PLoS One (2014) 0.87
The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers. Hepatology (2009) 0.86
Rejuvenating Bi(d)ology. Oncogene (2012) 0.86
Modeling system states in liver cells: survival, apoptosis and their modifications in response to viral infection. BMC Syst Biol (2009) 0.85
Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo. Proc Natl Acad Sci U S A (2016) 0.82
Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2. Free Radic Biol Med (2016) 0.79
Activation of the JNK-c-Jun pathway in response to irradiation facilitates Fas ligand secretion in hepatoma cells and increases hepatocyte injury. J Exp Clin Cancer Res (2016) 0.78
TRAIL dependent fratricidal killing of gp120 primed hepatocytes by HCV core expressing hepatocytes. PLoS One (2011) 0.76
Mouse genetic background contributes to hepatocyte susceptibility to Fas-mediated apoptosis. Mol Biol Cell (2016) 0.75
Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix. Biotechnol Bioeng (2014) 0.75
Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25
The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol (2008) 20.89
The pathophysiology of mitochondrial cell death. Science (2004) 13.87
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
Two CD95 (APO-1/Fas) signaling pathways. EMBO J (1998) 10.42
Lethal effect of the anti-Fas antibody in mice. Nature (1993) 9.20
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95
Tumor necrosis factor signaling. Cell Death Differ (2003) 8.48
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature (1999) 6.37
Mitochondria as the central control point of apoptosis. Trends Cell Biol (2000) 5.91
CD95's deadly mission in the immune system. Nature (2000) 5.55
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell (2006) 5.18
The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ (2003) 4.72
Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J (1995) 4.68
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56
The CD95 receptor: apoptosis revisited. Cell (2007) 3.13
The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell (2007) 3.13
Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J Cell Biol (1996) 3.13
Apoptosis: the nexus of liver injury and fibrosis. Hepatology (2004) 2.70
A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem (1998) 2.64
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol Cell Biol (2003) 2.50
Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta (2006) 2.18
Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J Biol Chem (2002) 2.10
Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell (2001) 2.02
A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell (2002) 1.82
Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes. Cell Death Differ (2004) 1.81
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Syst Biol (Stevenage) (2006) 1.63
Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med (2000) 1.60
Cytokine regulation of liver injury and repair. Immunol Rev (2000) 1.58
An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep (2002) 1.44
Apoptosis and the liver. Semin Cancer Biol (2000) 1.37
Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J Biol Chem (2002) 1.37
Post-translational modification of Bid has differential effects on its susceptibility to cleavage by caspase 8 or caspase 3. J Biol Chem (2003) 1.17
CD95-induced apoptosis in human liver disease. Semin Liver Dis (1998) 1.10
Induction of antitumor immunity with Fas/APO-1 ligand (CD95L)-transfected neuroblastoma neuro-2a cells. J Immunol (1999) 0.99
The FLIP-side of Fas signaling. Clin Cancer Res (2006) 0.96
cMet and Fas receptor interaction inhibits death-inducing signaling complex formation in endothelial cells. Hypertension (2005) 0.92
Promotion of Fas-mediated apoptosis in Type II cells by high doses of hepatocyte growth factor bypasses the mitochondrial requirement. J Cell Physiol (2007) 0.85
The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol (2008) 20.89
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science (2007) 10.60
Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science (2003) 9.94
ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature (2002) 5.98
Cell death. N Engl J Med (2009) 4.75
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell (2007) 4.22
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature (2002) 3.15
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15
The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell (2007) 3.13
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med (2007) 3.09
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci U S A (2006) 3.06
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol (2003) 3.01
XIAP discriminates between type I and type II FAS-induced apoptosis. Nature (2009) 3.00
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A (2003) 2.91
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med (2003) 2.77
Detection of alcohol consumption in patients with alcoholic liver cirrhosis during the evaluation process for liver transplantation. Liver Transpl (2012) 2.70
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol (2003) 2.69
Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu Rev Immunol (2001) 2.65
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med (2006) 2.65
Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity (2008) 2.62
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell (2007) 2.60
T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol (2005) 2.58
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood (2005) 2.54
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature (2009) 2.54
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev (2012) 2.44
Mcl-1 is essential for germinal center formation and B cell memory. Science (2010) 2.42
Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate. Nat Cell Biol (2004) 2.42
BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J Cell Sci (2002) 2.30
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J (2003) 2.30
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol (2009) 2.27
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol (2013) 2.21
Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic. J Clin Invest (2008) 2.17
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol (2009) 2.05
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat Rev Cancer (2009) 2.02
p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa. Cell Rep (2013) 2.00
Is tumor growth sustained by rare cancer stem cells or dominant clones? Cancer Res (2008) 1.99
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood (2014) 1.97
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol (2007) 1.97
Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution. Hepatology (2006) 1.96
Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling. Cell Host Microbe (2013) 1.95
Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. Blood (2002) 1.91
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med (2002) 1.89
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell (2003) 1.88
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. J Exp Med (2004) 1.83
APOBEC-mediated interference with hepadnavirus production. Hepatology (2005) 1.82
Conformational control of Bax localization and apoptotic activity by Pro168. J Cell Biol (2004) 1.80
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J Exp Med (2008) 1.78
Dasatinib inhibits proinflammatory functions of mature human neutrophils. Blood (2012) 1.75
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J (2007) 1.73
Mcl-1 is essential for the survival of plasma cells. Nat Immunol (2013) 1.73
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity (2009) 1.73
Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nat Biotechnol (2008) 1.70
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell (2012) 1.66
A type III effector antagonizes death receptor signalling during bacterial gut infection. Nature (2013) 1.65
Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection. Hepatology (2005) 1.61
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol (2006) 1.60
The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells. Proc Natl Acad Sci U S A (2002) 1.59
Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. Proc Natl Acad Sci U S A (2007) 1.58
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity (2004) 1.57
Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro. Anesthesiology (2005) 1.55
ON/OFF and beyond--a boolean model of apoptosis. PLoS Comput Biol (2009) 1.53
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa. J Cell Biol (2007) 1.53
Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med (2008) 1.53
Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol (2006) 1.52
T cell survival and function requires the c-Abl tyrosine kinase. Cell Cycle (2008) 1.51
Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death. Genes Dev (2010) 1.51
Tormentil for active ulcerative colitis: an open-label, dose-escalating study. J Clin Gastroenterol (2007) 1.50
Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis. EMBO J (2005) 1.49
Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Mol Cell Biol (2004) 1.48
Pathogenesis of hepatitis B virus infection. World J Gastroenterol (2007) 1.47
Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737. Proc Natl Acad Sci U S A (2011) 1.45
CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers. Nat Immunol (2005) 1.43
GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. Mol Cell (2004) 1.42
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.41
Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response. Blood (2013) 1.41
Comment on "Inhibition of hepatitis B virus replication by APOBEC3G". Science (2004) 1.41
Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci (2007) 1.41
Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes (2009) 1.37
Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA. J Virol (2004) 1.36
Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood (2006) 1.31
Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia. Brain Res (2006) 1.31
The role of the Bcl-2 protein family in cancer. Semin Cancer Biol (2003) 1.31